Equine Product Range
Second Edition
Contents
Antibiotics
Pages 3 - 12
DevomycinPage 4
Metabolites
Pages 27 - 28
Glutalyte Page 28
®
Devomycin DPage 5
Norocillin LAPage 6
Anthelmintics
OpticloxPage 7
Noromectin® Page 30
Pen & Strep®Page 8
Cefenil®Page 9
Sulphonamides
Pages 13 - 18
Norodine 24Page 14
®
Norodine PastePage 16
Pages 29 - 30
Vitamins
Pages 31 - 34
Intravit 12 Page 32
CombivitPage 33
MultivitaminPage 34
®
Norodine® GranulesPage 17
Anti-inflammatories
Pages 19 - 26
Pages 35 - 40
Lignocaine and Adrenaline
Page 36
Multi Derm Range
Page 37
ColvasonePage 20
Norofulvin® PastePage 38
EquinixinPage 21
Norofulvin® Granules
Page 39
FlunixinPage 22
Water for Injections
Page 40
NorocarpPage 24
Loxicom® Injection Page 25
Loxicom® Equine Oral Paste
2
Miscellaneous
Page 26
ContactsPage 41
Products Overview
Page 42 - 43
Antibiotics
3
Devomycin 250mg/ml
Solution for Injection
Presentation
Operator Warnings
A clear, pale yellow sterile aqueous solution containing:
Streptomycin Sulphate 250mg/ml
Do not handle this product if you are sensitised (allergic) to
aminoglycoside antibiotics.
Chlorocresol 1.0mg/ml
In case of accidental contact with skin or eyes, wash the affected area
with plenty of water immediately.
Sodium Metabisulphate 1.0mg/ml
Wash hands after use.
Uses
Devomycin is active against a wide range of Gram-negative organisms
and some Gram-positive pathogens. It is indicated in the treatment of
organisms sensitive to streptomycin. In particular E. coli, Klebsiella spp,
Mycobacterium tuberculosis and some species of Proteus, Pasteurella and
Salmonella.
Use of the product should be based on susceptibility testing of
bacteria isolated from the animal. If this is not possible, therapy should
be based on local (regional, farm level) epidemiological information
about susceptibility of the target bacteria.
Dosage and Administration
For intramuscular injection only.
The injection site should be massaged after administration.
Horses, cattle and sheep: 1ml/25kg for up to 3 days (10mg
streptomycin/kg bw).
For cattle, the maximum dose volume to be administered at a single
site is 10ml and for sheep is 5ml.
Dogs and cats: 1ml/10kg (25mg streptomycin/kg bw).
Care should be taken in computing the dose to avoid overdosage.
Withdrawal Period
Animals must not be slaughtered for human consumption during
treatment. Cattle may be slaughtered for human consumption only
after 16 days from the last treatment.
Milk for human consumption may only be taken from cattle after
48 hours from the last treatment.
Sheep may be slaughtered for human consumption only after 18 days
from the last treatment.
Not to be used in ewes producing milk for human consumption.
Not to be used in horses intended for human consumption.
Treated horses may never be slaughtered for human consumption.
The horse must have been declared as not intended for human
consumption under national horse passport legislation.
Contraindications, Warnings, etc
Contraindicated in cases of known hypersensitivity to the active
ingredients.
Excessive and prolonged administration can lead to interference with
balance and hearing. In extreme cases damage can be permanent.
Cats are the most susceptible animals.
4
Contraindicated in cases of known hypersensitivity to the active
ingredients.
Take particular care when treating animals suffering from renal damage.
Pharmaceutical Precautions
Do not store above 25ºC.
Protect from light.
Following withdrawal of the first dose, use the product within 28 days.
When the container is broached for the first time, using the in-use
shelf-life which is specified on the package insert, the date on which
any product remaining in the container should be discarded should be
worked out. This discard date should be written in the space provided
on the label.
Dispose of any unused product and empty containers in accordance
with guidance from your local waste regulation authority.
Legal Category
POM-V To be supplied only on Veterinary Prescription.
Package Quantities
Multidose vials of 50ml and 100ml.
VM No: 02000/4018
For Animal Treatment Only
Keep out of reach and sight of Children
Devomycin D
Solution for Injection
Presentation
Operator Warnings
A clear pale yellow sterile aqueous solution containing:
Streptomycin Sulphate 150mg/ml
Do not handle this product if you are sensitised (allergic) to
aminoglycoside antibiotics.
Dihydrostreptomycin Sulphate 150mg/ml
Care should be taken to avoid accidental self-injection. In case of
accidental injection seek medical advice.
Chlorocresol 1.0mg/ml
Sodium Metabisulphate 1.0mg/ml
In case of accidental contact with skin or eyes, wash the affected area
with plenty of water immediately.
Uses
Wash hands after use.
For treatment of Horses, Cattle, Sheep, Dogs and Cats.
Devomycin D Injection is active against a wide range of Gram-negative
organisms and some Gram-positive pathogens. It is indicated in the
treatment of organisms sensitive to Streptomycin. Among the more
sensitive to streptomycin in vitro are Actinobacillus equuli, A. Lignieresii,
Actinomyces bovis, Brucella spp, E. coli, Haemophilus spp, Klebsiella
spp, Leptospira canicola and L. ictero-haemorrhagiae, Pseudomonas
aeruginosa and some species of Proteus, Pasteurella and Salmonella.
Pharmaceutical Precautions
Do not store above 25ºC.
Protect from light.
Following withdrawal of the first dose, use the product within 28 days.
Dispose of any unused product and empty containers in accordance
with guidance from your local waste regulation authority
Use of the product should be based on susceptibility testing of
bacteria isolated from the animal. If this is not possible, therapy should
be based on local (regional, farm level) epidemiological information
about susceptibility of the target bacteria.
Legal Category
Dosage and Administration
Multidose vials of 100ml.
For intramuscular injection only.
VM No: 02000/4034
Horses, cattle and sheep: 10mg active ingredients/kg bodyweight
daily (1ml/30kg bodyweight) for a maximum of 3 days.
Dogs and cats: 25mg active ingredients/kg bodyweight daily
(1ml/12kg bodyweight) for a maximum of 3 days.
For Animal Treatment Only
POM-V To be supplied only on Veterinary Prescription.
Package Quantities
Keep out of reach and sight of Children
Care should be taken in computing the dose to avoid overdosage.
Withdrawal Period
Cattle Meat and Offal: 14 days
Cattle Milk: 48 hours
Do not inject more than 10ml of this product into any one injection
site. Failure to heed this warning may lead to residues above the legal
limit in food for human consumption.
Sheep Meat and Offal: 14 days
Not to be used in sheep producing milk for human consumption.
Horses: Not to be used in horses intended for human consumption.
Treated horses may never be slaughtered for human consumption.
The horse must have been declared as not intended for human
consumption under national horse passport legislation.
Contraindications, Warnings, etc
Excessive and prolonged administration can lead to interference with
balance and hearing. In extreme cases damage can be permanent.
Cats are the most susceptible animals.
Contraindicated in cases of known hypersensitivity to the active
ingredients.
Take particular care when treating animals suffering from renal damage.
5
Norocillin® LA
Suspension for Injection
Presentation
Norocillin LA is a sterile white aqueous suspension. Each ml contains:
Benzathine Penicillin 112.5mg
Procaine Penicillin. 150.0mg
Methyl Hydroxybenzoate 0.200% w/v
Propyl Hydroxybenzoate 0.020% w/v as antimicrobial preservatives.
Uses
Norocillin LA is indicated in the treatment of systemic infections
caused by or associated with organisms sensitive to penicillin in Horses,
Dogs and Cats.
Procaine Penicillin when administered by intramuscular injection will
provide effective therapeutic blood levels for approximately 24 hours,
whilst benzathine penicillin is absorbed slowly in the tissue fluid and
maintains blood levels for three to four days.
Hypersensitivity to penicillin may lead to cross reactions to
cephalosporins and vice versa. Allergic reactions to these substances
may occasionally be serious.
1. Do not handle this product if you know you are sensitised, or if you
have been advised not to work with such preparations.
2. Handle this type of product with great care to avoid exposure, taking
all recommended precautions.
3. If you develop symptoms following exposure such as a skin rash, you
should seek medical advice and show the doctor this warning. Swelling
of the face, lips or eyes or difficulty with breathing are more serious
symptoms and require urgent medical attention.
Wash hands after use.
Norocillin LA is of particular value in reducing the number of injections
in a course of penicillin therapy.
Pharmaceutical Precautions
Use of the product should be based on susceptibility testing of the
bacteria isolated from the animal. If this is not possible, therapy should
be based on local epidemiological information.
Protect from light.
Dosage and Administration
By deep intramuscular injection only. This product is recommended for
a single administration only.
Horses: 6mg/kg bodyweight procaine penicillin with 4.5mg/kg
bodyweight benzathine penicillin equivalent to 1ml per 25kg
bodyweight.
Dogs and Cats: 15mg/kg procaine penicillin with 11.25mg/kg
benzathine penicillin equivalent to 1ml per 10kg bodyweight e.g.
Store below 25ºC.
Following withdrawal of the first dose, use the product within 28 days.
Discard unused material.
When the container is broached (opened) for the first time, using the
in-use shelf-life which is specified on this package leaflet, the date on
which any product remaining in the container should be worked out.
This discard date should be written in the space provided on the label.
Keep the container in outer carton.
Dispose of any unused product and empty containers in accordance
with guidance from your local waste regulation authority.
Species Weight Dose Volume
Legal Category
Horses Dogs Cats 500kg 10kg 5kg 20ml
1ml
0.5ml
POM-V To be supplied only on Veterinary Prescription.
Shake the container before use. An appropriately graduated syringe
must be used to allow accurate administration of the required dose
volume. This is particularly important when injecting small dose
volumes. This product is recommended for single administration only.
Withdrawal Periods
Not to be used in horses intended for human consumption. Treated
horses may never be slaughtered for human consumption.
The horse must have been declared as not intended for human
consumption under national horse passport legislation.
Contraindications, Warnings, etc
Contraindicated in known cases of hypersensitivity to penicillins.
Do not inject intravenously.
Care should be taken not to overdose.
Not to be used on very small herbivores such as guinea pigs, gerbils
and hamsters.
6
Not effective against beta-lactamase producing organisms. Penicillins
and cephalosporins may cause hypersensitivity (allergy) following
injection, inhalation, ingestion or skin contact.
Package Quantities
50ml/100ml
VM No: 02000/4057
For Animal Treatment Only
Keep out of reach and sight of Children
Opticlox
Eye Ointment 16.7% w/w
Presentation
Pharmaceutical Precautions
A smooth sterile cream for ophthalmic use.
Do not store above 25ºC.
Each 5g syringe contains:
16.7% w/w Cloxacillin (as cloxacillin benzathine 21.3% w/w)
In a long- acting base.
Each syringe should be used on one occasion only.
Cloxacillin Benzathine is a semi-synthetic penicillin derived from 6
amino-penicillanic acid.
Uses
For the treatment of eye infections caused by Staphylococcus spp, and
Bacillus spp, in cattle, sheep, horses, dogs and cats.
Dosage and Administration
For topical administration only.
Evert the lower eyelid and instil a steady flow of ointment into the
lower conjunctival sac.
Dosage Guide
Unused ointment should be discarded after treatment.
For external use only.
Dispose of any unused product and empty containers in accordance
with guidance from your local waste regulation authority.
Legal Category
POM-V To be supplied only on Veterinary Prescription.
Package Quantities
Opticlox Eye Ointment is supplied in cartons of 4 x 5g syringes.
VM No: 02000/4075
For Animal Treatment Only
Keep out of reach and sight of Children
Cattle and Horses: Approximately 5-10 cm of ointment per eye.
Sheep: Approximately 5 cm of ointment per eye.
Dogs and Cats: Approximately 2 cm of ointment per eye.
Normally a single application only is required; but treatment may be
repeated after 48 to 72 hours if necessary.
For animals with only a single infected eye it is recommended
to prevent cross infection, that both eyes be treated; treating the
uninfected eye first to avoid transferring the infection.
Each syringe should be used on one occasion only.
Withdrawal Period
Withdrawal period: Meat/milk - Nil.
Contraindications, Warnings, etc
Operator Warning
Penicillin/Cephalosporin Sensitivity: Penicillins and cephalosporins
may cause hypersensitivity (allergy) following injection, inhalation,
ingestion or skin contact. Hypersensitivity to penicillins may lead to
cross reactions to cephalosporins and vice versa. Allergic reactions to
these substances may occasionally be serious.
1. Do not handle this product if you know you are sensitised or if you
have been advised not to work with such preparations.
2. Handle this product with great care to avoid exposure, taking all
recommended precautions.
3. If you develop symptoms following exposure such as a skin rash, you
should seek medical advice and show the doctor this warning. Swelling
of the face, lips or eyes or difficulty with breathing, are more serious
symptoms and require urgent medical attention.
Wash hands after use.
7
Pen & Strep®
Suspension for Injection
Presentation
Contraindications, Warnings, etc
A white to off-white aqueous suspension for parenteral administration.
Each ml contains:
Procaine Penicillin 200mg
Contraindicated in known cases of hypersensitivity to penicillins.
Occasionally in sucking and fattening pigs administration of this
product may cause a transient pyrexia, vomiting, shivering, listlessness
and incoordination. Additionally in pregnant sows and gilts, a vulval
discharge which could be associated with abortion, has been reported.
Care should be taken not to exceed the recommended dosage.
Dihydrostreptomycin Sulphate 250mg
Hydroxybenzoate Esters (as Nipasept sodium) as antimicrobial
preservative 1.5mg
Sodium Formaldehyde Sulphoxylate Dihydrate as antioxidant 1.25mg
Uses
Pen & Strep Injection is indicated for use in cattle, horses, pigs and
sheep for the treatment of infections caused by, or associated with,
organisms sensitive to Penicillin and/or Streptomycin including:
Arcanobacterium pyogenes, Erysipelothrix rhusiopathiae, Klebsiella
pneumonia, Listeria spp, Mannheimia haemolytica, Pasteurella multocida,
Staphylococcus spp, Streptococcus spp and Salmonella spp.
Pen & Strep will therefore be effective in the treatment of infections
caused by susceptible organisms including:
Erysipelas; navel/joint ill; respiratory tract infections including
pneumonia and atrophic rhinitis; listeriosis; meningitis; septicaemia;
toxaemia associated with mastitis; urogenital tract infections; enteritis
associated with Salmonella spp, salmonellosis; and the control of
secondary bacterial invaders in diseases of primary viral origin.
The combination of penicillin and dihydrostreptomycin is especially
useful in the treatment of mixed infections involving both
Gram-positive and Gram-negative organisms.
Penicillin/Cephalosporin Sensitivity:
Care should be taken to avoid accidental self-injection. In the case of
accidental self-injection, seek medical advice immediately.
Penicillins and cephalosporins may cause sensitisation following
injection, inhalation, ingestion or skin contact. Sensitivity to penicillins
may lead to cross sensitivity to cephalosporins and vice versa. Allergic
reactions to these substances are occasionally serious.
1. Do not handle this product if you know you are sensitised, or if you
have been advised not to work with such preparations.
2. Handle this product with great care to avoid exposure taking all
recommended precautions.
3. If you develop symptoms following exposure, such as a skin rash,
you should seek medical advice and show the doctor this warning.
Swelling of the face, lips or eyes or difficulty breathing are more serious
symptoms and require urgent medical attention.
4. Wash hands after use.
Pharmaceutical Precautions
Dosage and Administration
Shake the container before use.
The recommended daily dose for cattle, horses, pigs and sheep is
8mg procaine penicillin and 10mg dihydrostreptomycin sulphate
per kg bodyweight achieved by administering 1ml Pen & Strep per
25kg bodyweight. The dose should be given once daily by deep
intramuscular injection for up to three consecutive days. The maximum
dose volume administered at one site should not exceed 15ml for
horses, 6ml for cattle, 3ml for sheep and 1.5ml for pigs.
Do not store above 25ºC. Protect from light.
Withdrawal Period
Following withdrawal of the first dose, use the product within 28 days.
Discard unused material.
Keep container in outer carton.
Dispose of any unused product and empty containers in accordance
with guidance from your local waste regulation authority.
Legal Category
POM-V To be supplied only on Veterinary Prescription.
Animals must not be slaughtered for human consumption during
treatment.
Sheep, Milk: Not to be used in sheep producing milk for human
consumption.
Package Quantities
Sheep, Meat: 31 days.
VM No: 02000/4100
Cattle, Milk: 60 hours. Milk for human consumption must not be taken
during treatment.
For Animal Treatment Only
Cattle, Meat: 23 days.
Pigs, Meat: 18 days.
Horses: Not to be used in horses intended for human consumption.
Treated horses may never be slaughtered for human consumption.
The horse must have been declared as not intended for human
consumption under national horse passport legislation.
8
Operator Warnings
50ml and 100ml vials.
Keep out of reach and sight of Children
Cefenil® 50mg/ml
Powder and Solvent for Solution for
Injection for Cattle, Pigs and Horses
Presentation
Vials containing a powder for solution for injection. Vials contain
either 1g or 4g ceftiofur as the sterile, freeze-dried sodium salt.
Ceftiofur sodium is an off-white to brown coloured powder requiring
reconstitution with water for injection. Each ml reconstituted solution
contains ceftiofur sodium equivalent to 50mg ceftiofur.
In pigs, an appropriately-graduated syringe must be used to allow
accurate administration of the required dose volume. This is particularly
important when injecting piglets weighing less than 16kg.
Do not administer more than 10ml per injection site.
Do not exceed 20 broachings per vial. If more than 20 broachings are
required, the use of a draw-off needle is recommended.
Uses
Contraindications, Warnings etc.
Cattle: Treatment of cattle with acute bacterial respiratory disease in
which Mannheimia haemolytica, Pasteurella multocida or Histophilus
somni sensitive to ceftiofur are involved. Treatment of cattle with acute
interdigital necrobacillosis (foul in the foot) in which Fusobacterium
necrophorum and Bacteroides melaninogenicus are involved.
Do not use in animals previously found to be hypersensitive to
ceftiofur and other b-lactam antibiotics.
Pigs: Treatment of pigs with bacterial respiratory disease in which
Actinobacillus (Haemophilus) pleuropneumoniae, Pasteurella multocida
and/or Streptococcus suis sensitive to ceftiofur are involved.
Horses: Treatment of horses with bacterial respiratory disease in
which Streptococcus spp including Streptococcus zooepidermicus and
Streptococcus equi, Staphylococcus spp and/or Pasteurella spp are involved.
Dosage and Administration
This product is for intramuscular use only. See section 4.5(i). Normal
aseptic injection technique should be practiced.
Reconstitution
1 g vial: reconstitute by adding 20ml of water for injection.
4 g vial: reconstitute by adding 80ml of water for injection.
Directions for Reconstitution
1. Remove stopper overseal from diluent and sterile powder vials.
2. Remove exactly 20ml (80ml) Water for Injections using a sterile 18G
needle and syringe.
3. Inject the exact volume of diluent into sterile powder vial.
4. Shake solution until complete reconstitution of powder occurs.
Rapid addition of diluent maintained at room temperature will give
best results. Normally accepted aseptic technique should be followed
during reconstitution to avoid microbial contamination. The resulting
solution contains 50mg of ceftiofur per ml.
Dosage in Cattle, Pigs and Horses
Target species
Dosage
Dosage of
reconstituted product
Indication
Frequency of administration
Respiratory
disease
Once daily at 24 hour intervals for 3-5
days in total
Do not use in case of known resistance to the active substance.
Do not use in poultry (including eggs) due to risk of spread of
antimicrobial resistance to humans.
Special Warnings for Each Target Species
The administration of antimicrobials to horses under conditions of
stress may be associated with acute diarrhoea, which could be fatal. If
acute diarrhoea is observed, discontinue use of this antimicrobial and
initiate appropriate therapy.
Special Precautions for Use
Cefenil 50mg/ml Powder and Solvent for Solution for Injection selects
for resistant strains such as bacteria carrying extended spectrum
betalactamases (ESBL) and may constitute a risk to human health
if these strains disseminate to humans e.g. via food. For this reason,
Cefenil 50mg/ml Powder and Solvent for Solution for Injection should
be reserved for the treatment of clinical conditions which have
responded poorly, or are expected to respond poorly (refers to very
acute cases when treatment must be initiated without bacteriological
diagnosis) to first line treatment. Official, national and regional
antimicrobial policies should be taken into account when the product
is used.
Increased use, including use of the product deviating from the
instructions given in the SPC, may increase the prevalence of such
resistance.
Whenever possible, Cefenil 50mg/ml Powder and Solvent for Solution
for Injection should only be used based on susceptibility testing.
Cefenil 50mg/ml Powder and Solvent for Solution for Injection is
intended for treatment of individual animals. Do not use for disease
prevention or as a part of herd health programmes. Treatment of
groups of animals should be strictly restricted to ongoing disease
outbreaks according to the approved conditions of use.
Foul in
the foot
Once daily at 24 hour intervals for 3
days in total
If this is not possible, therapy should be based on local (regional, farm
level) epidemiological information about susceptibility of the target
bacteria and may decrease the effectiveness of treatment with other
cephalosporins, due to the potential for cross resistance.
1ml/16kg
Respiratory
disease
Once daily at 24 hour intervals for 3
days in total
In the pig, particular care must be taken to avoid injection into the fat
tissue.
2ml/50kg
Respiratory
disease
Once daily at 24 hour intervals for up
to 10 days in total (or 48 hours after
clinical signs have disappeared)
Avoid repeated injection at the same site.
Cattle
1mg/kg
1ml/50kg
Pigs
3mg/kg
Horses
2mg/kg
9
Cefenil® 50mg/ml
Powder and Solvent for Solution for
Injection for Cattle, Pigs and Horses
Continued
Special precautions to be taken by the person administering the
veterinary medicinal product to animals. Penicillins and cephalosporins
may cause hypersensitivity (allergy) following injection, inhalation,
ingestion or skin contact. Hypersensitivity to penicillins may lead to
cross reactions to cephalosporins and vice versa. Allergic reactions to
these substances may occasionally be serious.
Pharmaceutical Precautions
Do not handle this product if you are sensitised or if you have been
advised not to work with such preparations.
Shelf-life of diluent: 2 years.
Handle this product with great care to avoid exposure, taking all
recommended precautions.
Keep the container in the outer carton in order to protect from light.
If you develop symptoms following exposure such as a skin rash, you
should seek medical advice and show the doctor this warning.
Any reconstituted product remaining after the stated periods should
be discarded.
Swelling of the face, lips or eyes or difficulty with breathing are more
serious symptoms and require urgent medical attention.
Diluent: Store in the refrigerator (2°C to 8°C).
Wash hands after use.
Adverse Reactions (Frequency and Seriousness)
Use of this product may cause transient local discomfort at the site of
the injection.
Hypersensitivity reactions can occasionally occur. In the case of an
allergic reaction, treatment should be stopped.
In pigs, local irritation at the injection site may occur and can persist for
5 days or more.
Use During Pregnancy, Lactation or Lay
Laboratory studies in the rat have not produced any evidence of
teratogenic, foetotoxic or maternotoxic effects.
The safety of the veterinary medicinal product has not been assessed
during pregnancy and lactation in cattle, pigs or horses. Use only
according to the benefit/risk assessment by the responsible veterinarian.
Interaction with Other Medicinal Products and Other
Forms of Interaction
None known.
Overdose (Symptoms, Emergency Procedures, Antidotes),
if Necessary
In cattle, no evidence of systemic toxicity was observed following
administration of an overdose.
In pigs, no evidence of systemic toxicity was observed following the
administration of doses of up to 8 times the recommended dose,
administered daily by intramuscular injection for 15 days.
Withdrawal Periods
Cattle Meat and offal 1 day
Milk zero hours
Pigs Meat and offal 2 days
Not to be used in horses intended for human consumption.
Treated horses may never be slaughtered for human consumption.
The horse must have been declared as not intended for human
consumption under national horse passport legislation.
10
In the absence of compatibility studies, this veterinary medicinal
product must not be mixed with other veterinary medicinal products.
Shelf life of the veterinary medicinal product as packaged for sale: 18 months.
Shelf-life of the veterinary medicinal product after reconstitution: 24 hours.
Store unreconstituted product in the refrigerator (2°C to 8°C).
After reconstitution, store in a refrigerator (2°C to 8°C).
Any unused veterinary medicinal product or waste materials derived
from such veterinary medicinal products should be disposed of in
accordance with local requirements.
Package Quantities
Powder: Type II clear glass vials sealed by bromobutyl stoppers and an
aluminium seal with a cool green (1g) or yellow (4g) flip-off plastic disc.
Diluent: Type I clear glass vials sealed with bromobutyl stoppers and
aluminium caps.
One vial with 1 g Cefenil Sterile Powder with one vial with 20ml Water
for Injections per carton in packs of 1, 6 and 12 presentations.
One vial with 4 g Cefenil Sterile Powder with one vial with 80ml Water
for Injections per carton in packs of 1, 6 and 12 presentations.
Not all pack sizes may be marketed.
Pharmacodynamic Properties
The active ingredient, ceftiofur sodium, is a third-generation cephalosporin
(beta-lactam antibiotic) which acts against both gram-positive and
gram-negative bacteria, including betalactam-producing bacteria. Also its
main metabolite, desfuroylceftiofur, shows some antibacterial activity.
Ceftiofur is a bactericidal antibiotic in vitro which acts by interfering
with bacterial cell-wall synthesis.
In cattle, ceftiofur is active against the following microorganisms
found in respiratory-tract infections: Mannheimia haemolytica,
Pasteurella multocida, Histophilus somni as well as the following bacteria
responsible for acute interdigital necrobacillosis: Fusobacterium
necrophorum and Bacteroides melaninogenicus.
In pigs, ceftiofur is active against the following microorganisms:
Actinobacillus (Haemophilus) pleuropneumoniae, Pasteurella multocida
and/or Streptococcus suis.
In horses, ceftiofur is active against the following microorganisms,
found in respiratory-tract infections: Streptococcus spp (including
Streptococcus zooepidermicus and Streptococcus equi), Staphylococcus
spp, Pasteurella spp. Cell wall synthesis is dependent on enzymes that
are called penicillin-binding proteins (PBP’s).
Bacteria develop resistance to cephalosporins by four basic
mechanisms:
1) altering or acquiring penicillin binding proteins insensitive to an
otherwise effective b-lactam; 2) altering the permeability of the cell to
Cefenil® 50mg/ml
Powder and Solvent for Solution for
Injection for Cattle, Pigs and Horses
Continued
b-lactams; 3) producing b-lactamases that cleave the b-lactam ring of
the molecule, or 4) active efflux.
The following ceftiofur breakpoints are used: 2 μg/mL (Susceptible),
4 μg/mL (Intermediate) and 8 μg/mL (Resistant).
The following Minimum Inhibitory Concentrations (MIC) have been
determined for ceftiofur in European isolates (France, United Kingdom,
Netherlands, Denmark, Germany, Belgium, Italy, Czech Republic, Ireland,
Poland and Spain) collected from diseased animals between 2000
to 2007:
MIC of ceftiofur (μg/mL)
Bacteria species
Origin
Year
No. of
strains
Range
MIC50
MIC90
Pasteurella
multocida
Cattle
2004 to 2006
82
0.0019 – 0.0625
0.003
0.005
Pigs
2004 to 2006
66
0.0019 – 0.0156
0.003
0.006
Mannheimia
haemolytica
Cattle
2004 to 2006
72
0.0019 – 0.0156
0.005
0.008
Haemophilus
somnus
Cattle
2005 to 2007
62
0.0019 – 0.125
0.004
0.02
Actinobacillus
pleuropneumoniae
Pigs
2003 / 2004
58
0.0039 – 0.0312
0.006
0.02
Streptococcus suis
Pigs
2004 to 2006
44
0.0312 – 0.5
0.2
0.3
Fusobacterium
necrophorum
Cattle
2000 to 2006
27
0.015 – 16 0
0.1
0.2
Rhodoccus equi
Horses
2002 to 2003
64
0.5 - 2
0.5
2.0
Streptococcus spp
Horses
2002 to 2003
47
0.5
0.5
0.5
Staphylococcus spp
Horses
2002 to 2003
18
0.5 - 4
0.5
4.0
Pasteurella spp
Horses
2002 to 2003
11
0.5
0.5
0.5
The following ceftiofur breakpoints are used: 2 μg/mL (Susceptible),
4 μg/mL (Intermediate) and 8 μg/mL (Resistant).
Pharmacokinetic Particulars
After intramuscular administration ceftiofur is quickly metabolised to
desfuroylceftiofur which reaches maximum plasma concentration
within 1 hour. The plasma half-life for desfuroylceftiofur is on average
over 9 hours in cattle and 13 hours in pigs. No accumulation has
been shown after several administrations.
Legal Category
POM-V To be supplied only on Veterinary Prescription.
Marketing Authorisation Number
VM No: 02000/4306
For Animal Treatment Only.
Keep out of reach and sight of Children.
11
“ When you are on a great horse, you
“
have the best seat you will ever have.
Sir Winston Churchill
12
Sulphonamides
13
Norodine® 24
Solution for Injection
Presentation
Withdrawal Period
A clear yellow aqueous solution for parenteral administration containing
as active ingredients per ml:
Sulfadiazine 200mg
Milk for human consumption must not be taken from a cow during
treatment.
Trimethoprim 40mg
Animals must not be slaughtered for human consumption during
treatment.
Preservative: Chlorocresol 1mg/ml
Not to be used in horses intended for human consumption.
Antioxidant:
Sodium Formaldehyde Sulphoxylate Dihydrate 1mg/ml
Treated horses may never be slaughtered for human consumption.
Uses
Norodine 24 is indicated in the treatment of acute, subacute and chronic
conditions of bacterial origin in horses, cattle, pigs, dogs and cats.
The therapeutic spectrum includes both Gram-negative and Gram-positive
bacteria including Streptococci, Staphylococci, Actinobacilli, Actinomycae,
Salmonella, Pasteurella, Pneumococci, Proteus, E. coli, Corynebacteria, Vibrio,
Bordetella, Brucella, Klebsiellae and Haemophilae.
It is also indicated in species where there may be an existing antibiotic
drug resistance. Norodine 24 may be administered in respiratory
infections of bacterial origin including rhinitis, pneumonia, bronchitis
and in bacterial infections secondary to viral disease such as viral
pneumonia or mycoplasma infections. It is also indicated in urogenital
tract infections (cystitis, vaginitis, urethritis, nephritis and metritis) and
alimentary tract infections (including neonatal diarrhoea and
salmonellosis). Other infections include foul-in-the-foot, severe mastitis,
bacterial agalactia of sows, and infections of eye, ear and mouth.
Dosage and Administration
For cattle and pigs the dose is 1ml per 16kg bodyweight daily by
intramuscular or slow intravenous injection.
Norodine 24 may be administered by intravenous injection when rapid
blood levels of sulfadiazine and trimethoprim are required.
For horses the dose is 1ml per 16kg bodyweight by slow intravenous
injection.
For dogs and cats the dose is 1ml per 8kg bodyweight, by subcutaneous
injection only. The recommended site in dogs is the loose skin at the
top of the neck. A single injection may be sufficient in uncomplicated
conditions, but in severe infections they may be repeated daily until
two days after the symptoms resolve, up to a maximum of 5 days.
An appropriately graduated syringe must be used to allow accurate
administration of the required dose volume. This is particularly important
when injecting small volumes.
Advice on Correct Administration
Injections should not be given by routes other than those recommended.
Not to be administered intraperitoneally.
14
The horse must have been declared as not intended for human
consumption under national horse passport legislation.
Cattle: Meat 12 days
Milk 48 hours
Pigs: Meat 20 days
Contraindications, Warnings, etc
Norodine 24 is contraindicated in animals with known sulfonamide
sensitivity, severe liver parenchymal damage, or blood dyscrasias.
If you notice any serious effects or other effects not mentioned in this
leaflet, please inform your veterinary surgeon.
Pharmaceutical Precautions
Do not store above 25ºC. Protect from freezing. Crystallization of the
product at low temperatures can be reversed by gentle warming.
Protect from light.
Following withdrawal of the first dose, use the product within 28 days.
Discard unused material.
Adequate drinking water should be available during the therapeutic
effect of the product.
Do not administer to horses exhibiting drug-induced cardiac arrhythmias.
Such arrhythmias may be associated with the administration of certain
anaesthetic and sedative agents. Anaphylactic shock, potentially fatal,
has been observed on rare occasions following administration of
potentiated sulfonamide preparations, particularly by the intravenous
route.
Veterinary surgeons should be mindful of this possibility during the
injection process. For intravenous administration the product should
be warmed to body temperature and injected slowly over as long a
period as is reasonably practical.
At the first sign of intolerance the injection should be interrupted and
shock treatment initiated.
Dispose of any unused product and empty containers in accordance
with guidance from your local waste regulation authority.
Norodine® 24
Solution for Injection
Continued
User Warnings
Legal Category
Care should be taken to avoid accidental self-injection and contact
with the skin.
POM-V To be supplied only on Veterinary Prescription.
Wash hands after use.
Package Quantities
Sulphonamides may cause hypersensitivity (allergy) following injection,
inhalation, ingestion or skin contact. Hypersensitivity to sulphonamides
may lead to cross reactions with other antibiotics.
Multidose vials of 50ml and 100ml.
Allergic reactions to these substances may occasionally be serious.
For Animal Treatment Only
1. Do not handle this product if you know you are sensitive to
sulphonamides.
Keep out of reach and sight of Children
Not all pack sizes may be marketed.
VM No: 02000/4061
2. If you develop symptoms following exposure such as a skin rash, you
should seek medical advice and show the doctor this warning.
Further Information
When the container is broached (opened) for the first time, using the
in-use shelf-life which is specified on this package insert, the date on
which any product remaining in the container should be discarded
should be worked out. This discard date should be written in the space
provided on the label.
15
Norodine®
Equine Oral Paste
Presentation
Contraindications, Warnings, etc
Each syringe contains 45g of oral paste containing:
Trimethoprim 5.80% w/w
Sulfadiazine 28.83% w/w
Do not use in cases of known hypersensitivity, severe hepatic
dysfunction or cardiac arrhythmias. Do not use the same syringe to
treat more than one animal unless horses are running together or in
direct contact with each other on the same premises. The product can
be safely administered during pregnancy and lactation.
Uses
Indicated in the treatment of bacterial infections in horses caused
by sensitive microorganisms including: Escherichia coli, Rhodococcus
(Corynebacterium) equi, Staphylococcus spp and Streptococcus spp.
Norodine Equine Paste may be effective in treating the following
conditions. Alimentary tract infections including diarrhoea. Respiratory
infections including pneumonia, pleurisy, strangles. Wounds,
septicaemia and general infections.
Use of the following product should be based on susceptibility testing
and take into account official and local antimicrobial policies.
Take care to avoid skin and eye contact.
Gloves and suitable eye protection should be worn whilst handling
this product.
Wash hands and exposed skin after use.
Sulphonamides may cause hypersensitivity (allergy) following injection,
inhalation, ingestion or skin contact. Hypersensitivity to sulphonamides
may lead to cross reactions with other antibiotics. Allergic reactions to
these substances may occasionally be serious.
Dosage and Administration
1. Do not handle this product if you know you are sensitive to
sulphonamides.
Dosages: The daily dose is 30mg combined active ingredients per kg
bodyweight.
2. If you develop symptoms following exposure such as a skin rash, you
should seek medical advice and show the doctor this warning.
Each syringe provides one daily dose for a 500kg horse. Each division
on the dial-a-dose plunger provides sufficient product to treat 50kg of
bodyweight.
Treatment should be continued for up to five days or until two days
after symptoms have resolved. Drug absorption may be greater if food
is withheld for a few hours prior to dosing.
Administration: Adjust screw gauge on dial-a-dose plunger to the
bodyweight of the horse. Remove cap from nozzle. Place nozzle in
corner of mouth. Depress plunger depositing paste on upper surface
of tongue. Replace cap after use.
Pharmaceutical Precautions
Do not store above 25°C. Do not freeze.
Dispose of any unused product and empty containers in accordance
with guidance from your local waste regulation authority.
Legal Category
POM-V To be supplied only on Veterinary Prescription.
Package Quantities
3 x 45g dial-a-dose Syringe.
Withdrawal Period
VM No: 02000/4098
Not to be used in horses intended for human consumption.
For Animal Treatment Only
Treated horses may never be slaughtered for human consumption.
Keep out of reach and sight of Children
The horse must have been declared as not intended for human
consumption under national horse passport legislation.
16
Norodine®
Granules
Presentation
Withdrawal Period
White to off-white granules with broad-spectrum antibacterial activity.
Presented in aluminium foil sachets. Norodine Granules are for oral
administration to horses after mixing with feed.
Not to be used in horses intended for human consumption.
Each sachet contains 37.5 g of product containing:
Trimethoprim 2.5g
Sulfadiazine 12.5g
Uses
For the treatment of bacterial infections in horses.
Norodine is a broad-spectrum antibacterial, active against a wide range
of Gram-positive and Gram-negative organisms.
Together the active ingredients produce a double blockade of folinic
acid synthesis in bacteria resulting in a level of activity much greater
than that obtained from either drug alone.
In vitro Norodine is effective against Escherichia coli, Rhodococcus equi,
Staphylococcus spp and Streptococcus spp.
When susceptible organisms are present Norodine Granules may be
effective in treating the following conditions:
Alimentary tract infections including diarrhoea.
Respiratory tract infections including pneumonia, pleurisy and strangles.
Treated horses may never be slaughtered for human consumption.
The horse must have been declared as not intended for human
consumption under national horse passport legislation.
Contraindications, Warnings, etc
Do not use in horses with known sulphonamide sensitivity, with
hepatic damage or with blood dyscrasias. If you notice any serious
effects or other effects not mentioned in this leaflet, please inform your
veterinary surgeon.
Operator Warnings
Avoid inhalation and take care to avoid skin and eye contact. Gloves
and suitable eye protection should be worn whilst handling this
product.
Wash hands and exposed skin after use.
Sulphonamides may cause hypersensitivity (allergy) following injection,
inhalation, ingestion or skin contact. Hypersensitivity to sulphonamides
may lead to cross reactions with other antibiotics. Allergic reactions to
these substances may occasionally be serious.
Wounds, septicaemia and general infections.
1. Do not handle this product if you know you are sensitive to
sulphonamides.
Use of the product should be based on susceptibility testing and take
into account official and local antimicrobial policies.
2. If you develop symptoms following exposure such as a skin rash, you
should seek medical advice and show the doctor this warning.
Dosage and Administration
Pharmaceutical Precautions
Dosage: The daily dose is 30mg combined active ingredients per
kg bodyweight (25mg sulfadiazine and 5mg trimethoprim per kg
bodyweight). Each sachet contains one daily dose for a 500kg horse.
Any unused drug in open sachets remaining after the course of
treatment should be discarded.
Daily Dosage Guide:
Bodyweight 100kg 200kg 300kg 400kg 500kg Weight of Norodine Granules 7.5g 15g 22.5g 30g 37.5g Number
of Scoops
½
1
1½
2
Whole Sachet
Treatment should be continued for up to 5 days or until 2 days after
symptoms have resolved.
The scoop provided dispenses 15g of granules.
Administration
Do not store above 25ºC.
Dispose of any unused product, unused medicated feed and empty
containers in accordance with guidance from your local waste
regulation authority.
Legal Category
POM-V To be supplied only on Veterinary Prescription.
Package Quantities
Cartons of 10 sachets, each sachet containing 37.5g of Norodine Granules.
VM No: 02000/4114
For Animal Treatment Only
Keep out of reach and sight of Children
After careful estimation of the weight of the horse, the required dose of
Norodine Granules should be mixed well with the horse’s feed prior to
administration.
Add to feed immediately before administration.
Discard any remaining medicated feed.
17
“
“ A horse! A horse! My kingdom for a horse!
William Shakespeare (Richard III)
18
Anti-inflammatories
19
Colvasone 0.2% w/v
Solution for Injection
Presentation
A sterile solution for injection containing:
Dexamethasone Sodium Phosphate 2mg/ml
Benzyl Alcohol as preservative 20mg/ml
Uses
Dexamethasone is a synthetic corticosteroid with a potent
anti-inflammatory action: Colvasone can be used for:
1. Intravenous therapy in cases where emergency treatment is
indicated, particularly shock and circulatory collapse, fog fever, acute
mastitis and burns.
2. Acetonaemia (Ketosis) in cattle: Colvasone has a marked glucogenic action.
3. Inflammatory conditions in all species: Colvasone will suppress
inflammation and is indicated in the treatment of arthritis, laminitis
(excluding horses), dermititis, etc.
Dosage and Administration
By intravenous or intramuscular injection.
Normal aseptic precautions should be observed.
Horses and cattle: 1ml per 25kg bodyweight
Dogs and cats: 1ml per 10kg bodyweight
Animal Weight kg Dose
Horses
Cattle Dogs
Cats 500kg
400kg 10kg 5kg 20ml
16ml
1ml
0.5ml
To ensure accuracy of dosing, a suitably graduated syringe should be
used when treating small animals.
Withdrawal Period
Cattle must not be slaughted for human consumption during
treatment. Cattle may be slaughtered for human consumption only
after 21 days from the last treatment. Milk must not be taken for
human consumption during treatment. Milk for human consumption
may be taken from cows only from 84 hours after the last treatment.
Do not use in horses intended for human consumption.
Contraindications, Warnings, etc
Care should be taken to avoid accidental self-injection.
Consideration should therefore be given to means of minimising
problems of adrenal insufficiency following the withdrawal of
treatment, e.g. a gradual reduction of dosage (for further discussion see
standard texts).
Systemically acting corticosteroids may cause polyuria, polydipsia and
polyphagia, particularly during the early stages of therapy.
Some corticosteroids may cause sodium and water retention and
hypokalaemia in long term use. Systemic corticosteroids have caused
deposition of calcium in the skin (calcinosis cutis). Corticosteroids are
not recommended for use in pregnant animals. Administration in early
pregnancy is known to have caused foetal abnormalities in laboratory
animals. Administration in late pregnancy may cause early parturition
or abortion.
Corticosteroids may delay wound healing and the immunosuppressant
actions may weaken resistance to or exacerbate existing infections. In
the presence of bacterial infection, anti-bacterial drug cover is usually
required when steroids are used. In the presence of viral infections,
steroids may worsen or hasten the progress of the disease. Gastrointestinal
ulceration has been reported in animals treated with corticosteroids and
gastrointestinal ulceration may be exacerbated by steroids in patients
given non-steroidal anti-inflammatory drugs and in corticosteroid-treated
animals with spinal cord trauma. Steroids may cause enlargement of the
liver (hepatomegaly) with increased serum hepatic enzymes.
Use of the product in horses could induce laminitis and therefore
careful observations during treatment should be made.
During a course of treatment the situation should be reviewed
frequently by close veterinary supervision.
Pharmaceutical Precautions
Do not store above 25°C.
Once a vial has been broached, the contents should be used within
28 days.
Discard any unused material. Dispose of any unused product and
empty containers in accordance with guidance from your local waste
regulation authority.
Systemic corticosteroid therapy is generally contraindicated in patients
with renal disease and diabetes mellitus.
Wash hands after use.
Anti-inflammatory corticosteroids, such as dexamethasone, are known
to exert a wide range of side effects. Whilst single high doses are
generally well tolerated, they may induce severe side-effects in long
term use and when esters possessing a long duration of action are
administered.
Legal Category
Dosage in medium to long term use should therefore generally
be kept to the minimum necessary to control symptoms. Steroids
themselves, during treatment, may cause Cushingoid symptoms
involving significant alteration of fat, carbohydrate, protein and mineral
20
metabolism, e.g. redistribution of body fat, muscle weakness and
wastage and osteoporosis may result.
During therapy effective doses suppress the Hypothalamo-PituitrealAdrenal axis. Following cessation of treatment, symptoms of adrenal
insufficiency extending to adrenocorticol atrophy can arise and this may
render the animal unable to deal adequately with stressful situations.
POM-V To be supplied only on Veterinary Prescription.
Package Quantities
Multidose vials of 50ml.
VM No: 02000/4009
For Animal Treatment Only
Keep out of reach and sight of Children
Equinixin 2.5% w/w
Granules for Horses
Presentation
White to cream coloured granules containing:
250mg Flunixin, as Flunixin Meglumine per 10 gram sachet.
Uses
Flunixin meglumine is a relatively potent non-narcotic, non-steroidal
analgesic with anti-inflammatory and anti-pyretic properties for use in
treating horses.
Horses intended for racing and competition should be prevented from
racing or competing when in need of treatment and horses which
have been recently treated should be dealt with according to local
requirements.
Appropriate precautions must be taken to ensure compliance with
competition regulations.
If adverse reactions occur, treatment should be discontinued and the
advice of a veterinarian should be sought.
In the horse, Equinixin Granules are indicated for the alleviation of
inflammation and pain associated with musculoskeletal disorders.
Overdosage is associated with gastrointestinal toxicity.
Dosage and Administration
Avoid inhalation, contact with eyes and direct contact with skin. In
case of spillage onto skin wash immediately with water. In the case of
accidental contact with eyes, rinse immediately with plenty of water
and seek medical advice.
Equinixin Granules is indicated for oral administration to horses. Easily
administered by sprinkling on a small amount of food. Add to feed
immediately before administration.
Discard any remaining medicated feed. The recommended dosage is the
contents of one sachet (10 grams) Equinixin Granules per 227kg (500 lbs)
bodyweight (equivalent to 1.1mg flunixin per kg) once daily for up to 5
consecutive days according to clinical response.
Withdrawal Period
Horses may be slaughtered for human consumption only after 15 days
from the last treatment.
Operator Warnings
To avoid possible sensitisation reactions, avoid contact with the skin.
Gloves should be worn during application.
Wash hands after use.
The product may cause reactions in sensitive individuals. If you have
known hypersensitivity for non-steroidal anti-inflammatory products
do not handle the product.
Reactions may be serious.
Do not use in mares producing milk for human consumption.
Pharmaceutical Precautions
Contraindications, Warnings, etc
Do not store above 25°C.
Do not administer the product to pregnant mares.
Do not administer other non-steroidal anti-inflammatory drugs
(NSAIDs) concurrently or within 24 hours of each other. Some NSAIDs
may be highly bound to plasma proteins and compete with other
highly bound drugs which can lead to toxic effects.
Keep the sachet in the outer carton.
Gastrointestinal tract ulceration may be exacerbated by corticosteroids
in patients given NSAIDs.
POM-V To be supplied only on Veterinary Prescription.
Concurrent administration of potentially nephrotoxic drugs should be
avoided.
Package Quantities
It is preferable that NSAID’s which inhibit prostaglandin synthesis are
not administered to animals undergoing general anaesthesia until fully
recovered.
Use is contraindicated in animals suffering from cardiac, hepatic
or renal disease, where there is the possibility of gastrointestinal
ulceration or bleeding, where there is evidence of a blood dyscrasia or
hypersensitivity to the product.
Dispose of any unused product and empty containers in accordance
with guidance from your local waste regulation authority.
Legal Category
10 gram laminated foil sachets containing white to cream coloured
granules. Cartons of 10 sachets, each sachet contains 250mg of Flunixin.
VM No: 02000/4241
For Animal Treatment Only
Keep out of reach and sight of Children
Do not exceed the recommended dose or the duration of treatment.
Use in any animal less than 6 weeks of age or in aged animals may
involve additional risk. If such use cannot be avoided animals may
require a reduced dosage and careful clinical management.
Avoid use in any dehydrated, hypovolaemic or hypotensive animals, as
there is a potential risk of increased renal toxicity.
21
Flunixin 50mg/ml
Solution for Injection for
Cattle, Horses and Pigs
Presentation
Withdrawal Period
Flunixin Injection is a clear colourless solution for injection containing, per ml:
Flunixin, as Flunixin Meglumine 50mg
Cattle: Meat: 7 Days
Milk: 36 Hours
Phenol, as preservative 5mg
Horses: Meat: 7 Days
Sodium Formaldehyde Sulphoxylate Dihydrate 2.5mg
Pigs: Meat: 22 Days
Uses
Do not use in mares producing milk for human consumption.
Flunixin meglumine is a relatively potent non-narcotic, non-steroidal
analgesic with anti-inflammatory, anti-endotoxic and anti-pyretic properties.
In horses, indicated for the alleviation of inflammation and pain
associated with musculoskeletal disorders and for the alleviation of
visceral pain associated with colic, also indicated for the treatment
of endotoxaemia or septic shock associated with gastric torsion
and for other conditions in which the circulation of the blood to the
gastrointestinal tract is compromised.
Contraindications, Warnings, etc
In cattle, indicated for the control of acute inflammation associated
with respiratory disease. It may also be used as adjunctive therapy in
the treatment of acute mastitis.
In Pigs, Flunixin Injection is indicated as an adjunctive therapy in the
treatment of swine respiratory diseases.
Dosage and Administration
Flunixin Injection is indicated for intravenous administration to cattle
and horses and intramuscular injection to pigs.
Horses: For use in equine colic, the recommended dose rate is 1.1mg
flunixin/kg bodyweight equivalent to 1ml per 45kg bodyweight.
Treatment may be repeated once or twice if colic recurs.
For use in musculoskeletal disorders, the recommended dose rate is
1.1mg flunixin/kg bodyweight equivalent to 1ml per 45kg bodyweight,
once daily for up to 5 days according to clinical response.
For the treatment of endotoxaemia or septic shock associated with
gastric torsion and with other conditions in which the circulation of
blood to the gastrointestinal tract is compromised: 0.25mg/kg (1ml per
200kg) every 6-8 hours.
Cattle: The recommended dose rate is 2.2mg flunixin/kg bodyweight
equivalent to 2ml per 45kg bodyweight. Repeat as necessary at 24
hour intervals for up to 5 consecutive days.
Pigs: For use in pigs, the recommended dose rate is 2ml per 45kg
bodyweight (equivalent to 2.2mg flunixin/kg) once by intramuscular
injection, in the neck, in conjunction with appropriate antimicrobial
therapy. The injection volume should be limited to a maximum of 5ml
per injection site. The stopper should not be punctured more than 50
times. A draw off needle should be used to avoid excessive puncturing
of the stopper.
Do not exceed the recommended dose or duration of treatment.
An appropriately graduated syringe must be used to allow accurate
administration of the required dose volume. This is particularly
important when injecting small volumes. Cattle should be treated
with flunixin in conjunction with disease-specific therapy and an
improvement in housing conditions.
The use of flunixin in conjunction with disease-specific antibiotic
therapy may mask antibiotic resistance of the bacteria, due to
alleviation of inflammation symptoms.
22
Do not exceed the recommended dose or the duration of treatment.
Use is contraindicated in animals suffering from cardiac, hepatic
or renal disease, where there is the possibility of gastro-intestinal
ulceration or bleeding, where there is evidence of a blood dyscrasia or
hypersensitivity to the product.
Do not use in dehydrated animals suffering from ileus associated colic.
The cause of the underlying inflammatory condition or colic should be
determined and treated with appropriate concomitant therapy.
Non-steroidal anti-inflammatory drugs are not permitted under the
Rules of Racing and under rules covering other competitive events.
Horses intended for racing and competition should be prevented from
racing or competing when in need of treatment and horses which
have been Flunixin Injection recently treated should be dealt with
according to local requirements. Appropriate precautions must be
taken to ensure compliance with competition regulations.
Due to the excipient propylene glycol, life-threatening shock reactions
may occur in rare cases. The solution for injection should therefore be
injected slowly and be of approximate body temperature.
Avoid intra-arterial injection.
Use in any animal less than 6 weeks of age or in aged animals may
involve additional risk. If such use cannot be avoided animals may
require a reduced dosage and careful clinical management.
Do not use in piglets weighing less than 6kg.
Avoid use in any dehydrated, hypovolaemic or hypotensive animal
except in the case of endotoxaemia or septic shock.
It is preferable that NSAIDs, which inhibit prostaglandin synthesis are
not administered to animals undergoing general anaesthesia until fully
recovered.
Flunixin meglumine is a non-steroidal anti-inflammatory drug (NSAID).
Untoward effects include gastrointestinal irritation, ulceration and, in
dehydrated or hypovolaemic animals, potential for renal damage.
In pigs, transient irritation may occur at the injection site, this resolves
spontaneously within 14 days.
Rare cases of anaphylactic reaction have been reported.
May be used in pregnant and lactating cattle.
Do not administer to pregnant mares.
Do not administer to pregnant sows, gilts at mating and in breeding
boars.
Safety studies in pregnant mares or sows have not been conducted.
The product should not be used in lactating sows.
Monitor drug compatibility closely where adjunctive therapy is required.
Do not administer other non-steroidal anti-inflammatory drugs (NSAIDs)
concurrently or within 24 hours of each other.
Flunixin 50mg/ml
Solution for Injection for
Cattle, Horses and Pigs
Continued
Some NSAIDs may be highly bound to plasma proteins and compete
with other highly bound drugs which can lead to toxic effects.
Concurrent administration of potentially nephrotoxic drugs should
be avoided.
Overdose studies in the target species have shown the product to be
well tolerated. Overdosage is associated with gastrointestinal toxicity.
In the absence of incompatibility studies, this medicinal product must
not be mixed with other medicinal products.
Operator Warnings
Avoid eye contact and direct contact with skin.
In the case of accidental contact with eyes, rinse immediately with
plenty of water and seek medical advice.
Avoid accidental self-injection.
To avoid possible sensitisation reactions, avoid contact with the skin.
Gloves should be worn during application.
The product may cause reactions in sensitive individuals. If you have
known hypersensitivity for non-steroidal anti-inflammatory products
do not handle the product.
Reactions may be serious.
Wash hands after use.
Pharmaceutical Precautions
Do not store above 25°C.
Keep the vial in the outer carton to protect from light.
Avoid introduction of contamination.
Following withdrawal of the first dose, use the product within 28 days.
Discard unused product.
Dispose of any unused product and empty containers in accordance
with guidance from your local waste regulation authority.
Legal Category
POM-V To be supplied only on Veterinary Prescription.
Package Quantities
Multi-dose vials of 50ml, 100ml and 250ml.
VM No: 02000/4170
For Animal Treatment Only
Keep out of reach and sight of Children
23
Norocarp 50mg/ml
Solution for Injection for
Cattle and Horses
Presentation
Norocarp 50mg/ml Solution for Injection for Cattle and Horses is a clear
colourless to pale yellow solution for injection, containing: Carprofen 50mg/ml
Ethanol (as preservative) 100μl/ml
Sodium Formaldehyde Sulphoxylate (as antioxidant) 2mg/ml
Uses
Carprofen is a non-steroidal anti-inflammatory drug (NSAID) with
analgesic and anti-pyretic properties. In young cattle (under 12 months
old) the product is indicated as adjunctive therapy for the control of
acute inflammation associated with respiratory disease. The cause of
the condition should be determined and treated with an appropriate
antimicrobial. In horses and ponies, it is indicated for analgesic and
anti-inflammatory action in musculoskeletal disorders and after surgery.
Dosage and Administration
Do not use in animals suffering from cardiac, hepatic, or renal disease,
where there is a possibility of gastrointestinal ulceration or bleeding, or
where there is evidence of a blood dyscrasia or hypersensitivity to the
product.
Adverse Reactions
If adverse reactions occur, use of the product should be stopped and
the advice of a veterinarian should be sought. Typical undesirable effects
associated with NSAID administration such as faecal occult blood, loss
of appetite and lethargy have been reported. These adverse reactions
occur generally within the first week and in most cases are transient and
disappear following termination of treatment, but in rare cases may be
serious or fatal. Transient injection site reactions may be observed in young
cattle after subcutaneous administration, these resolve within 24 hours.
In young cattle, the recommended dosage is 1.4mg carprofen per
kilogram (1ml/35kg) bodyweight once, administered by subcutaneous
or intravenous injection. In horses and ponies, the recommended dosage
is 0.7mg/kg (1ml/70kg) bodyweight by intravenous injection as a single
dose. This can be repeated after 24 hours, or followed by therapy with an
oral formulation of carprofen, according to the duration of clinical signs.
After this, further use should follow another clinical evaluation.
Special Precautions for Use
Do not exceed stated dose or duration of treatment.
Avoid use in any dehydrated, hypovolaemic or hypotensive animal, as
there is potential risk of increased renal toxicity.
Withdrawal Period
Cattle: Do not use in cows producing milk for human consumption.
Cattle must not be slaughtered for human consumption during
treatment. Cattle may be slaughtered for human consumption only
after 21 days from last treatment.
Horses: Not to be used in horses intended for human consumption.
Treated horses may never be slaughtered for human consumption.
The horse must have been declared as not intended for human
consumption under the national horse passport legislation.
Contraindications, Warnings, etc
For intravenous use only in the horse.
For specific information about the time which must elapse between the
treatment and competition, veterinary surgeons are advised to consult
the authority responsible for the competition in question (e.g the Jockey
club in the case of racing in the UK). Do not administer other NSAIDs
or glucocorticoids concurrently or within 24 hours of each other. Some
NSAIDs may be highly bound to plasma proteins and compete with
other highly bound drugs, which can lead to toxic effects.
Use in any animal less than 6 weeks of age, or aged animals, may involve
additional risk. If such use cannot be avoided, animals may require a
reduced dosage and careful clinical management.
In the absence of any specific studies the use in pregnant or lactating
animals is not recommended.
Carprofen is well tolerated at doses up to 3 times the recommended
dose for cattle and 2 times the recommended dose for horses. There is
no specific antidote for carprofen overdosage but general supportive
therapy as applied to clinical overdosage with NSAIDs should be applied.
Avoid skin contact with the product. Wash off any splashes immediately.
Take care to avoid accidental self injection. Wash hands after use.
Pharmaceutical Precautions
Do not store above 25°C.
Protect from light.
Following withdrawal of the first dose, use the remainder of the
product within 28 days.
When the container is broached for the first time, using the in use shelf life
which is specified on the package insert, the date on which any product
remaining in the container should be discarded should be worked out.
The discard date should be written in the space provided on the label.
Any unused veterinary medicinal product or waste material derived
from such veterinary medicinal products should be disposed of in
accordance with local requirements.
Gastrointestinal tract ulceration may be exacerbated by corticosteroids
in patients given NSAIDs.
Legal Category
No significant drug interactions have been reported for Carprofen.
POM-V To be supplied only on Veterinary Prescription.
During clinical studies in cattle four different antibiotic classes were used,
macrolides, tetracyclines, cephalosporins and potentiated penicillins
without known interactions. The acute toxicity of Carprofen in
animals was not significantly affected in tests with 15 concomitantly
administered drugs. These were acetylsalicylic acid, amphetamine,
atropine, chloropromazine, diazepam, diphenhydramine, ethyl alcohol,
24
hydrochlorothiazide, imipramine, meperidine, proxyphene,
phenobarbital, sulfisoxazole, tetracycline and tolbutamide.
Package Quantities
50ml multidose amber glass vials
VM No: 02000/4277
For Animal Treatment Only
Keep out of reach and sight of Children
Loxicom® 20mg/ml
Solution for Injection for
Cattle, Pigs and Horses
Presentation
One ml contains:
Meloxicam 20mg
Ethanol 150mg
Uses
Cattle: For use in acute respiratory infection with appropriate antibiotic
therapy to reduce clinical signs in cattle. For use in diarrhoea in
combination with oral re-hydration therapy to reduce clinical signs
in calves of over one week of age and young, non-lactating cattle. For
adjunctive therapy in the treatment of acute mastitis, in combination
with antibiotic therapy.
Pigs: For use in non-infectious locomotor disorders to reduce the
symptoms of lameness and inflammation.
For adjunctive therapy in the treatment of puerperal septicaemia
and toxaemia (mastitis-metritis-agalactia syndrome) with appropriate
antibiotic therapy.
Horses: For use in the alleviation of inflammation and relief of pain in
both acute and chronic musculoskeletal disorders. For the relief of pain
associated with equine colic.
Dosage and Administration
Cattle: Single subcutaneous or intravenous injection at a dosage of
0.5mg meloxicam/kg body weight (i.e., 2.5ml/100kg body weight)
in combination with antibiotic therapy or with oral re-hydration
therapy, as appropriate. The recommended maximum volume to be
administered at a single injection site is 10ml.
Pigs: Single intramuscular injection at a dosage of 0.4mg meloxicam/kg
body weight (i.e., 2.0ml/100kg body weight) in combination with
antibiotic therapy, as appropriate. If required, a second administration of
meloxicam can be given after 24 hours. The recommended maximum
volume to be administered at a single injection site is 2ml.
Horses: Single intravenous injection at a dosage of 0.6mg meloxicam/kg
body weight (i.e., 3.0ml/100kg body weight). For use in the alleviation
of inflammation and the relief of pain in both acute and chronic
musculoskeletal disorders. A suitable oral therapy containing
meloxicam, administered in accordance with label recommendations,
may be used for continuation of treatment.
Avoid introduction of contamination during use.
If adverse reactions occur, treatment should be discontinued and the
advice of a veterinarian should be sought. Avoid use in very severely
dehydrated, hypovolaemic or hypotensive animals which require
parenteral rehydration, as there may be a potential risk of renal toxicity.
In case of inadequate relief of pain when used in the treatment of
equine colic, careful re-evaluation of the diagnosis should be made as
this could indicate the need for surgical intervention.
Accidental self-injection may give rise to pain. People with known
hypersensitivity to non-steroidal anti-inflammatory Drugs (NSAIDs)
should avoid contact with the veterinary medicinal product.
In case of accidental self-injection, seek medical advice immediately
and show this package leaflet or the label to the physician.
Use During Pregnancy and Lactation
Cattle and pigs: Can be used during pregnancy and lactation.
Horses: See section “Contraindications”.
Do not administer concurrently with glucocorticosteroids, other
non-steroidal anti-inflammatory drugs or with anti-coagulant agents.
In the case of overdose, symptomatic treatment should be initiated.
Waste materials should be disposed of in accordance with local
requirements.
Pharmaceuticals Precautions
Keep out of the reach and sight of children.
This veterinary medicinal product does not require any special storage
conditions.
Do not use after the expiry date (EXP) stated on the carton and vial.
Shelf life after first broaching the glass vial: 28 days.
Legal Category
UK: POM-V To be supplied only on Veterinary Prescription.
ROI: POM
To be supplied only on veterinary prescription.
Packaging Quantities
50ml, 100ml and 250ml vials
Withdrawal Periods
Contraindications and Warnings
Cattle: Meat and offal:
Milk: Pigs: Meat and offal: Horses: Meat and offal: Do not use in horses less than 6 weeks of age.
Not authorised for use in horses producing milk for human consumption.
Do not use in pregnant or lactating mares. Do not use in animals
suffering from impaired hepatic, cardiac or renal function and
haemorrhagic disorders, or where there is evidence of ulcerogenic
gastrointestinal lesions.
Authorised Veterinary Medicinal Product
Do not use in case of hypersensitivity to the active substance or to any
of the excipients.
EU/2/08/090/005
Do not exceed 50 broachings per vial. If more than 50 broachings are
required, the use of a draw-off needle is recommended.
15 days
5 days
5 days
5 days.
EU/2/08/090/003
EU/2/08/090/004
For Animal Treatment Only
For the treatment of diarrhoea in cattle.
Do not use in animals of less than one week of age.
25
Loxicom® 50mg/g
Oral Paste for Horses
Presentation
Pharmaceutical Precautions
A pale yellow homogenous oral paste.
Store below 30 ºC
One gram contains:
Active substance: Meloxicam - 50 mg
Special Warnings
Excipient: Benzyl Alcohol - 10 mg
Special precautions for use in animals:
Uses
Avoid use in any dehydrated, hypovolaemic or hypotensive animals as
there is a potential risk of renal toxicity.
Alleviation of inflammation and relief of pain in both acute and chronic
musculo-skeletal disorders in horses.
Do not exceed the recommended dose or duration of treatment due
to the possibility of severe adverse reactions.
Dosage And Administration
Special precautions to be taken by the person administering
the veterinary medicinal product to animals:
Administer 0.6 mg/kg body weight, once daily for up to 14 days.
To be administered directly into the mouth over the back of the
tongue keeping the animal’s head raised until swallowed.
One syringe division of paste should be administered per 50 kg
bodyweight. The syringe has an integrated adapter and has a kg/
bodyweight graduation. Each syringe delivers 420 mg meloxicam,
sufficient to treat 700 kg of bodyweight.
Withdrawal Period
Meat and offal:
3 days.
Not authorised for use in animals producing milk for human
consumption.
Contraindications, Warnings, Etc
Do not use in pregnant or lactating mares.
Do not use in horses suffering from gastrointestinal disorders such as
irritation and haemorrhage, impaired hepatic, cardiac or renal function
and haemorrhagic disorders.
People with known hypersensitivity to Non-Steroidal
Anti-Inflammatory Drugs (NSAIDs) should avoid contact with the
veterinary medicinal product.
Avoid skin and eye contact with the product. If skin and/or eye contact
occurs, wash the affected parts immediately with water. Should
irritation occur and persist, seek medical advice.
In case of accidental ingestion, seek medical advice immediately and
show the package leaflet or the label to the physician.
Shelf life of the veterinary medicinal product as packaged for sales:
18 months.
Shelf life after first opening the immediate packaging: 28 days.
Disposal
Any unused veterinary medicinal product or waste materials derived
from such veterinary medicinal products should be disposed of in
accordance with local requirements.
Legal Category
Do not use in case of hypersensitivity to the active substance or to any
of the excipients.
UK POM-V To be supplied only on veterinary prescription.
Do not use in horses less than 6 weeks of age.
Package Quantities
Laboratory studies in cattle have not provided any evidence for
teratogenic, foetotoxic, or maternotoxic effects. However, no data
have been generated in horses. Therefore the use in this species is not
recommended during pregnancy and lactation.
Low-density polyethylene pre-filled syringes containing 8.4 g of
product in cartons of 1, 7, or 14 syringes. Each syringe has an integrated
adapter and with a “kg/body weight” graduation, in divisions of paste
per 50 kg bodyweight.
Do not administer concurrently with glucocorticosteroids, other
non-steroidal anti-inflammatory drugs or with anticoagulant agents.
Not all pack sizes may be marketed.
Adverse Reactions:
Isolated cases of adverse reactions typically associated with
NSAIDs were observed in clinical trials (slight urticaria, diarrhoea).
Symptoms were reversible. Commonly, a reduction in blood albumin
concentration will occur during the period of treatment (up to 14 days).
“
Marketing Authorisation Numbers
EU/2/08/090/029 (1 syringe)
EU/2/08/090/030 (1 x 7 syringes)
EU/2/08/090/031 (1 x 14 syringes)
I can make a General in five minutes but a
good horse is hard to replace.
Advice On Correct Administration
Avoid introduction of contamination during use.
26
“
In very rare cases loss of appetite, lethargy, abdominal pain and colitis
have been reported. In very rare cases anaphylactoid reactions, which
may be serious (including fatal), may occur and should be treated
symptomatically. If adverse reactions occur, treatment should be
discontinued and the advice of a veterinarian should be sought.
For Animal Treatment Only
Keep Out Of Reach And Sight Of Children
Abraham Lincoln
Metabolites
27
Glutalyte®
Equine
Presentation
Administration
A powder which is a dietetic feed source of predominately electrolytes
and easily absorbable carbohydrates.
Administer for up to 3 days as required. If necessary administration may
be continued for a further 4 days (up to seven days in total).
More specifically it includes: % w/w
Dextrose Glutamine Sodium Citrate Glutamine Sodium Chloride Potassium Chloride Magnesium Acetate Calcium Chloride Sodium Propionate Sodium Acetate 75.689
5.446
4.879
3.379
2.490
1.434
1.108
1.067
0.731
Contents 180g
Energy values: Each sachet provides: 13.469 kj/g
2,424.42 kj
Uses
A readily available nutritional source of highly digestible ingredients
to help stabilise water and electrolyte balance in horses and ponies to
compensate for electrolyte loss following heavy sweating or during
periods of convalescence and when nutritional restoration is required.
Dosage and Administration
Dosage: Glutalyte is intended for oral administration only.
Dissolve the contents of one sachet in 2 litres (3.5 pints) of warm water.
Offer the solution in place of drinking water.
Water should be made available to animals that will not take Glutalyte
for horses and ponies.
Make a fresh solution every 24 hours.
28
Precautions
It is recommended that a Veterinary Surgeon’s advice is sought
before use.
Store in a dry place below 25ºC.
Package Quantities
Cartons of 8 x 180g sachets.
Net weight not less than 180g.
One sachet made up in 2 litres of warm water.
Further Information
A fine deposit of insoluble carrier may remain after dissolving the
contents of the sachet, this does not affect the efficacy of the product.
This is not an authorised veterinary medicine.
For Animal Treatment Only
Keep out of reach and sight of Children
Anthelmintics
29
Noromectin® 1.87%
Oral Paste for Horses
Presentation
Withdrawal Period
Ivermectin 1.87% w/w
Animals must not be slaughtered for human consumption during treatment.
Horses must not be treated within 34 days of slaughter for human
consumption. Do not use in mares producing milk for human consumption.
Uses
Noromectin 1.87% Oral Paste for Horses kills the adult and some larval
stages of the important internal parasites of horses. Noromectin 1.87%
Oral Paste for Horses at the recommended dose rate of 200 μg ivermectin
per kg bodyweight is indicated for the treatment of the following internal
parasites of horses:
Large strongyles (redworms): adults and 4th larval (arterial) stages of
Strongylus vulgaris, adults and tissue larval stages of S. edentatus and
adults of S. equinus.
Adult small strongyles (redworms) including benzimidazole
resistant strains: Cyathostomum catinatum, Cyathostomum pateratum,
Cylicocyclus ashworthi, Cylicocyclus elongatus, Cylicocyclus insigne, Cylicocyclus
leptostomum, Cylicocyclus nassatus, Cylicocyclus radiatus, Cylicostephanus
asymetricus, Cylicostephanus bidentatus, Cylicostephanus calicatus,
Cylicostephanus goldi, Cylicostephanus longibursatus, Cylicostephanus
minutus, Cylicodontophorus bicornatus and Gyalocephalus capitatus.
Adult and immature lungworms: Dictyocaulus arnfieldi.
Pinworms: Adult and immature Oxyuris equi.
Ascarids: Adult and 3rd and 4th stage Parascaris equorum.
Hairworms: Adult Trichostrongylus axei.
Intestinal threadworms: Adult Strongyloides westeri.
Neck threadworms: Microfilariae of Onchocerca spp.
Oral and gastric larval stages of stomach bots: Gasterophilus spp.
Ivermectin is not effective against encysted larval stages of the small
strongyles.
Dosage and Administration
Noromectin 1.87% Oral Paste for Horses is administered orally at a single
dose rate of 200 μg/kg of bodyweight. One syringe division of paste should
be administered per 100kg bodyweight (based on the recommended
dosage of 200 μg/kg). Each syringe delivers 140mg ivermectin, sufficient to
treat 700kg of bodyweight. The tip of the syringe barrel should be inserted
at the interdental space (the gap between the front and back teeth). The
horse’s head should be raised for a few seconds after dosing.
Horses’ weight should be accurately determined for the correct use of the
paste. The animal’s mouth should be free of food to ensure swallowing.
For best results all horses in a yard or grazing together should be included
in a regular parasite control programme and treated at the same time.
All horses should be included in a regular parasite control programme,
with particular attention being paid to mares, foals and yearlings. Foals
should be treated initially at 6-8 weeks of age and routine treatment
repeated as appropriate.
Retreatment should be carried out according to the epidemiological
situation, but not less than at a 30 day interval.
Do not use the same syringe to treat more than one animal unless horses
are running together or in direct contact with each other on the same
premises. As with all anthelmintics, a veterinary surgeon should establish
appropriate dosing programmes and stock management to achieve
adequate parasite control and reduce the likelihood of anthelmintic
resistance developing.
Contraindications, Warnings, etc
Noromectin 1.87% Oral Paste for Horses has been formulated for use
in horses only. Dogs and cats may be adversely affected by the
concentration of ivermectin in the veterinary medicinal product if they are
allowed to ingest spilled paste or have access to used syringes. Avermectins
may not be well tolerated in all non-target species (cases of intolerance
with fatal outcome are reported in dogs, especially Collies, Old English
Sheepdogs and related breeds or crosses, and also in turtles/tortoises).
Do not use in dogs or cats as severe adverse reactions may occur. This is
a unidose product which should be disposed of after use. Frequent and
repeated use may lead to the development of resistance.
Some horses have experienced reactions involving cutaneous swelling
and itching shortly after treatment. In most of these cases, the horses have
been diagnosed as carrying heavy infections of Onchocerca microfilariae,
and it is assumed the reactions are a result of the microfilariae dying in
large numbers. Although the signs will resolve spontaneously in a few days,
symptomatic treatment may be advisable. Consult your veterinary surgeon
should these signs persist.
Horses of all ages, including young foals, pregnant mares and breeding
stallions have been treated with no adverse effects on their health and
fertility. Ivermectin passes readily into milk. When administering to lactating
females, residues of ivermectin could be present in the maternal milk.
No studies have been reported on the effect of ingestion of milk on the
development of newborn foals, therefore it would be prudent not to feed
very young animals with milk obtained from the mother.
Mild transitory signs (slowed pupillary light response and depression) have
been seen at a higher dose of 1.8mg/kg (9 times the recommended dose
level). Other signs seen at higher doses include mydriasis, ataxia, tremors,
stupor, coma and death. The less severe signs have been transitory.
Although no antidote has been identified, symptomatic therapy may be
beneficial.
Pharmaceutical Precautions
Do not smoke or eat while handling the product. Wash hands after use.
Avoid eye contact.
Do not store above 25ºC. Keep the container in the outer carton in
order to protect from light.
EXTREMELY DANGEROUS TO FISH AND AQUATIC LIFE.
Do not contaminate surface water or ditches with product or used
containers. Dispose of any unused product and empty containers in
accordance with guidance from your local waste regulation authority.
Legal Category
POM-VPS
Package Quantities
Syringes containing 7.49g of product in cartons of: 1,2, and 10 syringes.
VM No: 02000/4208
For Animal Treatment Only
Keep out of reach and sight of Children
30
Vitamins
31
Intravit 12
Solution for Injection 0.05% w/v
Presentation
Pharmaceutical Precautions
An aqueous solution for injection, containing:
Cyanocobalamin 0.05% w/v
Dispose of any unused product and empty containers in accordance
with guidance from your local waste regulation authority.
Phenol as a preservative 0.5% w/v
Uses
POM-VPS
Cyanocobalamin (Vitamin B12) is essential for the synthesis of nucleic
acids. Consequently it plays an essential role in cell metabolism and the
maintenance of metabolic functions including haemopoiesis.
Package Quantities
Dosage and Administration
Further Information
By intramuscular or subcutaneous injection, once or twice a week.
Normal aseptic precautions should be observed.
When administering the product to a large number of animals a
multiple dose injector must be used.
Ensure that suitable equipment is used when administering small dose
volumes.
When the container is broached for the first time, using the in-use
shelf-life which is specified on this package insert, the date on which
any product remaining in the container should be discarded should be
worked out.
Cattle, Horses: 2–5ml
Calves, Foals: 1–3ml
Sheep and Pigs: 0.5–1.5ml
Withdrawal Period
Withdrawal period for meat/milk: Nil.
Contraindications, Warnings, etc
No known contraindications.
Care should be taken to avoid accidental self-injection or ingestion. In
case of accidental self-injection, seek medical advice as a precautionary
measure. Following skin/eye contamination, wash/irrigate area
thoroughly with cold water. Seek medical attention if irritation persists.
Following withdrawal of the first dose, use the product within 28 days.
Wash hands after use.
32
Legal Category
Multidose vials of 100ml.
This discard date should be written in the space provided on the label.
VM No: 02000/4116
For Animal Treatment Only
Keep out of reach and sight of Children
Combivit
Solution for Injection
Presentation
Contraindications, Warnings, etc
Combivit is a pale yellow to brown sterile solution for injection
containing four members of the B-complex vitamins together with
vitamin C.
Anaphylactoid reactions, particularly in the horse may occur following
intravenous administration. When this route is used Combivit should
be given slowly and may be diluted with sterile saline or sterile
dextrose saline solution. This may be achieved by drawing sterile
diluting solution into a syringe, followed by the required volume of
Combivit.
Each ml contains:
Thiamine Hydrochloride (Vitamin B1) 35mg
Riboflavine Sodium Phosphate (Vitamin B2) 0.5mg
Pyridoxine Hydrochloride (Vitamin B6) 7mg
Nicotinamide 23mg
Ascorbic Acid (Vitamin C) 70mg
Chlorocresol (preservative) 1mg
The diluted product must be administered immediately after
preparation and must not be stored. Aseptic precautions should be
observed. There may be slight irritation at the site of injection when the
product is given by the subcutaneous or intramuscular routes.
Pharmaceutical Precautions
Uses
Do not store above 25ºC.
Combivit may be used in the following cases:
1. Wherever deficiency of vitamin B group is suspected in horses, cattle
and sheep.
Protect from light.
2. In treatment of cerebrocortical necrosis in cattle and sheep.
3. In treatment of bracken poisoning in horses.
Dispose of any unused product and empty containers in accordance
with guidance from your local waste regulation authority.
Dosage and Administration
Legal Category
Administer by subcutaneous, deep intramuscular or slow intravenous
injection. The dose should be repeated daily as required. Normal
aseptic precautions should be observed.
POM-VPS
Following withdrawal of the first dose, use the product within 28 days.
Discard unused material.
Package Quantities
Multidose vials of 50ml and 100ml.
Species Dosage
Horses, Cattle: 20–30ml
Further Information
Calves, Foals: 5–10ml
Sheep: 5–10ml
When the container is broached (opened) for the first time, using the
in-use shelf life which is specified on this carton, the date on which any
product remaining in the container should be discarded should be
worked out.
Withdrawal Period
Withdrawal period for meat and milk: Zero days.
This discard date should be written in the space provided on the label.
VM No: 02000/4118
For Animal Treatment Only
Keep out of reach and sight of Children
33
Multivitamin
Injection
Presentation
Withdrawal Period
A golden brown sterile aqueous solution, containing per ml:
Not to be used in animals intended for human consumption.
Retinol Palmitate (Vitamin A)
15,000iu
Cholecalciferol (Vitamin D3)
25mcg
Alpha tocopheryl Acetate (Vitamin E)
20mg
Thiamine Hydrochloride (Vitamin B1)
10mg
Riboflavin Sodium Phosphate (Vitamin B2)
5mg
Pyridoxine Hydrochloride (Vitamin B6)
3mg
Nicotinamide35mg
Dexpanthenol25mg
Cyanocobalamin (Vitamin B12)
25mg
Treated horses may never be slaughtered for human consumption.
Excipient(s):
Discard unused material.
Chlorocresol (as preservative)
1mg
Butylhydroxyanisole (E320)0.1mg
Butylhydroxhtoluene (E321)0.1mg
Disodium Edetate0.5mg
Pharmaceutical Precautions
Store below 25°C.
Protect from light.
Following withdrawal of the first dose, use the product within 14 days.
Legal Category
POM-VPS
Package Quantities
Uses
Multidose vials of 100ml.
Multivitamin Injection is indicated for the prevention and treatment
of vitamin deficiencies in horses, particularly during periods of illness,
convalescence and general unthriftiness.
VM No: 02000/4131
Dosage and Administration
Administer by intramuscular or subcutaneous injection.
Horses: 20 - 30ml
The injection may be repeated at intervals of 10 – 14 days.
Normal aseptic precautions should be observed.
34
The horse must have been declared as not intended for human
consumption under the national Horse Passport Legislation.
For Animal Treatment Only
Keep out of reach and sight of Children
Miscellaneous
35
Lignocaine and Adrenaline
Solution for Injection
Presentation
Pharmaceutical Precautions
A bright almost colourless solution containing:
Lignocaine Hydrochloride 2.0% w/v
Protect from light.
Adrenaline (as Acid Tartrate) 0.00227% w/v
Following withdrawal of the first dose, use the product within 28 days.
Antimicrobial preservative: Chlorocresol 0.1% w/v
Discard any unused material.
Uses
When the container is broached (opened) for the first time, the date
on which any product remaining in the container should be discarded
should be calculated. A statement of the in-use shelf life of the product
is given on the package insert.
Local anaesthetic for parenteral administration to horses. It may be
used for infiltration anaesthesia (local or field block) and regional
anaesthesia including paravertebral nerve blocks.
Dosage and Administration
This discard date should be written in the space provided on the label.
Dispose of any unused product and empty containers in accordance
with guidance from your local waste regulation authority.
•
For intramuscular and subcutaneous injection only.
•
Local infiltration and field block anaesthesia:
Legal Category
•
The recommended dose is:
Horses: up to 100 - 200ml per surgical site
POM-VPS
•
In cases of repeated administration, the total volume
administered should not exceed 0.5ml/kg bodyweight.
Package Quantities
•
Paravertebral anaesthesia: Approx 7ml per site
VM No: 02000/4135
Withdrawal Period
Not to be used in horses intended for human consumption.
Treated horses may never be slaughtered for human consumption.
The horse must have been declared as not intended for human
consumption under national horse passport legislation.
Contraindications, Warnings, etc
Avoid accidental intravascular injection. In mild cases of overdose,
animals become anxious and restless. The symptoms are transient and
will pass off with little or no treatment being necessary. In severe cases
of overdose convulsions may occur, and respiratory and circulatory
failure may follow. Overdosage may be treated by administering
respiratory stimulants and keeping animals warm.
In case of accidental self-injection seek medical advice immediately.
In case of eye contamination or excessive skin contact, irrigate/wash
immediately with plenty of clean water.
Seek medical attention if irritation persists.
Wash hands after use.
Care should be taken in the administration of repeat doses in cases
where the desired degree of anaesthesia has not been attained.
36
Do not store above 25ºC.
Multidose vials of 100ml.
For Animal Treatment Only
Keep out of reach and sight of Children
Multi Derm
Aerosol, Powder
and Ointment
Presentation
Package Quantities:
Multi Derm Aerosol, Powder and Ointment contains:
Crude Fish Oil
Multi Derm Aerosol 140g
Multi Derm Powder 125g
Multi Derm Ointment 125g
Raw Linseed Oil
Spirits of Turpentine
Balsam of Fir
Contraindications, Warnings, etc
Withdrawal period for meat/milk: Nil.
Uses
Avoid contact with the eyes.
•
Conditions and softens hard or chapped skin tissues.
Wash and dry the teats prior to milking to remove residual product.
•
Aids in the management of cuts and sores on cattle and horses.
For external use only.
•
Provides a protective and flexible barrier for wounds.
•
Promotes natural healing and tissue regeneration.
In case of deep puncture wounds or serious burns consult a
veterinary surgeon.
Directions
If redness, irritation or swelling persists or increases, discontinue use
and consult a veterinary surgeon.
Clean area before application.
This is not an authorised veterinary medicine.
Small cut: Apply once daily.
For Animal Treatment Only
Larger wounds: Apply once/twice daily, washing wound on alternate
days and re-apply.
Keep out of reach and sight of Children
Multi Derm acts as a breathable bandage: Do not wrap the wound,
apply thoroughly.
37
Norofulvin® 33.3%
Equine Oral Paste
Presentation
A white viscous paste containing:
33.3% w/w Griseofulvin in a 70g dial-a-dose syringe.
Long-term administration of high doses of griseofulvin with foods has
been reported to induce hepatomas in mice and thyroid tumours in
rats, but not hamsters.
The clinical significance of those findings for man is not known.
Uses
Norofulvin Equine Paste is an oral antifungal antibiotic effective in
the treatment of ringworm in horses caused by Trichophyton and
Microsporum spp.
After absorption from the gastrointestinal tract the antifungal
antibiotic is concentrated in the newly formed keratin enabling the
cells of the skin and hair to resist fungal attack.
Pharmaceutical Precautions
Do not store above 25ºC.
Dispose of any unused product and empty containers in accordance
with guidance from your local waste regulation authority.
Legal Category
POM-V To be supplied only on Veterinary Prescription.
Dosage and Administration
There are 15 x 150kg doses marked on the syringe.
For oral administration using a dial-a-dose syringe, 10mg Griseofulvin/kg
bodyweight daily for 7 consecutive days.
The following is the dosing regimen recommended for each of the
7 days dosing period.
Horse Liveweight Dose (Expressed as number of Dial turns)
150kg 300kg 450kg 600kg 1
2
3
4
Where the animals weight is other than above weight, ¼, ½, or ¾ turns
of the dial may be given where appropriate.
Prophylactic administration of Norofulvin Equine Paste is advisable for
in contact animals only.
Withdrawal Period
Not to be used in horses intended for human consumption.
Treated horses may never be slaughtered for human consumption.
The horse must have been declared as not intended for human
consumption under national horse passport legislation.
Contraindications, Warnings, etc
Concurrent administration of substances such as Phenylbutazone
and sedatives which induce drug metabolizing enzymes may result in
impaired efficacy of Norofulvin. Norofulvin is not recommended for use
in pregnant mares. Other systemic fungal infections including Candida
albicans and Aspergillis spp do not respond to Griseofulvin therapy.
Norofulvin Equine Paste must not be handled by women of child
bearing potential.
Protective gloves should be worn when using this product.
Take care to avoid skin contact. In the case of skin contact wash affected
area thoroughly. If irritation occurs/persists seek medical advice.
Take care to avoid accidental eye contact. In case of accidental eye
contact flush thoroughly with clean water and seek medical advice.
Ingestion: If accidentally swallowed, seek medical attention and show
product label and/or pack insert to the doctor.
Wash hands thoroughly after using this product.
38
Package Quantities
70g dial-a-dose syringe.
Further Information
The normal seven day course is recommended. Stables occupied by
infected horses should be thoroughly disinfected and cleaned; all
equipment used during the treatment should also be cleaned and
disinfected.
These measures will minimize the risk of cross infection.
VM No: 02000/4055
For Animal Treatment Only
Keep out of reach and sight of Children
Norofulvin® 7.5% w/w
Granules for Top Dressing Use
Presentation
Contraindications, Warnings, etc
White to off-white granules containing:
Griseofulvin 7.5% w/w
Norofulvin Granules must not be used for the treatment of pregnant
mares.
Uses
Other systemic fungal infections including those caused by Candida
albicans and Aspergillus spp do not respond to griseofulvin therapy.
Griseofulvin is an antifungal antibiotic, for the treatment of ringworm
in horses caused by Trichophyton spp and Microsporum spp. After
absorption from the gastrointestinal tract, griseofulvin is concentrated
in the newly formed keratin enabling the cells of the skin and hair to
resist fungal attack.
Dosage and Administration
Norofulvin Granules should be administered orally, by addition to the
feed ration.
Operator Warnings
Impervious gloves must be worn when handling this product or feed
containing the product.
The product or feed containing the product must not be handled by
women with child bearing potential.
General Precautions
The recommended dose rate is 10mg griseofulvin per kg bodyweight
daily for seven consecutive days.
Long-term administration of high doses of griseofulvin with food has
been reported to be hepatotoxic in cats and to induce hepatomas in
mice and thyroid tumours in rats but not hamsters.
This is achieved by administering 10g Norofulvin Granules per 75kg
bodyweight daily.
The clinical significance of these findings for man or the target species
is not known.
Dosage Guide:
Do not use in horses with severe hepatic impairment.
Bodyweight 150kg 225kg 300kg 375kg 450kg 525kg Over 525kg Daily Dose
20g
30g
40g
50g
60g
70g
70g + 10g for each additional 75kg bodyweight.
Pharmaceutical Precautions
Do not store above 25ºC.
Protect from light.
Store separately from animal feeds.
Disposal of any unused product and empty container in accordance
with guidance from your local waste regulation authority.
In severe cases treatment may be continued for an additional seven
days at the same dose rate.
Legal Category
Norofulvin Granules should be mixed thoroughly with the total feed
ration so that the required dose is contained in the amount each
animal will consume at one feed.
Package Quantities
Add to feed immediately prior to administration.
POM-V To be supplied only on Veterinary Prescription.
500g, 1kg and 3.5kg bulk packs.
Discard any remaining medicated feed.
Further Information
Norofulvin Granules may be used for the treatment of groups of
animals or for individuals. For group dosing animals should be
approximately equal in bodyweight. Adequate trough space should
be available and shy feeders should be fed individually to ensure
adequate dosage.
Prophylactic therapy is advised for in-contact animals only.
Withdrawal Period
These measures will minimise risk of infection.
Not to be used in horses intended for human consumption.
VM No: 02000/4084
Treated horses may never be slaughtered for human consumption.
The horse must have been declared as not intended for human
consumption under national horse passport legislation.
For Animal Treatment Only
The normal 7 day course is recommended.
Buildings occupied by infected animals should be thoroughly cleaned
and disinfected; all equipment used during the treatment should also
be cleaned and disinfected.
Keep out of reach and sight of Children
39
Water for Injections
100% v/v Solvent for Parenteral Use
Presentation
Legal Category
Sterile Water contains no preservative.
Sterile Water 100% v/v
POM-V To be supplied only on Veterinary Prescription.
Package Quantities
Uses
Water for Injections is available in 20ml, 50ml and 100ml vials.
Water for Injections is intended for use as a sterile solvent for the
preparation of medicines intended for parenteral administration. Where
water is a component of the preparation and for reconstituting or
diluting medicines for parenteral administration immediately before use.
VM No: 02000/4122
Dosage and Administration
As required.
Pharmaceutical Precautions
Do not store above 25°C.
Take adequate precautions to maintain sterility.
After initial use discard remainder of product.
Dispose of any unused product and empty containers in accordance
with guidance from your local waste regulation authority.
40
For Animal Treatment Only
Keep out of reach and sight of Children
for horses
powder & paste
power
high performance
horse
A naturally superior and highly palatable
nutritional supplement to help maintain
healthy cartilage and joint fluid in horses
(paste only)
For more information about the entire equine product range
contact your Norbrook® territory manager:
Laura Tattersfield Northern England & Scottish Borders 07798 607081
Jane Hutcheon Scotland (North) 07798 607093
Barbara Harrison Scotland (South) 07825 883315
Joanne Beardsworth North 07788 436035
Gary Sheils North West 07798 607087
Shane Brewer East Anglia 07798 607082
Jayne Painter South East 07909 538565
Lyn Hanson London 07786 338305
Domenico Traversari South 07798 607088
Stephen Bull South West 07795 563290
Karen Harrison Wales (South) 07887 827232
Gerald Hegarty Wales (North) 07833 256416
Paul Uglow Midlands 07769 897016
or visit www.norbrook.com
41
Products Overview
Category
Antibiotics
Product
Devomycin Injection
Active
Streptomycin Sulphate
Species
Horses
Cattle
Withdrawal
*
Milk: 48 hrs
Sheep
Meat: 16 days
Meat: 18 days
Dogs, Cats
Horses
**
Nil
*
Sheep
Meat: 14 days
Cattle
**
Milk: 48 hrs
Dogs and Cats
Meat: 14 days
Nil
Benzathine Penicillin,
Horses
*
Procaine Penicillin
Dogs and Cats
Cattle
Nil
Milk/meat: Nil
Devomycin D Injection Streptomycin Sulphate,
Dihydrostreptomycin Sulphate
Norocillin LA
Suspension for
Injection
Opticlox Eye Ointment Cloxacillin Benzathine
16.7% w/w
Pen and Strep
Cefenil Powder and
Solvent 1g and 4g
Sulphonamides
Norodine 24%
Solution for Injection
Procaine Penicillin,
Dihydrostreptomycin Sulphate
Ceftiofur Sodium
Sulfadiazine,
Trimethoprim
Specific indications
Indicated for the treatment of organisms sensitive to
Streptomycin. In particular E.coli, Klebsiella spp,
Mycobacterium tuberculosis and some species of Proteus,
Pasturella and Salmonella.
Packaging quantities and sizes
50ml and 100ml vial
Indicated for the treatment of organisms sensitive to
100ml vial
Streptomycin. Among the more sensitive to streptomycin in
vitro are Actinobacillus equuli, A. Lignieresii, Actinomyces bovis,
Brucella spp, E.coli, Haemophilus spp, Klebsiella spp,
Leptospira canicola and L.ictero-haemorrhagiae, Pseudomonas
aeruginosa and some species of Proteus, Pasturella and
Salmonella.
Norocillin LA is quick acting, long lasting treatment of systemic 50ml and 100ml vial
infections caused by or associated with organisms sensitive to
penicillin in horses, dogs and cats.
Eye infections caused by Staphylococcus spp. and Bacillus spp.
4 x5g syringes
Horses
Sheep
Horses
*
Cattle
Milk: 60 hrs
Sheep
Meat: 23 days
Milk: **
Pigs
Horses
Meat: 31 days
Meat: 18 days
*
Cattle
Milk: 0 hrs
Pigs
Horses
Cattle
Meat: 1 day
Meat: 2 days
Meat: 28 days
Milk: 48 hrs
Pigs
Dogs
Effective in the treatment of the following: Erysipelas; Navel/ 50ml and 100ml vials
joint ill; respiratory tract infections including pneumonia and
atrophic rhinitis; listeriosis; meningitis; septicaemia; toxaemia
associated with mastitis; urogenital tract infections; enteritis
associated with Salmonella spp, salmonellosis; and the control
of secondary bacterial invaders in disease of primary viral
origin.
Bacterial respiratory disease.
1g and 4g vial
Treatment of acute bacterial respiratory disease and acute
interdigital necrobacillosis (foul in the foot).
Bacterial respiratory disease.
Respiratory infections, urogenital tract infections and
alimentary tract infections.
50ml and 100ml vial
Alimentary tract infections;
3 x 45 g dial-a-dose syringe
Meat : 12 days
Meat: 20 days
Cats
Norodine Equine Oral
Paste
Sulfadiazine,
Norodine granules
Sulfadiazine,
Anti-inflammatories Colvasone 2mg/ml
Solution for Injection
Horses
Meat: 28 days
Trimethoprim
Trimethoprim
Dexamethasone Sodium Phosphate
Respiratory tract infections;
Horses
Horses
Cattle
Meat 28 days
Wounds, septicaemia and general infections.
Respiratory tract infections;
Meat:21 days
Meat 21 days
Wounds, septicaemia and general infections.
Intravenous therapy; Acetonaemia in cattle; inflammatory
conditions (all indicated species).
10 sachets of 37.5g
50ml vial
Milk: 72 hrs
Equinixin 25 mg/g
Granules for Horses
Flunixin Meglumine
Flunixin 50mg/ml
Injection
Flunixin Meglumine
Norocarp 50mg/ml
Solution for Injection
Carprofen
Loxicom 20mg/ml
Solution for Injection
Meloxicam
Loxicom 5% Oral
Paste for Horses
Meloxicam
Dogs
Cats
Horses
Meat: 15 days
Horses
Cattle
Meat: 7 days
Meat: 7 days
Pigs
Milk: 36 hrs
Meat 24 days
Horses
*
Cattle
Milk: **
Horses
Meat: 21 days
Meat: 5 days
Cattle
Meat: 15 days
Pigs
Horses
Milk: 5 days
Meat: 5 days
Meat: 3 days
Peppermint flavoured granules indicated for the alleviation
10 x 10g sachets containing 250mg
of inflammation and pain associated with musculoskeletal
Flunixin
disorders.
Potent non-narcotic, non-steroidal analgesic with
50ml, 100ml and 250ml
anti-inflammatory, anti-endotoxic and anti-pyretic properties.
Species dependent inflammatory conditions.
NSAID with analgesic, anti-pyretic and anti-inflammatory
properties. Used for adjunctive therapy in cattle, for control of
acute inflammation associated with respiratory disease.
50ml glass vials
Species dependent (alleviation of inflammation and relief
from pain - both chronic and acute; in combination with
antibiotic therapy or oral rehydration.)
50ml and 100ml
Anti-inflammatory, analgesic, anti-exudative, anti-pyretic and
anti-endotoxic properties for alleviation of musculo-skeletal
disorders in horses.
1 syringe, 7 pack, 14 pack
Apple flavours, dial-a-dose syringe.
42
Category
Metabolites
Product
Glutalyte Equine
Active
Glutamine, Sodium Citrate,
Sodium Chloride, Potassium Chloride,
Magnesium Acetate, etc.
Ivermectin
Anthelmintics
Noromectin
Miscellaneous
Intravit 12 0.05% w/v Cyanocobalamin
Solution for Injection (B12)
Species
Horses
Withdrawal
Nil
Specific indications
Oral rehydration following heavy sweating or during periods
of convalescence when nutrition restoration is required.
Packaging quantities and sizes
8 x 180g sachets
Horses
Meat: 34 days
1,2, 10 syringes
Horses
Nil
Nematodes and insect (Bots) - see data sheet for in depth
nematodes. (not indicated for tapeworm or small encysted
redworm).
Administer in cases of un-thriftiness, debility and
convalescence in known cases of B12 deficiency.
Nil
Indicated for deficiencies (vit B), cerebrocortical necrosis in
cattle and sheep and also the treatment of bracken poisoning
in horses.
50ml and 100ml
100ml vial
100ml vial
Cattle
Sheep
Pigs
Goats
Combivit Solution for
Injection
Thiamine Hydrochloride,
Riboflavine Sodium Phosphate,
Pyridoxine Hydrochloride,
Nicotinamide, Ascorbic Acid,
Chlorocresol
Dogs/cats
Horses
Cattle
Sheep
Multivitamin Injection Vitamin A, D3, E, B1, B2,B6, B12,
Nicotinamide and Dexpanthenol
Horses
*
Indicated for the treatment and prevention of vitamin
deficiencies in horses particularly during periods of illness,
convalescence and general unthriftiness.
Norocaine
Lidocaine Hydrochloride,
Adrenaline
Crude Fish Oil, Raw Linseed Oil,
Spirits of Turpentine, Balsam of Fir,
Sulphuric Acid
Horses
*
Local anaesthetic for horses (local or field block and Regional). 100ml Vial
Horses
Nil
Conditions and softens hard or chapped skin;
Norfulvin 33.3 %
Equine paste
Griseofulvin
Horses
*
Oral antifungal antibiotic effective in the treatment of
ringworm.
70g dial-a-dose syringe
Norfulvin 7.5%w/w
Granules
Griseofulvin
Horses
*
Oral antifungal antibiotic effective in the treatment of
ringworm.
500g, 1kg, 3.5kg.
Noroquin Joint
Supplement
Glucosamine, Chrondroitin Sulphate,
N-Acetyl-D-Glucosamine,
Ascorbic Acid, Zinc Sulphate
Horses
Nil
A naturally superior and highly palatable nutritional
supplement to help maintain health cartilage and joint fluid
in horses.
10g powder sachets, 1kg powder,
17g paste, 102g paste
Muti Derm Range
Cattle
Management in cuts and sores; controls proud flesh;
management of sweet itch.
Multiderm Aerosol 140g
Powder: 125g
Ointment: 125g
*Not to be used in animals slaughtered for human consumption
**Not to be used in animals producing milk for human consumption
43
Championing Animal Healthcare
Since its foundation in 1968, Norbrook® has grown to be one of the world’s
leading pharmaceutical companies with manufacturing facilities on four
continents and sales and marketing offices in over 30 countries.
The Company exports to more than 120 countries worldwide and was
awarded the Queen’s Award for Enterprise in International Trade in 2011.
Get our FREE
Veterinary Excellence
iPhone App
or visit norbrook.com
to download the
Compendium!
www.norbrook.com
Manufactured and distributed in NI by: Norbrook Laboratories Ltd, Station Works, Newry, Co. Down, BT35 6JP.
Distributed in GB by: Norbrook Laboratories (GB) Ltd, 1 Saxon Way East, Oakley Hay Industrial Estate, Corby, NN18 9EX.
1649-EQ-v2-UK-15/07/13