Section 2 Infectious Diseases I N F E C T I O U S D I S E A S E S Chain of Transmission Individuals may have traits that affect their susceptibility and/or severity of disease Microorganisms capable of causing illness and/or disease Place in which the infectious organism lives, grows and reproduces Ways in which the infectious agent leaves the reservoir Ways in which the infectious agent enters the susceptible host Ways in which the infectious agent is spread from the reservoir to the susceptible host Diagram adapted from: Ontario Agency for Health Protection and Promotion, Provincial Infectious Diseases Advisory Committee. Routine practices and additional precautions in all health care settings. Toronto, ON: Queen’s Printer for Ontario; 2011 I N F E C T I O U S D I S E A S E S Modes of Transmission Direct Contact Involves contact between the infectious agent and a susceptible host. E.g. Scabies, Chickenpox, Influenza, C. difficile, MRSA, VRE, etc. Indirect Contact Involves contact between a susceptible host and a contaminated object. E.g. Scabies, Influenza, C. difficile, MRSA, VRE, etc. Droplet Contact of mucous membranes or conjunctivae with large infectious droplets (>five microns) through face-to-face contact < two metres from an infectious person. < 2 metres Droplets do not remain suspended in the air. E.g. Influenza, Streptococcus pneumoniae, Pertussis, Mumps, etc. Airborne Small droplets (five microns or less) remain suspended in the air for long periods of time and can be carried by air currents. E.g. Tuberculosis, Measles, Legionnaires’ Disease, etc. Vectorborne Transmission through the bite of an insect harbouring an infectious agent E.g. West Nile virus, Malaria, Lyme Disease, etc. Vehicle Contaminated substances (e.g.: food, water) can transmit infectious agent when consumed/ingested. E.g. Salmonella, Hepatitis A The more modes of transmission that an infectious agent has, the more easily it can spread from one person to another. Adapted from: Public Health Agency of Canada. Canada Communicable Disease Report: Routine Practices and Transmission of Infection in Health Care I N F E C T I O U S D I S E A S E S Breaking the Chain of Transmission Transmission of an infectious agent can be broken anywhere in the chain by implementing appropriate measures and precautions. Diagram from: Ontario Agency for Health Protection and Promotion, Provincial Infectious Diseases Advisory Committee. Routine practices and additional precautions in all health care settings. Toronto, ON: Queen’s Printer for Ontario; 2011 I N F E C T I O U S D I S E A S E S Preventing Transmission of Infection Prevention is the key to protecting Emergency Service Workers against potential exposures to blood and/or body fluids. Although it may be impossible to completely avoid exposures to infectious agents due to the nature of the emergency services environment, following best practice guidelines can greatly reduce transmission risks. In order to prevent the transmission of infectious diseases, ESWs and Designated Officers should have a basic knowledge and understanding of: • Disease categories and specific diseases • Exposure Risks • Transmission Risks • Routine Practices and Additional Precautions (see Section 3 in this guide) Disease Categories Blood-Borne Infections (BBI) are infections that are spread through exposure to blood through needle stick injury or other sharp related injury, mucous membrane, broken skin and high risk behaviours. Examples of these diseases are Hepatitis B, Hepatitis C and HIV infection. Gastroenteritis Infections can be caused by bacteria, viruses, or parasites. Symptoms of an infection are vomiting, diarrhea, headache and lethargy. Gastroenteritis can be contracted through the consumption of contaminated foods or beverages and through contaminated items or infected persons. Some infections, like Norovirus can also be spread aerosolized particles (through vomitus). Examples are Norovirus, Giardia, and Campylobacter. Respiratory Infections are infections that can affect the upper or lower respiratory tracts. These infections cause a variety of symptoms such as runny nose, sore throat, fever, cough and shortness of breath. Respiratory infections are spread through direct or indirect contact. Examples of respiratory infection are Influenza (flu), Rhinovirus and Coronavirus. Vaccine Preventable Diseases (VPD) are diseases that can be prevented through one or a series of immunizations throughout one’s lifetime. The goal with any immunization is the elimination of the vaccine preventable disease. Some examples of VPD are measles, mumps, rubella, Hepatitis B, Tetanus. Antibiotic Resistant Organisms (AROs) have been around for many years but are becoming more common. These bacteria have developed resistance to several antimicrobial agents (antibiotics) and thus cannot be killed with the usual antibiotic medications. As a result, they are a threat to the treatment of infectious diseases. ARO’s are most commonly found in hospitals and long-term care facilities, as well as in the community. Examples of AROs include Methicillin Resistant Staphylococcus aureus (MRSA), Vancomycin Resistant Enterococci (VRE), Carbapenem Resistant Enterobacteriacae (CRE) and Extended Spectrum Beta-Lactamase producing bacteria (ESBL). *Fact Sheets about specific AROs are located in the Valuable Resource Section of this manual * AROs are NOT part of the Designated Officer program: information is for general reference only. I N F E C T I O U S D I S E A S E S Exposure Risks In general, the risk of contracting an infectious disease following an exposure is dependent upon several factors including: • Type of exposure • Amount of blood/body fluid involved • Risk factors related to the source • Factors related to the ability of the infectious pathogen to survive in the environment Survival of Pathogens on Environmental Surfaces > 1 week Hepatitis C virus 4 weeks Human Immunodeficiency virus HIV > 7 days Clostridium difficile (spores) 5 months Escherichia coli 1.5 hours – 16 months Hepatitis A virus (also a VPD) 2 hours – 60 days Listeria 1 day – months Norovirus 8 hours – 7 days Rotavirus 6 – 60 days Vibrio cholera 1 – 7 days Coronavirus 3 hours Haemophilus influenza (also a VPD) 12 days Influenza virus (also a VPD) 1 – 2 days Mycobacterium tuberculosis 1 day – 4 months Respiratory Syncytial virus RSV up to 6 hours Rhinovirus 2 hours – 7 days SARS associated virus 72 – 96 hours Streptococcus pyogenes (iGAS) 3 days – 6.5 months Staphylococcus aureus, including MRSA 7 days – 7 months Vancomycin-Resistant Enterococci VRE 5 days – 4 months Adenovirus 7 days – 3 months Cytomegalovirus 8 hours Herpes simplex virus ( type 1 and 2) 4.5 hours – 8 weeks Acinetobacter 3 days – 5 months Other AROs Respiratory Hepatitis B virus (also a VPD) BBIs Length of Time Gastrointestinal (GI) Pathogen Source: Kramer, A., Schwebke, I. & Kampf, G. (2006). How long do nosocomial pathogens persist on inanimate surfaces? A systematic review. BMC Infectious Diseases, 6:130. I N F E C T I O U S D I S E A S E S Transmission Risks The following chart outlines the estimated transmission rates associated with Blood Borne Infections that ESWs may come into contact with during the line of duty. Estimated Blood-Borne Infection Transmission Rates Disease Exposure Transmission Rate Needle-stick injury with HIV infected blood Approximately 0.1 – 0.3% Mucous membrane exposure Approximately 0.09% Human bite involving blood-tinged saliva Rare, few documented cases Hepatitis B Needle-stick injury with HBV infected blood Ranges from 6-60% Hepatitis C Needle-stick injury with HCV infected blood Approximately 2% HIV World Health Organization (2011). International Travel and Health Guide – Chapter 8: Exposure to Blood or Other Body Fluids. Public Health Agency of Canada. Prevention and control of occupational infections in health care. CCDR 2002; 28S1.