Course Syllabus for Chemistry 3351
Analytical Chemical Methods
Spring Semester 2009
Class Time: Tuesdays and Thursdays 9:30 AM - 10:50 AM
Place:
Instructor:
Chemistry, Room 107
Professor Carol Korzeniewski (Office: Chemistry Room 328C)
Phone: 742-4181; Email: carol.korzeniewski@ttu.edu
Office Hours: T and Th from 11 AM to Noon, or by appointment
Textbook: Required - Select from one of the following options (A, B or C):
A) D.C. Harris “ Quantitative Chemical Analysis ”, 7 th
Ed., (2007) W.H. Freeman &
Co (new text plus free access to web-based eBook – ISBN1429203080).
B) Obtain a used copy of the Harris text indicated in option A. (Option B supplies the text only and does not provide access to the web-based eBook).
C) Purchase the standard version of the web-based eBook (ISBN-1429216662) directly from the publisher at http://ebooks.bfwpub.com/qchem.php
. (Option C provides web access to the electronic version of the text for a period of 365 days.)
Note: The chemistry department plans to use the Harris text in the CHEM 4314
(Instrumental Analysis) course. If you plan to take CHEM 4314 in the future, it would probably be worthwhile to select one of the hard copy options (A or B) for the
Harris text at this point.
Optional: Quantitative Chemical Analysis Student Solutions Manual (ISBN-10: 0-
7167-7260-4).
Laboratory: Students enrolled in the laboratory course (Chemistry 3251) can obtain a bound set of experiments “ Chemistry 3251 Laboratory Manual ” from Copy Tech. There is a fee (about $10) that covers copying costs.
Calculator: A basic scientific calculator with exponential, logarithmic, trigonometric and statistics functions is required .
Course
Web-page: The course web-page is located at:
http://www.webpages.ttu.edu/ckorzeni/3351/3351S09_HP.html
The page can also be reached from the “Chemistry 3351, Spring 2009” link on the instructor’s chemistry department homepage. Homework assignments, quizzes, in class practice problems and quiz and exam dates will be posted there.

Raiderlink : Exam and quiz keys and any copyrighted material will be available by login to the course eLearning channel from the Raiderlink Portal accessible at http://www.raiderlink.ttu.edu
. Instructions for adding the eLearning channel to your
Raiderlink Portal can be found by accessing “Help” from the Raiderlink homepage
(top, right-hand corner) after sign-in.
Homework: Homework will be assigned from problems at the end of the chapters. Select problems will be reviewed in class and at occasional out of class problem sessions.
Quizzes: Quizzes are take-home assignments designed to help students prepare for major examinations and keep pace in the course. The quizzes will be based on homework exercises and material presented in class. The quizzes are worth 20 % of the total points. Quizzes are due at the start of class on the following dates:
Quiz 1: Thurs., Jan. 15; Quiz 2: Thurs., Feb. 5; Quiz 3: Thurs., Feb. 19
Quiz 4: Tues., March 31; Quiz 5: Thurs., April 23
Exams and Grading: Exam 1: Thurs., Jan. 22, 9:30 AM to 10:50 AM 100 pts.
100 pts.
100 pts.
Final 150 pts.
Quizzes: 5 for a total of 150 pts.
Total: 600 pts.
AM – 10:00 AM). The exam will consist of two parts: A) a written portion worth 50 pts and B) the standardized American Chemical Society (ACS) examination in quantitative analysis (worth 150 pts, with 50 of these counting toward bonus points for the course). The ACS exam provides practice and assists preparation for the type of standardized tests required for admission to professional and graduate schools in the sciences and diagnostic exams used in chemistry graduate programs.
Assignment of final grades: The final letter grade will be based on the final numerical grade as follows:
> 537 pts. (> 90%)
536 - 477 (89-80 %)
476 - 417 (79-70 %)
416 - 357 (69-60 %)
A
B
C
D
Exam Policy: Each exam will be a combination of multiple choice and free response questions.
You will be responsible for all material presented in lecture and assigned in the text.
Exam questions generally are at the same level of difficulty as the homework and quizzes, and stress fundamental concepts and problem-solving skills. You are

permitted to bring a 4 x 6 inch “crib card” to the hour exams. However, during the
ACS portion of the final exam only a calculator will be permitted . You will need the following items for each exam: photo identification, pencils, a calculator with extra batteries.
Please note: You must notify me in advance if sickness or another unavoidable circumstance will prevent you from taking an examination at the scheduled time. A message may be left at 742-3067 (department office), if you are unable to reach me.
There will be no make-up exams . If you miss an exam for a reason beyond your control, you may request to be excused from that exam provided you have valid written documentation.
Expected
Learning
Outcomes: Upon completion of this course, students will be able to:
•
Describe general principles and techniques of quantitative chemical analysis
•
Perform stoichiometric calculations required for analysis by titration and volumetric measurements
•
Explain standardization procedures employed in volumetric analysis
•
Discuss capabilities and applications of analytical balances
•
Perform basic statistical calculations, including the determination of confidence limits and the application of significance testing
•
Explain the meaning of equilibrium constants with account of activity effects
•
Recognize specific types of equilibrium constants, such as those that describe acid dissociation, solubility, and complexation phenomena
•
Describe the properties of protic acids and bases
•
Explain the properties of buffer solutions and procedures for their preparation
•
Perform calculations involving complex and competitive equilibrium phenomena
•
Discuss principles of instrumental analytical methods based on electrochemistry, spectroscopy, mass spectrometry and chromatography
Assessment: The expected learning outcomes for the course will be assessed through in class exams, take-home quizzes, non-graded homework assignments, polling the class and related non-graded quiz activities, and discussions in class and at optional out of class review sessions. In addition, students will be given an opportunity to take a standardized, nationally normed American Chemical Society examination in analytical chemistry at the conclusion of the course.
Assistance: Please do not delay in seeking help when a problem or concept gives you difficulty.
See me during my office hours or make an appointment. Assistance is also available in the TA Help Room (Room 111, Chemistry) and through the Pass Center (West
Hall).

Academic
Honesty: Academic dishonesty of any sort will not be tolerated. Students caught cheating or plagiarizing will be dealt with according to the policies of the University. Students are strongly cautioned not to cheat in any way, as their academic careers will be adversely affected. It is the students’ responsibility to familiarize themselves with the University’s academic policy.
Special
Conditions: Any student who, because of a disabling condition, may require some special arrangements in order to meet course requirements should contact the instructor as soon as possible so that the necessary accommodations can be made.

I. Introduction
Chemical analysis (Ch. 0)
Lecture Topics Outline
Chemistry 3351 -- Spring 2009
SI Units and Prefixes (Ch. 1-1)
Chemical Concentration in Solution (M, mM; wt %, vol %; ppm, ppb) (Ch. 1-2)
Preparing Solutions (1-3)
II. Measurements
Lab safety (Ch. 2-1)
Mass and Volume measurements (Ch. 2-3 to 2-6; 2-9)
Significant Figures (Ch. 3-1 to 3-2)
Errors, precision, accuracy, uncertainty (Ch. 3-3 to 3-4)
Random errors; normal distribution; mean (Ch. 4-1)
Sample and population standard deviations (Ch. 4-1)
Least-squares method (general) (Ch. 4-7)
Calibration curves (Ch. 4-8; Fig 0-7)
Graphing with Spreadsheet Programs (2-10; 2-11; 4-9)
IV. Introduction to Titrations
Principles of volumetric analysis (Ch. 7-1; Fig 7.1)
Stoichiometry and titration calculations (Ch. 7-2)
Standards and standardization procedures (Ch. 7-1 to 7-2; Exercise 7B;
Problems 7-10 to 7-12; Table 11-5)
Titration curves for strong acids and strong bases (Ch. 11-1; Table 11-5)
V. Chemical Equilibrium
Equilibrium constants and thermodynamic principles (Ch. 6-1 to 6-2)
Overview of K sp
and complexation (Ch. 6-3 to 6-4)
Protic acids and bases, K w
, pK w
and pH (Ch. 6-5 to 6-6)
Weak acids and bases, K a
and K b
(Ch. 6-7)
Polyprotic acids and bases (Ch. 6-7)
EXAM I (Thursday, Jan. 22)
VI. Activity and Systematic Treatment of Equilibrium
Ionic strength (Ch. 8-1)
Activity coefficients and the extended Debye-Hückel eqn (Ch. 8-2)
Effect on pH (Ch. 8-3)
Mass and charge balance equations (Ch 8-4)
VII. Monoprotic Acid-Base Equilibria
Strong acids, strong bases and dilute solutions (Ch. 9-1) pH of weak acid and weak base solutions (Ch. 9-2 to 9-4)
Buffers (Ch. 9-5; Table 9-2)
Henderson-Hasselbalch eq. (Ch. 9-5)

Buffer preparation and capacity (Ch. 9-5)
Titration curves for weak acids and weak bases (Ch. 11-2 to 11-3)
Acid-base indicators (Ch. 11-6, Table 11-4)
VIII. Polyprotic Acids and Bases
Polyprotic acids and bases (Ch. 10-1 to 10-3)
Amino acids (Ch. 10-1; Table 10-1)
Fractional composition (Ch. 10-4 to 10-5)
Titration curves for polyprotic acids and bases (Ch. 11-4)
IX. Precipitation and Complex-Formation
Solubility product constants (K sp
) and common ion effects (Ch. 6-3; 8-5)
Chelation (Ch. 12-1)
EDTA properties and complexes with metal ions (Ch. 12-2)
EDTA titrations (Ch. 12-3, 12-6, 12-7)
EXAM II (Thursday, Feb. 26)
X. Spectrophotometric Analysis
Introductory concepts (Ch. 18-1 to 18-3 and 18-5)
Beer’s law (Ch. 18-4)
Spectrophotometry instrumentation (Fig 18-4; Ch. 20-1 to 20-3)
Luminescence (Ch. 18-6)
Analysis of a mixture (Ch. 19-1)
Optical sensors and sensing (Ch. 20-4; 19-5 to 19-6)
XI. Advanced Statistics
Gaussian distribution and confidence intervals (Ch. 4-1 and 4-2)
Student’s t (Ch. 4-2 and 4-3)
F test (Ch. 4-4)
Least-squares fitting (detail) (Ch. 4-7 to 4-9)
Limits of Detection (Ch. 5-2)
Standard Addition (Ch. 5-3)
XII. Electrochemistry: Part I
Introduction (Ch. 14-1)
Electrochemical cells (Ch. 14-2)
Standard potentials and the Nernst equation (Ch. 14-3 to 14-4)
Reference Electrodes (Ch. 15-1)
Indicator electrodes and potentiometric sensors (Ch. 15-2)
Ion selective electrodes (Ch. 15-4 and 15-6)
Glass pH electrode (Ch. 15-5)
XIII. Electrochemistry: Part II
Redox titrations (Ch. 16-1; Exercise 7A)
Titrations involving permanganate and iodine (Ch. 16-4 and 16-7)
EXAM III (Tuesday, April 7)

XIV. Mass Spectrometry and Separation methods
Mass spectrometry (Ch. 22)
Extractions (Ch. 23-1)
Introduction to chromatography (Ch. 23-2 to 23-3)
Band broadening and separation efficiency (Ch. 23-4)
Gas chromatography (Ch. 24)
HPLC (Ch. 25)
Ion chromatography (Ch.26-1 to 26-2)
Molecular exclusion and affinity chromatography (Ch 26-3 and 26-4)
Capillary electrophoresis (Ch. 26-5 to 26-6)
FINAL EXAM (Thurs., April 30, 7:30 AM – 10:00 AM)
*Chapters indicated are from D.C. Harris “ Quantitative Chemical Analysis ”, 7 th
Ed., (2007) W.H.
Freeman & Co.