Rabbit anti-human asialoglycoprotein receptor 1 polyclonal Antibody Catalog Number: CSB-PA002207GA01HU Synonym Names ASGP-R 1,ASGPR 1,C-type lectin domain family 4 member H1,Hepatic lectin H1,HL-1,ASGR1,CLEC4H1 Product type Primary antibodies Description Rabbit polyclonal to ASGR1 Clonality Polyclonal Isotype IgG Reacts with Human, Mouse,Rat; Other species are not tested. Please decide the specificity by homology. Conjugate Non-conjugated Purity Antigen Affinity Purified Storage buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. Storage Shipped at 4°C Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze. Form Liquid Raised in Rabbit Tested applications WB: 1:200-1:2000 IHC: 1:50-1:200 Positive WB detected in Human liver tissue, mouse liver tissue Positive IHC detected in Human liver cancer (Recommender dilutions) Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes Function terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. "Crystal structure of the carbohydrate recognition domain of the H1 subunit of the asialoglycoprotein receptor."Meier M., Bider M.D., Malashkevich V.N., Spiess M., Burkhard P.J. Mol. Biol. 300:857-865(2000) . "Initial characterization of the human central proteome."Burkard T.R., Planyavsky M., References Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011). "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.J. Proteome Res. 8:651-661(2009).