To Test or Not To Test, That Is the Question From time immemorial, humans used and abused animals in lots of areas. The next two articles are discussing the question: does animal research beneficial to medicine? The first article claims that animal research is vital to medicine, while the other one claims that this research is wasteful and misleading. The article "Animal Research Is Vital to Medicine", written by Jack H.Botting and Adrian R.Morrison, first introduces the significance of animal researches to all areas of medical research in the past and towards the future. It begins with the widespread effects of Pastuer's research on domestic animals, which was carried out in order to identify the offending organism of bacterial and viral infections, and in addition promoted the development of vaccines. Then the authors describe how vivisection led also to the development of antibacterial and antibiotic drugs (for example sulfonamide drugs and antibiotic penicillin). Nevertheless, they emphasize the fact that infectious disease still considered as a great threat to humankind, and experiments using animals will be vital to develop treatments. To strengthen their argument, they continue to list medical treatments that were develop based on animal researches, such as open heart surgery, treatments for kidney failure, insulin for diabetes et cetera. Later, accusations of opponents of animal experiments (considered as misconceptions by the authors) about the differences between humans and animals, the necessity of those researches and more, are being refuted. Does a paging black hole in place of animal researches will delay the progress of developing medical treatments? The authors convinced it will. Are there any complete substitutes to animal experiments? They believe that in most cases there are no absolute alternative procedures that can provide the same benefits, and therefore they find it difficult to envision progresses in many fields without experiments using animals. The second article "Animal Research Is Wasteful and Misleading" written by Neal D. Barnard and Stephen R. Kaufman introduce the exact opposite approach. As the time passes and especially in the recent period, organizations that work against violence toward animal in general, and against the use of animals for research and studying in particular, become more common. Those groups take one of the two approaches: 1. Animal welfare, which refers the pain that the animals experience because of human needs. 2. Animals rights, which claim that we should not refer animals different than humans. The authors use several important points in order to support their ideas. First they claim that animal experiments are not feasible to medicine because they are poorly suited to addressing the urgent health problems that exist in the real world. Afterwards, they represent better methods to deal with the researches needs. Finally, the issue of animal testing as a rhetorical device is discussed. They describe to the reader the argument that animal tests are not feasible to medicine by showing several cases in which the effects of medicines on animals were entirely different from their effects on human beings. Better methods are being suggested, such as epidemiological studies, autopsy studies and endoscopic examination and biopsy. Furthermore, the authors give examples of successful research produced by them, like atherosclerotic heart disease which was produced by epidemiological studies. To support the argument that animal testing used as a rhetorical device, the drug thalidomide example is being pointed out with the claim that animal tests could have predicted the birth defects caused by this drug. Towards the end, the authors highlight the fact that they did not broached the ethical objections to animal experimentation in this article. In brief, although animal researches have great contribution to progresses in many fields, they are not essential because there are many other substitutes that could bring up the same results.