MOLECULAR
PHARMACOLOGY
May 2004
Volume 65
Number 5
http://molpharm.aspetjournals.org
ISSN 0026-895X
MINIREVIEW
Regulation of Uterine Function: a Biochemical Conundrum in the Regulation of Smooth Muscle
Relaxation
Iain L. O. Buxton
1051
PERSPECTIVE
Agonist Binding: A Multistep Process M
Brian Kobilka
1060
ARTICLES
Justicidin A Inhibits the Transport of Tumor Necrosis Factor -a to Cell Surface in LipopolysaccharideStimulated RAW 264.7 Macrophages
Lo-Ti Tsao, Chun-Nan Lin, and Jih-Pyang Wang
1063
Tumor Cell Responses to a Novel Glutathione S-Transferase-Activated Nitric Oxide-Releasing Prodrug
Victoria J. Findlay, Danyelle M. Townsend, Joseph E. Saavedra, Gregory S. Buzard,
Michael L. Citro, Larry K. Keefer, Xinhua Ji, and Kenneth D. Tew
1070
Elevated Racl Activity Changes the M 3 Muscarinic Acetylcholine Receptor-Mediated Inhibition of
Proliferation to Induction of Cell Death
Shulamith H. Shafer and Carol L. Williams
1080
Nuclear Factor-«B Mediates Up-Regulation of Cathepsin B by Doxorubicin in Tumor Cells
Sandra Bien, Christoph A. Ritter, Matthias Gratz, Bernhard Sperker, Ju'rgen Sonnemann,
James F. Beck, and Heyo K. Kroemer
1092
Regulation of mGlu4 Metabotropic Glutamate Receptor Signaling by Type-2 G-Protein Coupled
Receptor Kinase (GRK2)
L. Iacovelli, L. Capobianco, M. Iula, V. Di Giorgi Gerevini, A. Picascia, J. Blahos, D. Melchiorri,
F. Nicoletti, and A. De Blasi
1103
Inhibition of cGMP-Dependent Protein Kinase by the Cell-Permeable Peptide DT-2 Reveals a Novel
Mechanism of Vasoregulation
Mark S. Taylor, Chris Okwuchukwuasanya, Christian K. Nickl, Werner Tegge, Joseph E. Brayden,
and Wolfgang R. G. Dostmann
1111
Molecular Determinants for High-Affinity Block of Human EAG Potassium Channels by
Antiarrhythmic Agents
Guido Gessner, Martin Zacharias, Susanne Bechstedt, Roland Schbnherr, and
Stefan H. Heinemann
1120
Nitric Oxide Inhibits Matrix Metalloproteinase-2 Expression via the Induction of Activating
Transcription Factor 3 in Endothelial Cells
Hsuan-Hsu Chen and Danny Ling Wang
1130
The Role of Glycine Residues in the Function of Human Organic Anion Transporter 4
Fanfan Zhou, Kunihiko Tanaka, Zui Pan, Jianjie Ma, and Guofeng You
1141
Cloning, Expression, and Characterization of Three New Mouse Cytochrome P450 Enzymes and Partial
Characterization of Their Fatty Acid Oxidation Activities
Hong Wang, Yun Zhao, J. Alyce Bradbury, Joan P. Graves, Julie Foley, Joyce A. Blaisdell,
Joyce A. Goldstein, and Darryl C. Zeldin
1148
Activators of the Rat Pregnane X Receptor Differentially Modulate Hepatic and Intestinal G ene
Expression
Dylan P. Hartley, Xudong Dai, Yudong D. He, Edward J. Carlini, Bonnie Wang, Su-er W. Huskey,
Roger G. Ulrich, Thomas H. Rushmore, Raymond Evers, and David C. Evans
1159
Isoflurane Preconditioning Induces Neuroprotection against Ischemia via Activation of P38 MitogenActivated Protein Kinases
Shuqiu Zheng and Zhiyi Zuo
1172
Synergistic Contributions of the Functional Groups of Epinephrine to Its Affinity and Efficacy at the
/32 Adrenergic Receptor
George Liapakis, Wai Chi Chan, Maria Papadokostaki, and Jonathan A. Javitch
1181
Selective Antagonism of 5a-Reduced Neurosteroid Effects at GABA A Receptors
Steven Mennerick, Yejun He, Xin Jiang, Brad D. Manion, Mingde Wang, Amanda Shute,
Ann Benz, Alex S. Evers, Douglas F. Covey, and Charles F. Zorumski
1191
The Nucleotide-Binding Domains of Sulfonylurea Receptor 2A and 2B Play Different Functional Roles in
Nicorandil-Induced Activation of ATP-Sensitive K + Channels
Mitsuhiko Yamada and Yoshihisa Karachi
1198
Flavonoids Are Inhibitors of Breast Cancer Resistance Protein (ABCG2)-Mediated Transport
Shuzhong Zhang, Xinning Yang, and Marilyn E. Morris
1208
Down-Regulation and Altered Localization of y-Catenin in Cisplatin-Resistant Adenocarcinoma Cells
Xing-Jie Liang, Ding-Wu Shen, and Michael M. Gottesman
1217
Oral Exposure to Benzo[a]pyrene in the Mouse: Detoxication by Inducible Cytochrome P450 Is More
Important Than Metabolic Activation
Shigeyuki Uno, Timothy P. Dalian, Sandrine Derkenne, Christine P. Curran, Marian L. Miller,
Howard G. Shertzer, and Daniel W. Nebert
1225
NAD(P)H:Quinone Oxidoreductase 1: Role as a Superoxide Scavenger
David Siegel, Daniel L. Gustafson, Donna L. Dehn, Jin Yi Han, Preecha Boonchoong,
Lawrence J. Berliner, and David Ross
1238
Different Structural States of the Proteolipid Membrane Are Produced by Ligand Binding to the
Human S-Opioid Receptor as Shown by Plasmon-Waveguide Resonance Spectroscopy
Isabel D, Alves, Scott M. Cornell, Zdzislaw Salamon, Savitha Devanathan, Gordon Tollin, and
Victor J. Hruby
Functional Regulation of the Cardiac Ryanodine Receptor by Suramin and Calmodulin Involves
Multiple Binding Sites Adam Parker Hill, Olivia Kingston, and Rebecca Sitsapesan
Ca^l.3 Is Preferentially Coupled to Glucose-Induced [Ca 2+li Oscillations in the Pancreatic j3 Cell Line
INS-1
Guohong Liu, Nathan Milliard, and Gregory H. Hockerman
1269
Activation of the Anticancer Prodrugs Cyclophosphamide and Ifosfamide: Identification of Cytochrome
P450 2B Enzymes and Site-Specific Mutants with Improved Enzyme Kinetics
Ckong-Sheng Chen, Jack T. Lin, Kendrick A. Goss, You-ai He, James R. Halpert, and
David J. Waxman
1278
Acetylation of Nuclear Factor-KB in Rat Amygdala Improves Long-Term but not Short-Term Retention
of Fear Memory
Shiu-Hwa Yeh, Chia-Ho Lin, and Po-Wu Gean
1286
Regulations of Methamphetamine Reward by Extracellular Signal-Regulated Kinase 1/2/ets-Like
Gene-1 Signaling Pathway via the Activation of Dopamine Receptors
Hiroyuki Mizoguchi, Kiyofumi Yamada, Makoto Mizuno, Tomoko Mizuno, Atsumi Nitta,
Yukihiro Noda, and Toshitaka Nabeshima
1293
Induction of CYP3A by 2,3-Oxidosqualene:Lanosterol Cyclase Inhibitors Is Mediated by an Endogenous
Squalene Metabolite in Primary Cultured Rat Hepatocytes
Sarita D. Shenoy, Thomas A. Spencer, Nancy A. Mercer-Haines, Masumeh Abdolalipour,
William L. Wurster, Melissa Runge-Morris, and Thomas A. Kocarek
1302
Epinephrine Activates Both G s and Gj Pathways, but Norepinephrine Activates Only the G s Pathway
through Human j3 2-Adrenoceptors Overexpressed in Mouse Heart
Jiirgen F. Heubach, Ursula Ravens, and Alberto J. Kaumann
1313