International Life Sciences Institute 2011 ILSI Annual Report 2 Letters from the President and Chair 12 Global Issue: Obesity 4 Global Issue: Water 15 2011 ILSI Board of Trustees 6 Global Issue: Risk Assessment 16 2011 ILSI Members 8 Global Issue: Biotechnology 20 2011 Revenue and Expenses 10 Global Issue: Functional Foods ILSI believes scientists from industry, academia, and government can and should work together in an open, transparent manner. The collaborative nature of our work – which is part of the larger body of scientific evidence – helps industries make safe, healthy products and helps governments provide effective and practical guidance to ensure public health and well-being and environmental safety. Fresh. Energetic. Bold. ILSI adopted a new logo in 2011 – While logo interpretation is often The fresh, bold, and energetic logo is one designed to catch the eye subjective, the abstract nature of an effective tool to catch attention and and convey the dynamism of the symbol has underlying meaning. build recognition of our contribution the organization. It reflects the The concentric circles simultaneously to the science that helps makes the enthusiasm we have for our mission portray a stylized plasmid map world a better place. Its implementation to deliver science that leads to a signifying our focus on the life online and in print is part of an healthier world. sciences and a world globe ongoing communications strategy representing our international reach. to raise awareness of ILSI’s value within The way in which the individual lines the scientific community. work together to create a whole expresses our commitment to collaboration and is an emblem of the synergy of our work among ILSI entities and with our partners. From the President T Peter van Bladeren, PhD President International Life Sciences Institute he central challenge laid out in the ILSI strategic plan is to “enhance ILSI’s scientific contribution to improve human health and the environment.” ILSI strives to achieve this goal by continually examining how well our scientific portfolio is meeting important health and environmental concerns. Our Global Issues – common topics of interest across ILSI entities and featured in this annual report – are how we prioritize the science to meet this central challenge. In 2011, we added Water to our existing issues: Risk Assessment; Biotechnology; Functional Foods; and Obesity. This is a response to the global threat of diminishing sources of safe water, and our programs are being designed to help achieve cost-effective sustainability for drinking water and food production. Another goal outlined in our strategic plan is to become a preferred resource for science; that is, to be recognized for delivering quality, useful science. While the Five Global Issues structure allows us to manage our dynamic scientific portfolio, proactive communications is making people aware of our role in today’s important issues and in getting the science into the hands of the people who make decisions affecting the health and well-being of all of us. As part of this invigorated communications effort, ILSI has adopted a bold new logo – one that catches and keeps attention. Also, many branches are taking the initiative to reach out to new audiences in creative ways. ILSI Europe and ILSI Brasil are examples where the media is being engaged to effectively raise awareness of ILSI’s scientific products. The quantitative results are illustrative; in the past two years our website has gone from having about 1,000 visits per month to an average of 9,000 hits per month. Every week we receive requests to join our newsletter distribution list from our core audiences: scientists in academia; government; and industry. Our objective for 2012 is to accelerate this communications momentum. The bright logo, an assertive and coordinated communications effort across ILSI entities, and a foundation of excellent science will further position ILSI as a go-to scientific organization. 2 From the Chair I Sushila Chang, PhD Chair ILSI Board of Trustees LSI’s global network is one of our greatest assets. Our branches, international committees, and the Research Foundation work at the national, regional, and international level allowing ILSI to nurture partnerships and foster collaboration at the very local level and the global level simultaneously and seamlessly. You can see this in the joint programs we develop between entities and with the external partners we have “on the ground,” as they say. International collaboration – true collaboration where more than one partner shares in the process for designing, implementing, and funding programs – is hard work. It requires patience, dedication, and sometimes finesse to establish a partnership and maintain it. This is why another of our greatest assets is our staff. It takes the perseverance and creativity of committed individuals to recognize opportunities, to mobilize resources, and assist our volunteer leadership in taking full advantage of prospects for forging new partnerships and expanding existing relationships, and all this across time zones. Therefore, in 2011, the ILSI Board of Trustees made a commitment to help staff help each other grow. We instituted a grants process by which we can support an exchange program. Staff from one branch will spend time at another branch sharing ideas and learning new ways of approaching their work. The exchange is designed so both the visiting branch and the hosting branch benefit from a cross-fertilization of ideas, whether it be on basic project management, on communications, or on fostering meaningful collaboration. In addition to the hands-on learning it provides, the exchange creates lasting relationships in themselves. It brings branches closer together and makes cooperation more second nature. Several members have already given generously to fund the exchange and we hope more will do the same. The program meets a tenet of the ILSI strategic plan to build staff capacity at all levels. It also invests in people – for the sake of the organization but also for the sake of the individual his or herself. It is a way to strengthen the skills of the very people who make ILSI strong. I look forward to the success stories stemming from this exciting exchange program. 3 Water Sustainability for Drinking and Food Production T he ILSI Board of Trustees identifies health and scientific topics of common concern or interest. These are issues affecting millions of people in all parts of the world. The Board refers to these as “Global Issues” – broadly defined categories used to track how ILSI’s work is improving our scientific understanding of today’s important concerns. Previously, the ILSI Board defined four Global Issues: Risk Assessment; Biotechnology; Functional Foods; and Obesity. In 2011, the Board added a new issue: Water. Although ILSI’s work on water issues is not new, the Board of Trustees elevated the topic as access to clean water has become as a more critical, global health problem in recent years. National governments and international health agencies are increasingly worried about shortages of water and inadequate water sanitation in urban and rural settings. More recently, the food and beverage industries are concerned about barriers to sustaining safe water supplies, which is due in part to a lack of best practices in the application of current technology; out-dated science policy on risks; confounding national and political pressures for water use; and even perceptions of what kind of water can be used in what ways. ILSI programs, both existing and new, are designed to bring together health and technical experts from a range of disciplines to work to fully understand the situation on local, regional, and international scales so appropriate solutions can be implemented. ILSI Europe Leads a Global outline for an overview publication, ILSI Europe is building a broad Initiative on Water which is in development and coalition of program partners. Eight ILSI Europe established a new expected to be published in 2012. ILSI branches (India, Japan, Korea, program on water known as The publication looks at fresh produce México, North Andean, South Andean, “Water and Sanitation Perspectives.” and microbial safety concerns; the South Africa, and Southeast Asia While the program is comprehensive, quality of irrigation waters used in fresh Region) are collaborating with an initial focus has been set on the produce production; microbial hazards ILSI Europe. The World Health quality of water used in the production linked to irrigation and process waters; Organization and the Food and of fresh produce. In March 2011, and microbial risk assessment. The Agriculture Organization of the ILSI Europe convened a meeting to publication will provide a scientific gap United Nations are providing technical define the scope of activities and the analysis and make recommendations support. Representatives from these shared responsibilities among the for next steps. groups and additional ones, such as initiative’s participants and supporters. the International Water Association and The meeting resulted in a specific the International Water Management Institute, serve on an Advisory Group to the initiative. 4 Innovation in Water Reuse in The guidelines, developed by a panel the Bottling Industry of experts, will lead to reductions in In 2011, the ILSI Research Foundation’s the bottling industry’s water footprint Center for Risk Science Innovation and (total liters of water required to produce Application launched a water program a liter of product) by guiding the designed to apply new and sometimes application of monitoring and safety innovative engineering, monitoring, evaluation protocols for purification and risk management approaches to processes and technologies that the reduction of water use in the food have so far only been used in pilot or and beverage industry. An initial project experimental applications. focuses on establishing guidelines for water reuse in the bottling industry. 5 Changing the Philosophy Behind Risk Assessment T hroughout 2011, the ILSI Health and Environmental Sciences Institute (HESI) built momentum on its initiative to improve how risk assessment is conducted: Risk Assessment for the 21st Century (RISK21). This effort, with the potential for far-reaching impact, seeks to improve human and environmental health by fundamentally shifting the focus of risk assessment to thinking about the problem that needs to be addressed first, followed by leveraging existing information; conducting additional toxicology testing and gathering more exposure information when needed; and incorporating new methods into the risk assessment process. 6 This shift places emphasis on problem formulation – i.e., thinking about the problem that needs to be addressed first. Problem formulation defines the scope of an exposure and effect of concern and the objectives for addressing them, and generates and evaluates preliminary hypotheses to address the concern. Problem formulation first uses existing information to help inform the risk assessment and applies new methods to the risk assessment whenever available and appropriate. RISK21 views problem formulation as an iterative process that identifies data gaps and leads to full understanding of a necessary level of certainty. Problem formulation is key to RISK21’s mission to bring applicable, accurate, and resource appropriate approaches to an evolving world of human health risk assessment. In 2011, HESI held a workshop and presented at the International Society of Exposure Science to educate audiences about RISK21 and to get feedback from diverse stakeholders on the project’s goals and how to achieve them. With over 50 participating organizations from academia, government, and industry, RISK21 epitomizes HESI’s commitment to the tripartite approach to generating scientific knowledge. In 2012, HESI will work with its partners on case studies designed to validate the effectiveness of the paradigm shift RISK21 represents. Risk Management Harmonization national, regional, and international A Risk from Risk Perception? In today’s globalized world, the stakeholders. ILSI Southeast Asia The Research Foundation’s Center for movement of agricultural products Region’s 2011 seminar “Food Risk Science Innovation and Application and food across national borders Contaminants: Emerging Issues (RSIA) examined the unintended creates a shared responsibility for and Risk Management Strategies” consequences of the perception of risk public health and safety. Whether brought together industry and (versus actual risk) on decision making. potential contamination is intentional government decision-makers to Recognizing human perception of risk or unintended, governments, industries, discuss common concerns about can lead to behavior that reduces health and important world bodies such the prevention and management risk (avoids a risk); increases health risk as the World Health Organization of chemical and microbial food (replaces an avoided risk with something must cooperate on setting standards contamination. In conjunction with riskier); or does not affect health risk and risk assessment methods for this event, ILSI Southeast Asia but has adverse economic effects, harmonized approaches. ILSI facilitated the “9th ASEAN Food RSIA convened a 2011 workshop on risk Southeast Asia Region has been a Safety Standards Harmonization perception. RSIA gathered risk assessment, leader in promoting the importance of Workshop,” where industry, academic, risk policy, and economics experts harmonization throughout Southeast and ASEAN country representatives from academia, government, industry, Asia and Australasia and in facilitating discussed how to fill scientific gaps im- and nongovernmental organizations to the exchange of perspectives among peding the progress of harmonization. explore public health risks stemming from errant perceptions of risk. The workshop spurred interest in case studies, to be initiated in 2012, which will further help identify, assess, and address public health risk from perceptions of risk. RISK21’s efforts will lead to the ability to assess more exposure situations, toxicity scenarios, and chemicals with existing resources; use far fewer animals in animal testing; and reduce the number of false positive and false negatives while simultaneously increasing confidence in the risk assessment. 7 International Colloboration on Biotechnology T he ILSI Research Foundation’s Center for Environmental Risk Assessment (CERA) is providing technical support to the Government of India as it works to establish an appropriate framework for conducting environmental risk assessment (ERA) of genetically engineered (GE) plants in India. The approach has been to assess the vast international experience in ERA, focusing on the scientific aspects of ERA versus policy or political considerations, so India can develop country-appropriate ERA guidance based on established principles and tested methods. ILSI’s biotechnology programs address scientific issues related to the safe development and distribution of products derived from modern agricultural biotechnologies. Success through Collaboration with ILSI Southeast Asia Region, workshops with ILSI Mexico, ILSI North Biotechnology is an area where ILSI ILSI Korea, and ILSI India to examine Andean, ILSI South Andean, ILSI Korea is especially successful in collaborating the latest developments in sampling and ILSI Japan; events that brought across entities. Led by the ILSI and detection methods. It also together regulators, academic experts, International Food Biotechnology presented at a workshop organized and industry scientists to discuss Committee’s (IFBiC) commitment to by the ILSI Health and Environmental improving systematic approaches to scientific outreach and capacity Sciences Institute and ILSI Focal Point the environmental risk assessment building, and the ILSI Research in China on the use of mammalian (ERA) of genetically engineered Foundation’s focus on creating toxicology studies in the safety assess- plants. CERA is also working with sustainable partnerships, ILSI and its ment of whole foods from genetically ILSI Argentina on a multi-year research branches have been able to connect engineered crops. The ILSI Research project exploring the issue of data local thought leaders and international Foundation, through the Foundation’s transportability in ERA. experts throughout 2011. IFBiC worked Center for Environmental Risk Assessment (CERA), co-organized 8 In 2011, this collaboration included the seminal “South Asia Conference on Current Approaches to Environmental Risk Assessment of Genetically Engineered Crops.” This important three-day event, which included symposia and a technical workshop, was organized by CERA and Biotech Consortium India Limited with support from the Indian government’s Department of Biotechnology and Ministry of Environment and Forests, and the United States Agency for International Development. The conference succeeded in its goal to bring together scientists and professionals from India and abroad to discuss in detail the science and the practice of ERA. Case studies of experience with ERA in Australia, India, The Philippines, and other countries set the stage for the discussions and established basic points of agreement. This included recognition that the science of ERA remains largely the same from country to country and that ERA harmonization across national borders can be achieved. Technical sessions then addressed the importance of problem formulation as the essential first step in ERA; field trial data collection and interpretation; understanding gene flow; post release environmental surveillance; and insect resistance management. Panel sessions were used to review horizontal gene transfer; the use of antibiotic resistance genes as selectable markers in GE plant development; and management of herbicide tolerance. The case studies, technical sessions, and panel discussions exposed participants from Indian Central and State governments; state agricultural universities; research institutes; and industry to a wealth of knowledge and experience on ERA. Throughout the conference, participants were encouraged to make observations and provide suggestions based on the information shared. The collective “way forward” determined by presenters and participants included a recommendation to develop guidance that will facilitate the establishment of data requirements and methods for data collection, that leads to a transparent and predictable ERA process and public confidence in the ability of ERA to address environmental safety. ILSI Recognized as a Recognizing ILSI’s scientific expertise comparing safety assessments for Scientific Resource in biotechnology, OECD invited ILSI allergens; safety assessment of The Organization for Economic to conduct an educational workshop stacked events; and the use of Cooperation and Development (OECD) on a range of relevant topics. Held in mammalian toxicology studies for has been involved in biotechnology 2011 in France, the workshop was the safety evaluation of genetically for over 30 years, with current interest organized by the ILSI International derived crops. IFBiC also showcased in the safety of novel foods and feed; Food Biotechnology Committee its Crop Composition Database harmonization of regulatory oversight (IFBiC) in collaboration with the (www.cropcomposition.org). of biotechnology across national ILSI Health and Environmental borders; the role biotech can play in Sciences Institute. Industry and OECD delegates were impressed adaption to climate change; and the academic experts delivered technical with the scientific scope and technical ability of biotech to support their information on quantifying and focus of the workshop and have “Green Growth Strategy” whereby suggested similar workshops be countries meet development goals organized in the future. while safeguarding their natural assets. 9 Functional Foods – Beyond Basic Nutrition I LSI has been at the front of the science supporting functional foods – foods and food components that provide health benefits beyond basic nutrition – since its pivotal 1995 conference “Functional Foods: East–West Perspectives.” At that event, experts from Asia, Europe, and the Americas debated basic concepts related to definition, measuring efficacy, and claim substantiation. ILSI Europe organized additional international conferences in 2001, 2007, and, most recently, 2011. The programs of these meetings reflect how sophisticated the science has become over the years and how some of the questions still to be answered have become more exciting because of their potential to improve health and well-being. As its title implies, the 2011 conference “Health Benefits of Foods – from Emerging Science to Innovative Products” focused on the possibilities of functional foods. Not only did experts present on fundamental principles such as food characterization (i.e., evaluation of food components), they also speculated on the role functional foods can play in preventative health and thereby relieve pressure on global health care costs. 10 The conference was also an inauguration of ILSI Europe’s new program “Marker Initiative in Nutrition Research.” Clinical endpoints and biological markers are critical to objectively measuring purported health effects of a specific food or food component. The comparison of existing and new data, however, is hampered in part by a lack of consistency in marker selection. Through its Marker Initiative, ILSI Europe is facilitating the development and acceptance of criteria for using markers in different fields of nutrition. Functional Foods in South Asia and South America ILSI-India held a conference in early 2011 entitled “Processed Food and Beverages for Health: Beyond Basic Nutrition” whose program highlighted the east–west perspectives on functional foods. Leading authorities on functional foods and health claims came from Europe, India, Japan, and Singapore to review general principles and specific food components and also to compare what science is required in different regulatory systems and/or guidelines around the world. Later in the year, ILSI-India organized the conference “Health and Longevity through Chai” which looked specifically at tea consumption and health and the potential to enhance tea with herbs and micronutrients. ILSI North Andean and ILSI South Andean also fostered an exchange of ideas on functional foods in 2011. ILSI North Andean’s program featured a keynote speaker from ILSI Europe and focused on what was learned from both successful and unsuccessful attempts to substantiate health claims. Through the case studies presented at the meeting, ILSI North Andean demonstrated how existing knowledge can be used in the regional context of Colombia, Ecuador, and Venezuela. ILSI South Andean’s symposium examined the health benefits of specific components (e.g., vitamin D and Omega-3 fatty acids) and explored cutting-edge developments in the field of nutraceuticals – foods and food components used to treat illness. Communicating the Science ILSI Europe took a bold, creative step with its conference “Health Benefits of Foods” by inviting members of the press to attend and report on the science. While ILSI has begun engaging science journalists, notably in ILSI Korea and ILSI Brasil, ILSI Europe’s efforts were especially comprehensive. They facilitated interviews between speakers and reporters, including for TV broadcast, and sent daily news releases to science writers throughout Europe. The goal is two-fold: increase awareness of the science and of ILSI’s role in contributing to that science. The success of their proactive efforts is reflected by the number of visits ILSI Europe’s website receives. Similarly, ILSI Argentina has been active in reaching out to new audiences. In 2011, it partnered with the Argentine Foundation of Nutrition and ArgenBio to create the Council for Food Safety and Nutrition Information (CISAN). ILSI’s work on functional foods is instrumental in establishing the science needed to substantiate health claims for foods and food components that go beyond basic nutrition. Using web-delivered information via news articles, fact sheets, videos, and other tools, CISAN is extending the reach of science to health professionals, science communicators, and the general public. 11 ILSI is Recognized for its Obesity Work O besity is a global epidemic affecting developed and developing countries alike, and its causes and consequences are complex and far-reaching. Over the years ILSI has contributed to the science of mechanisms associated with energy balance; improved our understanding of obesity’s comorbidities; examined how food and food components can play a role in maintenance of ideal weight, prevent weight gain, or promote weigh loss; and developed school- and community based intervention programs that promote healthy lifestyles. However, obesity remains an international health challenge and ILSI remains committed to this important and complicated public health threat. The Health Ministry of China has commissioned ILSI Focal Point in China to develop “The Method to Determine Overweight and Obesity in Chinese Adults.” The document, which will include categories determined by body mass index, will help health practitioners identify at-risk individuals. The Ministry’s recognition of ILSI Focal Point in China for this important task is a result of the Focal Point’s successful work on the first ever Physical Activity Guidelines for Chinese Adults. Drafted by experts in physical activity and sport medicine and in context of Chinese 12 society and culture, the guidelines were formally put into trial use in 2011 by the Ministry of Health. The Guidelines document is a tool for health and physical education professionals to develop individual and communitybased physical activity programs. It is also a reference for the science underlying the importance of adequate physical activity for achieving and maintaining healthy weight and overall health. Also in 2011, ILSI Focal Point in China began an intervention study to better understand motivation and compliance when it comes to weight-loss programs. In partnership with Weight Watchers International, preliminary results show a mean weight loss of 4kg in subjects. The final results of the study will be used to design and implement better public health strategies for individual and population-based weight management programs. Community-based Solutions in Australia In a second collaborative meeting with the Sydney (Australia) West Area Health Service and its Centre for Health Innovation and Partnership, ILSI Southeast Asia Region coorganized a 2011meeting to share best practices on how to encourage and enable healthy eating and active living. ILSI Southeast Asia Region and the Sydney West Area Health Service are especially interested in building successful community initiatives through innovative partnerships; food interventions; and promoting physical activity in households, workplaces, and schools. The meeting resulted in an updated evidence-based understanding of issues related to the promotion of sustainable community health. The two organizations plan to continue their collaboration to determine how to implement best practices in different community settings. Understanding Caloric and Non-Caloric “Sweetness” The 2010 Dietary Guidelines for Americans issued by the US Department of Agriculture (USDA) state that “replacing added sugars with non-caloric sweeteners may reduce calorie intake in the short-term…” but then go on to say “…yet questions remain about their effectiveness as a weight management strategy.” The statement reflects a questioning within the health professional community about the appropriate role for non- or low-calorie sweeteners as a weight management tool. The debate in part prompted ILSI North America to review the current science with the goal to identify and resolve outstanding concerns. As part of their efforts, ILSI North America convened a 2011 workshop on low-calorie sweeteners. The comprehensive program first examined the neuroscience of sweet taste and the role sweetness plays in food intake; then reviewed the obesity epidemic, focusing on the problem of childhood overweight now and into the future. Workshop participants discussed the limitations of observational studies and the use of animal toxicological studies of sweeteners in predicting effects on human weight management. Experts compared the effects of sugars and low-calorie sweeteners on satiety, glucose response, and insulin levels. ILSI North America will publish proceedings from the meeting in 2012. The individual papers will summarize what is currently known about low-calorie sweeteners and outline opportunities for additional research. In addition, ILSI North America sought to immediately extend the reach of what is already known about low-calorie sweeteners, especially to health educators. To do this, ILSI North America partnered with the USDA’s eXtension program to create and disseminate a webinar on low-calorie sweeteners. eXtension is an online resource for information on human and animal health. The webinar presented findings from the workshop to over 100 USDA extension agents across the United States. ILSI Research Foundation with short periods of structured is a supplier of tools and resources Partners with FlagHouse physical activity. Research shows intended for educators in physical The ILSI Research Foundation chose children who participate in TAKE 10! activity, recreation, education, and FlagHouse, Inc. to be its exclusive have improved attention spans, test special needs. Together, the Research distributor of TAKE 10!® and launched scores, and body mass indices. It is Foundation and FlagHouse are a redesigned website (www.take10.net). currently in over 55,000 classrooms in promoting this research-developed TAKE 10! is a 5-K classroom-based the United States and pilots are being and validated program as a tool to intervention program combining grade- tested internationally by ILSI Brasil, improve lifestyles. specific academic learning objectives ILSI Europe, ILSI Focal Point in China, and ILSI North Andean. FlagHouse 13 14 2011 ILSI Board of Trustees ILSI is governed by its Board of Trustees, the members of which come from academia, government, and industry. These dedicated volunteers establish organizational policy, guide scientific direction, and ensure scientific integrity and financial transparency. Dr. Peter van Bladeren ILSI President Nestlé Research Center Switzerland Dr. Sushila Chang Chair, ILSI Board of Trustees Singapore University of Technology and Design Singapore Dr. Todd Abraham Kraft Foods USA Dr. Marc Bonnefoi sanofi-aventis USA Dr. Alan Boobis Imperial College London United Kingdom Dr. Henry Chin Coca-Cola Company USA Dr. Marion Ehrich VA-MD Regional College of Veterinary Medicine USA Dr. Mark Empie Archer Daniels Midland USA Dr. Gerhard Eisenbrand University of Kaiserslautern Germany Mr. Reginald Fletcher Kellogg’s Europe Ireland Dr. Jay Goodman Michigan State University USA Dr. Phil Guzelian University of Colorado Health Science Center (Retired) USA Dr. Jerry Hjelle Monsanto Company USA Dr. Michael Knowles Coca-Cola Europe Belgium Dr. Samuel Cohen University of Nebraska Medical Center USA Dr. Milan Kovác (resigned July 2011) Ministry of Agriculture & Rural Development Slovakia Dr. John Doull University of Kansas Medical School USA Dr. Tamotsu Kuwata University of Human Arts and Sciences Japan Dr. Ik-Boo Kwon Lotte Company Korea Dr. John Milner National Cancer Institute USA Mr. Felipe Rodríquez Pepsico México Dr. P. K. Seth Lucknow Biotechology Park India Mr. Geoff Smith Nutrition Strategies International Singapore Dr. Lewis Smith Medical Research Council United Kingdom Dr. Geoff Thompson Groupe Danone France Dr. Sara Valdés Martínez University of México México Dr. Connie Weaver Purdue University USA Dr. Elizabeth Westring General Mills USA Dr. Flávio A.D. Zambrone Planitox Brazil Dr. Barry L. Zoumas (deceased August 2011) The Pennsylvania State University USA Dr. Asahi Matsuyama Kikkoman Corporation Japan 15 2011 ILSI Members ILSI is proud of its member support for its goal to foster collaboration among leading scientists from academia, government, and industry to identify and resolve scientific issues of common concern. ILSI Argentina Bayer S.A. Chacra Experimental Agrícola Santa Rosa Coca-Cola de Argentina S.A. Danone Argentina S.A. Danone Baby Nutrition Dow AgroSciences Argentina S.A. Grupo Arrayanes Kraft Foods Argentina S.A. Kromberg Fine Chemical S.R.L. Merisant Argentina S.R.L. Monsanto Argentina S.A.I.C. PepsiCo de Argentina S.R.L. Publitec S.A. Editora Syngenta Agro S.A. Unilever de Argentina S.A. ILSI Brasil Abbott Laboratórios do Brasil Ltda. Ajinomoto Interamericana Indústria e Comércio Ltda. Arcor do Brasil Ltda. Arysta Lifescience do Brasil Ltda BASF S.A. Bayer S.A. Beneo-Orafti Latinoamerica Coord. Regional Ltda. Bunge Alimentos Coca-Cola Indústrias Ltda. Corn Products Brasil Danisco Brasil Ltda. Danone Ltda. Dow Agrosciences Industrial Ltda. DSM Produtos Nutricionais Brasil Ltda. Fortitech South America Industrial e Comercial Ltda. Futuragene Brasil Tecnologia Ltda. Herbalife International do Brasil Ltda. 16 Iharabras S.A. Indústrias Químicas Kellogg Brasil Ltda. Kraft Foods Brasil Ltda. Masterfoods Brasil Alimentos Ltda. Mead Johnson Nutritional Milenia Agro Ciências S.A. Monsanto do Brasil Ltda. Nestlé Brasil Ltda. Nutrimental S/A Industria e Comercio de Alimentos Pfizer Consumer Home Health Red Bull do Brasil Ltda. Sadia S.A. Sanavita Indústria e Comércio de Alimentos Funcionais Ltda. Solae do Brasil Ind. e Com. de Alimentos Ltda. Support Produtos Nutricionais Ltda. Syngenta Proteçao de Cultivos Ltda. Yakult S.A. Indústria e Comércio ILSI Europe Abbott Nutrition Ajinomoto Europe Barilla G&R Fratelli BASF SE Bayer CropScience BioScience Beverage Partners Worldwide (Europe) AG Bionov Biosearch Life Bunge Europe Campbell Soup Company Cargill Chiquita Brands International Clasado Coca-Cola Europe Colloïdes Naturels International Cosucra Groupe Warcoing Danisco Danone Dow Europe DSM DuPont de Nemours Firmenich FrieslandCampina Givaudan Schweiz Group Roquette H.J. Heinz Institut Mérieux Kellogg Europe Kikkoman Foods Europe Kraft Foods Europe Lallemand SAS Lavazza S.p.A Mars Martek Biosciences Corporation McDonald’s Europe McNeil Nutritionals Europe Mead Johnson Nutrition Merck Consumer Healthcare Monsanto Europe National Starch Food Innovation Naturex Nestlé PepsiCo International Pfizer Consumer Healthcare Premier Foods Procter & Gamble Puratos Group Red Bull Schwabegroup Sensus Seven Seas Solae Europe Soremartec - Ferrero Group SQTS - Swiss Quality Testing Services Südzucker/BENEO Group Syngenta Crop Protection Tate & Lyle Tereos-Syral Tetra Pak Research The International Nutrition Company Ülker Bisküvi San. Ve Tic A. S. Unilever Wild Flavors Yakult Europe B.V. ILSI Focal Point in China Abbott Laboratories Ajinomoto Co., Inc. Almond Board of California Amway (China) Co., Ltd. BASF (China) Co., Ltd. Bunge Limited Cargill Investments (China) Ltd. Carrefour (China) Foundation for Food Safety Coca-Cola (Shanghai) Beverages Ltd. Danisco (China) Co., Ltd. DSM (China) Ltd. Fonterra Commercial Trading (Shanghai) Company Groupe Danone (China) Givaudan Flavours (Shanghai) Ltd Herbalife H.J. Heinz Company IFF (China) Ltd. Kellogg Kraft Foods (China) Company Limited Mars Foods (China) Co., LTD. McDonald’s (China) Co., Ltd. Mead Johnson Pediatric Nutrition Institute (China) Monsanto Far East Ltd. Meiji Dairies Corporation Nestlé (China) Ltd. Nutrexpa-Cola Cao Tianjin Food Co., Ltd. PepsiCo (China) Limited Red Bull Roquette Shanghai Wyeth Nutritional Co., Ltd Symrise (Shanghai) Ltd. Tingyi (Cayman Islands) Holding Corp. Unilever Bestfoods (China) Co., Ltd. Wei Chuan Foods Corporation Wrigley Confectionery (China) Limited Yum! Restaurants China ILSI Health and Environmental Sciences Institute Abbott Laboratories Actelion Pharmaceuticals Ltd Allergan Amgen, Inc. Astellas Pharma Inc. AstraZeneca AB BASF Corporation Battelle Memorial Institute Bayer AG/Bayer CropScience Biogen Idec MA Inc. Boehringer Ingelheim GmbH Bristol-Myers Squibb Company Charles River Laboratories The Coca-Cola Company Covance Laboratories, Inc. Daiichi-Sankyo Co., Ltd. Data Sciences International, Inc. Dow AgroSciences, LLC/The Dow Chemical Company Dow Corning Corporation E.I. du Pont de Nemours and Company Eli Lilly and Company Experimental Pathology Laboratories, Inc. ExxonMobil Biomedical Sciences Inc. GlaxoSmithKline Hoffmann-La Roche, Inc. Institut de Recherches Int. SERVIER Johnson & Johnson Pharmaceuticals L’Oreal Corporation LyondellBasell Industries Merck & Co., Inc. Mitsubishi Tanabe Pharma Corp. Monsanto Company Novartis Pharmaceuticals Corporation Pfizer, Inc. Portola Pharmaceuticals Inc. The Procter & Gamble Company Purdue Pharma L.P. Sanofi S.C. Johnson & Son, Inc. Shell Chemicals, Ltd. Stellar Biotechnologies Sumitomo Chemical Co., Ltd. Syngenta Ltd. Takeda Pharmaceutical Company Limited ILSI-India Abbott Healthcare Pvt. Ltd. Ajinomoto Co., Inc. Akzo Nobel Chemicals BV Research & Technology Chemicals BASF India Ltd. Bayer Bioscience Pvt. Ltd. Bikanerwala Foods Pvt. Ltd. Britannia Industries Ltd. Cargill India Pvt. Ltd. Coca-Cola India DSM Nutritional Product India Pvt. Ltd. General Mills India Pvt. Ltd. Herbalife International India Pvt. Ltd. Hexagon Nutrition Pvt. Ltd. Hindustan Unilever Ltd. ITC Food Business ITC Ltd. Kejriwal Enterprises Kellogg India Private Ltd. Lonza India Pvt. Ltd. Mars Incorporated Monsanto Holdings Pvt. Ltd. Monsanto Holdings Pvt. Ltd. National Dairy Development Board Nestlé India Ltd. Nicholas Piramal India Ltd. PepsiCo India Holdings (P) Ltd. (Frito Lay Division) Roha Dyechem Pvt. Ltd. Sayaji Sethness Ltd. Wockhardt Ltd. 17 2011 ILSI Members continued ILSI Japan ADEKA Corporation Ajinomoto Co., Inc. Ajinomoto General Foods, Inc. Amano Enzyme Inc. Aohata Corporation API Co., Ltd. Asahi Group Holdings, Ltd. BASF Japan Ltd. Bayer Crop Science K.K. Calpis Co., Ltd. Coca-Cola (Japan) Co., Ltd. Coca-Cola Tokyo Research and Development Co., Ltd. Danisco Japan Ltd. Dow Chemical Japan Ltd. DuPont Kabushiki Kaisha Ensuiko Sugar Refining Co., Ltd. Fuji Oil Co., Ltd. FUJIFILM Corporation International Flavors & Fragrances (Japan) Ltd. Itoen, Ltd. Kagome Co., Ltd. Kaneka Corporation Kao Corporation Kikkoman Corporation Kirin Holdings Co., Ltd. Knorr Foods Co., Ltd. Kyowa Hakko Bio Co., Ltd. Lotte Co., Ltd. Matsutani Chemical Industry Co., Ltd. Megmilk Snow Brand Co., Ltd. Meiji Corporation Ltd. Mitsubishi Shoji Foodtech Co., Ltd. Mitsui Norin Co., Ltd. Mitsui Sugar Co., Ltd. Miyoshi Oil & Fat Co., Ltd. Monsanto Japan Ltd. Morinaga & Co., Ltd. Morinaga Milk Industry Co., Ltd. Nestlé Japan Ltd. Nichirei Foods Inc. Nihon Firmenich K.K. Nihon Kraft Foods Ltd. 18 Nippi Inc. Nippon Flour Mills Co., Ltd. Nippon Meat Packers, Inc. Nippon Suisan Kaisha Ltd. Nisshin Seifun Group Inc. NOF Corporation Ogawa & Co., Ltd. Otsuka Pharmaceutical Co., Ltd. Prima Meat Packers, Ltd. Procter & Gamble Japan K.K. Riken Vitamin Company, Ltd. San-Ei Gen F.F.I., Inc. Sapporo Breweries Ltd. Shiono Koryo Kaisha, Ltd. Showa Sangyo Company, Ltd. Soda Aromatic Co, Ltd. Suntory Holdings Limited Syngenta Japan K.K. T. Hasegawa Co., Ltd. Taisho Pharmaceutical Co., Ltd. Taiyo Kagaku Co., Ltd. Takasago International Corporation The Nisshin OilliO Group, Ltd. Tsukishima Foods Industry Co., Ltd. Unilever Japan Service K.K. Yakult Honsha Co., Ltd. Yamazaki Baking Company, Ltd. ILSI Korea Ajinomoto Korea, Inc. Amway Korea, Ltd. BASF Co., Ltd. Bayer CropScience BIOFOOD Network Center CJ CheilJedang Corporation Coca-Cola Korea Company, Ltd. Corn Products Korea Co., Ltd. Daesang Co., Ltd. Danisco Cultor Dow AgroSciences International Ltd. DuPont Korea, Inc. HAITAI Confectionery & Foods Ilshin Wells Co., Ltd JMC Corporation Korea Yakult Co., Ltd. LOTTE R&D Center MARS Korea McDonald’s Korea Monsanto Korea Inc. Nongshim Co., Ltd. Pulmuone Co., Ltd Samsung Everland Inc. Samyang Corporation SPC Food Safety Center Syngenta Korea Inc. ILSI México Abbott Laboratories de México, S.A. de C.V. Colloides Naturels de México, S. A. de C. V. Corporativo Bimbo, S.A. de C.V. DSM Nutritional Products México, S.A. de C.V Effem México, Inc. y Compañías S. en N.C. de C. V. Grupo Danone de México, S. A. de C. V. Kellogg de México, S. de R. L. de C. V. Kraft Foods de México, S. de R. L. de C. V. Mead & Johnson Nutricionales de México, S. de R. L. de C. V. Monsanto Comercial, S. A. de C. V. Nestlé México, S.A. de C.V. Sabritas S. de R. L. de C. V. (Frito-Lay; PepsiCo) Sensient Colors, S. A. de C. V. SIAAG, S.A. de C.V. (Coca-Cola) Silliker México, S. A. de C. V. Unilever de México, S.A. de C.V. Yakult, S.A. de C.V. Bayer de México, S.A. De C.V. FIRMENICH de México, S. A de C. V. Tate & Lyle México, S de R L. de C.V. ILSI North America Abbott Nutrition Ajinomoto USA Inc Archer Daniels Midland Company BENEO Group - Palatinit Suedzucker Bunge Limited Cadbury Adams USA, LLC Campbell Soup Company Cargill, Incorporated The Coca-Cola Company Cognis Nutrition and Health ConAgra Foods, Inc. Danisco USA, Inc. The Dannon Company, Inc. Dr Pepper Snapple Group DSM Nutritional Products AG General Mills The Hershey Company H.J. Heinz Company Kellogg Company Kraft Foods, Inc. Mars, Incorporated Martek Biosciences Corporation McNeil Nutritionals, LLC Mead Johnson Company, LLC Monsanto Company National Starch/Corn Products International Nestlé USA, Inc. Ocean Spray Cranberries, Inc. PepsiCo, Inc. Procter & Gamble Company Red Bull GmbH Sara Lee Corporation Senomyx, Inc. Solae Company, Inc. Tate & Lyle Unilever ILSI North Africa & Gulf Region Akzo Nobel Company Atlantic Industry (Coca-Cola Egypt) Chamber of Food Industries (CFI) Holding Company for Food Industries Kraft Foods Company Pepsi-Cola International Safola Egypt ILSI North Andean Abbott Laboratories de Colombia S.A. Agrícola Ganadera Reysahiwal S.A. Alfonzo Rivas y Cía Alimentos Polar Colombia S.A.S. Alpina Productos Alimenticios S.A. Cargill de Venezuela CA Cervecería Polar Clariant (Colombia) S.A./Beneo Orafti Latinoamérica Coca-Cola de Venezuela Coca-Cola Servicios de Colombia, S.A. Compañía Agrícola Colombiana Compañía de Galletas Noel S.A. Congelagro S.A. Corn Products Andina Colombia Danisco Colombia Ltda. DSM Nutritional Products Colombia S.A. Ecarni S.A. Empresas Polar Venezuela Industrial Danec S.A. Kellogg de Colombia Kraft Foods Colombia Ltda. Kraft Foods Ecuador Kraft Foods Venezuela C.A. La Fabril S.A. Mead Johnson Nutritionals Colombia Mead Johnson Nutritionals Ecuador Mead Johnson Nutritionals Venezuela Meals de Colombia S.A. Monsanto - Ecuador Monsanto - Venezuela Nestlé de Colombia Nestlé del Ecuador Nestlé Venezuela Omnilife de Colombia S.A.S. Pepsico Alimentos colombia L.T.D.A. Pfizer S.A. Postobón S.A. Productos Alimenticios Doria S.A.S. PRONACA C.A. Refreshment Product Services Ecuador S.A. (Coca-Cola) Seatech International (Van Camp´s) Snacks America Latina Venezuela Sociedad Agrícola e Industrial San Carlos Tecnas S.A. Unilever Andina Colombia ILSI South Africa Coca-Cola Southern Africa DSM Nutritional Products MARS Africa Monsanto South Africa (Pty.) Ltd. Nampak Ltd. Nestlé South Africa Pioneer Foods(Pty.) Ltd. Unilever South Africa Ltd. ILSI South Andean Coca-Cola de Chile SA Danisco Chile S.A. DSM Nutritional Products Chile SA Herbalife Interacional de Chile Kraft Foods Argentina S.A. Monsanto Chile S.A. Nestle S.A. Tresmontes Lucchetti Unilever ILSI Southeast Asia Abbott Nutrition Ajinomoto Co, Inc, ASEAN Headquarters Almond Board of California BASF East Asia Regional Headquarters Limited Bayer CropScience Pty Ltd BENEO Asia-Pacific Pte. Ltd Campbell Arnotts Cerebos Pacific Limited Danisco New Zealand Ltd Danone Research Centre for Specialized Nutrition DSM Nutritional Products Asia Pacific Pte. Ltd. Fonterra Cooperative Group Limited Kraft Foods MARS Incorporated Mead Johnson Nutrition (Thailand) Ltd Monsanto Singapore Co (Pte) Ltd Nestlé R&D Center (Pte.) Ltd. Nutrition Strategies International LLC Pfizer Inc PT Cargill Indonesia PT Coca-Cola Indonesia Simplot Australia Pty Ltd Unilever - Greater China East Asia Australia New Zealand (GCEA-ANZ) Yeo Hiap Seng Ltd. 19 2011 Revenue & Expenses Funding comes from membership revenues, government grants, corporate contributions, and sale of publications. Revenues and expenses shown are based on unaudited 2011 year-end projections. ILSI combines public and private resources to achieve more with less. Revenue Sources Member Support: 70% Grants & Contributions: 21% Publications: 3% Interest & Dividend Income: 3% Conference Registration: 2% Other Income: 1% Expenses General & Administrative: 21% Conferences & Workshops: 26% Publications: 7% Research: 7% Governance: 5% Development: 1% Other Program Expenses: 33% For information about ILSI, contact: International Life Sciences Institute 1156 Fifteenth Street, NW Suite 200 Washington, DC 20005 USA www.ilsi.org 20 International Life Sciences Institute®, ILSI®, Nutrition Reviews®, and the ILSI logo image of concentric circles are trademarks of ILSI. ©2011 International Life Sciences Institute All Rights Reserved All photographs ©Dreamstime® Contact Information ILSI www.ilsi.org Suzanne Harris, PhD Executive Director ILSI Research Foundation www.ilsi.org/ReseachFoundation Suzanne Harris, PhD Executive Director Global Branch ILSI Health and Environmental Sciences Institute www.hesiglobal.org Syril Pettit Executive Director Regional and National Branches ILSI Argentina www.ilsi.org/Argentina Patricia Torres Branch Coordinator ILSI Brasil www.ilsi.org/Brasil Mariela Weingarten Beresovsky Executive Director ILSI Europe Celebrating 25 years in 2011! www.ilsi.org/Europe Nico van Belzen, PhD Executive Director ILSI Focal Point in China www.ilsi.org/China Junshi Chen, PhD Executive Director ILSI North America www.ilsina.org Eric Hentges, PhD Executive Director ILSI North Andean www.ilsi.org/NorthAndean Marta Elena Soto Rojas Executive Director ILSI-India www.ilsi.org/India Rekha Sinha Executive Director ILSI Japan Celebrating 30 years in 2011! www.ilsi.org/Japan Ryuji Yamaguchi, PhD. Executive Director ILSI Korea www.ilsi.org/Korea Myeong-Ae Yu, PhD Executive Director ILSI México Celebrating 20 years in 2011! www.ilsi.org/Mexico Cecilia Robles Executive Director The International Life Sciences Institute (ILSI) is a nonprofit, worldwide organization established in 1978 to advance scientific understanding of nutrition, food safety, toxicology, risk assessment, and the environment. ILSI North Africa & Gulf Region www.ilsi.org/NorthAfrica Hanan Zaki Branch Coordinator ILSI South Africa www.ilsi.org/SouthAfrica Nick Starke Branch Coordinator ILSI South Andean www.ilsi.org/SouthAndean Cristina Cisternas Branch Coordinator ILSI Southeast Asia Region www.ilsi.org/SEA_Region Yeong Boon-Yee Executive Director ILSI brings together scientists from academia, government, industry, and the public sector who work together to solve problems of common interest for the health and well-being of the public. International Life Sciences Institute 1156 15th Street, NW Suite 200 Washington, DC 20005 1.202.659.0074 telephone 1.202.659.3859 facsimile www.ilsi.org