MATERIAL SAFETY DATA SHEET
NFPA
HMIS
Personal Protective Equipment
See Section 8.
1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
Product code:
Product Name:
Chemical Name:
Synonyms:
BE130
BENZOCAINE, USP
No information available
p-Aminobenzoic acid ethyl ester
4-Aminobenzoic acid, ethyl esterAmericaine
Anaesthesin
Anesthesin
Anesthone
Keloform
Topcaine
Ethyl aminobenzoate
Ethyl p-aminobenzoate
Ethyl 4-aminobenzoateNorcain
Orthesin
Parathesin
Recommended use:
CAS #:
RTECS #
Formula:
CI#:
Supplier:
Topical anesthetic.
94-09-7
DG2450000
C9-H11-N-O2
Not available
Spectrum Chemicals and Laboratory Products, Inc.
14422 South San Pedro St.
Gardena, CA 90248
(310) 516-8000
https://www.spectrumchemical.com
CHEMTREC: 1-800-424-9300
Regina Wachenheim (East Coast)
Martin LaBenz (West Coast)
Order Online At:
Emergency Telephone Number:
Contact Person:
Contact Person:
2. HAZARDS IDENTIFICATION
Product code: BE130
Product name: BENZOCAINE, USP
1 / 10
2. HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
WARNING! IRRITANT
Irritating to eyes
May cause allergic skin reaction
Odor:
No information available
Physical state:
Solid.
Appearance:
Crystalline. Crystalline powder.
Powder.
Color:
White.
This material is considered hazardous by the OSHA Hazard Communication
Standard (29 CFR 1910.1200)
OSHA Regulatory Status
POTENTIAL HEALTH EFFECTS
Principal Routes of Exposure:
Ingestion. Inhalation. Skin.
Acute Potential Health Effects:
Skin Contact:
May cause skin irritation. Mild skin irritation. May cause allergic skin reaction.
Eye Contact:
Causes eye irritation. Mild eye irritation.
Inhalation:
May cause irritation of respiratory tract.
Ingestion:
May cause digestive (gastrointestinal) tract irritation. May cause nausea and vomiting. May cause central nervous system
effects. May cause methemoglobinemia. May cause cyanosis. May cause numbness of the mouth (lips and tongue).
Chronic Potential Health Effects:
Component
Carcinogen Status:
No information available
Benzocaine
94-09-7 (100)
Target Organs:
Blood. Methemoglobin formation.
Mutagenic Effects:
No information available
Teratogenic Effects:
No information available
Aggravated Medical Conditions: No information available
See Section 11 for additional Toxicological Information
POTENTIAL ENVIRONMENTAL EFFECTS
No information available
3. COMPOSITION/INFORMATION ON INGREDIENTS
Components
Product code: BE130
CAS-No.
Product name: BENZOCAINE, USP
Weight %
2 / 10
3. COMPOSITION/INFORMATION ON INGREDIENTS
Benzocaine
94-09-7
100
4. FIRST AID MEASURES
General Advice:
Poison information centres in each State capital city can provide additional
assistance for scheduled poisons (13 1126).
Skin Contact:
Wash off immediately with soap and plenty of water removing all contaminated
clothes and shoes. Get medical attention. If skin irritation persists, call a physician.
Eye Contact:
Flush eye with water for 15 minutes. Get medical attention.
Inhalation:
Move to fresh air. If not breathing, give artificial respiration. If breathing is difficult,
give oxygen. Get medical attention.
Ingestion:
Do not induce vomiting without medical advice. Never give anything by mouth to an
unconscious person. Obtain medical attention.
Notes to Physician:
Treat symptomatically
5. FIRE-FIGHTING MEASURES
Flammable Properties
Flashpoint (°C/°F):
No information available.
Flash Point Tested according to:
Not applicable
Lower Explosion Limit (%):
Upper Explosion Limit (%):
No information available
No information available
Autoignition Temperature (°C/°F): No information available
Suitable Extinguishing Media:
Dry chemical. Carbon dioxide (CO2). Water spray mist or
foam.
Unsuitable Extinguishing Media:
No information available.
Hazardous Combustion Products:
Carbon monoxide; Carbon dioxide; Nitrogen oxides
Specific hazards:
May be combustible at high temperatures.
Special Protective Equipment for Firefighters:
As in any fire, wear self-contained breathing apparatus
pressure-demand, MSHA/NIOSH (approved or equivalent)
and full protective gear
Specific Methods:
No information available.
6. ACCIDENTAL RELEASE MEASURES
Personal Precautions:
Ensure adequate ventilation. Avoid contact with skin, eyes and clothing. Use personal protective equipment. Avoid dust
formation. Remove all sources of ignition.
Product code: BE130
Product name: BENZOCAINE, USP
3 / 10
Environmental Precautions:
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Prevent entry into waterways, sewers,
basements or confined areas.
Methods for Cleaning Up:
Sweep up and shovel into suitable containers for disposal. Clean contaminated surface thoroughly.
7. HANDLING AND STORAGE
Handling
Technical Measures/Precautions:
Provide sufficient air exchange and/or exhaust in work rooms. Avoid dust formation. All equipment used when
handling the product must be grounded. Keep away from incompatible materials.
Safe Handling Advice:
Wear personal protective equipment. Avoid contact with skin, eyes and clothing. Avoid dust formation. Do not
ingest. Do not breathe vapours/dust. Keep away from heat and sources of ignition. Handle in accordance with good
industrial hygiene and safety practice.
Storage
Technical Measures/Storage Conditions:
Keep container tightly closed in a dry and well-ventilated place. Store at room temperature in the original container.
Protect from light. Sensitive to light. Store in light-resistant containers. Store away from incompatible materials.
Incompatible Materials:
Oxidizing agents. Bases. Acids. Reducing agents.
8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Ensure adequate ventilation. Use process enclosures, local
exhaust ventilation, or other engineering controls to keep
airborne levels below recommended exposure limits. If user
operations generate dust, fume or mist, use ventilation to
keep exposure to airborne contaminants below the exposure
limit.
Engineering measures to reduce exposure:
Personal Protective Equipment
Eye protection:
Goggles.
Skin and body protection:
Long sleeved clothing. Chemical resistant apron. Gloves.
Respiratory protection:
Wear respirator with dust filter..
Hygiene measures:
Avoid contact with skin, eyes and clothing. Wash hands before breaks and
immediately after handling the product. When using, do not eat, drink or smoke.
National occupational exposure limits
United States
Components
OSHA
None
NIOSH
None
ACGIH
None
AIHA WHEEL
None
Benzocaine - 94-09-7
Canada
Components
Benzocaine
94-09-7
Product code: BE130
Alberta
None
British Columbia
None
Product name: BENZOCAINE, USP
Ontario
None
Quebec
None
4 / 10
Australia and Mexico
Components
Benzocaine
94-09-7
Australia
None
Mexico
None
9. PHYSICAL AND CHEMICAL PROPERTIES
Physical state:
Solid.
Color:
Appearance:
Crystalline. Crystalline powder. Powder. White.
Odor:
No information available
Taste
No information available
Molecular/Formula weight:
165.19
Flash point (°C):
No data available
Lower Explosion Limit (%):
No information available
Upper Explosion Limit (%):
No information available
Autoignition Temperature (°C/°F):
No information available
Melting point/range(°C/°F):
89-92 °C/192.2-197.6 °F
Boiling point/range(°C/°F):
310 °C/590 °F
pH:
No information available
Specific gravity:
No information available
Density (g/cm3):
No information available
Decomposition temperature(°C/°F):
No information available
Bulk density:
No information available
Vapor pressure @ 20°C (kPa):
No information available
Evaporation rate:
No information available
Vapor density:
No information available
VOC content (g/L):
No information available
Odor threshold (ppm):
No information available
Partition coefficient
(n-octanol/water):
1.86
Miscibility:
No information available
Solubility:
Practically insoluble in water
Solubility in Water: 1,310 mg/l (0.1
g/100 ml) of water at 25 deg. C
Soluble in dilute acids
Solubility in Chloroform: 1 gram
dissolves in 2 ml of chloroform
Solubility in Ether: 1 gram dissolves in
about 4 ml of Ether
Solubility in alcohol: 1 gram dissolves
in about 5 ml of alcohol
10. STABILITY AND REACTIVITY
Stability:
Stable at normal conditions
Conditions to avoid:
Heat. Exposure to light. Avoid dust formation. Fine dust dispersed in air in sufficient
concentrations, and in the presence of an ignition source is a potential dust explosion
hazard. Incompatible materials.
Incompatible Materials:
Oxidizing agents. Bases. Acids. Reducing agents.
Hazardous decomposition
products:
Carbon monoxide. Carbon dioxide. Nitrogen oxides (NOx).
Possibility of Hazardous
Reactions:
No information available
Product code: BE130
Product name: BENZOCAINE, USP
5 / 10
Polymerization:
Hazardous polymerisation does not occur
Corrosivity:
No information available
Special Remarks on Corrosivity: No information available
11. TOXICOLOGICAL INFORMATION
Acute Toxicity
Component Information
Benzocaine - 94-09-7
LD50/oral/rat = 3042 mg/kg
LD50/oral/mouse = 2500 mg/kg
LD50/dermal/rat = No information available
LD50/dermal/rabbit = No information available
LC50/inhalation/rat = No information available
LC50/inhalation/mouse = No infomation available
Other LD50 or LC50information = No information available
Product Information
LC50/inhalation/rat No information available
LC50/Inhalation/mouse No information available
LD50/dermal/rabbit No information available
LD50/dermal/rat No information available
LD50/oral/mouse = 2500mg/kg
LD50/oral/rat = 3042mg/kg
Local Effects
Skin irritation:
May cause skin irritation. Mild skin irritation.
Eye irritation:
Causes eye irritation. Mild eye irritation.
Inhalation:
May cause irritation of respiratory tract.
Ingestion:
May cause digestive (gastointestinal) tract irritation. May cause numbness of the
mouth (lips and tongue). May cause methemoglobinemia, (the formation of
methemoglobin in the blood which causes deficient oxygenation of the blood due to
decreased available hemoglobin). Signs and symptoms of methemoglobinemia
include shortness of breath, cyanosis (a bluish discoloration of the mucous
membranes and unpigmented areas of the body), mental status changes such as
headache, mental impairment, fatigue, muscular weakness, exercise intolerance,
lightheadness, dizziness, incoordination, seizures, and loss of consciousness.
Arterial blood with elevated methemoglobin levels has a characteristic chocolatebrown color as compared to normal bright red oxygen containing arterial blood.
Severe methemoglobinemia is characterized by bradycardia or tachydardia (slow or
fast heart beat), dysrhythmias, seizures, coma and death. May affect respiration
(respiratory depression).
Sensitization:
May cause sensitization by skin contact
Chronic Toxicity
Product code: BE130
Product name: BENZOCAINE, USP
6 / 10
Chronic Toxicity
Prolonged or repeated skin contact may cause allergic reaction. Prolonged or
repeated skin contact may cause allergic contact dermatitis. Prolonged or repeated
ingestion may cause methemoglobinemia, which is characterized by chocolatebrown colored blood, headache, weakness, dizziness, shortness of breath, cyanosis
(a bluish discoloration of the skin, lips, nails due to deficient oxygenation of the
blood), rapid heart rate, unconsciouosness.
Carcinogenic effects:
Not considered carcinogenic
Components
Benzocaine
NTP
Not listed
IARC
Not listed
OSHA HCS - ACGIH - Carcinogens Australia - Prohibited Australia - Notifiable
Carcinogens
Carcinogenic
Carcinogenic
Substances
Substances
Not listed
Not listed
Not listed
Not listed
Mutagenic Effects:
No information available
Reproductive Effects:
No information available
Teratogenic Effects:
No information available
Target Organs:
Blood. Methemoglobin formation.
12. ECOLOGICAL INFORMATION
ECOTOXICITY
Toxicity to terrestrial and aquatic plants and animals:
Information given is based on data on the components and
the ecotoxicology of similar products
Aquatic environment.
Ecotoxicity effects:
Aquatic toxicity:
Benzocaine - 94-09-7
Freshwater Fish Species Data:
17.9 - 20.1 mg/L LC50 Cyprinus carpio 96 h static 1
24.9 - 26.9 mg/L LC50 Pimephales promelas 96 h static 1
34.6 - 36.1 mg/L LC50 Pimephales promelas 96 h flow-through 1
5.92 - 9.76 mg/L LC50 Oncorhynchus mykiss 96 h static 1
7.48 - 11.3 mg/L LC50 Lepomis macrochirus 96 h static 1
Mobility:
It is expected to have moderate mobility based upon estimated Koc.
Persistence and degradability:
Inherently biodegradable
Bioaccumulative potential:
Potential for bioconcentration in aquatic organisms is low.
13. DISPOSAL CONSIDERATIONS
Waste from residues / unused products:
Waste must be disposed of in accordance with Federal, State and Local regulation.
Contaminated packaging:
Empty containers should be taken for local recycling, recovery or waste disposal
Components
Benzocaine
RCRA - F Series Wastes RCRA - K Series Wastes RCRA - P Series Wastes
RCRA - U Series Wastes
None
None
None
None
14. TRANSPORT INFORMATION
Product code: BE130
Product name: BENZOCAINE, USP
7 / 10
DOT
UN-No:
Proper Shipping Name:
Hazard Class:
Packing Group:
Subsidiary Risk:
Marine Pollutant
ERG No:
DOT RQ (lbs):
Not regulated
No information available
No information available
None
Not applicable
No data available
No information available
No information available
TDG (Canada)
UN-No:
Proper Shipping Name:
Hazard Class:
Packing Group:
Subsidiary Risk:
Description:
Not Regulated
No information available
No information available
No information available
No information available
No information available
ADR
UN-No:
Proper Shipping Name:
Hazard Class:
Packing Group:
Subsidiary Risk:
Classification Code:
Description:
CEFIC Tremcard No:
No information available
No information available
No information available
No information available
No information available
No information available
No information available
No information available
IMO / IMDG
UN-No:
Proper Shipping Name:
Hazard Class:
Packing Group:
Subsidiary Risk:
Description:
IMDG Page:
Marine Pollutant
MFAG:
Maximum Quantity:
Not Regulated
No information available
No information available
No information available
No information available
No information available
No information available
No information available
No information available
No information available
RID
UN-No:
Proper Shipping Name:
Hazard Class:
Packing Group:
Subsidiary Risk:
Classification Code:
Description:
No information available
No information available
No information available
No information available
No information available
No information available
No information available
UN-No:
Proper Shipping Name:
Hazard Class:
Packing Group:
Subsidiary Risk:
Description:
No information available
No information available
No information available
No information available
No information available
No information available
ICAO
IATA
Product code: BE130
Product name: BENZOCAINE, USP
8 / 10
UN-No:
Proper Shipping Name:
Hazard Class:
Packing Group:
Subsidiary Risk:
Description:
Not Regulated
No information available
No information available
No information available
No information available
No information available
15. REGULATORY INFORMATION
International Inventories
Components
U.S. TSCA
Benzocaine
Philippines KOREA KECL Japan ENCS
(PICCS)
Present
Present KE- Present (3)01203
1443
Present
CHINA
Present
Australia
(AICS)
Present
EINECS-No.
Present 202-303-5
U.S. Regulations
California Prop. 65: Safe Drinking Water and Toxic Enforcement Act of 1986.
Chemicals Known to the State of California to Cause Cancer:
This product does not contain a chemical requiring a warning under California Prop. 65. (See table below)
Chemicals Known to the State of California to Cause Reproductive Toxicity:
This product does not contain a chemical requiring a warning under California Prop. 65. (See table below)
Components
Carcinogen
Developmental Toxicity
Benzocaine
Not Listed
Not Listed
Male Reproductive
Toxicity
Not Listed
Female Reproductive
Toxicity:
Not Listed
CERCLA/SARA
Components
Benzocaine
CERCLA - Hazardous Section 302 Extremely Section 302 Extremely
Section 313 Section 313 - Reporting
de minimis
Substances and their
Hazardous
Hazardous
Chemical Category
Reportable Quantities Substances and TPQs Substances and RQs
None
None
None
None
None
U.S. TSCA
Components
Benzocaine
TSCA Section 5(a)2 - Chemicals With Significant
New Use Rules (SNURS)
Not Applicable
TSCA 8(d) -Health and Safety Reporting
Not Applicable
Canada
WHMIS hazard class:
D2B Toxic materials
Canada Controlled Products Regulation:
This product has been classified according to the hazard criteria of the CPR (Controlled Products Regulation) and the MSDS contains
all of the information required by the CPR.
Inventory
Components
Benzocaine
Product code: BE130
Canada (DSL)
Present
Canada (NDSL)
Not Listed
Product name: BENZOCAINE, USP
9 / 10
Components
CEPA Schedule I - Toxic Substances
Benzocaine
Not listed
CEPA - 2010 Greenhouse Gases Subject to Manditory
Reporting
Not listed
EU Classification
R-phrase(s)
R36 - Irritating to eyes.
R43 - May cause sensitization by skin contact.
S -phrase(s)
S24 - Avoid contact with skin.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39 - Wear suitable gloves and eye/face protection.
Components
Benzocaine
Classification
Concentration Limits:
No information
Safety Phrases
The product is classified in accordance with Annex VI to Directive 67/548/EEC
Indication of danger:
Xi - Irritant.
16. OTHER INFORMATION
The MSDS format complies with ANSI Z400.1/Z129.1-2010 standards.
Preparation Date:
08-Aug-2014
Reason for revision:
Not applicable
Prepared by:
Sonia Owen
Literature reference:
No information available
All chemicals may pose unknown hazards and should be used with caution. This Material Safety Data Sheet (MSDS)
applies only to the material as packaged. If this product is combined with other materials, deteriorates, or becomes
contaminated, it may pose hazards not mentioned in this MSDS. The physical properties reported in this MSDS are
obtained from the literature and do not constitute product specifications. Information contained herein does not constitute
a warranty, whether expressed or implied, as to the safety, merchantability or fitness of the goods for a particular purpose.
Spectrum Chemicals & Laboratory Products, Inc. assumes no responsibility for results obtained or for incidental or
consequential damages, including lost profits, arising from the use of these data. No warranty against infringement of any
patent, copyright or trademark is made or implied. It shall be the user's responsibility to develop proper methods of
handling and personal protection based on the actual conditions of use. While this MSDS is based on technical data
judged to be reliable, Spectrum assumes no responsibility for the completeness or accuracy of the information contained
herein.
Product code: BE130
Product name: BENZOCAINE, USP
10 / 10
SAFETY DATA SHEET
Preparation Date: 8/7/2014
Revision Date: 8/7/2014
Revision Number: G1
1. IDENTIFICATION
Product identifier
Product code:
Product Name:
Other means of identification
Synonyms:
CAS #:
RTECS #
CI#:
BE130
BENZOCAINE, USP
p-Aminobenzoic acid ethyl ester
4-Aminobenzoic acid, ethyl esterAmericaine
Anaesthesin
Anesthesin
Anesthone
Keloform
Topcaine
Ethyl aminobenzoate
Ethyl p-aminobenzoate
Ethyl 4-aminobenzoateNorcain
Orthesin
Parathesin
94-09-7
DG2450000
Not available
Recommended use of the chemical and restrictions on use
Topical anesthetic.
Recommended use:
Uses advised against
No information available
Supplier:
Order Online At:
Spectrum Chemicals and Laboratory Products, Inc.
14422 South San Pedro St.
Gardena, CA 90248
(310) 516-8000
https://www.spectrumchemical.com
Emergency telephone number
Chemtrec 1-800-424-9300
Contact Person:
Contact Person:
Martin LaBenz (West Coast)
Regina Wachenheim (East Coast)
2. HAZARDS IDENTIFICATION
Classification
This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200)
Serious eye damage/eye irritation
Skin sensitization
Product code: BE130
Category 2B
Category 1
Product name: BENZOCAINE, USP
1 / 11
Label elements
Warning
Hazard statements
Causes eye irritation
May cause an allergic skin reaction
Hazards not otherwise classified (HNOC)
Not Applicable
Other hazards
May be harmful if swallowed
Causes mild skin irritation
Precautionary Statements - Prevention
Wash face, hands and any exposed skin thoroughly after handling
Avoid breathing dust/fume/gas/mist/vapors/spray
Contaminated work clothing should not be allowed out of the workplace
Wear protective gloves
Precautionary Statements - Response
Specific treatment (see .? on this label)
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye
irritation persists: Get medical advice/attention.
IF ON SKIN: Wash with plenty of soap and water
If skin irritation or rash occurs: Get medical advice/attention
Wash contaminated clothing before reuse
Precautionary Statements - Disposal
Dispose of contents/container to an approved waste disposal plant
3. COMPOSITION/INFORMATION ON INGREDIENTS
Components
Benzocaine
94-09-7
CAS-No.
94-09-7
Weight %
100
Trade Secret
*
4. FIRST AID MEASURES
First aid measures
General Advice:
Poison information centres in each State capital city can provide additional
assistance for scheduled poisons (13 1126).
Skin Contact:
Wash off immediately with soap and plenty of water removing all contaminated clothes and
shoes. Get medical attention. If skin irritation persists, call a physician.
Eye Contact:
Flush eye with water for 15 minutes. Get medical attention.
Product code: BE130
Product name: BENZOCAINE, USP
2 / 11
Inhalation:
Move to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Get medical attention.
Ingestion:
Do not induce vomiting without medical advice. Never give anything by mouth to an
unconscious person. Obtain medical attention.
Most important symptoms and effects, both acute and delayed
Causes eye irritation. Mild skin irritation. May cause allergic skin reaction. It may cause
Symptoms
dermatitis. May cause methemoglobinemia and cyanosis. Numbness and irritation of the mouth
(tongue and lips). May cause nausea and vomiting. Dizziness. Ataxia. Dyspnea (Difficulty
breathing and shortness of breath). Respiratory depression.
Indication of any immediate medical attention and special treatment needed
Treat symptomatically
Notes to Physician:
Protection of first-aiders
First-Aid Providers: Avoid exposure to blood or body fluids. Wear gloves and other necessary protective clothing. Dispose of
contaminated clothing and equipment as bio-hazardous waste
5. FIRE-FIGHTING MEASURES
Extinguishing Media
Suitable Extinguishing Media:
Dry chemical. Carbon dioxide (CO2). Water spray mist or
foam.
Unsuitable Extinguishing Media:
No information available.
Specific hazards arising from the chemical
Hazardous Combustion Products:
Carbon monoxide; Carbon dioxide; Nitrogen oxides
Specific hazards:
May be combustible at high temperatures
Special Protective Actions for Firefighters
Specific Methods:
No information available.
Special Protective Equipment for Firefighters:
As in any fire, wear self-contained breathing apparatus
pressure-demand, MSHA/NIOSH (approved or equivalent)
and full protective gear
6. ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures
Personal Precautions:
Ensure adequate ventilation. Avoid contact with skin, eyes and clothing. Use personal
protective equipment. Avoid dust formation. Remove all sources of ignition.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Prevent entry into waterways, sewers, basements or confined areas.
Methods and material for containment and cleaning up
Methods for containment
Stop leak if you can do it without risk. Cover with plastic sheet to prevent spreading.
Methods for cleaning up
Sweep up and shovel into suitable containers for disposal. Clean contaminated
surface thoroughly.
7. HANDLING AND STORAGE
Product code: BE130
Product name: BENZOCAINE, USP
3 / 11
7. HANDLING AND STORAGE
Precautions for safe handling
Technical Measures/Precautions:
Provide sufficient air exchange and/or exhaust in work rooms. Avoid dust formation. All equipment used when
handling the product must be grounded. Keep away from incompatible materials.
Safe Handling Advice:
Wear personal protective equipment. Avoid contact with skin, eyes and clothing. Avoid dust formation. Do not
ingest. Do not breathe vapours/dust. Keep away from heat and sources of ignition. Handle in accordance with good
industrial hygiene and safety practice.
Conditions for safe storage, including any incompatibilities
Technical Measures/Storage Conditions:
Keep container tightly closed in a dry and well-ventilated place. Store at room temperature in the original container.
Protect from light. Sensitive to light. Store in light-resistant containers. Store away from incompatible materials.
Incompatible Materials:
Oxidizing agents. Bases. Acids. Reducing agents.
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Control parameters
National occupational exposure limits
United States
Components
OSHA
None
NIOSH
None
ACGIH
None
AIHA WHEEL
None
Benzocaine - 94-09-7
Canada
Components
Alberta
None
British Columbia
None
Ontario
None
Quebec
None
Benzocaine - 94-09-7
Australia and Mexico
Components
Benzocaine
94-09-7
Australia
None
Mexico
None
Appropriate engineering controls
Engineering measures to reduce exposure:
Ensure adequate ventilation. Use process enclosures, local
exhaust ventilation, or other engineering controls to keep
airborne levels below recommended exposure limits. If user
operations generate dust, fume or mist, use ventilation to
keep exposure to airborne contaminants below the exposure
limit.
Individual protection measures, such as personal protective equipment
Personal Protective Equipment
Eye protection:
Goggles.
Skin and body protection:
Long sleeved clothing. Chemical resistant apron. Gloves.
Respiratory protection:
Wear respirator with dust filter..
Product code: BE130
Product name: BENZOCAINE, USP
4 / 11
Avoid contact with skin, eyes and clothing. Wash hands before breaks and
immediately after handling the product. When using, do not eat, drink or smoke.
Hygiene measures:
9. PHYSICAL AND CHEMICAL PROPERTIES
Physical state:
Solid.
Appearance:
Color:
Crystalline. Crystalline powder. Powder. White.
Odor:
No information available
Taste
No information available
Formula:
C9-H11-N-O2
Molecular/Formula weight:
165.19
Flash point (°C):
No data available
Flashpoint (°C/°F):
No information available.
Flash Point Tested according to:
Not applicable
Lower Explosion Limit (%):
No information available
Upper Explosion Limit (%):
No information available
Autoignition Temperature (°C/°F):
No information available
pH:
No information available
Melting point/range(°C/°F):
89-92 °C/192.2-197.6 °F
Boiling point/range(°C/°F):
310 °C/590 °F
Decomposition temperature(°C/°F):
No information available
Specific gravity:
No information available
Density (g/cm3):
No information available
Bulk density:
No information available
Vapor pressure @ 20°C (kPa):
No information available
Evaporation rate:
No information available
Vapor density:
No information available
VOC content (g/L):
No information available
Odor threshold (ppm):
No information available
Partition coefficient
(n-octanol/water):
1.86
Viscosity:
No information available
Miscibility:
No information available
Solubility:
Practically insoluble in water
Solubility in Water: 1,310 mg/l (0.1
g/100 ml) of water at 25 deg. C
Soluble in dilute acids
Solubility in Chloroform: 1 gram
dissolves in 2 ml of chloroform
Solubility in Ether: 1 gram dissolves in
about 4 ml of Ether
Solubility in alcohol: 1 gram dissolves in
about 5 ml of alcohol
10. STABILITY AND REACTIVITY
Reactivity
Reactive with oxidizing agents
Reacts with bases
Reactive with acids
Reacts with reducing agents
Chemical stability
Stability:
Stable at normal conditions
Possibility of Hazardous Reactions: Hazardous polymerization does not occur
Product code: BE130
Product name: BENZOCAINE, USP
5 / 11
Conditions to avoid:
Heat. Exposure to light. Avoid dust formation. Fine dust dispersed in air in sufficient
concentrations, and in the presence of an ignition source is a potential dust explosion
hazard. Incompatible materials.
Incompatible Materials:
Oxidizing agents. Bases. Acids. Reducing agents.
Hazardous decomposition products: Carbon monoxide. Carbon dioxide. Nitrogen oxides (NOx).
Other Information
Corrosivity:
No information available
Special Remarks on Corrosivity: No information available
11. TOXICOLOGICAL INFORMATION
Information on likely routes of exposure
Principal Routes of Exposure:
Ingestion. Inhalation. Skin.
Acute Toxicity
Component Information
Benzocaine - 94-09-7
LD50/oral/rat = 3042 mg/kg
LD50/oral/mouse = 2500 mg/kg
LD50/dermal/rabbit = No information available
LD50/dermal/rat = No information available
LC50/inhalation/rat = No information available
LC50/inhalation/mouse = No infomation available
Other LD50 or LC50information = No information available
Product Information
LD50/oral/rat =
VALUE- Acute Tox Oral = 3042mg/kg
LD50/oral/mouse =
Value - Acute Tox Oral = 2500mg/kg
LD50/dermal/rabbit
VALUE-Acute Tox Dermal = No information available
LD50/dermal/rat
VALUE -Acute Tox Dermal = No information available
LC50/inhalation/rat
VALUE-Vapor = No information available
VALUE-Gas = No information available
VALUE-Dust/Mist = No information available
LC50/Inhalation/mouse
VALUE-Vapor = No information available
VALUE - Gas = No information available
VALUE - Dust/Mist = No information available
Product code: BE130
Product name: BENZOCAINE, USP
6 / 11
Symptoms
Skin Contact:
May cause skin irritation. Mild skin irritation. May cause allergic skin reaction.
Eye Contact:
Causes eye irritation. Mild eye irritation.
Inhalation
Ingestion
May cause irritation of respiratory tract.
May cause digestive (gastointestinal) tract irritation. May cause numbness of the
mouth (lips and tongue). May cause methemoglobinemia, (the formation of
methemoglobin in the blood which causes deficient oxygenation of the blood due to
decreased available hemoglobin). Signs and symptoms of methemoglobinemia
include shortness of breath, cyanosis (a bluish discoloration of the mucous
membranes and unpigmented areas of the body), mental status changes such as
headache, mental impairment, fatigue, muscular weakness, exercise intolerance,
lightheadness, dizziness, incoordination, seizures, and loss of consciousness.
Arterial blood with elevated methemoglobin levels has a characteristic chocolatebrown color as compared to normal bright red oxygen containing arterial blood.
Severe methemoglobinemia is characterized by bradycardia or tachydardia (slow or
fast heart beat), dysrhythmias, seizures, coma and death. May affect respiration
(respiratory depression).
Aspiration hazard
No information available
Delayed and immediate effects as well as chronic effects from short and long-term exposure
Sensitization:
Prolonged or repeated skin contact may cause allergic reaction
Prolonged or repeated skin contact may cause allergic contact dermatitis
Prolonged or repeated ingestion may cause methemoglobinemia, which is
characterized by chocolate-brown colored blood, headache, weakness, dizziness,
shortness of breath, cyanosis (a bluish discoloration of the skin, lips, nails due to
deficient oxygenation of the blood), rapid heart rate, unconsciouosness
May cause sensitization by skin contact
Mutagenic Effects:
No information available
Carcinogenic effects:
Not considered carcinogenic
Chronic Toxicity
Components
Benzocaine
ACGIH Carcinogens
Not listed
IARC
Not listed
NTP
Not listed
Reproductive toxicity
No data is available
Reproductive Effects:
Developmental Effects:
Teratogenic Effects:
No information available
No information available
No information available
OSHA HCS Carcinogens
Not listed
Australia - Prohibited Australia - Notifiable
Carcinogenic
Carcinogenic
Substances
Substances
Not listed
Not listed
Specific Target Organ Toxicity
STOT - single exposure
STOT - repeated exposure
Target Organs:
No information available
No information available
Blood. Methemoglobin formation.
12. ECOLOGICAL INFORMATION
Product code: BE130
Product name: BENZOCAINE, USP
7 / 11
12. ECOLOGICAL INFORMATION
Ecotoxicity
Ecotoxicity effects:
Benzocaine - 94-09-7
Freshwater Fish Species Data:
Aquatic environment.
17.9 - 20.1 mg/L LC50 Cyprinus carpio 96 h static 1
24.9 - 26.9 mg/L LC50 Pimephales promelas 96 h static 1
34.6 - 36.1 mg/L LC50 Pimephales promelas 96 h flow-through 1
5.92 - 9.76 mg/L LC50 Oncorhynchus mykiss 96 h static 1
7.48 - 11.3 mg/L LC50 Lepomis macrochirus 96 h static 1
Persistence and degradability:
Inherently biodegradable
Bioaccumulative potential:
Potential for bioconcentration in aquatic organisms is low.
Mobility:
It is expected to have moderate mobility based upon estimated Koc.
13. DISPOSAL CONSIDERATIONS
Disposal Methods
Waste from residues / unused products:
Waste must be disposed of in accordance with Federal, State and Local regulation.
Contaminated packaging:
Empty containers should be taken for local recycling, recovery or waste disposal
Components
Benzocaine
RCRA - F Series
Wastes
None
RCRA - K Series
Wastes
None
RCRA - P
Series
Wastes
None
RCRA - U Series Wastes
None
14. TRANSPORT INFORMATION
DOT
UN-No:
Proper Shipping Name:
Hazard Class:
Subsidiary Risk:
Packing Group:
Marine Pollutant
ERG No:
DOT RQ (lbs):
Not regulated
No information available
No information available
Not applicable
None
No data available
No information available
No information available
TDG (Canada)
UN-No:
Proper Shipping Name:
Hazard Class:
Subsidiary Risk:
Packing Group:
Description:
Not Regulated
No information available
No information available
No information available
No information available
No information available
ADR
UN-No:
Product code: BE130
Not Regulated
Product name: BENZOCAINE, USP
8 / 11
14. TRANSPORT INFORMATION
Proper Shipping Name:
Hazard Class:
Packing Group:
Subsidiary Risk:
Classification Code:
Description:
CEFIC Tremcard No:
No information available
No information available
No information available
No information available
No information available
No information available
No information available
IMO / IMDG
UN-No:
Proper Shipping Name:
Hazard Class:
Subsidiary Risk:
Packing Group:
Description:
IMDG Page:
Marine Pollutant
MFAG:
Maximum Quantity:
Not Regulated
No information available
No information available
No information available
No information available
No information available
No information available
No information available
No information available
No information available
RID
UN-No:
Proper Shipping Name:
Hazard Class:
Subsidiary Risk:
Packing Group:
Classification Code:
Description:
Not Regulated
No information available
No information available
No information available
No information available
No information available
No information available
UN-No:
Proper Shipping Name:
Hazard Class:
Subsidiary Risk:
Packing Group:
Description:
Not Regulated
No information available
No information available
No information available
No information available
No information available
UN-No:
Proper Shipping Name:
Hazard Class:
Subsidiary Risk:
Packing Group:
Description:
Not Regulated
No information available
No information available
No information available
No information available
No information available
ICAO
IATA
15. REGULATORY INFORMATION
International Inventories
Components
Benzocaine
U.S. TSCA KOREA KECL Philippines
(PICCS)
Present
Present KEPresent
01203
Japan ENCS
CHINA
Present (3)1443
Present
Australia
(AICS)
Present
EINECS-No.
Present 202-303-5
U.S. Regulations
California Prop. 65: Safe Drinking Water and Toxic Enforcement Act of 1986.
Product code: BE130
Product name: BENZOCAINE, USP
9 / 11
Chemicals Known to the State of California to Cause Cancer:
This product does not contain a chemical requiring a warning under California Prop. 65. (See table below)
Chemicals Known to the State of California to Cause Reproductive Toxicity:
This product does not contain a chemical requiring a warning under California Prop. 65. (See table below)
Components
Carcinogen
Developmental Toxicity
Benzocaine
Not Listed
Not Listed
Male Reproductive
Toxicity
Not Listed
Female Reproductive
Toxicity:
Not Listed
CERCLA/SARA
Components
Benzocaine
CERCLA - Hazardous Section 302 Extremely Section 302 Extremely
Section 313 Section 313 - Reporting
de minimis
Substances and their
Hazardous
Hazardous
Chemical Category
Reportable Quantities Substances and TPQs Substances and RQs
None
None
None
None
None
U.S. TSCA
Components
Benzocaine
TSCA Section 5(a)2 - Chemicals With Significant
New Use Rules (SNURS)
Not Applicable
TSCA 8(d) -Health and Safety Reporting
Not Applicable
Canada
WHMIS hazard class:
D2B Toxic materials
Canada Controlled Products Regulation:
This product has been classified according to the hazard criteria of the CPR (Controlled Products Regulation) and the MSDS contains
all of the information required by the CPR.
Inventory
Components
Benzocaine
Canada (DSL)
Present
Canada (NDSL)
Not Listed
Components
CEPA Schedule I - Toxic Substances
Benzocaine
Not listed
CEPA - 2010 Greenhouse Gases Subject to Manditory
Reporting
Not listed
EU Classification
R-phrase(s)
R36 - Irritating to eyes.
R43 - May cause sensitization by skin contact.
S -phrase(s)
S24 - Avoid contact with skin.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39 - Wear suitable gloves and eye/face protection.
Components
Benzocaine
Product code: BE130
Classification
Concentration Limits:
No information
Product name: BENZOCAINE, USP
Safety Phrases
10 / 11
The product is classified in accordance with Annex VI to Directive 67/548/EEC
Indication of danger:
Xi - Irritant.
16. OTHER INFORMATION
HMIS
NFPA
Personal Protective Equipment
See Section 8.
Preparation Date:
Revision Date:
Prepared by:
8/7/2014
8/7/2014
Sonia Owen
Disclaimer:
All chemicals may pose unknown hazards and should be used with caution. This
Safety Data Sheet (SDS) applies only to the material as packaged. If this product is
combined with other materials, deteriorates, or becomes contaminated, it may pose
hazards not mentioned in this SDS. The physical properties reported in this SDS are
obtained from the literature and do not constitute product specifications. Information
contained herein does not constitute a warranty, whether expressed or implied, as to
the safety, merchantability or fitness of the goods for a particular purpose. Spectrum
Chemicals & Laboratory Products, Inc. assumes no responsibility for results obtained
or for incidental or consequential damages, including lost profits, arising from the use
of these data. No warranty against infringement of any patent, copyright or trademark
is made or implied. It shall be the user's responsibility to develop proper methods of
handling and personal protection based on the actual conditions of use. While this
SDS is based on technical data judged to be reliable, Spectrum assumes no
responsibility for the completeness or accuracy of the information contained herein.
End of Material Safety Data Sheet
Product code: BE130
Product name: BENZOCAINE, USP
11 / 11