Module 3. Analysis of the quality of drug substances of heterocyclic structures, which
are used as components of pharmaceuticals.
CH3
CH3
C
C
CH2
CH2
O
CH3 O
N
O
N
C6H5
1. The structural formula corresponds to a drug:
A. *Tribuzone
B. Polyvinylpyrrolidone
C. Phenazone
D. Propiophenazone
E. Dipyrone
2. The structural formula corresponds to a drug:
O
H3C
H2C
H2C
H2C
N
O
A.
B.
C.
D.
E.
N
Polyvinylpyrrolidone
Phenazone
Propiophenazone
*Phenylbutazone
Dipyrone
H3C
CH
CH3
H3C
N
O
CH3
N
3. The structural formula corresponds to a drug:
A. Polyvinylpyrrolidone
B. Thiotriazoline
C. *Propiphenazone
D. Phenazone
E. Dipyrone
H3C
N
CH3
NaO3SH2C
N
O
4. The structural formula corresponds to a drug:
A. Nitrofurazone
B. Polyvinylpyrrolidone
C. Thiotriazoline
D. Phenazone
E. *Dipyrone (metamizole sodium)
N
C6H5
CH3
C6H5
CH3
N
O
CH3
N
5. The structural formula corresponds to a drug:
A. Dipyrone
B. *Phenazone
C. Nitrofurazone
D. Polyvinylpyrrolidone
E. Thiotriazoline
O
N
C
H
6. The structural formula corresponds to a drug:
A. Clonidine hydrochloride
B. Phenazone
C. Nitrofurazone
D. *Polyvinylpyrrolidone
E. Thiotriazoline
n
CH2
Cl
N
.
NH
HCl
NH
Cl
7. The structural formula corresponds to a drug:
A. Nitrofurantion
B. *Clonidine hydrochloride
C. Phenazone
D. Nitrofurazone
E. Thiotriazoline
N
N
O
H3Ñ
S
N
8. The structural formula corresponds to a drug:
A. Nitrofurantion
B. Furazolidone
C. Phenazone
D. Nitrofurazone
E. *Thiotriazoline
C
H2
C
- +
O H2N
O
H
O
O2N
9. The structural formula corresponds to a drug:
A. Nitrofurantion
B. *Furazolidone
C. Phenazone
CH
N
N
O
O
D. Nitrofurazone
E. Dipyrone
O
O
O2N
CH
N
10. The structural formula corresponds to a drug:
A. *Nitrofurantion
B. Furazolidone
C. Phenazone
D. Nitrofurazone
E. Dipyrone
N
NH
.
H2O
O
O
O2N
O
H
C
N
N
H
C
NH2
11. The structural formula corresponds to a drug:
A. Nitrofurantion
B. Furazolidone
C. Phenazone
D. *Nitrofurazone
E. Dipyrone
12. What indicator use for titration of phenazone by means of iodometry, back titration?
A. Phenolphtalein
B. *Starch solution
C. Ether
D. Potassium chromate
E. Methyl red
13. What solvent use for titration of propiophenazonum (budirol) by means of acidimetry,
non-aqueous titration?
A. *Dioxane
B. Water
C. Ether
D. Alcohol
E. Acetone
14. The chemical name of phenylbutazone is:
A. 1,2-diphenyl-4-(3-oxobuthyl)-pirazolidindion-3,5
B. 1-phenyl-2,3-dimethyl-4-isopropyl-pyrazolone-5
C. 1-phenyl-2,3-dimethyl-4-methylamino- pyrazolone-5
D. 1,2-Diphenyl-4-buthylpirazolidindion-3,5
E. *4-Butyl-1,2-diphenylpyrazolidine-3,5-dione
15. The chemical name of phenylbutazone is:
A. 1,2-diphenyl-4-(3-oxobuthyl)-pirazolidindion-3,5
B. *1-phenyl-2,3-dimethyl-4-isopropyl-pyrazolone-5
C. 1-phenyl-2,3-dimethyl-4-methylamino- pyrazolone-5
D. 4-Butyl-1,2-diphenylpyrazolidine-3,5-dione
E. 1,2-Diphenyl-4-buthylpirazolidindion-3,
16. Pharmacopoeial method of assay for phenylbutazone is alkalimetry, direct titration in the
presence of acetone. The molecular weight of equivalent (Em) of preparation is
equal:
A. M. m./3
B. M. m./4
C. M.m./2
D. *M.m.
E. M. m./6
17. Action and use of propiophenazonum (budirol) are:
A. Anti-inflammatory; analgesic
B. Hypertensive
C. *Anaesthetic, antipyretic, resolvent
D. Bactericidal
E. Antispasmodic, antihypertensive
18. The characters of dipyrone is:
A. A colourless solution
B. A blue powder
C. Yellow gas
D. A green or orange-yellow powder
E. *A white or almost white, crystalline powder
19. For identification of propiophenazonum (budirol) use silver nitrate solution. What colour
of precipitate is formed?
A. Green
B. Blue
C. Yellow
D. *Black
E. White
20. Pharmacopoeial method of assay for dipyrone is:
A. Chelatometry, direct titration
B. *Iodometry, direct titration
C. Mercurimetry, direct titration
D. Argentometry, back titration
E. Alkalimetry, direct titration
21. The chemist-laboratorian for identification of phenazone dissolved some crystals of a
substance in water and added some drops of iron(ІІІ) chloride solution. What is thus
observed?
A. *Intensive red colouring
B. Vials of gas
C. Opalescence
D. Black smoke
E. Yellow precipitate
22. For identification of phenazone use reaction with sodium nitrite solution in the sulphateacid medium. Analytical effect of reaction is:
A. Liberation of gas
B. Characteristic smell
C. *Solution of green colour
D. Precipitate of white colour
E. loudy solution
23. Action and use of phenylbutazone are:
A. *Anti-inflammatory; analgesic
B. Hypertensive
C. Resolvent
D. Antipyretic
E. Anaesthetic
24. For assay of propiophenazonum (budirol) use acidimetry, non-aqueous titration. As
titrant use standard solution of:
A. HNO3
B. H2SO4
C. HCl
D. *HClO4
E. H3PO4
25. For identification of phenylbutazone use reaction with copper sulphate solution in the
alkaline medium. Analytical effect of reaction is:
A. *Precipitate of light-blue colour
B. Characteristic smell
C. Liberation of gas
D. Precipitate of white colour
E. Cloudy solution
26. For assay of phenylbutazone, according to requirements of Pharmacopoeia, use a
method:
A. Acidimetry, direct titration in the presence of ether
B. Alkalimetry, direct not water titration
C. *Alkalimetry, direct titration in the presence of acetone
D. Acidimetry, back titration in the presence of acetone
E. Acidimetry, direct not water titration
27. Pharmacopoeial method of assay for phenazone is:
A. Chelatometry, direct titration
B. *Iodometry, back titration
C. Mercurimetry, direct titration
D. Argentometry, back titration
E. Acidimetry, direct titration
28. Pharmacopoeial reaction of identification for dipyrone is reaction with such reagents:
A. CuSO4, NaOH
B. H2SO4, HCOH
C. [Ag(NH3)2]NO3, HNO3
D. *K2CO3, K[Sb(OH)6]
E. FeCl3, H2O
29. The other name of dipyrone is:
A. Budirol
B. Antipyrine
C. Phenylbutazone
D. Phenazone
E. *Metamizole sodium
30. Phenazone is:
A. *A white or almost white, crystalline powder or colourless crystals
B. A blue powder
C. Yellow gas
D. A green or orange-yellow powder
E. A colourless solution
31. The initial substances for synthesis of phenazone are:
A. Imidazole and ethanol
B. Acetic acid and benzene
C. Pyrazole and phenole
D. Benzene and water
E. *Phenylhydrazine and acetacetic ester
32. As antiviral agent in medical practice use:
A. Benzocaine
B. Thiophene
C. Clonidine hydrochloride
D. Imidazone
E. *Thiotriazolinum
33. For assay of Thiotriazolinum chemist makes mineralization of drug substance with
concentrated HNO3 and passes Sulphur in sulphates-ions. What name this method?
A. Acidimetry
B. Refractometry
C. Alkalimetry
D. Keldal
E. *Gravimetry
34. The water solution of clonidine hydrochloride gives reaction (a) for chlorides. What
eagent can be used for identification of Chloride-ions?
A. Ammonia solution
B. Barium chloride in the sulphatic-acid medium
C. *Silver nitrate in the nitric-acid medium
D. Lead acetate in the alcohol medium
E. Tartaric acid
35. The chemical name of clonidine hydrochloride is:
A. Morpholine 3-methyl-1,2,4-triazolyl-5-thioacetate
B. *2,6-dichloro-N-(imidazolidin-2-ylidene)aniline
C. 2-[(5-nitrofuran-2-yl)methylene]diazanecarboxamide
D. 3-(5-nitrofurfurylideneamino)oxazolidin-2-one
E. 1-[[(5-nitrofuran-2-yl)methylene]amino]imidazolidine-2,4-dione
36. The pharmacopoeial method of assay for furazolidone is:
A. Cerimetry
B. Chelatometry
C. Thin-layer chromatography
D. *UV-spectrophotometry
E. Argentometry
37. The characters of furazolidone, according to Pharmacopoeia, is:
A. A white crystalline powder, very soluble in water, soluble in alcohol
B. A white or almost white, crystalline powder, soluble in water and in ethanol
C. A yellow, crystalline powder or yellow crystals, odourless or almost odourless,
very lightly soluble in water and in alcohol, soluble in dimethylformamide
D. *A yellow, crystalline powder, very slightly soluble in water and in ethanol
(96%); practically insoluble in ether
E. A yellow or brownish-yellow, crystalline powder, very slightly soluble in water,
slightly soluble in alcohol
38. In the medical practice nitrofurantoin use as agent:
A. Diuretic
B. Membrane-promoting
C. Expectorant
D. Anaesthetic
E. *Antibacterial
39. The initial substance for synthesis nitrofurantoin is:
A. Oxadiazole
B. Oxazole
C. Thiophene
D. Pyrrole
E. *5-Nitrofurfurol
40. The pharmacopoeial method of assay for nitrofurazone is:
A. Refractometry
B. Thin-layer chromatography
C. IR-spectroscopy
D. Photocolorimetry
E. *UV-spectrophotometry
41. At interaction solution of nitrofurazone in the dimethylformamide with alcoholic
potassium hydroxide solution can be observed:
A. Formation of a white precipitate
B. Ammonia allocation
C. Yellow colouring, which passes in the violet
D. *Violet-red colour of solution
E. Brown colour of solution
42. As antioxidant in medical practice use:
A. Piracetam
B. Furazolidone
C. Nitrofurantoin
D. Nitrofural
E. *Thiotriazolinum
43. The chemist makes pyrolysis of Thiotriazolinum dry substance (burning substance in
crucible) with the next revealing of sulphides-ions by means of filter paper
moistened by solution of:
A. Starch
B. Barium chloride
C. Potassium iodide
D. *Lead acetate
E. Water
44. The pharmacopoeial method of assay for clonidine hydrochloride is:
A. lkalimetry, back titration
B. Acidimetry, back titration
C. Acidimetry direct non-aqueous titration
D. *Alkalimetry in the alcohol medium, direct titration
E. Acidimetry, direct titration
45. Clonidine hydrochloride is derivative of such heterocyclic compound:
A. Pyridine
B. Pyrimidine
C. *Imidazoline
D. Imidazole
E. Furan
46. What analytical effect of reaction furazolidone with dimethylformamide and alcoholic
potassium hydroxide?
A. White colour
B. Ammonia allocation
C. *Blue colour
D. Red gas
E. Brown colour
47. For synthesis furazolidone can be used condensation of 5-nitrofurfurol with:
A. Aniline
B. Morpholine
C. *3-aminooxazolidone-2
D. 1-Aminohydantoin
E. Semicarbazide
48. Alkalimetry, non-aqueous titration – is a method of assay for nitrifurantoin. As titrant in
his method use standard solution of:
A. Perchloric acid in the presents of ice acetic acid
B. *Sodium methylate in the presents of DMFA (dimethylformamide)
C. Potassium hydroxide in the presents of ethanol and benzene
D. Sodium hydroxide in the presents of benzene and methylene
E. Water solution of sodium hydroxide
49. What characters of nitrifurantoin, according to Pharmacopoeia?
A. A white crystalline powder, very soluble in water, soluble in alcohol
B. A white or almost white, crystalline powder, soluble in water and in ethanol
C. A yellow, crystalline powder, very slightly soluble in water and in ethanol
(96%); practically insoluble in ether
D. A yellow or brownish-yellow, crystalline powder, very slightly soluble in water,
slightly soluble in alcohol
E. *A yellow, crystalline powder or yellow crystals, odourless or almost odourless,
very slightly soluble in water and in alcohol, soluble in dimethylformamide
50. For identification of nitrifurazone can be used reaction with:
A. Perhydrol in the alkaline medium
B. Nesler reagent
C. 10 % copper sulphate solution
D. Water solution of alkali
E. *Dimethylformamide and alcoholic potassium hydroxide solution
51. The chemical name of nitrifurazone is:
A. morpholine 3-methyl-1,2,4-triazolyl-5-thioacetate
B. 2,6-dichloro-N-(imidazolidin-2-ylidene)aniline
C. *2-[(5-nitrofuran-2-yl)methylene]diazanecarboxamide
D. 3-(5-nitrofurfurylideneamino)oxazolidin-2-one
E. 1-[[(5-nitrofuran-2-yl)methylene]amino]imidazolidine-2,4-dione
8
NH2
9
1
7
52.
The structural formula
drug:
A. Isoniazid
B.
C.
D.
E.
H 2N 6
2
5
N
10
OC2H5
3
. H 3C
O
H
C
C
OH
OH
4
corresponds to a
Nikethamide
*Ethacridine lactate
Phthivazid
Flurenizidum
H
N
O
C2H5
NaO
C2H5
N
53.
O
The structural formula corresponds to a drug:
A. Phenobarbital
B. Barbital
C. Benzonal
D. Thiopental sodium
E. *Barbital sodium
O
HN
C2H5
NaS
C5H11
N
54.
The structural formula corresponds a medical product:
A. Phenobarbital
B. Barbital
C. Benzonal
D. *Thiopental sodium
E. Barbamyl
O
O
HN
C 2 H5
NaO
C5H11
N
55.
The structural formula corresponds to a drug:
A. Hexenal
B. *Barbamyl
C. Phenobarbital
D. Barbital
E. Benzonal
O
O
N
CH3
NaO
N
H3C
56.
57.
58.
59.
O
The structural formula corresponds to a drug:
A. *Hexenal
B. Phenobarbital
C. Barbital
D. Benzonal
E. Thiopental sodium
For assay of chlorpropamide, by means of alkalimetry, shot of substance dissolves
in:
A. *Alcohol R previously neutralised using phenolphthalein solution R1
B. Methanol
C. Water
D. Ice acetic acid
E. Dimethylforamide
What reagents can be used for identification of Sodium cations in the diclofenac
sodium?
A. Potassium oxalate, glyoxalhydroxyanil
B. *Potassium hexahydroxostibat (V), methoxyphenylacetic acid reagent
C. Potassium ferrocyanide, potassium hexahydroxostibat (V)
D. Dyphenilamine, potassium dichromate
E. Antipyrine, chloride acid
Sulfadimidine is soluble in the mineral acids and alkalis because in its molecule is
such functional groups:
A. Aromatic ring, sulfamide groups
B. *Primary aromatic amino group, sulfamide group
C. Sulfamide group, atoms of Oxygen
D. Atoms of Sulfur, methyl groups
E. Methyl groups, primary aromatic amino group
O
C
C2H5
N
C2H5
60.
The structural formula corresponds to a drug:
A. *Nikethamide
B. Phthivazid
C. Isoniazid
D. Nicodine
E. Ethacridine lactate
N
NH2
OC2H5
61.
The structural formula corresponds to a drug: H2N
A. Nicodine
B. Isoniazid
C. Phthivazid
D. *Ethacridine
E. Flurenizidum
N
O
N
62.
63.
NH
C
The structural formula corresponds to a drug:
A. Nikethamide
B. Nicodine
C. Isoniazid
D. Phthivazid
E. *Flurenizidum
The initial substances for synthesis of sulfadimethoxine is:
A. 2,4-Dimethoxypyrimidine, sulphatic acid
B. Sulphatic acid, 2,4-dimethoxy-pyrimidine
C. Sulfanilic acid, 2,4-dimethoxy-6-aminopyrimidine
D. N-Carbomethoxyaniline, 2,4-dimethoxy-6-aminopyrimidine
E. *2,4-Dimethoxypyrimidine, sulfanilic acid
O
C
NH
64.
The structural formula corresponds to a drug:
A. Nicodine
B. *Isoniazid
C. Ethacridine lactate
D. Phthivazid
E. Nikethamide
NH2
N
O
C
H
N
65.
The structural formula corresponds to a drug:
A. *Nicodine
B. Ethacridine lactate
C. Phthivazid
D. Isoniazid
E. Niketamide injection
N
CH2OH
N
O
C
C2H5
N
C2H5
66.
67.
68.
69.
70.
71.
72.
73.
N
The structural formula corresponds to a drug:
A. Ethacridine lactate
B. Phthivazid
C. Isoniazid
D. Nicodine
E. *Cordiamine (niketamide injection)
The pharmacist-analyst makes pyrolysis of sulfanilamide at heating. What analytical
effect of reaction?
A. Brown smoke
B. Azo dye of red colour
C. *Melt of dark blue colour, ammonia smell
D. Flower smell
E. White precipitate
For identification of Sodium cations in the thiopental sodium can be used?
A. *Potassium pyroantimonate
B. Potassium permanganate
C. Silver nitrate
D. Copper sulphate
E. Iron(III) chloride
The Benzoate ion in a molecule of benzonal is possible identify by means of a
solution:
A. HClO4
B. CuSO4
C. HCl
D. NaOH
E. *FeCl3
The method of assay for hexenal is iodo-chlorometry, back titration. As titrant use
standard solution of:
A. *Na2S2O3
B. HCl
C. HClO4
D. I2
E. ICl
One reaction of identification for barbamyl is interaction with cobalt nitrate and
calcium chloride solutions. What analytical effect this reaction?
A. Black liquid
B. *Precipitate of blue-violet colour
C. Violet gas
D. Characteristic smell
E. Colourless liquid
For identification Sodium cations inn the molecule of sodium salt of mefenamic acid
use potassium pyroantimonate. What is formula for this reagent?
A. SbCl3 and K
B. *K[Sb(OH)6]
C. SbCl5 and KNO3
D. Sb and KCl
E. KOH and SbCl3
The method of assay for phenobarbital is acidimetry, non-aqueous titration. As
titrant use standard solution of:
A. H2SO4
HCl
HNO3
*HClO4
H3PO4
The chemist-laboratorian makes pirochemical reaction for identification of Sodium
cations in the barbital-sodium. What colour of flame he observed?
A. Green
B. Black
C. *Yellow
D. White
E. Violet
The chemical name - 5-Ethyl-5-phenyldihydropyrimidine-4,6(1H,5H)-dione is for
such drug:
A. Barbital sodium
B. Phenobarbital
C. Tiopental sodium
D. Hexenal
E. *Primidone
What gast is allocated at melting of barbital with alkali?
A. O2
B. N2O
C. CO
D. CO2
E. *NH3
Action and use of primidone is:
A. Anticancer
B. Antituberculosis
C. Antibacterial
D. Purgative
E. *Anticonvulsant
For assay of trimecaine hydrochloride use use-aquaous acidimetry, direct titration.
As titrant use:
A. CH3COOH
B. HCl
C. HNO3
D. *HClO4
E. H2SO4
For assay of thiopental sodium it is possible to use a method:
A. Alkalimetry, direct titration
B. Iodometry, direct titration
C. *Acidimetry, direct titration
D. Chelatometry, direct titration
E. Permanganatometry, direct titration
For identification of Sulphur in molecule of tiopental-sodium it is possible by means
of boiling a preparation with an alkaline solution of :
A. *Lead acetate
B. Barium sulphate
C. Potassium permanganate
D. Barium chloride
E. Silvet nitrate
The chemist-analyst spends dissolution of tetracaine hydrochloride. Tetracaine
hydrochloride freely soluble in:
A. Methylenchloride
B. DMFA
B.
C.
D.
E.
74.
75.
76.
77.
78.
79.
80.
81.
C. p-Aminobenzoic acid
D. Acetone
E. *Water
82.
83.
84.
85.
86.
87.
88.
The Sodium cation in the barbital sodium solution it is possible to identify by means
of such reagents:
A. Potassium dichromate, sulphatic acid
B. *Methoxyphenylacetic acid, tetramethylammonium hydroxide
C. Ammonia solution of silver nitrate, water
D. Barium chloride, sulphatic acid
E. Silver nitrate, nitric acid
For identification of sulfamide group in molecule of phthalylsulfathiazole it is
possible to use such reagents:
A. NaNO2, HCl
B. *NaOH and CuSO4
C. NaNO2, KCl and naphthol solution
D. Resorcinol, concentrated H2SO4, NaOH
E. NaNO2, HCl and naphtol solution
What characters of barbital?
A. Yellow crystalline powder, sparingly soluble in water, very slightly soluble in
alcohol, practically insoluble in the methylene chloride
B. Fine-crystalline powder or plate powder yellow or greenish-yellow colour,
without a smell, soluble in acetic acid, slowly soluble in chloroform, practically
insoluble in water, slightly soluble in alcohol
C. *A white, crystalline powder or colourless crystals, slightly soluble in water,
soluble in boiling water and in alcohol
D. White fine-crystalline powder, without a smell, soluble in water, difficultly
soluble in 95 % alcohol, practically insoluble in ether
E. An oily liquid or a crystalline mass, colourless or slightly yellowish, miscible
with ater and with alcohol
For assay of flurenizidum use acidimetry, non-aqueous titration. As titrant use
tandard solution of:
A. H2SO4
B. HCl
C. *HClO4
D. HNO3
E. H3PO4
The equivalent weight (Em) of mefenamic acid at assay by means of alkalimetry its
solution in the dimethyl formamide is:
A. 2 M m
B. M. m./16
C. M m./ 5
D. M.m./8
E. *M m.
For identification of nicodine the chemist-analyst makes reaction - alkaline
hydrolysis of preparation. Analytical effect of this reaction is characteristic odour.
What gas is allocated?
A. O2
B. N2O
C. CO
D. CO2
E. *NH3
Analytical effect reaction of isoniazid with copper(II) sulphate is:
A. Yellowish liquid
B. *Green precipitate
C. Solution with vanillin smell
D. Red gas
E. Black precipitate
89.
90.
91.
Action and use of cordiamine are:
A. *Respiratory stimulant
B. Hypertensive
C. Resolvent
D. Anti-inflammatory; analgesic.
E. Anaesthetic
For identity of isoniazid the chemist-analyst makes reaction of "silver mirror”. He
must add such reagents?
A. *Ammoniac solution of silver nitrate, water
B. Silver nitrate solution, water
C. Ammoniac, silver
D. Silver, sulphatic acid
E. Silver nitrate solution, nitric acid
The structural formula corresponds to a
CH3
H
H2N
SO2
N
N
N
92.
93.
94.
95.
CH3
drug:
A. Sulfaguanidine
B. *Sulfadimezine
C. Sulfacarbamide
D. Sulfathiazole
E. Streptocide
Cordiamine is water solution of nikethamide. How many percents of nikethamide
must be in preparation:
A. 10
B. 50
C. *25
D. 100
E. 1
The chemical name 3-methoxy-4-oxybenzylidenehydrazide pyridine-4-carboxylic
acid hydrate is for a preparation:
A. Nicodine
B. Isoniazid
C. Cordiamine
D. Nikethamide
E. *Phthivazid
Pharmacopoeial method of assay for nikethamide is:
A. Chelatometry, direct titration
B. Coppermetry, direct titration
C. Mercurimetry, direct titration
D. Argentometry, back titration
E. *Acidimetry, non-aqueous titration
The chemical name of ethacridine lactate is:
A. N,N-diethylpyridine-3-carboxamide
B. N- oxymethylamide nicotinic acid
C. pyridine-4-carbohydrazide
D. 3-metoxy-4-oxybenzylidenehydrazide pyridine-4-carboxylic acid hydrate
E. *7-Ethoxyacridine-3,9-diamine (2RS)-2-hydroxypropanoate
96.
97.
Initial substances for synthesis of flurenizidum are:
A. Isoniazid, formaldehyde
B. Isoniazid, phenol
C. *Isoniazid, 9-fluorenone
D. Isoniazid, water
E. Isoniazid, vanillin
The structural formula corresponds to a
O
H2N
98.
99.
100.
101.
102.
NH
C
N
C4H9
drug:
A. *Carbutamide
B. Tolbutamide
C. Chlorpropamide
D. Pantosept
E. Chloramine
Pharmacopoeial method of assay for isoniazid is bromatometry, direct titration. The
molecular weight of equivalent (Em) of preparation is:
A. *M. m./4
B. M. m./3
C. 3M.m.
D. M.m.
E. 2M. m.
For identification of isoniazid it is possible to use reaction with a solution:
A. H2SO4
B. NaNO2
C. *CuSO4 at heating
D. HCl
E. HNO3
The chemical name pyridine-4-carbohydrazide is for a preparation:
A. Nicodine
B. *Isoniazid
C. Cordiamine
D. Nikethamide
E. Phthivazid
For assay of cordiamine it is possible to use a method:
A. Coppermetry, direct titration
B. IR-spectroscopy
C. Thin layer chromatography
D. *Refraktometry
E. Polarimetry
Glutaconic aldehyde derivative is product of interaction nikethamide with:
A. Silver nitrate solution
*Sodium hydroxide solution
Copper sulphate solution
Barium chloride solution
Iron(III) chloride solution
The method of assay for nicodine is:
A. Bromatometry, back titration, with iodometric finishing
B. Permanganatometry, direct titration
C. Chelatometry, direct titration
D. *Iodometry, back titration, after alkaline hydrolysis
E. Argentometry, back titration
B.
C.
D.
E.
103.
SO2
H
104.
What characters of nikethamide?
A. Yellow crystalline powder, sparingly soluble in water, very slightly soluble in
alcohol, practically insoluble in the methylene chloride
B. Fine-crystalline powder or plate (lamellar) powder yellow or greenish-yellow
colour, without a smell, soluble in acetic acid, slowly soluble in chloroform,
practically insoluble in water, slightly soluble in alcohol
C. A white, crystalline powder or colourless crystals, freely soluble in water,
sparingly soluble in alcohol
D. White fine-crystalline powder, without a smell, soluble in water, difficultly
soluble in 95 % alcohol, practically insoluble in ether
E. *An oily liquid or a crystalline mass, colourless or slightly yellowish, miscible
with water and with alcohol