IRISH NEUROLOGICAL ASSOCIATION 48th Annual Meeting 10th and 11th May 2012 Western Gateway Building, University College Cork. INA Thursday, 10th May 2012 12.00noon Registration 12.30pm Lunch 13.25pm Opening & Welcome Dr. Brian Sweeney and Mr. Michael O’Sullivan, co Presidents, Irish Neurological Association 2012 SESSION 1 O1 O2 O3 O4 O5 O6 O7 O8 O9 O10 15.10 13.30 A 10-year audit of intracranial tumour surgery. Sajjad J, Yousaf I, Kaliaperumal C, O’Sullivan MJ 13.40 Paediatric head injury: six months at the national paediatric neurosurgical centre. Mandiwanza T, Duddy J, Okafo U, Kehoe J, Allcutt D, Caird J, Crimmins D, Sattar MT. 13.50 A 2-Year Study of CNS Tumours: Clinical Features, Management and Quality of Services. Muhamat Nor FE. Marks JC. 14.00 Assessment of the value of ictal EEG recordings in Frontal Lobe Epilepsy. Hassan Elamin E, Sweeney BJ, Ryan AM, McNamara B, Costello DJ. 14.10 An audit of the inpatient neurology consultation at North West Hospital Ireland. Farid MS, Quealy J, Abdejalel WS, Doherty J, Murphy K. 14.20 The importance of CSF analysis in primary progressive Multiple Sclerosis. Kelly SB, Kinsella K, Duggan M, Tubridy N, McGuigan C, Hutchinson M. 14.30 The Impact of Increasing Disability on Quality of Life in Multiple Sclerosis. Fogarty E, Walsh C, McGuigan C, Barry M, Tubridy N. 14.40 Factors relating to unmet Needs of Irish MS Patients. Lonergan R, Kinsella K, Fitzpatrick P, Duggan M, Jordan S, Bradley D, Hutchinson M, Tubridy N. 14.50 Pregnancy and multiple sclerosis: using the MSBase Registry to examine predictors of postpartum relapses. Hughes SE, Spelman T, Gray OM, Boz C, McDonnell GV, Hawkins SA, Kee F, Butzkueven H on behalf of the MSBase study group. 15.00 Results of Alemtuzamab Phase III Trials on behalf of the CARE I and Care II Trial Groups. Vincent SG. Posters & Coffee SESSION 2 . O11 15.40 O12 15.50 O13 16.00 O14 16.10 O15 16.20 O16 16.30 O17 16.40 O18 16.50 O19 17.00 O20 17.10 Implementing the American Academy of Neurology Epilepsy Quality Measures - using an Epilepsy Electronic Patient Record as a Tool for Change. Fitzsimons M, Dunleavy B, O’Byrne P, Delanty N. Long-Term Outcome in Epilepsy and Febrile Seizures: 25 year follow-up of a prospective community based incident cohort. Neligan A, Bell GS, Giavasi C, Johnson AL, Goodridge DMG, Shorvon SD, Sander JW. Refractory Fatal Status Epilepticus due to POLG1 Mutations with Autopsy Results. Tobin WO, O’Toole O, Moroney J, O’Brien D, Delanty N, Murphy RP, Howley R, Brett F, Farrell MA. Increased levetiracetam clearance in pregnancy: Is seizure frequency affected? Hoeritzauer I, Mawhinney E, Irwin B, Hunt S1, Morrow J, Craig J on behalf of the UK Epilepsy and Pregnancy Register. The optimal EEG monitoring window for seizure identification in newborns with hypoxic ischemic encephalopathy in the era of therapeutic hypothermia. Lynch N, Stevenson N, Murphy B, Rennie J, Boylan G. Narcolepsy in close temporal relationship to H1N1 vaccination in Irish children. Mc Gann M, O’Rourke DJ, Peake D, Ni Shuibhne N, King MD, Lynch B, Crowe C. Cord Blood Proteins and Multichannel-EEG in Neonatal HypoxicIschaemic Encephalopathy; An Exploratory and Validation Study. Walsh BH, Murray DM, Livingstone V, Dempsey EM, Boylan GB. Characteristics of Electrographic Seizure Burden and Morphology in Term Neonates with Stroke and Hypoxic-ischemic Encephalopathy. Low E, Goulding R, Mathieson SR, Stevenson NJ, Ryan CA, Livingstone V, Bogue CO, Rennie JM, Boylan GB. What is the Aetiology of Thunderclap Headache? A Systematic Review of the causes of Acute Severe Headache Devenney E, Forbes R Infantile Botulism Caused By Clostridium Butyricum Type E In An Irish Baby: A Turtles Tale. O'Rourke DJ, Shelley E, McArdle E, McKeown P, Cunney R, NiSuibhne N, Lynch B, Al-Assaf N, Corcoran D, Costigan D, McNamara E, Grant K, Cosgrove C, Fitzgerald M, Garvey P, Griffin J, McGrane G, Murphy J, Prosser J. Irish Neurological Association Friday, 11th May 2012 08.30 INA Business Meeting (IICN Members) 09.15 Coffee SESSION 3 O21 09.30 O22 09.40 O23 09.50 O24 10.00 O25 10.10 O26 10.20 O27 10.30 O28 10.40 O29 10.50 11.00 The creation of a topographical world and its contents in the dreams of the congenitally blind. Staunton H, O’Rourke K. Deep Brain stimulation in a man with Fragile X Tremor Ataxia Syndrome. Roberts KA, O'Dowd ST, Magennis B, Goggin C, Lynch T. Decision-making, impulsivity and addictions: Do Parkinson's disease patients jump to conclusions? O’Sullivan SS, Djamshidian A, Sanotsky Y, Sharman S, Matviyenko Y, Foltynie T, Michalczuk R, Aviles-Olmos I, Fedoryshyn L, Doherty KM, Filts Y, Selikhova M, Bowden-Jones H, Joyce E, Lees AJ, Averbeck BB. Severe cervical dystonia (anterocollis) and upper limb dystonia responsive to unusual gestes antagonistes, superficial and deep peripheral electrical stimulation: stable symptom relief with surgically implanted stimulator (spinal cord type) terminating in deep cervical subcutaneous region. Costigan D, Aziz T. Baroreceptor sensitivity in patients with epilepsy: Does it play a role in sudden unexpected death in epilepsy? Laffan A, Langan Y. Clinical characteristics of patients with intractable non-lesional epilepsy. Chalissery AJ, Ryan AM, McNamara B, Sweeney BJ, Costello DJ. Recognition of psychogenic non-epileptic seizures – a curable neurophobia? O’Sullivan SS, Redwood R, Hunt D, McMahon EM, O’Sullivan S. Using a Bayesian Approach to Diagnose Epilepsy. Patterson V, Gautamb N, Pant P. Occurrence of ictal arrhythmia is associated with a first-degree family history of epilepsy. O’ Connor G, O’ Donnell A, Mullins G, Chaila E, Delanty N. Coffee and Posters SESSION 4 O30 11.30 O31 11.40 O32 11.50 O33 12.00 3-Tesla MRI of the optic nerve: a pilot study. Bradley D, Mudassir I, Costelloe L, O’Driscol D, Fagan A, McKenna M, Meaney J, Redmond J. Neuroimaging Biomarkers in Amyotrophic Lateral Sclerosis – phenotype, genotype and diagnostic considerations. Bede P, Bokde A, Elamin M, Byrne S, Hardiman O. The growth analysis of U87rGFP in an Orthotopic model, using 2 Photon Microscopy and IVIS Optical Imaging. O’Halloran P, Dussmann H, Chen G, Jarzabek M, O’Brien D, Byrne A, Prehn J Predictors of stem cell-mediated radiation resistance in human glioblastomas – an immunohistochemical study. Singh P, McQuaid S, Al-Rashid S, Prise K, Herron B, Healy E, Shoakazemi A, Donnelly M, McConnell R, Harney J, Conkey D, McGrath E, Lunsford LD, Kondziolka D, Niranjan A, Kano H, Hamilton R, Flannery T. SESSION 5 12.15 13.15 Callaghan Lecture Lunch SESSION 6 O34 O35 O36 O37 O38 O39 O40 14.30 Use of drain for treatment of symptomatic chronic subdural hematoma- Does type of drain of matter? - a prospective randomized study in a tertiary care centre. Kaliaperumal C, Khalil A, Okafo U, Fenton E, Kaar G, Marks C, O’Sullivan MJ. 14.40 Spondylodiscitis following lumbar micro discectomy - A retrospective analysis of 3063 patients in a tertiary care centre. Kaliaperumal C, Kuechler D, Kaar G, O’Sullivan MJ, Marks C. 14.50 FUS (fused in sarcoma) inclusions in Frontotemopral lobar degeneration; characteristics of the first Irish cases. Keohane C, Bermingham N, Revesz T, Sweeney BJ. 15.00 Ten years on: Diagnostic screening of mitochondrial mutations in Ireland. O’Brien M, Cryan J, Brett F, Howley R, Farrell M. 15.10 High Prevalence of Cognitive Impairment in HIV – Interim Results of a Cross Sectional Study of 470 patients. McNamara PH, Coen R, Bergin C, Redmond J, Doherty CP. 15.20 Preynaptic mechanisms in Lambert Eaton Myasthenic Syndromeeffect of LEMS antibodies on synaptic vesicle exocytosis. Spillane J, Ermolyuk YS, Volynksi KE, Kullmann DM 15.30 Aetiology and outcome of acute neuromuscular respiratory failure: A population-based study in Northern Ireland. Hoeritzauer I, Carr AS, Kee1 R, Kinney M, Campbell J, Hutchinson A, McDonnell GV. 15.40 Poster Highlights 16.10 Announcement and Presentation of Awards 16.30 Close of Meeting POSTERS A Neuromuscular B Neuropathology C Neurosurgery D Cerebrovascular E Epilepsy F Multiple Sclerosis G Movement Disorder H General Interest A. NEUROMUSCULAR A1 Myasthenia Gravis 2 Years after Radical Thymectomy. Eltayeb K, Crowley, P A2 Novel Biomarkers for ALS & ALS-FTD. Iyer PM, Lalor E, Reilly R, Hardiman O. A3 Population based epidemiological study of Myasthenia Gravis in the Republic of Ireland. Kenny O, McGuigan C, Tubridy N. A4 Diaphragmatic weakness in Myasthenia Gravis Spillane J, Hirsch NP, Kullmann DM, Howard RS. A5 Neuromyelitis optica in a patient with Myasthenia Gravis- an increasingly recognised association. Spillane J, Kullmann DM, Howard RS. A6 Audit of the current provision of Specialist Palliative Care to a cohort of patients attending a dedicated Motor Neurone Disease Clinic. Lowney AC, Ryan SA, Murphy M, Sweeney BJ, O’ Brien T, Ryan AM. . B. NEUROPATHOLOGY B1 Neurocytoma: An Uncommon Cause of Intraventricular Haemorrhage. Cryan J, Power S, Brett F. B2 Aicardi-Goutieres Syndrome simulating congenital infection. Keohane C, Bermingham N, Bolster MA, Filan P. B3 Are RNA extraction methods useful for real-time PCR analysis of the BRAF:KIAA1549 fusion gene in Pilocytic Astrocytoma’s ?? O'Sullivan J, Brett F, Buckley P. C. NEUROSURGERY C1 ‘Serpent in the spine’-an unusual case of giant spinal ependymoma and management challenge Ariffin A, Kaliaperumal C, Bermingham N, O’Sullivan MJ, Keohane C. C2 Diagnostic yield of CT brain studies in the emergency service in a tertiary care centre – a retrospective audit of 130 patients. Cronin D, Philbin D, Kaliaperumal C, O’Sullivan I, Marks JC. C3 Multiple territorial cerebral infarcts causing malignant oedema requiring decompressive craniectomy in a 45 year male with atrial myxoma. Cronin O, Ryan S, Chalissery A, Sweeney BJ. C4 Brain dead or not? - Diagnostic dilemma following severe Traumatic Brain Injury. Johnston R, Kaliaperumal C, Wyse G, Fanning N, Breen D, Kaar G. C5 Parry-Rhomberg syndrome and headache- an unusual presentation. Keuchler D, Kaliaperumal C, Wyse G, Fanning N, O’Sullivan MJ. C6 Are we justified in doing blood tests 'routinely' for all pre-operative neurosurgical patients?-a retrospective audit of 170 patients in a tertiary care centre. O’Grady J, McCarthy C, Kaliaperumal C, Kaar G, Marks C, O’Sullivan MJ. C7 Recurrence of a Paediatric arteriovenous malformation nine years post-complete excision. McCarthy C, Kaliaperumal C, Wyse G, Fanning N, O'Sullivan MJ. C8 ‘Teeth in the brain’- to extract or not? O’Grady J, Kobayter L, Kaliaperumal C, Bermingham N, O’Sullivan MJ. C9 L-asparaginase induced hemorrhagic stroke in a young man-a neurosurgical perspective. Ogbodo E, Kaliaperumal C, O’Sullivan MJ. C10 Sciatica in an Octogenarian: an unusual presentation and management of an occult malignancy. Ogbodo E, Kaliaperumal C, Bermingham N, Kaar G, Keohane C. C11 Abscess or tumour?- a lesson to learn. Sajjad J, Kaliaperumal C, O’Sullivan MJ. C12 Cervical Myelopathy 'When it's not there, look elsewhere'. Sunny O, Yousif I, Sattar TM. C13 Traumatic Extradural Hematoma- To treat the patient or Scan?- a novel algorithmic approach. Zakaria Z, Kaliaperumal C, Kaar G, Marks C, O’Sullivan MJ. D. CEREBROVASCULAR D1 Limitations of ABCD 2 Scoring For Risk-Stratification Of Referrals With Suspected TIA To A Rapid Access Stroke Prevention (RASP) Service Bradley D, Cronin S, Kinsella JA, Tobin WO, Mahon C, Lonergan R, O’Brien M, Cooney MT2, Kennelly S, Collins DR, O’Neill D, Coughlan T, McCabe DJH. D2 Dural Arteriovenous fistula in Bannayan-Riley-Ruvalcaba Syndrome Chalissery AJ, Wyse G, Fanning N, Sweeney BJ, D3 Thrombolysis for acute ischaemic stroke in the under 65's: a two year retrospective audit. Cronin O, Ryan S, Chalissery A, Sweeney BJ. D4 Multiple territorial cerebral infarcts causing malignant oedema requiring decompressive craniectomy in a 45 year male with atrial myxoma. Cronin O, Ryan S, Chalissery A, Sweeney BJ. D5 Raindrops keep falling on my head. Hoeritzauer I, Carr AS, Mc Kinley J, Hawkins SAH, D6 Therapeutic decision making in acute carotid dissection - a potential role for percutaneous vascular intervention. Lewis JB, Merwick Á, Williams L, Mullane D, O’Laoide R, O’Hare A, McGuigan C. D7 Reduced Glomerular Filtration Rate: A Risk For Stroke? Lynch B, Cooney MT, Carroll A, Kingston C. D8 Statin treatment at onset of transient ischaemic attack with carotid stenosis is associated with reduced early stroke risk. Merwick A, Albers GW, Arsava EM, Ay H, Calvet D, Coutts SB, Cucchiara BL, Demchuk AM, Giles MF, Mas JL, Olivot JM, Purroy F, Rothwell PM, Saver JL, Sharma VK, Tsivgoulis G, Kelly PJ. D9 Multi Infarct dementia in a 48 year old. Mok TH, O’Callaghan M, Wilkinson M, Weston M, Harrington H. D10 Young ischaemic stroke patients: What are we missing on TTE? Murphy A, Kinsella J, McGuigan C. D11 An Acquired Stuttering Caused by Subdural Haemorrhage. Ahmad MW, Monaghan T, Doherty CP D12 Fatal Multi-Territory Cerebral Infarction caused by Aortic Thrombosis in Early Pregnancy. Coveney SA, Ryan SA, Ryan AM, Sweeney BJ. E. EPILEPSY E1 Bone health in epilepsy. An audit of current practice in dedicated seizure clinics. Bell D, Irwin B, Craig J. E2 Bone health in epilepsy: are we doing enough? O’Connell K, McGuigan C. E3 Sudden unexpected death in epilepsy: awareness amongst an out-patient population. Laffan A, Langan Y, Doherty CP. E4 Audit of EEG requests at Sligo General Hospital Lee M, Murphy K, Harte P. E5 Seizure Burden in Neonatal Hypoxic Ischemic Encephalopathy: The Modifying Role of Phenobarbitone during Therapeutic Hypothermia. Lynch N, Stevenson N, Murphy B, Rennie J, Boylan G. E6 The temporal evolution of electrographic seizure burden in neonatal hypoxic ischemic encephalopathy. Lynch N, Stevenson N, Murphy B, Rennie J, Boylan G. E7 A case report describing concurrent presentation of Juvenile Myoclonic Epilepsy and McArdle’s disease, precipitating rhabdomyolysis and acute renal failure in an eighteen year old female. Ni Chonfhaola A, Murphy K, Farrell M, Mutwali A, David S. E8 Variation of phenotypes within Irish epilepsy pedigrees. O’ Connor G, Cavillieri G, Delanty N. E9 Analysis of fasting total cholesterol in a cohort of patients admitted to an Epilepsy Monitoring Unit. O’ Connor G, Chaila E, Ennis P, Corr P, Delanty N. E10 Impact of 3 tesla MRI in the assessment of potential candidates for epilepsy surgery. O’ Connor G, Corr P, Ennis P, O’Brien D, Delanty N. E11 A study of the value of a sleep EEG record in predicting seizure recurrence in children with a single afebrile seizure. Chukwu J, Gallagher P, McCoy B, Webb D. E12 Utility of MR Brain imaging in patients with acute seizures. Olszewska DA, Ryan AM, McNamara B, Sweeney BJ, Costello DJ. E13 Diffusion Imaging Study of Reading Epilepsy. Reynolds N, Shamsul Arefin ASM, MacCarthy A, Lynch T, Reilly RB. E14 A retrospective study of the use of minimally invasive sphenoidal electrodes in video electroencephalography monitoring. Shaikh E, O’Connor G, Corr P, Ennis P, O’Donnell A, Mullins G, Delanty N. F. MULTIPLE SCLEROSIS F1 Compliance with immunomodulatory therapy in patients with MS. Bradley D, Gaughan M, O’Donovan M, McKenna M, Ross E, Redmond J. F2 The Cost of Symptomatic Drug Therapy in Multiple Sclerosis. Fogarty E, Tilson L, Barry M. F3 Interferon-beta therapy exposure in early pregnancy; is there evidence of adverse pregnancy outcomes in women with multiple sclerosis? Hughes SE, Thompson H, Gray OM. F4 JC virus DNA detection versus JC virus antibody testing in a natalizumabtreated group of relapsing MS patients Kinsella K, Kelly SB, DeGascun CF, Carr M, Waters A, Duggan M, Hutchinson M, Tubridy N, McGuigan C. F5 The direct and indirect costs of a multiple sclerosis relapse. Kelly SB, Duggan M, Buckley L, Kinsella K, McGuigan C, Hutchinson M, Tubridy N. F6 Positive CSF oligoclonal bands in demyelinating versus non-demyelinating disorders. McEneaney F, Kelly S, Jackson J, Hutchinson M, Tubridy T, McGuigan C. F7 Long-term risk of leukaemia or cardiomyopathy after mitoxantrone therapy for multiple sclerosis. Mulroy E, Joyce E, Scott J, Melling J, Goggin C, Mahon N, O’Rourke K, Lynch T. F8 Usefulness of the Beck Anxiety Inventory (BAI) for the assessment of anxiety in multiple sclerosis. Ó Donnchadha S, Burke T, Bramham J, O’Brien MC, Whelan R, Reilly RB, Kelly SB, Lonergan R, Kinsella K, Kiiski H, McGuigan C, Hutchinson M, Tubridy N. F9 Risk stratification for development of Progressive Multifocal Leukoencephalopathy in a cohort of Multiple Sclerosis patients treated with Natalizumab at a tertiary referral center. Ryan SA, Coveney SA, Sweeney BJ. F10 Drug induced aseptic meningitis complicating intravenous immunoglobulin therapy. Williams L, Mullane D, Merwick Á, Tobin WO, McGuigan C. G. MOVEMENT DISORDER G1 Off Again, On Again- An audit on patients understanding and adherence to low protein diet in Parkinson’s Disease. Coffey AN, McGovern EM, Counihan TJ, Hennessy MH. G2 Use of Multimodal Virtual Reality Environments to Understand and Overcome Freezing of Gait in Parkinson’s Disease. Fearon C, Nolan H, Reilly RB, Lynch T. G3 An audit of the DBS clinic at the Dublin Neurological Institute Goggin, C, Roberts K, McCarthy A, Lynch T, Fahy E, Barlow E. G4 The penetrance of an abnormal temporal discrimination threshold as an endophenotype in unaffected first-degree relatives of adult onset primary cervical dystonia patients is age-related. Kimmich O, Molloy A, Bradley D, Whelan R, O’Riordan S, Reilly RB, Hutchinson S, Hutchinson M. G5 Orgasmic myoclonus: not as strange as it seems. Lonergan R, Goggin C, Kavanagh E, Connolly S, Lynch T G6 Young people with Parkinson’s Disease – how is employment affected? Murphy R, Tubridy N, Kevelighan H, O’Riordan S. G7 An unusual cause of Parkinsonism. O’Callaghan M, Mok TH, Sweeney BJ. G8 Is the Brain-Derived Neurotrophic Factor (BDNF) Val66Met genetic polymorphism associated with impulsive-compulsive behaviours in Parkinson’s disease? O’Sullivan SS, Cheshire P, Djamshidian A, Bertram K, Williams DR, LeesAJ, Foltynie T. G9 "Clubcutting" dystonic tremor - a novel occupational task-specific dystonia. Roberts KA, O'Dowd ST, O'Rourke K, Lynch T. H. GENERAL INTEREST H1 An audit of neurology outpatient activity and waiting times. Bradley D, McLarnon E, Gaughan M, Redmond J. H2 Is the hospital patient record system a good way to assess the amount of work doctors do? Iqbal M, Monaghan T, Redmond J. H3 The limitations of neuroimaging – a possible role for quantitative Electroencephalography. Wallace E, Ruedade L, Reilly RB, Doherty CP. H4 A prospective audit of neurological involvement in the intensive care unit in a tertiary referral centre. Hassan Elamin E, Sweeney BJ, Costello DJ, Ryan AM. H5 Anti-NMDA-receptor encephalitis; presentation and outcome in 3 cases referred for Complex Specialist Rehabilitation. Carroll A, Delargy M. H6 A Devastating Cause of Headache: 2 Cases. Devenney E, Herron B, Briggs G, Forbes R. H7 Diagnosis and Management of Headache in Acute Assessment Unit Farid MS, Elamin A, Tariq A, Alam J, Murphy K. H8 An audit of neurogenetic tests from a single service over a 5-year period. Crotty G, Ryan AM H9 O! what a noble mind is here o'erthrown! Ophelia Syndrome with metabotropic glutamate receptor 5 antibodies in cerebrospinal fluid. Adler H, Mat A, Merwick Á, Chadwick G, Gullo G, Dalmau J, Tubridy N. H10 Chicken, Egg or Churg Strauss? Doherty CM, Harley M, McCarron MO. H11 Acute catatonia during pregnancy secondary to anti NMDA-R encephalitis. Mc Carthy A, Dineen J, Lynch T, O’Rourke K. H12 Interim Results of Detailed Cognitive Assessment in Patients with HIV and Cognitive Impairment. McNamara PH, Coen R, Bergin C, Redmond J, Doherty CP. H13 Progressive ophthalmoplegia and ataxia after recurrent Campylobacter jejuni infection- a case of Bickerstaff's encephalitis. Merwick A, O'Rourke DA, Logan P, Molloy F3, Mullins G, Delanty N. H14 Intrathecal Gadolinium Enhanced MR in the Diagnosis of Cerebrospinal Fluid Leak; an Illustrative Case. Mok TH, Herlihy D, Fanning N, Ryan AM. H15 Posterior Reversible Encephalopathy Syndrome (PRES) associated with liquorice consumption. O’Connell K, Kinsella J, O’Riordan S. H16 Withdrawn. H17 Co-morbid psychiatric illness in a general neurology inpatient cohort: Diagnosis and reason for referral to Liason Psychiatry. Coveney SA, O’Sullivan R, Ryan SA, Cassidy EM, Sweeney BJ. H18 The Variability between Demyelination and Axonal loss in Patient’s with Carpal Tunnel Syndrome using Nerve Conduction Studies. Bowers L, Slamon N, Reid V.