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Ph.D. in Chemical Engineering
University of Notre Dame
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K.L. Yeung
Professor, CBME & Div of Environment, HKUST
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2("3,4("3,
1997
H5N1
2003
SARS
2009
H1N1
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Each year, about one billion people worldwide suffer from
influenza infection with fatalities reaching half a million. These
figures will further increase whenever a new strain of virus
emerges!
Drug-resistant bacteria (MRSA, VRSA, VRE, NDM-1) are becoming
an important global health threat !
Stopping disease transmission is therefore
critical for individual and community health...
-$*'0,!"#56%&'()%*+,7(*#"3,
Simple and easy to use
Simple and easy to use
Fast and effective: rapidly inactivates and kills virus,
bacteria and spores on contact
Long lasting: minimum 30 days in 1 application
Smart : self-disinfect on touch and contamination
Safe and environmentally friendly
!$
!!"#!"##$
-$*'0,!"#56%&'()%*+,7(*#"3/,
-%$8+1,*"9,:*/.,0(,;/1,
Anatomy of the Multilevel Anti-Microbial Formulation
Sprayed-on Formulation
! water/oil/water double
!!
emulsion;
Coating on Surface
1000 x
!!! smart materials for
encapsulant;
!!! long-term storage of
biocides;
P2
liquid
P1
!!! controlled release;
!!! smart/programmed release;
Biocides
<*/0,*"9,:=1&#>1,
!!! anti-adhesion.
?("3,?*/#"3,,
Sprayed-on Formulation
" 99.99 % within 1 min
Coating on Surface
Bacteria: 99.9 % within 1 min
Viruses: 99 % within 1 min
Spores: 99 % within 30 min
6.cm
10
S.subtilis
aureus
6.cm
-3-3B.
10
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!!"#!"##$
?("3,?*/#"3,,
-6!@A,
Minimum 60 days in single application
Persistent Release of Biocides
Effectiveness can be maintained for at least
60 days after coating
Contact Time (day)
0
10
Log Reduction
0
1
20
30
40
50
60
70
S. aureus
> 99.99%
Disinfect up to 3 mm from coating
2
3
4
5
1 mm
-6!@A,
-6!@A,
Rapid Self-disinfection
Self-Cleaning
1500 µg/g/day
3 mm
10 mm
The polymers used are anti-adherent tested for
E. coli and B. subtilis
Touch
Body Fluids
E. coli
Without coating
With coating
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!!"#!"##$
<%1+9,A1/0,
-$*'0,!"#56%&'()%*+,7(*#"3/,
January 2011
Virucidal Properties
No cytopathic activity after
1 min contact with coated plates!
Princess Margaret Hospital
HK Department of Health, Virus Division
99 % inactivation after 1 min contact with
coated plates!
H1N1 human swine flu virus
H3N2, human RSV, EV-71
A62,<%1+9,A1/0,
<%1+9,A1/0,
January 17 to April 12, 2011
Contamination by Touch
56 days
Percent Kill (%)
Dr. T.L. Que
Dr. Eric Yip
date
Challenge by touch (8 or 9 touches per item per day) with gloves contaminated
with 0.1 ml 1010 CFU/cm3 E. coli with 3 min contact.
19
*20*
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!!"#!"##$
B62,<%1+9,A1/0,
7(*#"3,:C&*&.,
May 11 to 26, 2011
Princess Margaret Hospital
5
Lab tests against MDRO
Log reduction
Dr. Ng
Dr. Bosco Lam
Long-term Study of Coating Performance (12 days)
Long-term Study of Coating Performance (12 days)
Objectives:
Coating efficacy and persistence against MDRO.
>99.99
>99.99
>99.97
>99.99
>99.99
>99.96
>99.99
4
>99.99
3
2
>98.38
99.75
>99.99
>99.99
99.14
>99.94
MRSA
Acinetobacter
>99.77
99.58
98.77
1
98.93
>97.88
93.52
0
1
2
3
4
5
6
7
8
10
12
Days
Challenged with 105 MDRO and sampling by swabbing after 10 min contact. Please note reduction is
calculated against control surface without coating.
*
7+%"%&*+,<%1+9,A1/#"3,DE:2F,
January 17 to March 28 2011
7+%"%&*+,<%1+9,A1/#"3,DE:2F,
January 17, 2011 (on-going)
Summary of 4 weeks study at ICU wards (>400 samples, >1200 analysis)
Dr. Dominic Tsang
Dr. Chris Lai
ICU computers
MDRO
control
coating
keyboard
mouse
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22/12/11 September 9, 2010 Press Conference
7