ChE 476
Biomedical Engineering
Spring 2007
Washington State University
School of Chemical Engineering & Bioengineering
Bernard J. Van Wie & Nehal I. Abu-Lail
Syllabus for ChE 476
Office Hours: BVW: EME B57 – Tu 2:30 - 3:30, Th 4:00 - 5:00p, otherwise by appointment
NIA: EME 59 – Tu & Th 10 -11, otherwise by appointment
Main Text:
Cooney, D.O., “Biomedical Engineering Principles: An Introduction to Fluid, Heat,
and Mass Transport Processes”, Marcel Dekker, Inc., 1976; Chapters 1-7.
Additional Text & Materials: Texts or portions thereof, journal papers and data will be provided, recommended or procured by students with the following for the 2nd half of the semester:
1) Morris, V.J.; Kirby, A. R.; Gunning, A. P., “Atomic Force Microscopy for biologists”, Imperial
College Press, 1999
2) Methods in Molecular Biology, Volume 242, “Atomic Force Microscopy: Biomedical methods
and Applications” Edited by: Braga, P. C. and Ricci, D., Humana Press Inc., 2004
3) “Atomic Force Microscopy in Cell Biology” Edited by Jena, B. P. and Heinrich HÖrber, J. K.
Course Overview: Course objectives are to demonstrate understanding and application of
chemical, bio- engineering and scientific principles as they pertain to the biomedical arena.
Grading:
Group Project – 25%
Homework – 25%
Exam I – 20%
Final – 30%
Group Projects: You will conduct a 3-person team project where you will demonstrate mastery
of course principles and solve a biomedically related problem in a 10-page report. In an oral
report you are to formalize, generalize and teach a set of concepts and provide insights to help
solve a substantial homework problem developed by your group. Your group should hold office
hours during the time in which others are working on your problem.
Homework: Due at 11:10a (unless otherwise agreed upon); if late then there is a 25% penalty if
turned in by 5:00p; 50% by 8:00a the following day; and no credit afterward. Individual and
group assignments will be given. On individual assignments group discussions are encouraged,
however, copied assignments are not acceptable. There must be a clear presentation of the
problem and a solution understandable by another engineer including:
1) Problem statement with a diagram
2) Approaches and equations used
3) Values w/ units used for the solution
4) Answers underlined with appropriate units
5) A discussion of implications of the answer
6) Computer graphics, linear regressions, etc.
Exams: A midterm and final will be given.
Disability Statement: We are committed to providing assistance to help you be successful in
this course. Reasonable accommodations are available for students with a documented disability. Please visit the Disability Resource Center (DRC) during the first two weeks of every semester to seek information or to qualify for accommodations. All accommodations MUST be approved through the DRC (Admin Annex Bldg, Room 205). Call 509-335-3417 to make an appointment with a disability counselor.
Academic Honesty: All information from outside sources must be properly cited. Though you
may consult with your group on individual homeworks they must be completed by the individual.
Cases of plagiarism and cheating will result in a penalty commensurate with the offense. The
university’s policy regarding cheating and plagiarism is found in the Schedule of Courses (Legal
Notices on Cheating and Plagiarism) or the University Catalog (Policies and Regulations).
ChE 476
Biomedical Engineering
Spring 2007
Washington State University
School of Chemical Engineering & Bioengineering
Bernard J. Van Wie & Nehal I. Abu-Lail
Spring 2007 Biomedical Engineering Semester Assignments
Date
Topic
Reading
Homework Due†
1/8
Introduction, History of Biomedical Engr.
1/10
Blood Properties
Chapters 1 & 2
1/12
G: 2.1 to 2.4; I: 2.5
1/15
MARTIN LUTHER KING JR. DAY
leisure
1/17
Blood Properties
Chapter 3
Group Project Idea
1/19
G: Van Wie & Hustvedt model
1/22
1/24
Circulatory System Dynamics
Chapter 4
Group Project Approval
1/26
G: 3.3; I: 3.4, 3.6
1/29
Chapter 5
1/31
Human Thermal System
J. Appl. Physiol. 30, pp 779-786, 1971
2/2
G: 4.4 & 4.5; I: 4.9 & 4.10
2/5
2/7
Modeling Body Compartments
Chapter 6
2/9
G: 5.3 & 5.5; I: 5.4 & 5.6
2/12
2/14
Transport through cell membranes
Chapter 7
3-page group project report
2/16
G: 6.3, 6.4; I: 6.5
2/19
PRESIDENTS DAY
leisure
2/21
G: 7.2, 7.4; I: 7.3, 7.5
2/23
Midterm Exam – Fluid Flow, Heat Transfer, Membrane Transport – Chapters 1-7
2/26
The atomic force microscope (AFM)
2/28
3/2
Imaging with AFM
3/5
3/7
Force Measurements with AFM
Meet w/ profs for project
3/9
3/12 - 3/16
SPRING VACATION – NO CLASS
3/19
Macromolecules (DNA, RNA, Polysaccharides)
3/21
3/23
Forced Unfolding of Proteins
3/26
Ordered Macromolecules
3/28
Single Molecules Detection
Project Problem
3/30
Cellular Investigation by AFM
4/2
Mechanical Properties of Cells
4/4
Scaling of AFM Measurements
Project Problem Approval
4/6
Frictional Force Microscopy
4/9
Applying AFM to Study Contact Lenses
4/11
Applying AFM to Studies in Cardiac Physiology
4/13
Bio-Sensing using Micro-Cantilever Arrays
4/16-20 Group Projects
10-page report due
Group project ideas may be from Chapters 8 – 11 on organs and artificial organs; articles on
hepatic (liver) assist devices; cell separations; monoclonal antibody production; biosensors;
nano-particles as vehicles for drug delivery, AFM imaging with carbon nano-tubes, AFM a tool for
disease diagnostics, molecular motors, tissue engineering, etc.
4/23-27 Group Projects
Group projects must be pre-approved by the professors and you must turn in preliminary project
reports and meet with the professors at least once for assistance with project details.
5/1
Final Exam
†
G = Group Assignments; I = Individual Assignments