Cartilage and Bone
Robert Scranton© 2008
Cartilage
y Few or many cells?
y Cell name?
y Vascular?
y The dense CT covering is _________, except for around __________
y Matrix{
{
{
{
{
{
CT+ ground substance
Collagen, type___
GAG= “keratin/ chondroitin sulfate
Chondronectain
Bound water
Territorial v. interterritorial
Cartilage
Perichondrium
y Define it
{ dense CT covering all cartilage but
articular
y Layers
y Functions:
{ Nutrition
{ Growth
{ Repair
{ Attachment point
y Cell nests
Cartilage
Word Games
y Perichondrial growth
y Hypertrophy
y Alkaline phosphatase v.
hydroxyapatite crystals
y Fibrillin +elastin
Cartilage
Types
y Hyaline, elastic, fibro
{ Give location, characteristics
Type
Hyaline
Location
Characteristics
articular, larynx, trachea, bronchi, Type II Collagen, GAGs, chondronectin, bound costal
water
Elastic
auricles, ext. auditory tube, eustachian tube, epiglottis
like hyaline, but with elastic fibers
Fibro
Intervertebral disks, pubic symphysis, TMJ
like dense irregular CT, Collagen type I&II, very little ground substance
Cartilage
Hyaline
Cartilage
Hyaline
Cartilage
Elastic
Cartilage
Fibro
Cartilage
Example of Articular
Cartilage
Bone
Metaphysis (in growing child)
y Compact bone= ____bone
Bone
Word Games
y Cancellous bone= ____ bone and
has ___ which are _____
y The space b/w trabeculae and
spicules filled with hematopoietic
or fatty tissue.
y Diploe
y Immature bone, give syn.
{
Found during
y Secondary Bone
y Osteon
Bone
Periosteum &
Endosteum
y Periosteum, how many layers?
{ 2- fibrous +osteogenic
{ How does it attach to bone?
Ù
{
Sharpey’s fibers=
Function?
Appositional growth
Ù Repair
Ù Attachment for ligaments and tendons
Ù sensation
Ù
Bone
Periosteum &
Endosteum
y Endosteum, how many layers?
{ What type of cells?
Ù
osteoblasts
Bone
y Name the major players
{ Osteoblasts
{ Osteocytes
{ Osteoclasts
{ Matrix
Bone
y Name the major players
{ Osteoblasts
Ù
{
{
{
Active, mitotic
Osteocytes
Osteoclasts
Matrix
Bone
y Name the major players
{ Osteoblasts
{ Osteocytes
Surrounded by matrix
Ù Can’t divide
Ù Lacunae & canaliculi
Ù
{
{
Osteoclasts
Matrix
Bone
y Name the major players
{ Osteoblasts
{ Osteocytes
{ Osteoclasts
Derived from?
Ù Function?
Ù Located in?
Ù Synthesize and secrete?
Ù
{
Matrix
Bone
y Name the major players
{ Osteoblasts
{ Osteocytes
{ Osteoclasts
Derived from?
Ù Function?
Ù Located in?
Ù Synthesize and secrete?
Ù
{
Matrix
Bone
y Name the major players
{ Osteoblasts
{ Osteocytes
{ Osteoclasts
{ Matrix
Inorganic> Organic
Ù Inorganic- hydroxyapatite, rigidity
Ù Organic- Type I collagen, GAG, elasticity
Ù
{
Bone is vascular
The Haversian System
The Volkmann’s Canal
The Haversian System
Bone
Haversian Canal
Volkmann’s Canal
Hormone Effects
Hormone Effects
Hormone Effects
Don’t neglect
y Section on Spongy Bone
y Joints
{ What is the origin of the secretory epithelial lining the joint
space