4/3/2014 What is a “Pathogen What is a “ Pathogen”? ”? Definition: a disease causing agent. V: Introduction to Viruses What is a “Virus What is a “ Virus”? ”? Definition: a pathogen, or disease causing agent, not considered living because it cannot reproduce on its own. Virus Reproduction A virus must have a HOST CELL to reproduce. 1 4/3/2014 Structure of a “ Structure of a “Virus Virus”” Capsid: outer protein coat. Genetic Material: DNA or RNA. V: Invasion of the Virus “Lytic Cycle Lytic Cycle”” “Lytic Cycle Lytic Cycle”” Definition: process in which a virus enters a cell, makes a copy of itself, and causes the cell to burst. (Viral Reproduction) 2 4/3/2014 “Stage A (1) Stage A (1)”” “Stage B (2) Stage B (2)”” The virus lands on the host cell and then injects its genetic material into the host cell. The virus using the host cell to synthesize, or make, viral proteins (capsids) and nucleic acids (genetic material‐DNA or RNA). “Stage C (3) Stage C (3)”” “Stage D (4) Stage D (4)”” The virus assembles (puts together) capsids and nucleic acids to prepare for release. The host cell breaks open (lysing) and the newly assembled viruses begin to be released. “Lysogenic Cycle Lysogenic Cycle”” Definition: process by which a virus embeds its DNA into the DNA of the host cell and is replicated along with the host cell's DNA. Lysogenic cycle is a viral reproduction cycle in which the virus is dormant until it enters the lytic cycle. V: : Bacteriophage Bacteriophage Lytic Cycle Lytic Cycle 3 4/3/2014 “Lysogenic Cycle Lysogenic Cycle”” What is a “Retrovirus What is a “ Retrovirus”? ”? Definition: a virus that contains RNA as its genetic material instead of DNA. Viruses cause “ Viruses cause “Disease Disease”” How: by disrupting the body’s normal equilibrium. In many viral infections, viruses attach and destroy certain cells in the body, causing the symptoms of the disease. “Influenza Influenza”” (Flu or Grippe) Definition: a highly infectious respiratory disease. Your best defense against this virus is to receive an annual vaccination (according to the Mayo Clinic). “HIV” HIV” (Human Immunodeficiency Virus) Definition: retrovirus that destroys white blood cells called helper T cells and causes the disease known as AIDS (Acquired I Immune Deficiency Syndrome). D fi i S d ) What is a “Vaccine What is a “ Vaccine”? ”? Definition: a preparation of weakened or killed pathogens. When injected into the body, a vaccine sometimes prompts the body to produce immunity to the disease. di 4 4/3/2014 What is “Immunity What is “ Immunity”? ”? Definition: the body's ability to destroy new pathogens. V: : How Vaccines Work How Vaccines Work What are “ What are “Antibiotics Antibiotics”? ”? Definition: compounds that block the growth and reproduction of bacteria. DO NOT work on viral infections! Who is a “Immunologist Who is a “ Immunologist”? ”? Definition: a person who specializes in the immune system, to study the mechanism used by the virus t i f t ll to infect cells. If a company wants to develop antiviral drugs, they would need to ask a research immunologist. 5