M O L E C U L A R
________ PHARMACOLOGY
November 2003 Volume 64 Number 5 http://molpharm.aspetjournals.org ISSN 0026-895X
MINIREVIEW
Pharmacological Modulation of Poly(ADP-ribose) Polymerase-Mediated Cell Death: Exploitation in
Cancer Chemotherapy
Paul A. Nguewa, Miguel A. Fuertes, Carlos Alonso, and Jose M. Perez 1007
PERSPECTIVE
Probing the Roles of Protein Kinases in G-Protein-Coupled Receptor Desensitization M
Richard B, Clark and Thomas C. Rich
ARTICLES
Expression of the Aflatoxin B^S^-Epoxide-Metabolizmg Murine Glutathfone S-Transferase A3 Subunit
Is Regulated by the Nrf2 Transcription Factor through an Antioxidant Response Element
Ian R. Jowsey, Qing Jiang, Ken Itoh, Masayuki Yamamoto, and John D. Hayes
1015
1018
Inhibition of Vascular Endothelial Growth Factor-Induced Angiogenesis by Resveratrol through
Interruption of Src-Dependent Vascular Endothelial Cadherin Tyrosine Phosphorylation
Ming-Tsan Lin, Men-Luh Yen, Chia-Yi Lin, and Min-Liang Kuo 1029
Different Affinities of Inhibitors to the Outwardly and Inwardly Directed Substrate Binding Site of
Organic Cation Transporter 2
Christopher Volk, Valentin Gorbouleu, Thomas Budiman, Georg Nagel, and Hermann Koepsell
The Third Intracellular Loop and the Carboxyl Terminus of /3
2
-Adrenergic Receptor Confer
Spontaneous Activity of the Receptor
Khalid Chakir, Yang Xiang, Dongmei Yang, Sheng-Jun Zhang, Heping Cheng, Brian K. Kobilka, and Rui-Ping Xiao
Specificity of G Protein-Coupled Receptor Kinase 6-Mediated Phosphorylation and Regulation of
Single-Cell M
3
Muscarinic Acetylcholine Receptor Signaling
Jonathan M. Willets, Rajendra Mistry, Stefan R. Nahorski, and R. A. John Challiss
1037
1048
1059

Cytoplasmic Accumulation of the Nuclear Receptor CAR by a Tetratricopeptide Repeat Protein i n
HepG2 Cells
Kaoru Kobayashi, Tatsuya Sueyoshi, Kaoru Inoue, Rick Moore, and Masahiko Negishi
Inhibition of Invasion and Angiogenesis by Zinc-Chelating Agent Disulfiram
Shine-Gwo Shiah, Yu-Rung Kao, Felicia Ying-Hsiueh Wu, and Cheng-Wen Wu
Interaction of G Protein /3 Subunit with Inward Rectifier K + Channel Kir3
Qi Zhao, Takeharu Kawano, Hiroko Nakata, Yasuko Nakajima, Shigehiro Nakajima, and
Tohru Kozasa
1069
1076
1085
Interaction Between the fx Opioid Receptor and Filamin A Is Involved in Receptor Regulation and
Trafficking
Irma Onoprishvili, Matthew L, Andria, Hal K. Kramer, Natasa Ancevska-Taneva, Jacob M. Hitler, and Eric J. Simon 1092
Acquired Cellular Resistance to Flavopiridol in a Human Colon Carcinoma Cell Line Involves Up -
Regulation of the Telomerase Catalytic Subunit and Telomere Elongation. Sensitivity of Resistant
Cells to Combination Treatment with a Telomerase Inhibitor
Christopher M. Incles, Christoph M. Schultes, Lloyd R. Kelland, and Stephen Neidle 1101
Role of Mitochondrial Aldehyde Dehydrogenase in Nitrate Tolerance
Jon Difabio, Yanbin Ji, Vasilis Vasiliou, Gregory R. J. Thatcher, and Brian M. Bennett
Up-Regulation of a
1B
-Adrenergic Receptors with Defects in G Protein Coupling; Ligand-Induced
Protection from Receptor Instability
Steven C. Prinster, Nancy A. Schulte, Megan R. Collins, and Myron L. Toews
1109 j3
2
-Adrenergic Signaling in Human Heart: Shift from the Cyclic AMP to the Arachidonic Acid Pathway
Catherine Pavoine, Niloufar Behforouz, Chantal Gauthier, Sabine he Gouvello,
Francoise Roudot-Thoraval, Catherine Rilcker Martin, Andre Pawlak, Chloe Feral, Nicole Defer,
Remi Houel, Sandrine Magne, Aissata Amadou, Daniel Loisance, Philippe Duvaldestin, and
Franqoise Pecker 1117
1126
Effect of Glutathione Depletion on Sites and Topology of Superoxide and Hydrogen Peroxide Production in Mitochondria
Derick Han, Raffaella Canali, Daniel Rettori, and Neil Kaplowitz 1136
An N-Terminal Histidine Is the Primary Determinant of a Subunit-Dependent Cu 2+ Sensitivity of a/33y2L GABA
A
Receptors
Heejeong Kim and Robert L. Macdonald
Small Interfering RNA Suppression of Polyamine Analog-Induced Spermidine/Spermine N 1 -
Acetyltransferase
Ying Chen, Debora L. Kramer, Jason Jell, Slavoljub Vujcic, and Carl W. Porter
1145
1153
The Peptide KLVFF-K
Q
Promotes /3-Amyloid(l-40) Protofibril Growth by Association but Does Not
Alter Protofibril Effects on Cellular Reduction of 3-(4,5-Dimethylthiazol-2-yl)-2,5- diphenyltetrazolium Bromide (MTTJ
Melissa A. Moss, Michael R. Nichols, Dana Kim Reed, Jan H. Hoh, and Terrone L , Rosenberry 1160
Inhibition of Interleukin-4 Production in CD4 + T Cells by Peroxisome Proliferator-Activated Receptor-7
(PPAR-y) Ligands: Involvement of Physical Association between PPAR-y and the Nuclear Factor of
Activated T Cells Transcription Factor
Su Wot Chung, Bok Yun Kang, and Tae Sung Kim 1169
Regulation of the Rat Phenylethanolamine iV-Methyltransferase Gene by Transcription Factors Spl andMAZ
Song Her, Robert Claycomb, T. C. Tai, and Dona L. Wong 1180

Ceramide Is Involved in i?(+)-Methanandamide-Induced Cyclooxygenase-2 Expression in Human
Neuroglioma Cells
Robert Ranter, Ulrike Weinzierl, Bianca Schwind, Kay Brune, and Burkhard Hinz 1189
Common Signaling Pathways Link Activation of Murine PAR-1, LPA, and SIP Receptors to
Proliferation of Astrocytes
Scott D. Sorensen, Olivier Nicole, Richard D. Peavy, Lisa M. Montoya, C. Justin Lee, T. J. Murphy,
Stephen F. Traynelis, and John R. Hepler 1199
Purification and Functional Reconstitution of the Human P2Y
12
Receptor
Erik T. Bodor, Gary L. Waldo, Shelley B. Hooks, James Corbitt, Jose L. Boyer, and
T. Kendall Harden
The Allosteric Potentiation of-Nicotinic Acetylcholine Receptors by Galantamine Is Transduced into
Cellular Responses in Neurons: Ca 2+ Signals and Neurotransmitter Release
Federico A. Dajas-Bailador, Kaisa Heimala, and Susan Wonnacott
Ligand—Receptor—G-Protein Molecular Assemblies on Beads for Mechanistic Studies and Screening by
Flow Cytometry :
Peter C. Simons, Mei Shi, Terry Foutz, Daniel F. Cimino, Jeremy Lewis, Tione Buranda,
William K. Lim, Richard R. Neubig, William E. Mclntire, James Garrison, Eric Prossnitz, and
Larry A. Sklar
1210
1217
1227
Selective Interaction of ARF1 with the Carboxy-Terminal Tail Domain of the 5-HT
2A
Receptor
Derek N. Robertson, Melanie S. Johnson, Louise O. Moggach, Pamela J. Holland, Eve M. Lutz, and
Rory Mitchell 1239
Expression of the Angiogenic Factor Thymidine Phosphorylase in THP-1 Monocytes: Induction by
Autocrine Tumor Necrosis Factor-a and Inhibition by Aspirin
Geng Hui Zhu, and Edward L. Schwartz
Cloning and Characterization of the Murine and Rat mrpl Promoter Regions
Mario Muredda, Ken-ichi Nunoya, Ruth A. Burtch-Wright, Ebba U. Kurz, Susan P. C. Cole, and
Roger G. Deeley
Correction to "Rescuing the traffic-deficient mutants of rat /x-opioid receptors with hydrophobic ligands"
1251
1259
1270