Shifa College of Medicine LOCOMOTOR SYSTEM (LMS) MODULE STUDENT’S STUDY GUIDE Class of 2016 Jan. 30-March 22, 2012 1 Module: Locomotor system Year: 1 Spiral: 1 Block: II Duration: 8 weeks Course Director: Dr. Ashraf Hussain Facilitating Departments: Anatomy, Physiology, Biochemistry, Surgery, Medicine, Radiology, Skills Lab, SIH Rehabilitation 2 CONTENTS 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. Page Introduction to the Locomotor Module How To Use This Guide Aims Overview of LMS Themes Learning Methodology Assessment Methods Recommended Textbooks Study Tips Themes objectives, cases & Vignettes Glossary 3 4 5 6 7 8 15 16 18 19-69 7o-73 Introduction to the Locomotor On behalf of the module team I welcome you to the Locomotor Module! Name of this module may sound a bit difficult to you but don’t worry, as the word “Locomotion” implies, we will have an excursion down the path of knowledge. Initially, due to new terminologies, you may feel overwhelmed, but still worry not. Once you learn these terminologies, you will start conversing fluently in the same language. For your convenience, we have included a glossary of difficult terminologies at the end of this guide. The musculoskeletal system provides locomotion, support and protection to the human body. This system consists of osteology (the study of bones), arthrology (the study of joints), and myology (the study of muscles). This module is designed to include clinical case scenarios, vignettes and SCIL Lab sessions to provide you an integrated approach to the learning of the structure and function of the body and appreciation of the features, diagnosis and management of common clinical conditions affecting muscles, bones and joints. We have tried our best to create relevance of information through incorporation of clinical cases. This will help you when you will be doing Rheumatology module in spiral 3. A visit to Shifa Hospital Rehabilitation Center has also been arranged to provide you with an opportunity to understand common disabilities and rehabilitative processes. 4 How to use this guide Read the guide carefully at least once to give you an idea of the format of the module. The “Learning Objectives" should prove critical in assisting you to define the areas that need to be covered. Detailed learning objectives of each session will be given to you at the beginning of each week, which will serve as a blueprint to the session, but do not limit yourself to those topics only. Look at the session titles and the learning objectives prior to attending them. This will give you a better focus of the area that will be discussed in the upcoming small or large group discussion. Remember, always do some preparatory readings before you come to the class. You are required to put a lot effort on self directed learning. Our ultimate aim is to guide you towards becoming a lifelong learner. 5 Aims The aims of this module are: 1) To facilitate students in the process of acquiring basic structural, biochemical and functional knowledge pertaining to locomotor system. 2) To impart the skill of history taking and examination in the context of locomotor system 3) To inculcate the habit of critical thinking, analysis, synthesis and knowledge application by using contextual case scenarios/vignettes 4) To create awareness about the ethical, social and preventive aspect of health care in the context of locomotor system 6 physical LMS THEMES 1) Skeletal Support & Body movements0 05% 2) Growth & Development of the Musculoskeletal system 05% 3) Muscle Weakness 25% 4) Painful Joint/Joints 10% 5) Painful Swollen Limb 10% 6) Biomechanics of Limb Joints 05% 7) Trauma nerve/vessels Injuries 15% 8) Gait/Limp 05% 9) Low Back Pain 05% 11) Ambivalence about Sports 10% 12) Stiff Neck 05% 7 Learning Modalities The content of this module will be delivered by a combination of different teaching strategies. These include small group discussions (SGD), large group interactive sessions (LGIS) problem based learning (PBL), journal club and practical sessions in dissection hall and laboratories. A significant proportion of your time will be spent working in small groups. We assume that MBBS Students are adult learners and hence spoon feeding will be avoided during the module. Instead, facilitators will only guide you toward your learning objectives, understanding and achieving them will be your responsibility. Handouts and other related reference material will be provided to you where necessary. Remember, all this effort must be supplemented by self-directed learning to make sure that you have a clear understanding of the module objectives. As a strategy, surprise quizzes and intermittent short practical (‘spotter’) tests will be held on material covered. Two PBL cases are also part of LMS module. These cases will be given to you before the session. Problem Based Learning (PBL) Since PBL forms an important component of teaching strategy in this module, a brief description of PBL and how it is conducted is given below: Problem based learning is the most significant innovation in medical education in the past 50 years. In this modality, 8 students integrate information from several content areas. This educational strategy promotes higher-order thinking and group functioning skills. In LMS module, two PBL cases are included to achieve the above mentioned objectives. These cases will be given to you on the day of PBL session. A brief description of how the PBL sessions are run is given below. LEARNERS’ RESPONSIBILITIES IN PBL Problem-based learning is a learner-centered process and it is the responsibility of the individual learner to participate fully, not only for his or her own learning, but also to aid the learning of others in the group. Although much time is spent alone in the library or at the computer, the full benefits of PBL cannot be realized in isolation. Each of the PBL sessions has three main parts: 1. Problem identification 2. Self study 3. Problem resolution In the first part, a problem is broken down and possible solutions are provided based on prior knowledge. Knowledge gaps are identified and learning objectives determined. This takes one hour. The second part is away from the class room setting. The learner will be given one or two days for addressing the learning objectives identified by the group during the first part. In the third session, the final solution will be constructed by sharing information learnt. This should take one hour. The 9 second hour of this session is spent on reading up a new problem. ROLES OF LEARNERS DURING PBL SESSIONS During every PBL session, a learner assumes the role of a group leader, a scribe or a group member. ROLE OF A GROUP LEADER Keeps the group on track Ensures that the 7 jump process is followed Ensures that the deadlines are met Helps in refining the problem statement Makes certain that each member of the group understands his or her role and responsibilities Ensures everybody’s participation Helps generate possible solutions Helps diffuse group conflict Makes sure that rules are followed not in a dictatorial manner but by taking everyone along ROLE OF A SCRIBE Summarizes group discussions/decisions taking place during various PBL steps Writes everything that is being said on the white board/flip chart Organizes information on the white board/flip chart Summarizes and clarifies ROLE OF A GROUP MEMBER 10 Actively participates in the process of learning Shares information Assists in the maintenance of group dynamics Follows the 7 jump process Thoroughly reads the literature provided Identifies gaps in one’s knowledge Searches for information from various sources Clarifies & summarizes Helps in resolving conflicts Reflects on group dynamics Reflects on learning that is taking place individually and in group Provides feedback Assists in the establishment of rules for group dynamics Follows established rules Be regular and punctual Seven steps of PBL: 1. The Chair and the group read the problem; the Chair will ask if any of the group do not understand any of the vocabulary in the problem - not concepts or theories but literally the vocabulary. Any queries can be resolved through the use of a dictionary! 2. The Chair asks the group to identify what they think the problem statement is about. At this stage, students may be clueless about the depth of the knowledge inherent in the statement but this will become clearer as the process 11 continues. Some of the answers therefore may be naïve or ignorant but this does not matter. The educator must resist the temptation at this point of stepping in and offering any form of knowledge transmission! 3. A brainstorm session is held to ascertain what, if anything, is known (or is believed to be known) about the subject matter by any of the students at this point in time. 4. The Minutes Secretary identifies the key issues that have been discussed. The Chair ensures that a clear list of what is known, what is unclear and what needs to be investigated in more detail is established. This is designed to help the group understand the issues surrounding the problem. 5. The group agrees on their learning objectives and the tasks that they will have to carry out before the next meeting. 6. Individual Study - members of the group collect the information identified in step 5. There is a choice of two routes here - either each student should tackle his or her own learning objectives, or each student covers all the learning objectives. The latter is more time consuming and may be off-putting for students and avoid inculcating the collaborative team based learning experience. The group meets for the second time. The Chair asks the Minutes Secretary to read out the learning objectives and each student has the opportunity to present their research to the rest of the group. It is suggested that this can be done either formally, i.e. in turn, or through group discussion. 7. The group meets for the second time. The Chair asks the Minutes Secretary to read out the learning objectives and each student has the opportunity to present their research 12 to the rest of the group. It is suggested that this can be done either formally, i.e. in turn, or through group discussion. 13 Remedial Sessions: Remedial tutorials or other aids to learning may be possible but if you do not tell us we will not know you have a problem. You can contact us personally or by e-mail: ashrafhussain9@gmail.com Your participation and performance in SGDs/ Demonstrations/LGIS is important and will be continuously monitored. This will be used in assessing your overall performance at the end of the year. Discipline: In the class rooms, dissection hall and laboratories you are required to wear a plain white coat, without accessories. Edible items and photography are not allowed inside the Dissection Hall. 14 Assessment In this eight weeks duration module, you will have surprise quizzes and intermittent short spotter tests. A full-fledged formative assessment compromising of both MCQs and IPE will be taken in the 5th week. This will give you an idea about the format of the examination that you will go through at the end of the module. Of course, this will be followed by feedback on your performance in the exam. Comprehensive end of module exam will comprise of: MCQ paper 80 % SAQ paper 20 % IPE 100 % Marks obtained in the end of module examination and your SGDs evaluation will contribute toward 30% of internal assessment marks for final Professional Examination. In Shifa College of Medicine, passing marks are considered to be 60%. Evaluation The Medical Education Department is particularly interested in finding out the views of students on their experience in each module. Focused group interview of the students will be conducted in the middle and at the end of module. If thought necessary, course evaluation forms can also be given to you near the end of the module. We would appreciate a few minutes of your time to fill in this form, as feedback will be used to assist in maintaining modules. 15 and improving the future Recommended textbooks Which book should I study? This is the most frequently asked question in every module. You can find dozens of medical textbooks in the shops, most of them are pretty good! Selecting a textbook is like selecting a car. All cars take you where you want to go but different features have appeal to different people. In case of books, it can be the writing style, diagrams and content information. Cost can be an issue for some students but not for others. Some text books we may like as teachers, but you may not find them “user friendly”. In this regard, the best advice is to read through a selection of textbooks and see which suits your style of learning. Talk to fellow students, seniors and friends for their opinions and preferences before making a final decision. Having said all this, there are some textbooks which most students and staff have found useful and relevant in the past. The names are as follows: Anatomy Recommended: 1. Clinical Anatomy by Snells 8th edition 2008 2. Clinically Oriented Anatomy by Keith. L. Moore 5th edition 2006 3. The Developing Human by Moore & Persaud 7th edition 2006 4. Basic Histology by Luiz Carlos Junqueira 12th edition 2010 Reference: 1. Last's Anatomy by RJ Last 11th edition 2006 16 2. Langman’s Embryology 10th edition 2006 3. Wheater’s Functional Histology, 5th Edition 2006 4. DiFiore’s Atlas of Histology 11th Edition Physiology 1. Textbook of Human Physiology (Guyton and Hall) 11th Edition 2. Human Physiology From Cells to Systems (Lauralee Sherwood) 6th Edition Biochemistry Recommended: 1. Lippincot’s Biochemistry review 4th edition 2. Harper’s Biochemistry 28th Edition Reference: 1. Mark’s Biochemistry 3rd Edition Clinical Macleod’s Clinical Examination 12th Edition 2009 Websites http://www.med.umich.edu/lrc/Hypermuscle/Hyper.htm http://www.ptcentral.com/muscles/ http://www.vesalius.com/ For clip art: http://www.clipartpal.com/clipart/science/anatomy1.html 17 Study Tips: 1. 2. 3. 4. 5. 6. We encourage you to study and work in small groups (maximum three) while preparing for SGD, dissection or large group discussion. Quiz each other and discuss complex topics. This will help you in clarifying misconceptions. Make sure you see and recognize the structures on the cadaver when having a session in the dissection hall. These structures are often asked in the IPE examination. See the objectives and prepare for sessions before hand. Study a little bit every day. If you have any questions, or you are not doing as well as you would like to do, please see us right away! We want you to Succeed and we are here to help. Good Luck!!! 18 THEME 1: Skeletal support & Body movements Video clip Knowledge a) Describe anatomical planes, terms of position and movements. b) Classify muscles on the basis of their structure and function. c) Classify bones according to their shape. d) Classify joints. e) Correlate histological features of bone and cartilage to their functions. Skill a) Identify various muscle groups according to their functions (prime movers, antagonists, synergist and fixators). b) Demonstrate various movements at the joints of upper limb, lower limb and back. c) Identify bones according to their shape. (models/X-rays/CT) d) Identify joints according to the manner and type of articulating material. e) Take history in the context of locomotor system. Attitude: Students should develop the following attitudes: a) Responsibility to remain a life-long learner and maintain the highest ethical and professional standards. b) Willingness to work in a team with other health professionals 19 20 c) THEME 2: Growth and Development of Human Musculoskeletal System Knowledge a) Correlate the process of osteogenesis and myogenesis to its anomalies. b) Describe developmental anomalies of limbs and joints c) Discuss calcium homeostasis and the common causes of hypercalcemia and hypocalcemia. d) Discuss phosphate homeostasis and the common causes of hyper- and hypo- phosphataemia. e) Classify collagen and its types. f) Illustrate the synthesis and distribution of different types of collagen. g) Outline the process of fracture healing. Skill a) Identify gross features of bones of the upper and lower limb (specimens/ models /x- ray/ CT). b) Identify histological features of bone and cartilage under light microscope. c) Identify the developmental anomalies of limbs and spines on specimen/diagram 21 Attitude d) Counsel an individual/community on the role of dietary and environmental factors for prevention of bone and joint diseases. CASE 1: Seven month old boy with history of repeated fractures Name: Ihsan Age: 7 Months Presenting Complaint:Painful swollen right leg for 2hrs History of Presenting Illness:Seven months old boy is brought to the emergency room with complain of swelling and pain in right lower limb after a fall while he was crawling on the bed. Past History: Patient had a right humerus fracture 2 months back and left femoral fracture 4 months back Family history: Collagen diseases. Social History: Not significant General Physical Examination: Seven months old boy with thin bones, presently in distress. 22 Vitals: Pulse: 130/min Respiratory Rate: 35/min BP: 110/70 mm Hg Temperature: Afebrile Systemic Examination: CVS: Normal. Resp: Normal vesicular breathing. Abdomen: Soft, on tender abdomen. CNS: Normal. Investigations: X-Ray lower limb: thin bones with few trabeculae and thin cortices. Diagnosis: Osteogenesis imperfecta Critical Questions: (1) Describe the composition, structure and extracellular matrix including collagen and elastin. 23 functions of (2) Describe the synthesis and degradation of collagen with associated defects. (3) Discuss the non-collagen components of bone matrix. Collagen disease, thin bone, trabeculae, cortices and osteogenesis imperfect. CASE 2: 72 YEAR OLD WOMAN WITH FRACTURE A 72-year-old woman has been living alone since the death of her husband 5 years ago. She spends her days mainly at home housekeeping, reading, and rarely goes out. She has been suffering from backache for the past one year and this is perhaps one reason why she is not as physically active as she should be. She lives mainly on canned food, soft drinks and fast food with no milk and milk products. One day she fell from the stool she was standing on. Immediately she felt a sharp pain in her right hip joint and was unable to bear weight. She presented to the emergency department with a fracture of the neck of femur shown by X-Ray of the hip joint. Other blood tests revealed: Hemoglobin = 10 g/dl, Na+: 144 mmol/liter (136 to 145), K+: 3.6 mmol/liter (3.5 to 4.5), Ca2+: 1.55 mmol/liter (2.20 to 2.55) and 24 Serum Phosphate = 0.52 mmol/liter (0.74 to 1.20). Alkaline Phosphatase = 380 U/liter Serum Parathyroid Hormone = increased. A radioimmunoassay for vitamin D showed that the blood level of 25OH-vitamin D3 was 2 ng/mL (normal, 14 to 60 ng/mL). Critical Questions: 1. Explain calcium and phosphate homeostasis and factors regulating serum calcium. 2. Describe different forms of vitamin D and its metabolism in health and disease. 3. What difference would you see in a normal X-ray of hip joint taken from a 72 year old woman and a ten year old girl? 4. How does healing occur in bone? 5. What are the cells involved in healing? 6. What factors influence bone formation? 7. What is osteoporosis? 25 8. Where are spongy and compact bones found? 9. How do they differ histologically? 10. Which part of the bone is mostly affected in this type of fracture and what is the mechanism? Backache, canned food, milk, fracture of neck of femur, hemoglobin, parathyroid calcium, phosphate, hormone, 26 alkaline Vitamin phosphate, D. THEME 3: Muscle weakness Knowledge a) Correlate the histological features to the molecular basis of skeletal muscle contraction. b) Illustrate the mechanism of generation of Resting Membrane Potential. c) Compare isotonic and isometric contraction in various body movements. d) Correlate the histological features of skeletal, smooth and cardiac muscle to their function. e) Correlate the energy sources of white and red skeletal muscle fibers to their use in sprinters and marathon runners. f) Describe neuroanatomic basis of flaccid and spastic paralysis (myasthenia gravis) g) Correlate the common injuries of lumbosacral plexus to their clinical presentation. Skill h) Differentiate the histological features of skeletal, smooth and cardiac muscle under a light microscope. i) Identify muscles of the lower limbs, their attachments and nerve supply on cadaver, specimen, model and imaging. j) Perform muscle function testing (in lower limb) by reciprocal peer teaching. k) Interpret the graph of an action potential with underlying mechanism responsible for different phases of action potential. 27 l) Interpret the graphs of simple muscle twitch and repetitive muscle contraction. m) Identify the role of different factors influencing the speed of conduction of an impulse. n) Draw and label lumbosacral plexus. Attitude: Take informed consent before examination CASE 3: Boy with broken tooth and severe pain Name: Ibrahim Age: 9 years Presenting Complaints: Tooth ache for 4 hours History of Presenting Illness: While playing, Ibrahim sustained an injury which resulted in a partially broken tooth (upper jaw incisor). Following this, he has severe pain and has difficulty in eating. During his dentist’s visit, he was advised complete tooth extraction under local anesthesia. Past Medical History: Not significant Family History: Not significant Social History: Not Significant 28 General Physical Examination: A young boy sitting anxiously, oriented in time place and person Vitals Pulse: 100/min BP:110/70mmHg Temp:98.6 F RR:18/min Systemic Examination HEENT: Normal Respiratory: Normal CVS: Normal Abdomen: Normal CNS: Normal Critical Questions 1. How resting membrane potential is generated? 2. Describe the role of different ions in the generation of resting membrane potential? 3. What is significance of sodium potassium pump in generation of concentration gradient inside with respect to outside and in the generation of resting membrane potential? 4. What mechanism is responsible for the transmission of pain from tooth to brain? Pain and anesthesia 29 CASE 4: 35 year old woman with progressive muscle weakness A 35 years old woman resident of Rawalpindi presented in foundation OPD with progressive weakness for the last 2 months. She has also noticed intermittent drooping of both of her eye lids, and progressive facial muscles weakness while speaking. She also complaints of weakness and tiredness while climbing the stairs of her office has difficulty while typing a lengthy official replies to their clients. Her general physical examination revealed a pulse of 82/min. B.P 120/80 mm of Hg. Temp. 98 F and Resp. rate 16/min. with drooping of both eyelids ( Ptosis +ive). Her laboratory investigations revealed positive anti-choline receptor antibodies. Rest of laboratory workup was unremarkable. Critical Questions: 1. What is wrong with this patient? 2. What is the cause of this condition? 3. What is the physiological basis progressive muscle weakness & drooping of eyelids? 4. How can this patient be helped? Progressive weakness, drooping of eyelids, anti-Ach receptor antibody 30 CASE 5: 21 Year old man with progressive stiffness & difficulty swallowing A 21-year-old man presents to a rural emergency center with a 1-day history of progressive stiffness of the neck and jaw, difficulty swallowing, stiff shoulders and back, and a rigid abdomen. Upon further questioning, the patient reports that the stiff jaw was the first symptom, followed by the stiff neck and dysphagia. On examination, he is noted to have stiffness in the neck, shoulder, and arm muscles. He has a grimace on his face that he cannot stop voluntarily and an arched back from contracted back muscles. The physician concludes that the patient has tetanic skeletal muscle contractions. A 3-cm laceration is noted on his left foot. The patient reports sustaining the laceration about 7 days ago while he was plowing the fields on his farm. He has not had a tetanus booster. He is diagnosed with a tetanus infection, and an injection of the tetanus antitoxin is given. 31 Critical Questions: 1. On which skeletal muscle filament is troponin located? 2. What is the function of the sarcoplasmic reticulum? 3. What is the molecular basis for the contraction of skeletal muscle? 4. Why is a skeletal muscle tetanized? 5. Which part of the body is safe from tetanization? 6. What is a sarcomere and how its length changes? 7. What keeps actin and myosin in place? 8. What is the walk along mechanism of muscle contraction? 9. Why dark and light bands are named so? SGD II 10. How muscle is able to produce tension of different grades? 11. Give examples of the two types of muscle contraction from daily life? 12. What are antigravity muscles? 13. How a person is able to stand over long periods of time? Progressive stiffness, dysphagia, involuntary grimace, arched back, tetanic skeletal muscle contractions, lacerations, tetanus, tetanus booster, tetanus antitoxin. 32 CASE 6: Patient with cramps and pain in both calves Name: Rahmat Ali Age: 30 years Presenting Complaint: Severe cramps and pain in calves ---- 03 hours History of Presenting Illness: According to the patient, he was in his usual state of health 3 hours ago when started having severe cramps and pain in both calves. He has just returned from a hiking trip with his friends in Margalla hills which lasted for around 4 hours. The pain started gradually after the first hour but he kept on moving. It got better when they stopped to have lunch but recurred as soon as they started moving back. He complains of similar pains of lesser severity when he goes out on weekends. Past medical history – Not significant Family History - Not significant Social History - He is a software programmer, who works from home and rarely goes out. General Physical Examination A young man in pain lying on a bed, well-aware of his surroundings. Vitals: Pulse: 80/min Respiratory rate: 18/min 33 B.P.: 110/70 mmHg Temperature: Afebrile Systemic Examination HEENT: Normal Respiratory: Normal CVS: Normal Abdomen: Normal CNS: Normal Musculoskeletal: His calves are tender to touch, although there are no signs of acute inflammation. Critical Questions 1. Compare and contrast between fast and slow muscle fibers in relation with. 2. Why do the muscles of body go into state of permanent contraction after death? 3. What are the differences between skeletal, smooth and cardiac muscles? Cramps, tender calves 34 THEME 4: Painful Joint Knowledge a) Correlate the structure of major joints in the human body to its functions. b) Discuss the role of raised serum uric acid in joint pain. c) Correlate the composition of synovial fluid to its role in joint function. d) Describe glycosaminoglycans and their role in regular wear and tear of joints. e) Discuss the epidemiology and prevention of rheumatic joint disease. Skill f) Identify normal & diseased joints of the limbs by clinical examination and imaging modalities. Attitude g) Counsel an individual on basic road traffic rules. h) Counsel an individual on healthy practices to prevent joint disease. 35 CASE 7: PBL Case will be provided in the class on the day of instruction. CASE 8: Businessman with pain in big toe NAME: David Bahadur AGE: 52 years Presenting complaint: Pain in big toe for 12 hours History Of Presenting Illness According to the patient, he was in his usual state of health, when he went to a dinner party yesterday. There he had an episode of binge eating and drinking beer. He had no complaints until early this morning when he started to have pain in his big toe. The pain was gradual in onset, severe in intensity, non-radiating with no aggravating or relieving factor. Past history: He had a lithotripsy for kidney stones 2 years back. He had similar attacks in the past. Family history: Not significant Social history: He is married for 22 years having 3 children. drinks a glass of beer every night. 36 He General Physical Examination: A middle aged man conscious and alert. Vitals: Pulse: 72/min, Temp: 100o F BP: 110/70 mmHg Respiratory Rate: 20/min. HEENT: Normal Resp: Normal CVS: Normal GIT: Normal CNS: Normal Musculoskeletal: The big toe was red, hot and swollen; painful to active and passive movement; tophaceous deposits in left ear and olecranon bursitis. Investigations: CBC: Hb: 12g/dl, WBCs: 12000, Serum Uric Acid: 6.5 mg/dL X-RAY: Punched-out erosions in right big toe at metatarsophalangeal joint, producing “overhanging’’ spicules 37 Critical Questions Can you think of reasons why… a) binge eating is related to gout b) gout primarily affects the extremities c) gout usually affects the first metatarsophalangeal joint or the olecranon bursa d) attacks of acute gout mostly take place at night or the early morning e) more men are affected by gout than women (male : female ratio, 3-9:1) f) tophaceous deposits are produced g) punched out lesions are produced Pain in big toe, binge eating, lithotripsy, tophaceous deposits, olecranon bursitis, uric acid, punched out erosions, overhanging spicules. 38 THEME 5: Painful Swollen limb Knowledge a) Correlate the venous and lymphatic drainage of lower limb to their clinical significance. b) Correlate the causes and effects of varicose veins to perforator incompetence and venous hypertension. c) Explain the organization of arterial system supplying the limbs and vertebral column. Skill d) Identify major veins of lower limb on cadaver/peers/ simulated patients. e) Mark the surface anatomy of the major veins of lower limb. CASE 9: Babloo’s increasing left leg pain Six hours after the accident, Babloo developed increasing left leg pain. He called out to a passing doctor who examined his leg. The leg was swollen and tender over the posterior, anterior and lateral aspects. Pedal pulses were weak but present. Motor power was reduced in the leg muscles. There was also decreased sensation in deep and superficial peroneal distribution. Active ankle planter flexion and inversion were present but weak due to pain. Capillary filling of the skin of the leg and foot was normal. 39 Critical Questions: 1. Where are the foot pulses palpated and why? 2. How will you check the motor power in this case? 3. Why was the motor power in Babloo’s case reduced? 4. Why was Babloo having decreased sensation in deep and superficial peroneal distribution area? 5. How are the compartments in the leg formed? 6. Which muscles are present in anterior, lateral and posterior compartments and what is the action and nerve supply? 7. What other structures are present in the compartments? 8. What is compartment syndrome? 9. What are the causes of compartment syndrome and how does it present? 10. What could be the cause in Babloo’s case? 11. Why did the doctor check for planter flexion? 40 12. How is capillary filling checked? 13 What is the name of the procedure done to relieve compartment syndrome? Increasing left leg pain, pedal pulses, motor power, decreased sensation, capillary filling. CASE 10: Babloo’s uncle has tortuous leg veins One of Babloo’s uncles serves in the Islamabad Traffic Police. He is 50–years old. He often complained of chronic dull ache in both legs and noticed irregular swelling in both legs. A friend advised him to consult a doctor. On examination, the doctor noticed dilated and tortuous veins on the medial side both legs. The skin on the medial malleolus was found to be discolored, dry and scaly. 41 Critical Questions: 1. What is the clinical condition called? 2. Where is the abnormality? 3. What causes this abnormality? 4. Who is more prone to get this? 5. What is the structure of a vein? How does it differ from an artery? 6. What is the direction of flow in leg veins? 7. What are perforating veins? 8. How does the venous system function against gravity in lower limb (factor facilitating venous return)? 9. Why is saphenous vein ideal for coronary artery grafts and how is it used? 10. What is the reason for dry scaly skin at medial malleolus? Tortuous veins, dry & scaly skin, chronic dull ache, irregular swelling CASE 11: Fifty-five year-old man with calf pain while walking Name: Ayaz Akhtar Age: 55 Presenting Complaints: Pain RT calf for 6 months 42 History Of Presenting Complaints: Patient was in his usual state of health 6 months back when he developed pain in his right calf. This pain was sudden in onset, moderate in intensity, non-radiating, aching in character. Patient noticed that this pain begins after walking around 100 yards and is relieved as he stops and sits for 10 minutes. For the last 2 months, the pain begins after he walks only 50 yards and he has to stop. There is mild discomfort in left calf but no pain. He took some analgesics but with no relief. Past medical History: Known hypertensive, on irregular treatment. Personal History: Smoker for last 20 years, 30 cigarettes per day. Family History: History of obesity, diabetes and hypertension in family. Social History: Married having 2 sons. General Physical Examination: An obese man lying in bed well oriented in time, place and person. Vitals TEMP. A/F BP: 150/90mmHg R/R: 18/min PULSE: 88/min Weight: 110 kg 43 Xanthelasmas present Systemic Examination Respiratory System: Normal Abdomen: Normal CVS: Normal CNS: Normal Musculoskeletal Examination: The right leg and foot is pale as compared to left. There is hair loss and skin is thin and shiny on right side, limb is cold as compared to the left. No ulceration present. Popliteal, posterior tibial and dorsal pedis pulses are absent on the right side, while pulses on the left side are normal. There is slight wasting of right calf muscles, while movement is normal. Laboratory Investigations: CBC: Hb: 12.0 g/dl; TLC: 7500 /mm3; PLT: 215000 /mm3 RBS: 146mg/dl Urea: 35 mg/dl Creatinine: 0.9 u Cholesterol: 220 mg/dl Investigations Ordered: ECG X Ray Chest Pa View Doppler U/S of legs 44 Critical Questions 1. What is the condition called? 2. Why is the pain relieved at rest? 3. Why the distance is walked decreasing? 4. Why the right leg is paler compared to the left? 5. Why are the distal pulses (popliteal, posterior tibial & dorsalis pedis) absent? 6. Why is there wasting of muscles while movement is normal on the right side? 7. How is smoking and xanthelasmas related to his condition? 8. Why has a Doppler U/S of legs been ordered? Sudden pain, HTN, smoker, pack years, xanthelasmas, pallor/pale, thin & shiny skin, ulceration and muscle wasting 45 THEME 6: BIOMECHANICS OF LIMB JOINT Knowledge a. Discuss the biomechanics of the ankle, and subtalar joints and the special features that help to maintain their stability. b. Describe the arches of foot. c. State their functional significance in normal life and sport activities. Skill d. Identify arches of foot on prosected specimen, diagram or model. e. Identify the bones involved in maintaining arches of foot on articulated foot. CASE 12: 23 year old runner with swollen ankle A 23-year-old basketballer twisted (inverted) her right ankle during warm-up. She complains of pain and swelling over the lateral aspect of the right ankle. Walking is also difficult secondary to pain. Physical exam reveals swelling over the lateral aspect, which is painful to palpation. 46 Critical Questions: 1. What is this injury called? 2. What is the mechanism of injury? 3. Why is her ankle swollen? 4. What is the source of her pain? 5. How is this injury different from Pott fracture? Swollen ankle, inversion 47 CASE 13: Babloo’s friend rejected for army recruitment Tipu is Babloo’s close friend. He likes adventures and is very keen to join the army. Although he cleared all the tests, he was still rejected because he was found to have pes planus (flat foot) in the medical check up. Babloo has brought worried Tipu with him to your place for advice. How will you explain the situation to Tipu? Critical Questions: 1) What are the effects of flat foot? 2) Why is Tipu rejected? 3) What are the anatomical factors responsible for this condition? 4) Which bone is the keystone for the medial and longitudinal arch? Pes planus 48 7) Nerve Injuries (Lower Limb) Knowledge a) Discuss the anatomical basis of peripheral nerve injuries. b) Interpret the neuroanatomical basis of the clinical conditions causing numbness in the limbs. Skill c) Identify common nerve injuries in the limbs and their implications (pictures/videos/diagram/SP). CASE 14: Policeman with superior gluteal nerve injury A policeman sustained a bullet shot injury in his left buttock in a street encounter. After convalescence, he developed a characteristic limp during walking. There was sagging of right hip while taking a step on left foot. On examination, Trendelenburg sign was positive. 49 Critical Questions: 1) Identify the nerve injured and give its course and branches? 2) What is Trendelenburg sign and what are the implications of positive Trendelenburg test? 3) Name the characteristic gait in unilateral injury and in bilateral injury to the nerve? 4) How does this gait abnormality occur? Superior gluteal nerve, limp, trendelenburg sign. 50 CASE 15: Imtinan loses sensation over lateral and anterior aspect of leg after removal of plaster A few days following the removal of plaster cast for fracture of the upper end of left fibula, Imtinan complained of loss of sensation on the lateral and anterior aspect of leg and on the intermediate area of the dorsum of foot including toes except the lateral side of little toe and first inter digital cleft. On examination, the Imtinan was unable to dorsiflex and evert the left foot. Critical Questions: 1) What is the deformity called? 2) Why is it common? 3) Which nerve is injured in this case? 4) Why is this nerve vulnerable to injury? 5) Describe the course and distribution of this nerve. 51 6) Inability to dorsiflex the foot is due to loss of function of which nerve. 7) What are the chief evertors of foot? Upper end of fibula, loss of sensation, dorsiflex, evert. 52 THEME 8: GAIT CYCLE Knowledge a) Describe the gait cycle and its phases. b) Explain the anatomicopathological basis of different types of limp. Skill c) Recognize various types of limp VIDEO OF GAIT 53 THEME 9: LOW BACK PAIN/NECK PAIN Knowledge b) Correlate the development of vertebral column to its anomalies. c) Correlate the skeletal components of spine to its function. d) Associate the structure of typical and atypical vertebrae with their regional characteristics. e) Underline the anatomical basis of acute and chronic low back pain. Skill f) Identify structure of typical vertebra and mention the regional characteristics of the vertebrae g) Identify salient features of cervical, thoracic, lumbar & sacral vertebrae. h) Using diagram and/or prosected specimens, identify the muscles, ligaments and tendons which support and act upon the spinal column. 54 CASE 16: Patient with abnormal curvature of spine Mother of a teenage girl is worried about the abnormal curvature of the spine of her daughter. The spine is crooked and curves to the side. Her right shoulder appears to be lower than the other. The doctors told that her daughter had scoliosis. Critical Questions: 1) What vertebral defect can produce scoliosis? 2) What is the embryological basis of the vertebral defect? 3) Does scoliosis cause any problem? 4) Define kyphosis and lordosis. Explain the factors responsible for these defects? Curvature of spine, scoliosis 55 CASE 17: Rashid and the heavy box Thirty five year-old Rashid disc in the posterolateral works as bellboy in a 5-star direction between L4 and L5 hotel. He has developed sudden vertebrae. and acute pain in lumbar region after lifting a heavy box of a foreign guest. The pain radiates down to the outer side of the left leg. MRI of the vertebral column showed herniation of the Critical Questions: 1) Which nerve root will be compressed if there is a disc prolapse between L4 and L5 vertebrae? 56 2) In which area will there be sensory loss in a disc prolapse at this level? 3) Name the parts of an intervertebral disc. 4) Enumerate the functions of the disc and describe the diurnal variations in it. 5) What are the age related changes seen in disc? 6) What effects do they produce on posture? 7) Define lumbago and sciatica. Lumbar region, radiating pain, herniation. CASE 18: RAJ’S TERRIBLE BACKACHE One day, Shazina came home from shopping to find Raj in agony. “I have a terrible back ache”, he groaned, “Probably will have to go off sick again”. “Well you’ll have to go and see Dr. Masroof, Shazina won’t said you?” rather unsympathetically. 57 Dr. Masroof asked Raj to bend forward, backwards and rotate his trunk from side to side. He was examining his range of movements. Dr. Masroof then tested Raj’s ability to passively raise his legs while lying down. Dr. Masroof asked Raj “Where is the pain?” Raj indicated his lower back, midway between his anterior superior iliac spines. “Does the pain run down your leg?” inquired Dr. Masroof. Raj said no. Critical Questions: 1) Which muscles are being used by Raj to extend, flex and rotate his spine? 2) Why did the doctor inquire about pain running down the leg? 3) Where are the paraspinous muscles located? What are their functions? Backache 58 THEME 10: AMBIVALENCE ABOUT SPORTS KNOWLEDGE a) Correlate hypertrophy and atrophy of muscle with its use and disuse. b) Explain the physiological basis of performance-enhancing drugs. c) Correlate the common injuries of brachial plexus to their clinical presentation d) Correlate the structure of major joints in upper limb to its functions. e) Correlate the venous and lymphatic drainage of upper limb to their clinical significance. f) Explain the organization of arterial system supplying the upper limbs and neck. g) Discuss the biomechanics of the shoulder, elbow, and wrist, and the special features that help to maintain their stability. h) Interpret the anatomical basis of common traumatic/sports injuries of the bones, joints and soft tissues of the limbs. SKILLS a) Identify gross features of bones of upper limb (specimens/ models /x- ray/ CT). b) Identify muscles of the upper limbs, their attachments and nerve supply on cadaver, specimen, model and imaging. c) Perform muscle function testing (in upper limb) by reciprocal peer teaching. d) Draw and label brachial plexus 59 e) Identify normal & diseased joints of the limbs by clinical examination and imaging modalities f) Identify major vessels of upper limb on cadaver/peers/ simulated patients. g) Mark the surface anatomy of the major vessels of upper limb. h) Perform intramuscular injection on mannequin (deltoid & gluteal region) ATTITUDE i) Counsel a person using performance-enhancing drugs for long periods. j) Demonstrate process of taking informed consent for examination/intramuscular injection on SP. CASE 19: 24 year old weight trainer sent for counseling Rashid, a 24 year old male had weight trained steadily for over the past year to compete in the city bodybuilding event. competition, he employed restrictive dietary Prior to the practices, intense exercise, and the self-administration of pharmaceuticals to reduce body fat and to gain lean body weight. He recorded his nutritional intake, pharmaceutical use, body weight, and skin fold measurements regularly. He also administered a variety of anabolic-androgenic steroids in various dosages and combinations. 60 At the end of his training, his records indicated a weight gain from 160 to 238 lbs. He competed and won the city championship. Six months later, he reappeared in an intercity championship weighing 190 lbs but was disqualified from the competition after testing positive for drugs. Authorities have sent him to you to for counseling. Weight trainer, body fat, lean body weight, anabolic steroids. CASE 20: PBL Babloo and his new motorbike… Case will be provided in the class on the day of instruction. CASE 21: Goalkeeper with pain in shoulder and long arm The goalkeeper in a soccer match fell on his outstretched left arm. He felt an immediate pain in the shoulder region and was unable to move his arm. At the hospital the arm was abducted and the deltoid muscle looked flat or hollow. The injured arm looked "too long", and there was intense pain on attempting to move the arm. A plain radiograph of the region showed that the humeral head was lying below the glenoid labrum and that there was no fracture of the humerus. The diagnosis 61 was an anterior dislocation of the shoulder, and the orthopedic surgeon recommended Kocher's maneuver for management. Critical Questions: 1. Why did the deltoid appear flat and hollow? 2. What neurovascular structures are liable to be injured in such a condition? How do you examine the patient to rule that out? 3. What is the anatomical principle in reducing a dislocated shoulder? 4. How is the shoulder joint formed? 5. Draw a diagram to show the relations of the shoulder joint 6. What is anterior dislocation of shoulder joint? 7. After retracting the deltoid and pectoralis major muscles from each other, which bony part of the scapula is exposed? 8. Which long blood vessel is located in the deltopectoral groove? 9. Name the two muscles which are attached to the bony part of the conjoint tendon? 10. Name the rotator cuff muscles and give nerve supply of each. 62 11. What is the significance of rotator cuff muscles? Outstretched left arm, shoulder, deltoid flat or hollow, arm too long, glenoid labrum, anterior dislocation, Kocher’s maneuver CASE 22: Wrestler with severe pain in his left elbow A 20 year old wrestler presents to the Emergency Department after being thrown out of the ring and landing on his left hand. He complains of severe pain in his left elbow, swelling and the area appears widened as compared to the right. He resists examination by the doctor as slight attempt to move the elbow elicits severe pain. A lateral view of the left elbow joint is ordered. The following image returns: 63 CRITICAL QUESTIONS: a) What is wrong with this patient? b) What is the basis of this injury and why? c) What are the bony landmarks that are readily palpable at the elbow? d) What nervous structure is particularly vulnerable in elbow injuries and where is it located? e) What other types of elbow injuries are common and how do they present? f) What type of elbow injuries are common in pre-school children? Elbow, lateral view of left elbow CASE 23: Basketballer with swollen wrist A 27-year-old-male basketball player presents to the emergency room following an awkward landing after a rebound in which he landed on his right hand. He was unable to carry on playing and reports that his right wrist became immediately swollen. On examination, the patient's right wrist is swollen with marked "dinner fork" deformity. There is 64 tenderness over the distal radius and hypoesthesia in the distribution of the medial nerve. Critical Questions 1. What is the basis of this injury? 2. Why is it called a dinner fork deformity? 3. How does Colle’s fracture differ in children? 4. Why is his wrist swollen? 5. What is mallet finger? Swollen wrist, dinner fork deformity, hypoesthesia, median nerve 65 CASE 24: Hunter with bullet injury of right arm Sher Dil 28 years old Male Computer Programmer Presenting Complaints: Bullet injury right arm for 3 hours History Of Presenting Complaints: Patient was in his usual state of health and hunting ducks with his friends 3 hours ago. After shooting at a flock of duck and successfully hitting one, he went to collect his prize. While picking up the shot duck, it resisted and in the commotion, his gun went off and injured his right arm. He fell unconscious and was later taken to the local clinic by accompanying hunters. There initial bandage was done and he was referred to a tertiary care hospital. He is complaining of severe pain in his arm, forearm and right hand. He received some analgesics at the local clinic but the pain is worsening. Past medical History: Not significant. Family History: History of tuberculosis in family. Personal History: No known addictions. Medication History: Not significant. Physical Examination: A young man lying on couch, in severe distress due to pain, well oriented in time, place and person. ABCDE of trauma protocol done 66 BP: 100/90mmHg PULSE: 110/min TEMP. A/F R/R: 20/min Musculoskeletal Examination: The right arm is bandaged, soaked with blood, forearm and hand appears dusky colored, pale and colder as compared to left side. On removing the bandage, wound of entry on medial side of mid arm with exit wound on lateral side. There is swelling of the arm with absent distal pulses. Respiratory System: Normal Cardiovascular System: Normal Abdomen: Normal Investigations: CBC and Blood Grouping sent. X-RAY Right Arm AP LAT views ordered. Critical Questions: 1. What is ABCDE of trauma protocol? 2. Why is his right arm dusky colored, pale and cold? 3. Which artery is the source of bleeding? 4. Why is his arm swollen? 5. What is the purpose of palpating distal pulses? 6. Why are distal pulses absent? 7. Are there any other conditions in which distal pulses are absent? 8. What do you expect to see in his CBC? 67 9. Why was an X-ray ordered? 10. Are there any other tests that you would like to perform? Analgesics, soaked with blood, dusky color, entry wound, exit wound, absent pulses. 68 THEME 11: STIFF NECK Knowledge a) Describe deep cervical fascia and division of neck into various compartments. b) Describe triangles of neck and their contents. c) Enumerate causes of cervical pain. Skills a) Identify salient features of cervical vertebrae. b) Identify various triangles of neck and structures contained. c) Identify the cervical vertebrae on radiographs. CASE 25: 52 year old woman with neck stiffness A 52-year-old woman presents with a history of several months' duration of involuntary spasms in her neck. She relates intermittently feeling the muscles in her neck tighten painfully. The episodes cause her head to turn slightly to the right. She has difficulty looking over her left shoulder when the muscle spasm occurs, which is particularly bothersome while driving. She has symptoms daily, and notes that symptoms are worse late in the day. They are exacerbated by fatigue and emotional stress. She can partially relieve symptoms by placing her hand on her chin during the spasms. 69 Critical Questions: 1. What is the source of pain in her neck? 2. Why is her head turned to the right? 3. Why are the symptoms exacerbated by fatigue and stress? 4. Why are the symptoms relieved by placing her hand on the chin? Involuntary spasms, head turned to right, difficulty looking over left shoulder, muscle spasms. 70 Glossary Abduction movement away from the central axis of the body/limbs. Acetabulum the cuplike cavity on the lateral aspect of the hip girdle that receives the head of the femur Adduction movement towards the central axis of the body/limbs. Anastamosis the union or joining of blood vessels (also used to describe surgical joining of tubular structures Anterior the front of an organism, organ or body part; same as ventral Aponeurosis a broad flattened tendon. Appendicular referring to the bones of the limbs and limb girdles that are attached to the axial skeleton Axial referring to the bones of the skull, vertebral column and bony thorax that form the central axis of the body Bursa a fibrous sac containing fluid that occurs between bones and tendons where it acts to decrease friction during movement Caudal literally towards the tail; in humans, towards the inferior portion of the trunk Condyle rounded projection at the end of a bone that articulates with another bone Circumduction a movement in which the limb describes a cone. It is not a primary movement, but in fact, a sequence of flexion, abduction, extension and adduction. Diaphysis the elongated shaft of a long bone Distal away from the attached end of a structure, especially a limb Dorsal posterior; pertaining to or towards the back; opposite to ventral Epicondyle 71 an elevation placed above the articular surface of a condyle. Epiphysis that part of a bone formed from a secondary center of ossification, commonly found at the ends of long bones on the margins of flat bones, and at tubercles and processes during the period of growth, epiphyses are separated from the main portion of bone by cartilage. Facet smooth, somewhat flat surface on a bone for articulation. Fascia membranous structure of collagen fibres, with these fibres arranged in two directions intersecting each other. It may be pulled maximally until the fibres are perpendicular to each other. Foramen hole in the bone. Fossa depression on a bony surface. Fovea small depression on a bony surface. Gomphosis joint in which a peg shaped process is inserted in a socket, connected to each other by fibrous tissue. Hamulus a hooklike process. Incisura a notch Inferior below; toward the feet; same as caudal Insertion the movable point at which the force of a muscle is applied. Ligament a band of fibrous tissue that connects bones on cartilages, serving to support and strengthen joints. Lumbar region of the back between the thorax and the pelvis Motor Unit the motor neuron together with the muscle fibres that it innervates. It varies in size greatly for extraocular muscles. It is 510 muscle fibres per motor nerve while for gastrocnemius it is 1600 1900 muscle fibres per motor nerve. Origin the more fixed attachment of a muscle. Posterior towards the back; same as dorsal Profundus deep; farther from the body surface. Prone refers to the body lying horizontally with the face downward; opposite of supine Proximal towards the attached end 72 of a limb or near the origin of a structure Ramus a broad process projecting from the main body. Sagittal plane the vertical plane dividing the body into left and right portions Sherrington’s law The principle of reciprocal innervation of muscles. The contraction of a group of prime movers is under normal circumstances always accompanied by a corresponding degree of the appropriate antagonists. Sulcus a groove or furrow on the bone. Superior closer to the head; above Supine refers to the body lying horizontally with the face upward; opposite of prone Suture a fibrous joint found only in the skull, in which articular surfaces of the bones are connected by a thin layer of fibrous tissue (the sutural ligament). Symphysis a secondary cartilaginous joint, in which the articular surfaces of the bone are covered by hyaline cartilage and are connected to each other by fibrocartilage. This joint is of a permanent nature and some movement is permitted (e.g. pubic symphysis). Synarthrosis an immovable joint Synchondrosis a primary cartilaginous joint where the interposing tissue is hyaline cartilage and no movement is permitted. Syndesmosis fibrous joint where the bones are connected by an interosseous ligament, at which practically no movement can take place. (e.g. tibiofibular syndesmosis). Synovial referring to the lubricating and nourishing fluid or the membrane which produces it; this fluid is found in freely mobile joints with articular cartilages and within the coverings of some tendons 73 Tendon cord like structure composed of numerous parallel fascicles of collagen fibres, by which a muscle is attached. Trochanter large blunt process on a bone; best known on the upper aspect of the femur Tubercle small rounded process on a bone Tuberosity large or broad process on a bone; larger than a tubercle 74