DRUGS CONTRAINDICATED IN PREGNANCY (part 1 of 2)

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DRUGS CONTRAINDICATED IN PREGNANCY (part 1 of 2)
This chart represents information on select drugs that are contraindicated (Pregnancy category X) for women who are
pregnant. This is not an inclusive list of products that carry that pregnancy category. Those drugs that are contraindicated
at a certain phase of the pregnancy are listed next to the product name. For more information on specific drug
monographs, see product entries or consult the manufacturer.
Macrodantin (nitrofurantoin
SSD (silver sulfadiazine) Late
ALLERGIC DISORDERS
macrocrystals) Pregnancy at term
pregnancy
Vistaril (hydroxyzine) Early pregnancy
Rebetol (ribavirin)
SSD AF (silver sulfadiazine) Late
Rebetron (ribavirin/interferon alfa -2b)
pregnancy
CARDIOVASCULAR SYSTEM
Septra (sulfamethoxazole/trimethoprim)
Tazorac (tazarotene)
Advicor (niacin ext-rel/lovastatin)
Tilia Fe (norethindrone acetate/ethinyl 3rd trimester
Aggrenox (dipyridamole/aspirin) 3rd
Sulfadiazine Pregnancy at term
estradiol)
trimester
Tri-Legest 21 (norethindrone acetate/ Tindamax (tinidazole) 1st trimester
Altoprev (lovastatin)
Urobiotic-250 (oxytetracycline HCl/
ethinyl estradiol)
Bayer (aspirin) 3rd trimester
sulfamethizole/phenazopyridine) Late
Tri-Legest Fe (norethindrone acetate/
Caduet (amlodipine/atorvastatin)
pregnancy
ethinyl estradiol)
Coumadin (warfarin sodium)
Virazole (ribavirin)
Tri-previfem (norgestimate/ethinyl
Crestor (rosuvastatin)
estradiol)
METABOLIC DISORDERS
Ecotrin (aspirin) 3rd trimester
Tri-sprintec (norgestimate/ethinyl
Juvisync (sitagliptin/simvastatin)
estradiol)
Zavesca (miglustat)
Lescol (fluvastatin)
Yaz (drospirenone/ethinyl estradiol)
MUSCULOSKELETAL DISORDERS
Lescol XL (fluvastatin)
ENDOCRINE SYSTEM
Letairis (ambrisentan)
Advil (ibuprofen) 3rd trimester
Lipitor (atorvastatin)
Aleve (naproxen sodium) 3rd trimester
Androderm (testosterone)
Livalo (pitavastatin)
Ansaid (flurbiprofen) Late pregnancy
Androgel (testosterone)
Mevacor (lovastatin)
Arava (leflunomide)
Android (methyltestosterone)
Multaq (dronedarone)
Arthrotec (diclofenac sodium/ misoprostol)
Axiron (testosterone)
Pravachol (pravastatin)
Bayer (aspirin) 3rd trimester
Delatestryl (testosterone enanthate)
Simcor (niacin ext-rel/simvastatin)
BC Arthritis Strength (aspirin/caffeine/
Depo-testosterone (testosterone
Tracleer (bosentan)
salicylamide) 3rd trimester
cypionate)
Vytorin (ezetimibe/simvastatin)
Cataflam (diclofenac potassium) Late
Egrifta (tesamorelin)
Zocor (simvastatin)
pregnancy
Fluoxymesterone
Celebrex (celecoxib) 3rd trimester
Fortesta (testosterone)
CENTRAL NERVOUS SYSTEM
Choline magnesium trisalicylate
Juvisync (sitagliptin/simvastatin)
Beyaz (drospirenone/ethinyl estradiol) Lupron (leuprolide acetate)
Pregnancy at term
Doral (quazepam)
Dantrium (dantrolene)
Methitest (methyltestosterone)
Estazolam
Daypro (oxaprozin) 3rd trimester
Oxandrin (oxandrolone)
Flurazepam
Diclofenac sodium Late pregnancy
Striant (testosterone)
Halcion (triazolam)
Diflunisal 3rd trimester
Supprelin LA (histrelin acetate)
Restoril (temazepam)
Duexis (ibuprofen/famotidine) Late
Synarel (nafarelin)
Vistaril (hydroxyzine) Early pregnancy
pregnancy (≥30wks)
Testim (testosterone)
Yaz (drospirenone/ethinyl estradiol)
Ecotrin (aspirin) 3rd trimester
Testred (methyltestosterone)
Etodolac Late pregnancy
Virilon (methyltestosterone)
DERMATOLOGICAL DISORDERS
Evista (raloxifene HCl)
Amnesteem (isotretinoin)
GASTROINTESTINAL TRACT
Feldene (piroxicam) Late pregnancy
Avage (tazarotene)
Ketoprofen Late pregnancy
Bellergal-S
(phenobarbital/ergotamine
Beyaz (drospirenone/ethinyl estradiol)
Mobic (meloxicam) 3rd trimester
tartrate)
Carac (fluorouracil)
Motrin (ibuprofen) 3rd trimester
Cytotec (misoprostol)
Claravis (isotretinoin)
Nabumetone 3rd trimester
Efudex (fluorouracil)
Nalfon (fenoprofen calcium) 3rd
INFECTIONS & INFESTATIONS
Estrostep Fe (norethindrone acetate/
trimester
Bactrim
(sulfamethoxazole/
ethinyl estradiol)
Naprelan (naproxen) 3rd trimester
trimethoprim)
3rd
trimester
Fluoroplex (fluorouracil)
Prevacid Naprapac (lansoprazole/
Loryna (drospirenone/ethinyl estradiol) Copegus (ribavirin)
naproxen) 3rd trimester
Flagyl
(metronidazole)
1st
trimester
for
Ortho Tri-Cyclen 28 (norgestimate/
Probenecid + Colchicine
trichomoniasis
ethinyl estradiol)
Prolia (denosumab)
Furadantin (nitrofurantoin) Pregnancy at Rheumatrex (methotrexate sodium)
Propecia (finasteride)
term
Silvadene (silver sulfadiazine) Late
Salsalate 3rd trimester
Gantrisin (sulfisoxazole) 3rd trimester
pregnancy
Soma Compound w. Codeine
Grifulvin
V
(griseofulvin)
Solage (mequinol/tretinoin)
(carisoprodol/aspirin/codeine) 3rd trimester
Gris-Peg
(griseofulvin)
Solaraze (diclofenac sodium) 3rd
Vimovo (naproxen/esomeprazole) Late
Macrobid
(nitrofurantoin
as
trimester
pregnancy (≥30wks)
macrocrystals and monohydrate)
Soriatane (acitretin)
Zipsor (diclofenac potassium) Late
Pregnancy
at
term
Sotret (isotretinoin)
pregnancy
Not an inclusive list.
(continued)
DRUGS CONTRAINDICATED IN PREGNANCY (part 2 of 2)
Flagyl (metronidazole) 1st trimester for
trichomoniasis
Follistim (follitropin beta)
Ganirelix acetate
Gonal-F (follitropin alfa)
Lupron Depot (leuprolide acetate)
Luveris (lutropin alfa)
Menopur (menoptropins)
Methergine (methylergonovine)
Midol cramp (ibuprofen) 3rd trimester
Midol menstrual (acetaminophen/
caffeine/pyrilamine) 3rd trimester
Midol PMS (acetaminophen/
pamabrom/pyrilamine) 3rd trimester
Midol teen (acetaminophen/pamabrom)
3rd trimester)
Mifeprex (mifepristone)
Motrin (ibuprofen) 3rd trimester)
Naprelan (naproxen) 3rd trimester
Ovidrel (choriogonadotropin alfa)
NUTRITION
Ponstel (mefenamic acid) Late
Didrex (benzphetamine)
pregnancy
Fosteum (genistein/citrated zinc/
Repronex 75 IU (follicle-stimulating
cholecalciferol)
hormone/luteinizing hormone)
Megace ES (megestrol acetate)
Repronex 150 IU (follicle-stimulating
Megace Suspension (megestrol acetate) hormone/luteinizing hormone)
Xenical (orlistat)
Serophene (clomiphene citrate)
Synarel (nafarelin acetate)
OB/GYN
Tindamax (tinidazole) 1st trimester
ALL ORAL CONTRACEPTIVES
Zoladex (goserelin)
ALL HORMONE REPLACEMENT
PAIN
& PYREXIA
THERAPY
Advil (ibuprofen) 3rd trimester
Advil (ibuprofen) 3rd trimester
Aleve (naproxen sodium) 3rd trimester Advil Migraine (ibuprofen) 3rd
Aygestin (norethindrone acetate)
trimester
Betadine douche (povidone-iodine)
Aleve (naproxen sodium) 3rd
Bravelle (urofollitropin)
trimester
Cataflam (diclofenac potassium) Late
Bayer (aspirin) 3rd trimester
pregnancy
BC Original Formula (aspirin/caffeine/
Celebrex (celecoxib) 3rd trimester
salicylamide) 3rd trimester
Cetrotide (cetrorelix)
Cafergot (ergotamine tartrate/
Clomid (clomiphene citrate)
caffeine)
Depo-subQ provera
Caldolor (ibuprofen) 3rd trimester
(medroxyprogesterone acetate)
Cataflam (diclofenac potassium) Late
Endometrin (micronized progesterone) pregnancy
Ectopic pregnancy
Celebrex (celecoxib) 3rd trimester
NEOPLASMS
Bexxar (tositumomab)
Casodex (bicalutamide)
Delestrogen (estradiol valerate)
Efudex (fluorouracil)
Eligard (leuprolide acetate)
Estrace (estradiol)
Evista (raloxifene HCl)
Firmagon (degarelix)
Fluoxymesterone
Menest (esterified estrogens)
Revlimid (lenalidomide)
Targretin (bexarotene)
Thalomid (thalidomide)
Trelstar (triptorelan pamoate)
Trexall (methotrexate)
Vantas (histrelin acetate)
Zytiga (abiraterone acetate)
Not an inclusive list.
Choline magnesium trisalicylate
Pregnancy at term
Combunox (oxycodone/ibuprofen) 3rd
trimester
D.H.E. 45 (dihydroergotamine
mesylate)
Diflunisal 3rd trimester
Etodolac Late pregnancy
Excedrin Migraine (acetaminophen/
aspirin/ caffeine) 3rd trimester
Fiorinal (butalbital/aspirin/caffeine)
3rd trimester
Fiorinal w. Codeine (butalbital/aspirin/
caffeine/codeine phosphate) 3rd
trimester
Ibudone (hydrocodone bitartrate/
ibuprofen) 3rd trimester
Ketorolac Late pregnancy
Migranal (dihydroergotamine
mesylate)
Motrin Migraine Pain (ibuprofen) 3rd
trimester
Nalfon (fenoprofen calcium) 3rd
trimester
Naprelan (naproxen) 3rd trimester
Percodan (oxycodone HCl/aspirin) 3rd
trimester
Ponstel (mefenamic acid) Late
pregnancy
Synalgos-DC (dihydrocodeine bitartrate/
aspirin/caffeine) 3rd trimester
Vicoprofen (hydrocodone bitartrate/
ibuprofen) 3rd trimester
RESPIRATORY TRACT
None available
UROGENITAL SYSTEM
Avodart (dutasteride HCl) AVOID
HANDLING CAPSULES
Caverject (alprostadil)
Edex (alprostadil)
Jalyn (dutasteride/tamsulosin HCl)
Lithostat (acetohydroxamic acid)
Proscar (finasteride) AVOID HANDLING
CRUSHED/BROKEN TABLETS
(Rev. 10/2012)
PREGNANCY CATEGORIES
When pregnancy appears as a contraindication or precaution to the use of a drug it is usually qualified by a
category.
Cat. A: Adequate studies in pregnant women have failed to show a risk to the fetus in the first trimester and there
is no evidence of risk in later trimesters.
Cat. B: Animal studies have failed to show a risk to the fetus but there are no adequate studies in pregnant
women; or animal studies have shown an adverse effect but human studies have not shown a risk to the fetus
in the first trimester and there is no evidence of risk in later trimesters.
Cat. C: Animal studies have shown an adverse effect on the fetus but there are no adequate studies in humans,
but the benefits may outweigh the risks; or there are no adequate human studies.
Cat. D: Positive evidence of human fetal risk but the benefits may outweigh the risks.
Cat. X: Animal or human studies have shown fetal abnormalities or toxicity and the risk outweighs the benefits.
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