Currículum vítae
MIGUEL BLANCA, MD, PhD
Updated 14 May 2010
PERSONAL DATA
DNI : 25284454w
Born 20-08-1949
Nationality : Spanish
PRESENT OCUPATITON
Organism: Servicio Andaluz de Salud.
CENTER : Servicio de Alergología, Hospital Regional Universitario Carlos Haya, Málaga.
Address: Hospital Civil, Plaza del Hospital Civil s/n pabellón 6, 1a planta.
Phone 34 609572992. Fax: 951030346.
Electronic mail: mblancag@gmail.com
Specialty: Internal Medicine. Subspecialty: Allergy and Clinical Immunology
Position: Head of Service, Associated Professor of Medicine
Date at present job: since march 2003
RESEARCH LINES IN COURSE
Intolerance to non steroidal antiinflammatory drugs: Studies on gene expresión including polimorphisms of genes
envolved in the response.
Allergic reactions to betalactams: Interaction between the drug and dendritic cells with the induction of lymphocyte
response.
Phenotipic and functional characterization of regulatory T cells (Treg CD4+CD25+) in with allergic disease in
active phase: atopic dermatitis versus bronchial asthma.
Allergic reactions to betalactams: characterization of hapten carrier conjugates and studies on the cellualr
mechanisms envolved.
Pharmacogenomic studies on the IgE response to betalactams.
Intrinsic rhinitis: immunological characterisation and studies of the local production of IgE.
Rhinitis and occupational asthma induced by wood dust: characterisation and purification of wood dust allergens.
Phase II clinical trials on the immnuotherpy response to alllergens.
ACADEMIC FORMATION
Basic negree in medicine University of Granada (Spain) 1968-1974.
PHD: University of Malaga 1991.
Professional Appointments:

2003-

2006- Visiting professor at Nancy University, France

2006 visiting professor at Department of Pulmonary Medicine University of Minneapolis,
Minnesota USA, in collaboration with Professor Malcom Blumenthal.

2000-2003 Head of Allergy Service of Hospital La Paz, Madrid, Spain.

1998-2000 Director of Research Department of Carlos Haya Hospital, Malaga, Spain.

1995 visiting professor of Department of Epidemiology, University of Maryland at Baltimore,
Professor John Stoley.

1993 visiting professor in the Department of Pharmacology, University of Liverpool UK in
collaboration with Professor John Coleman.

1988 visiting professor in the biochemistry department, East Carolina University Greenville,
USA under the direction or professor Donnald Hoffmann.

1982-1998 staff member in Allergy Unit of Carlos Haya Hospital, Málaga, Spain.

1980-1982 research fellow in immunology in the Immunology department of the Middlessex
Hospital, UK, under the direction of Professor Ivan Roitt.

1975-1979 Internal Medicine -Allergy Resident at Carlos Haya Hospital, Málaga, Spain
Head of Allergy Service of Hospital Carlos Haya, Málaga, Spain.
Memberships:
Spanish Society of Allergy and Clinical Immunology
British Society for Immunology.
American Academy of Allergy, Asthma and Immunology.
European Academy of Allergology and Clinical Immunology
British Society for Allergy and Clinical Immunology.
Collegium Allergologicum Internationale.
Foundation for Allergy Research in Europe.
Other professional activities
Reviewer of Journal of Allergy and Clinical Immunology, Allergy, Clinical and Experimental Allergy and International
Archives of Allergy and Immunology
Evaluator of project ision for Spanish Health Ministery (FIS) and Regional Health Ministry of the Andalusian
Government.
Publications (updated December 2009)
Total Publications:170
Times Cited: 2869 (updated august 2009)
Average Citations per Item: 8.49 (updated august 2009))
h-index: 30 (updated august 2009)
Lenguages: Spanish, English, French and Italian.
PARTICIPATION IN RESEARCH PROJECTS AS PRINCIPAL INVESTIGATOR (Previous 6 years).
Ministerio Salud
Ministerio Educacion y Ciencia
Consejeria Sanidad Junta Andalucia
Consejeria de Innovacion Junta Andalucia.
Title: Studies on the antigenic determinants involved in IgE reactions to beta lactams: Imporvements of the in Vitro
diagnostic methods for the detection of specific IgE antibodies.
Financing agency: Ministerio de Ciencia y Tecnología BQU2001-3624.
Title: Effects of neuropeptides in the production of citokines by peripherals T cells CLA+ with skin tropismo in
subjects with atópica dermatitis.
Financing agency: Ministerio de Salud (FIS 01/0865)
Title: Studies on the mechanisms involved in adverse drug reactions: Role of lymphocytes, COX-2 and the
generation of free radicals.
Financing agency: Ministerio Salud FIS 01/0014-02.
Title: Studies of the adverse reactions to drugs mediated by immunological and non immunological mechanisms.
Chemical and immunochemical characterisation of antigenic determinants from beta lactam antibiotics.
Financing agency: Ministerio Salud FIS 01/3031.
Title: Synthesis, Chemical and immunochemical characterisation of the cephallosporins determinants involved in
IgE response to betalactams.
Financing agency: Ministerio Salud FIS PIO20666.
Title: Studies on the lymphocytes subpopulations involved in adverse drug reactions with immunological basis.
Financing agency: Ministerio Salud FIS PIO20640
Title: Use of dendrimers as carrier molecules in immunoassays for detecting IgE antibodies to betalactams.
Financing agency: Consejeria Sanidad Junta Andalucia Ref 16/03.
Title: Studies on the immunological mechanisms involved in immediate, accelerated in delayed reactions to
betalactams.
Financing agency: Consejeria Sanidad Junta Andalucia Ref 14/03.
Title: Allergic reactons to betalactams. Characterisation of conjugates and studies of the cellular mechanisms
involved.
Financing agency: Ministerio Salud FIS PI031165.
Title: Studies of new structures involved in immediate reactions to betalactams based upon the classical model of
major and minor determinants of betaltams.
Financing agency: Consejeria Sanidad Junta Andalucia Ref 197/04.
Title: Allergic reactions to betalactams: role of dendritic cells in the initiation and maintenance of the
immunological response induced by T lymphocytes.
Financing agency: Consejería de Salud. Junta de Andalucía Ref 199/04.
Title: Phenotypic and functional characterisation of regulatory T cells (Treg CD4+CD25+) in patients with active
allergic disease: atopic dermatitis versus bronchical asthma.
Financing agency: Consejería de Salud. Junta de Andalucía Ref 198/04.
Title: Non immediate reactions to drugs: involvement of chemochines from T effector cells with skin tropismo.
Financing agency: Fundación de la SEAIC.
Title: Clinical and immunological implications of the cross reactivity between penicillins an cephallosporins in IgE
mediated reactions.
Financing agency: Consejería de Salud. Junta de Andalucía Ref 0300/05.
Title: Development of diagnostic strategies based on the metabolizing capacity of the skin and the role of dendritic
cells in the induction of allergic drug reactions.
Financing agency: Ministerio Salud FIS PI05290.
Title: Allergic drug reactions: Characterisation of conjugates and studies of the cellular mechanisms.
Financing agency: Consejeria Innovacion Cts-00570.
Title: Development of methods based on dendrimeric conjugates and minor determinants for the in vivo diagnosis
of allergy to betalactams.
Financing agency: Ministerio Salud FIS PIO61503.
Title: Allergic reactions to betalactams: Interaction between the drug and dendritic cells and the involvement of T
lymphocytes.
Financing agency: Ministerio Salud FIS PIO61561.
Title: Colonisation by staphilococcus aures and production of beta defensins in nasal poliposis and allergic rhinitis.
Financing agency: Consejeria Salud Junta de Andalucia SAS 0055.
Title:Characterisation of gene expresión profile in adverse drug reactions with immunological basis.
Financing agency: Consejeria Salud Junta de Andalucia SAS 0058..
Title: Ocupational asthma induced by isocyanates: clinical and immunological evaluation of the exponed
population.
Financing agency: Ministerio de Salud FIS Ref PI071220.
Title: Intolerance to non steroidal antiinflammatory drugs. Studiies on the expresión and polymorphisms of the
involved genes.
Financing agency: Ministerio de Salud FIS FIS Ref PI071220.
Title: Studies on the metabolising capacity of the skin and dendritic cells in the induction of allergic reactions to
anticonvulsivants
Financing agency: Ministerio de Salud PI-0199/2007.
Title: Preparation, evaluation and aplication of nanodendrimes strcuturated antigens and minor determinants in
the diagnosis of hypersensitivity to betalactams.
Financing agency: Ministerio de Salud PI-0243/2007
Title: Role of efector cells with skin tropismo ((Cd27-Ccr7-Ccr10+) in allergic drug reactions.
Financing agency: Ministerio de Salud PI-0201/2007.
Title: Development of dendrimers structures with capacity for including epitopes of allergens and
immunomodulators.
Financing agency: Consejeria Salud Junta de Andalucai PI-0200/2007.
Title: Network for the study of adverse reactions to drugs and allergens.
Financing agency: Ministerios de Sanidad y Consumo (01/007)
Title: Drug allergic reactions: clinical functional studies and involved genes.
Financing agency: Ministerios de Sanidad y Consumo (PS 09/02419).
Title: Evalaution of hypersensitivity mechanisms in adverse drug reactions to contrast media.
Financing agency: Consejeria de Sanidad Junta de Andalucia (PI 0488)
PUBLICATIONS
Torres MJ, Ariza A, Fernandez J, Moreno E, Laguna JJ, Montañez MI,
Ruiz-Sanchez AJ, Blanca M. Role of minor determinants of amoxicillin in the diagnosis of immediate allergic
reactions to amoxicillin. Allergy 2010 ; 65 :590-6.
Torres MJ, Ariza A, Mayorga C, Doña I, Blanca-Lopez N, Rondon C, Blanca M. Clavulanic acid can be the
component in amoxicillin-clavulanic acid responsible for immédiate hypersensitivity réactions. J Allergy Clin
Immunol 2010 ;125 :502-505.
Bellon T, Alvarez L, Mayorga C, Morel E, Torres MJ, Martin-Diaz MA, Diaz R,
Radial A, Carballo M, Blanca M. Differential gene expression in drug hypersensitivity reactions: induction of
alarmins in severe bullous diseases. Br J Dermatol. 2010;162 :1014-22.
Lopez S, Torres MJ, Antunez C, Rodriguez-Pena R, Canto G, Blanca M, Mayorga C.
Specific immunological response to budesonide in a patient with delayed-type hypersensitivity reaction. J Invest
Dermatol. 2010;130 :895-7.
Lopez S, Rondon C, Torres MJ, Campo P, Canto G, Fernandez R, Garcia R, Martinez-Cañavate A, Blanca M.
Immediate and dual response to nasal challenge with Dermatophagoides pteronyssinus in local allergic rhinitis.
Clin Exp Allergy. 2010 ;
Rondón C, Canto G, Blanca M. Local allergic rhinitis: a new entity, characterization and further studies. Curr Opin
Allergy Clin Immunol. 2010; 10 :1-7.
Rondon C, Fernnndez J, Lopez S, Campo P, Doña I, Torres MJ, Mayorga C, Blanca M. Nasal inflammatory
mediators and specific IgE production after nasal challenge with grass pollen in local allergic rhinitis. J Allergy Clin
Immunol 2009 ;124 :1005-11.
Cornejo-Garcia JA, Blanca-Lopez N, Doña I, Andreu I, Agundez JA, Carballo M, Blanca M, Canto MG.
Hypersensitivity reactions to non-steroidal anti-inflammatory drugs. Curr Drug Metab. 2009;10 :971-80.
De Weck AL, Sanz ML, Gamboa PM, Aberer W, Blanca M, Correia S, Erdman S, Jermann JM, Kanny G, Kowalski
M, Mayorga L, Medrala W, Merk A, Sturm GJ, Sainte-Laudy J, Schneider MS, Sczczeklik A, Weber JM, Wedi A.
Nonsteroidal anti-inflammatory drug hypersensitivity syndrome. A multicenter study. I. Clinical findings and in vitro
diagnosis. J Investig Allergol Clin Immunol. 2009;19355-69.
De Weck AL, Sanz ML, Gamboa PM, Aberer W, Blanca M, Correia S, Erdman S, Jermann JM, Kanny G, Kowalski
M, Mayorga L, Medrala W, Merk A, Sturm GJ, Sainte-Laudy J, Schneider MS, Sczczeklik A, Weber JM, Wedi A.
Nonsteroidal anti-inflammatory drug hypersensitivity syndrome. A multicenter study. I. Clinical findings and in vitro
diagnosis. J Investig Allergol Clin Immunol. 2009;19:355-69.
Rondon C, Fernandez J, Lopez S, Campo P, Dona I, Torres MJ, Mayorga C, Blanca M. Nasal inflammatory
mediators and specific IgE production after nasal challenge with grass pollen in local allergic rhinitis. J Allergy Clin
Immunol 2009 124:1005-11.
Mayorga C, Torres MJ, Fernandez J, Canto G, Blanca M. Cutaneous symptoms in drug allergy: what have we
learnt? Curr Opin Allergy Clin Immunol. 2009;9:431-6.
Ruano FJ, Garcimartin MI, Vazquez de la Torre M, Blanca M, Canto G. Desensitization of epoetin-alpha in a
confirmed case of acute exanthematic pustulosis. Allergy 2009;64:1797-8
Dona I, Chaves P, Gomez E, Torres MJ, Cantó LG, Blanca M. Drug rash with eosinophilia and systemic
symptoms after penicillin V administration in a patient with acquired C1 inhibitor acquired deficiency. J Investig
Allergol Clin Immunol. 2009;19:325-7.
Thong B, Blanca M. Advances in the understanding of hypersensitivity reactions to drugs. Curr Opin Allergy Clin
Immunol. 2009;9:291-2.
Antunez C, Torres MJ, Lopez S, Rodriguez-Pena R, Blanca M, Mayorga C, Santamaria-Babi LF. Calcitonin generelated peptide modulates interleukin-13 in circulating cutaneous lymphocyte-associated antigen-positive T cells in
patients with atopic dermatitis. Br J Dermatol. 2009;161:547-53.
Canto MG, Andreu I, Fernandez J, Blanca M. Selective immediate hypersensitivity reactions to NSAIDs. Curr Opin
Allergy Clin Immunol 2009;9:293-7.
De Week AL, Sanz ML, Gamboa PM, Aberer W, Sturm G, Bilo MB, Montroni M, Blanca M, Torres MJ, Mayorga L,
Campi P, Manfredi M, Drouet M, Sainte-Laudy J, Romano A, Merk H, Weber JM, Jermann TM; ENDA (European
Network for Drug Allergy). Diagnosis of immediate-type beta-lactam allergy in vitro by flow-cytometric basophil
activation test and sulfidoleukotriene production: a multicenter study. J Investig Allergol Clin Immunol.
2009;19:91-109.
Torres MJ, Mayorga C, Blanca M. Nonimmediate allergic reactions induced by drugs: pathogenesis and diagnostic
tests. J Investig Allergol Clin Immunol. 2009;19:80-90.
Garcia-Martin E, Ayuso P, Martinez C, Blanca M, Agundez JA. Histamine pharmacogenomics.
Pharmacogenomics. 2009;10:867-83.
Gomez E, Blanca-Lopez N, Torres MJ, Requena G, Rondon C, Canto G, Blanca M, Mayorga C. Immunoglobulin
E-mediated immediate allergic reactions to dipyrone: value of basophil activation test in the identification of
patients. Clin Exp Allergy. 2009;39:1217-24.
Fernández TD, Torres MJ, Blanca-López N, Rodríguez-Bada JL, Gomez E, Canto G, Mayorga C, Blanca M.
Negativization rates of IgE radioimmunoassay and basophil activation test in immediate reactions to penicillins.
Allergy 2009;64:242-8.
Blanca-López N, Zapatero L, Alonso E, Torres MJ, Fuentes V, Martínez-Molero MI, Blanca M. Skin testing and
drug provocation in the diagnosis of nonimmediate reactions to aminopenicillins in children. Allergy
2009;64(2):229-33.
Bousquet PJ, Demoly P, Romano A, Aberer W, Bircher A, Blanca M, Brockow K, Pichler W, Torres MJ,
Terreehorst I, Arnoux B, Atanaskovic-Markovic M, Barbaud A, Bijl A, Bonadonna P, Burney PG, Caimmi S,
Canonica GW, Cernadas J, Dahlen B, Daures JP, Fernandez J, Gomes E, Gueant JL, Kowalski ML, Kvedariene
V, Mertes PM, Martins P, Nizankowska-Mogilnicka E, Papadopoulos N, Ponvert C, Pirmohamed M, Ring J,
Salapatas M, Sanz ML, Szczeklik A, Van Ganse E, De Weck AL, Zuberbier T, Merk HF, Sachs B, Sidoroff A;
Global Allergy, Asthma European Network (GALEN) and Drug Allergy and Hypersensitivity Database (DAHD) and
the European Network for Drug Allergy (ENDA). Pharmacovigilance of drug allergy and hypersensitivity using the
ENDA-DAHD database and the GALEN platform. The Galenda project. Allergy 2009;64(2):194-203.
Blanca M, Romano A, Torres MJ, Férnandez J, Mayorga C, Rodriguez J, Demoly P, Bousquet PJ, Merk HF, Sanz
ML, Ott H, Atanasković-Marković M. Update on the evaluation of hypersensitivity reactions to betalactams. Allergy
2009;64(2):183-93.
Guéant JL, Guéant-Rodriguez RM, Cornejo-Garcia JA, Viola M, Blanca M, Romano A. Gene variants of IL13, IL4,
and IL4RA are predictors of beta-lactam allergy. J Allergy Clin Immunol 2009;123(2):509.
Guéant JL, Guéant-Rodriguez RM, Gastin IA, Cornejo-García JA, Viola M, Barbaud A, Mertes PM, Blanca M,
Romano A. Pharmacogenetic determinants of immediate and delayed reactions of drug hypersensitivity. Curr
Pharm Des 2008;14(27):2770-7.
Rondón C, Doña I, López S, Campo P, Romero JJ, Torres MJ, Mayorga C, Blanca M. Seasonal idiopathic rhinitis
with local inflammatory response and specific IgE in absence of systemic response. Allergy 2008;63(10):1352-8.
De Week AL, Sanz ML, Gamboa PM, Aberer W, Bienvenu J, Blanca M, Demoly P, Ebo DG, Mayorga L, Monneret
G, Sainte Laudy J. Diagnostic tests based on human basophils: more potentials and perspectives than pitfalls. II.
Technical issues. J Investig Allergol Clin Immunol 2008;18(3):143-55.
Montañez MI, Perez-Inestrosa E, Suau R, Mayorga C, Torres MJ, Blanca M. Dendrimerized cellulose as a scaffold
for artificial antigens with applications in drug allergy diagnosis. Biomacromolecules 2008;9(5):1461-6.
Fernandez TD, Mayorga C, Torres MJ, Cornejo-Garcia JA, López S, Chaves P, Rondon C, Blanca M. Cytokine
and chemokine expression in the skin from patients with maculopapular exanthema to drugs. Allergy
2008;63(6):712-9.
Torres MJ, Mayorga C, Cornejo-Garcia JA, Lopez S, Chaves P, Rondon C, Fernandez T, Blanca M. Monitoring
non-immediate allergic reactions to iodine contrast media. Clin Exp Immunol 2008;152(2):233-8.
Padial A, Antunez C, Blanca-Lopez N, Fernandez TD, Cornejo-Garcia JA, Mayorga C, Torres MJ, Blanca M. Nonimmediate reactions to beta-lactams: diagnostic value of skin testing and drug provocation test. Clin Exp Allergy
2008;38(5):822-8.
de Weck AL, Sanz ML, Gamboa PM, Aberer W, Bienvenu J, Blanca M, Demoly P, Ebo DG, Mayorga L, Monneret
G, Sainte- Laudy J. Diagnostic tests based on human basophils: more potentials and perspectives than pitfalls. Int
Arch Allergy Immunol. 2008;146(3):177-89.
Cornejo-Garcia JA, Fernandez TD, Torres MJ, Carballo M, Hernan I, Antunez C, Blanca M, Mayorga C.
Differential cytokine and transcription factor expression in patients with allergic reactions to drugs. Allergy
2007;62(12):1429-38.
Lopez S, Blanca-Lopez N, Cornejo-Garcia JA, Canto G, Torres MJ, Mayorga C, Blanca M. Nonimmediate
reactions to betalactams. Curr Opin Allergy Clin Immunol 2007;7(4):310-6.
Robles S, Torres MJ, Mayorga C, Rodríguez-Bada JL, Fernández TD, Blanca M, Bartolomé B. Anaphylaxis to
Mare's milk. Ann Allergy Asthma Immunol 2007;98(6):600-2.
Rondón C, Romero JJ, López S, Antúnez C, Martín-Casañez E, Torres MJ, Mayorga C, R-Pena R, Blanca M.
Local IgE production and positive nasal provocation test in patients with persistent nonallergic rhinitis. J Allergy
Clin Immunol 2007;119(4):899-905.
Blanca M, Romano A, Torres MJ, Demoly P, DeWeck A. Continued need of appropriate betalactam-derived skin
test reagents for the management of allergy to betalactams. Clin Exp Allergy 2007;37(2):166-73.
Fontaine C, Mayorga C, Bousquet PJ, Arnoux B, Torres MJ, Blanca M, Demoly P. Relevance of the determination
of serum- specific IgE antibodies in the diagnosis of immediate beta-lactam allergy. Allergy 2007;62(1):47-52.
Rodriguez-Pena R, Lopez S, Mayorga C, Antunez C, Fernandez TD, Torres MJ, Blanca M. Potential involvement
of dendritic cells in delayed-type hypersensitivity reactions to beta-lactams. J Allergy Clin Immunol
2006;118(4):949-56.
Antúnez C, Martín E, Cornejo-García JA, Blanca-Lopez N, R-Pena R, Mayorga C, Torres MJ, Blanca M.
Immediate hypersensitivity reactions to penicillins and other betalactams. Curr Pharm Des 2006;12(26):3327-33.
Cornejo-Garcia JA, Mayorga C, Torres MJ, Fernandez TD, R-Pena R, Bravo I, Mates JM, Blanca M. Anti-oxidant
enzyme activities and expression and oxidative damage in patients with non-immediate reactions to drugs. Clin
Exp Immunol 2006;145(2):287-95.
Rodríguez-Bada JL, Montañez MI, Torres MJ, Mayorga C, Canto G, Perez-Inestrosa E, Suau R, Blanca M. Skin
testing for immediate hypersensitivity to betalactams: comparison between two commercial kits. Allergy
2006;61(8):947-51.
Antúnez C, Fernández T, Blanca-Lopez N, Torres MJ, Mayorga C, Canto G, Fernández J, Moya MC, Blanca M.
IgE antibodies to betalactams: relationship between the triggering hapten and the specificity of the immune
response. Allergy 2006;61(8):940- 6.
Torres MJ, Blanca M; European Network for Drug Allergy (ENDA); EAACI Interest Group On Drug
Hypersensitivity. Importance of skin testing with major and minor determinants of benzylpenicillin in the diagnosis
of allergy to betalactams. Statement from the European Network for Drug Allergy concerning AllergoPen
withdrawal. Allergy 2006;61(8):910-1.
Mayoral M, Torres MJ, Muñoz M, Bartolomé B, Blanca M. Anaphylactic reaction following ingestion of fresh heart
of palm (Chamaerops humilis L.). Allergy 2006;61(6):785-6.
Antúnez C, Torres MJ, Mayorga C, Corzo JL, Jurado A, Santamaría-Babi LF, Vera A, Blanca M. Cytokine
production, activation marker, and skin homing receptor in children with atopic dermatitis and bronchial asthma.
Pediatr Allergy Immunol 2006;17(3):166-74.
Torres MJ, Mayorga C, Fernández TD, Cornejo-García JA, Antúnez C, Valenzuela M, Del Prado MF, RodriguezPena R, Blanca M. T cell assessment in allergic drug reactions during the acute phase according to the time of
occurrence. Int J Immunopathol Pharmacol 2006;19(1):119-30.
Antunez C, Blanca-Lopez N, Torres MJ, Mayorga C, Perez-Inestrosa E, Montañez MI, Fernandez T, Blanca M.
Immediate allergic reactions to cephalosporins: evaluation of cross-reactivity with a panel of penicillins and
cephalosporins. J Allergy Clin Immunol 2006;117(2):404-10.
Fernandez T, Torres MJ, R-Pena R, Fuentes MS, Robles S, Mayorga C, Blanca M. Decrease of selective
immunoglobulin E response to amoxicillin despite repeated administration of benzylpenicillin and penicillin V. Clin
Exp Allergy 2005;35(12):1645- 50.
Torres MJ, Blanca M. The contribution of major and minor determinants from benzylpenicillin to the diagnosis of
immediate allergy to beta-lactams. J Allergy Clin Immunol 2006;117(1):220-1.
Martin E, Mayorga C, Rodriguez R, Torres MJ, Blanca M. Drug hypersensitivity: insights into pathomechanisms.
Eur Ann Allergy Clin Immunol 2005;37(6):207-12.
Perez-Inestrosa E, Suau R, Montañez MI, Rodriguez R, Mayorga C, Torres MJ, Blanca M. Cephalosporin
chemical reactivity and its immunological implications. Curr Opin Allergy Clin Immunol 2005;5(4):323-30.
Padial A, Posadas S, Alvarez J, Torres MJ, Alvarez JA, Mayorga C, Blanca M. Nonimmediate reactions to
systemic corticosteroids suggest an immunological mechanism. Allergy 2005;60(5):665-70.
Blanca M, Cornejo-Garcia JA, Torres MJ, Mayorga C. Specificities of B cell reactions to drugs. The penicillin
model. Toxicology 2005;209(2):181-4.
Torres MJ, Padial A, Mayorga C, Fernández T, Sanchez-Sabate E, Cornejo-García JA, Antúnez C, Blanca M. The
diagnostic interpretation of basophil activation test in immediate allergic reactions to betalactams. Clin Exp Allergy
2004;34(11):1768-75.
Blanca M, Torres MJ, Mayorga C, Perez E, Suau R, Montañez I, Juarez C. Immediate allergic reactions to
betlactams. Facts and controversies. Curr Opin Allergy Clin Immunol 2004;4:261-66.
Romano A, Blanca M, Torres MJ, Bircher A, Aberer W, Brockow K, Pichler WJ, Demoly P; ENDA; EAACI.
Diagnosis of nonimmediate reactions to beta-lactam antibiotics. Allergy 2004;59(11):1153-60.
Antúnez C, Torres MJ, Corzo JL, Pena RR, Mayorga C, Jurado A, Santamaría-Babi LF, Blanca M. Different
lymphocyte markers and cytokine expression in peripheral blood mononuclear cells in children with acute atopic
dermatitis. Allergol Immunopathol 2004;32(5):252-8.
Tapia B, Padial A, Sánchez-Sabaté E, Alvarez-Ferreira J, Morel E, Blanca M, Bellón T. Involvement of CCL27CCR10 interactions in drug-induced cutaneous reactions. J Allergy Clin Immunol 2004;114(2):335-40.
Antúnez C, Torres MJ, Mayorga C, Cornejo-García JA, Santamaría-Babi LF, Blanca M. Different cytokine
production and activation marker profiles in circulating cutaneous-lymphocyte-associated antigen T cells from
patients with acute or chronic atopic dermatitis. Clin Exp Allergy 2004;34(4):559-66.
Torres MJ, Sánchez-Sabaté E, Alvarez J, Mayorga C, Fernández J, Padial A, Cornejo-García JA, Bellón T, Blanca
M. Skin test evaluation in nonimmediate allergic reactions to penicillins. Allergy 2004;59(2):219-24.
Padial MA, Alvarez-Ferreira J, Tapia B, Blanco R, Mañas C, Blanca M, Bellón T. Acute generalized
exanthematous pustulosis associated with pseudoephedrine. Br J Dermatol 2004;150(1):139-42.
Blanca M, Torres MJ, Fernández J, Demoly P, Romano A. Disagreement and concerns regarding the article
recently published by Macy and Burchette in Allergy 2002;57:1151. Allergy 2004;59(1):111-2. Blanca M, Torres
Jaen MJ, Mayorga C, Padial A. Penicillin allergy is a global problem: the European experience. J Allergy Clin
Immunol 2003;112(5):1014-5.
Torres MJ, Blanca M, Fernandez J, Romano A, Weck A, Aberer W, Brockow K, Pichler WJ, Demoly P; ENDA;
EAACI Interest Group on Drug Hypersensitivity. Diagnosis of immediate allergic reactions to beta-lactam
antibiotics. Allergy 2003;58(10):961- 72.
Aberer W, Bircher A, Romano A, Blanca M, Campi P, Fernandez J, Brockow K, Pichler WJ, Demoly P; European
Network for Drug Allergy (ENDA); EAACI interest group on drug hypersensitivity. Drug provocation testing in the
diagnosis of drug hypersensitivity reactions: general considerations. Allergy 2003;58(9):854-63.
Mayorga C, Torres MJ, Corzo JL, Sanchez-Sabate E, Alvarez J, Vera A, Posadas S, Jurado A, Blanca M.
Improvement of toxic epidermal necrolysis after the early administration of a single high dose of intravenous
immunoglobulin. Ann Allergy Asthma Immunol 2003;91(1):86-91.
Blanca M, Leyva L, Torres MJ, Mayorga C, Cornejo-Garcia J, Antunez-Rodriguez C, Santamaría LF, Juárez C.
Memory to the hapten in non-immediate cutaneous allergic reactions to betalactams resides in a lymphocyte
subpopulation expressing both CD45RO and CLA markers. Blood Cells Mol Dis 2003;31(1):75-9.
Blanca M, Torres MJ. Hypersensitivity reactions to beta-lactam antibiotics in childhood. Allergol Immunopathol
(Madr) 2003;31(3):103-9.
Torres MJ, Blanca M. Penicillin allergy. Clin Exp Allergy 2003;33(5):714. Torres MJ, Blanca M. Penicillin allergy.
Allergy 2003;58(5):452.
Torres MJ, Corzo JL, Leyva L, Mayorga C, Garcia-Martin FJ, Antunez C, Posadas S, Jurado A, Blanca M.
Differences in the immunological responses in drug- and virus-induced cutaneous reactions in children. Blood
Cells Mol Dis 2003;30(1):124-31.
Mayorga C, Torres MJ, Corzo JL, Alvarez J, García JA, Rodríguez CA, Blanca M, Jurado A. Immediate allergy to
tetanus toxoid vaccine: determination of immunoglobulin E and immunoglobulin G antibodies to allergenic
proteins. Ann Allergy Asthma Immunol 2003;90(2):238-43.
Posadas SJ, Torres MJ, Mayorga C, Juarez C, Blanca M. Gene expression levels of cytokine profile and cytotoxic
markers in non-immediate reactions to drugs. Blood Cells Mol Dis 2002;29(2):179-89.
Torres MJ, Mayorga C, Cornejo-García JA, Romano A, Blanca M. IgE antibodies to penicillin in skin test negative
patients. Allergy 2002;57(10):965.
Martín-Muñoz MF, Pereira MJ, Posadas S, Sánchez-Sabaté E, Blanca M, Alvarez J. Anaphylactic reaction to
diphtheria- tetanus vaccine in a child: specific IgE/IgG determinations and cross-reactivity studies. Vaccine
2002;20(27-28):3409-12.
Carnés J, Fernández-Caldas E, Boluda L, Casanovas M, Sastre J, Lluch Bernal M, Blanca M. Rapid release of
Ole e 1 from olive pollen using different solvents. Allergy 2002;57(9):798-804.
Romano A, Torres MJ, Namour F, Mayorga C, Artesani MC, Venuti A, Guéant JL, Blanca M. Immediate
hypersensitivity to cephalosporins. Allergy 2002;57:52-7.
Mayorga C, Torres MJ, Romano A, Moreno F, Sánchez-Sabater E, Juárez C, Blanca M. Monoclonal antibodies to
amoxicillin express different idiotypes determined by anti-idiotype antibodies production. Allergy 2002;57:45-51.
Sánchez E, Torres MJ, Mayorga C, Reche M, Padial A, Romano A, Blanca M. Adverse drug reactions with an
immunological basis: from clinical practice to basic research. Allergy 2002;57:41-4.
Sáenz de San Pedro B, Mayorga C, Torres MJ, Florido JF, Quiralte J, Blanca M. Boosted IgE response after
anaphylaxis reaction to cefuroxime with cross-reactivity with cefotaxime. Ann Allergy Asthma Immunol
2002;89(1):101-3.
Rosal-Sanchez M, Alvarez J, Torres MJ, Mayorga C, Pérez J, Blanca M. Pigeon Fancier's Lung after low
exposure. Allergy 2002;57(7):649.
Brockow K, Romano A, Blanca M, Ring J, Pichler W, Demoly P. General considerations for skin test procedures in
the diagnosis of drug hypersensitivity. Allergy 2002;57(1):45-51.
Torres MJ, Mayorga C, Leyva L, Guzman AE, Cornejo-García JA, Juarez C, Blanca M. Controlled administration
of penicillin to patients with a positive history but negative skin and specific serum IgE tests. Clin Exp Allergy
2002;32(2):270-6.
Blanca M, Mayorga C, Torres MJ, Warrington R, Romano A, Demoly P, Silviu-Dan F, Moya M, Fernandez J,
Juárez C. Side- chain-specific reactions to betalactams: 14 years later. Clin Exp Allergy 2002;32(2):192-7.
Akesson A, Ingvarsson S, Karlsson F, Leyva L, Blanca M, Cuerden SA, Smith JA, Coleman JW, Borrebaeck CA.
Characterization of specific IgE response in vitro against protein and drug allergens using atopic and normal
donors. Allergy 2002;57(3):193-200.
Mayorga C, Torres MJ, Blanca M. Cephalosporin allergy. N Engl J Med 2002;346(5):380-1.
Posadas SJ, Padial A, Torres MJ, Mayorga C, Leyva L, Sanchez E, Alvarez J, Romano A, Juarez C, Blanca M.
Delayed reactions to drugs show levels of perforin, granzyme B, and Fas-L to be related to disease severity. J
Allergy Clin Immunol 2002;109(1):155-61.
Romano A, Torres MJ, Di Fonso M, Leyva L, Andriolo M, Pettinato R, Blanca M. Delayed hypersensitivity to
cefazolin: report on a case involving lymphocyte transformation studies with different cephalosporins. Ann Allergy
Asthma Immunol 2001;87(3):238-42.
Blanca M, Mayorga C, Torres MJ, Reche M, Moya MC, Rodriguez JL, Romano A, Juarez C. Clinical evaluation of
Pharmacia CAP System RAST FEIA amoxicilloyl and benzylpenicilloyl in patients with penicillin allergy. Allergy
2001;56(9):862-70.
Torres MJ, Romano A, Mayorga C, Moya MC, Guzman AE, Reche M, Juarez C, Blanca M. Diagnostic evaluation
of a large group of patients with immediate allergy to penicillins: the role of skin testing. Allergy 2001;56(9):850-6.
Romano A, Torres MJ, Mayorga C, Artesani MC, Venuti A, Blanca M. Allergy to two drugs in a patient. Allergy
2001;56(8):786- 7.
Luque I, Leyva L, José Torres M, Rosal M, Mayorga C, Segura JM, Blanca M, Juárez C. In vitro T-cell responses
to beta- lactam drugs in immediate and nonimmediate allergic reactions. Allergy 2001;56(7):611-8.
Pérez-Gómez C, Segura JM, Blanca M, Asenjo M, Mates JM. Antioxidant activity levels and oxidative stress as
blood markers of allergic response to drugs. Biochem Cell Biol 2000;78(6):691-8.
Romano A, Mayorga C, Torres MJ, Artesani MC, Suau R, Sánchez F, Pérez E, Venuti A, Blanca M. Immediate
allergic reactions to cephalosporins: cross-reactivity and selective responses. J Allergy Clin Immunol
2000;106(6):1177-83.
Blanca M, Posadas S, Torres MJ, Leyva L, Mayorga C, Gonzalez L, Juarez C, Fernández J, Santamaria LF.
Expression of the skin-homing receptor in peripheral blood lymphocytes from subjects with nonimmediate
cutaneous allergic drug reactions. Allergy 2000;55(11):998-1004.
Posadas SJ, Leyva L, Torres MJ, Rodriguez JL, Bravo I, Rosal M, Fernandez J, Juarez C, Blanca M. Subjects
with allergic reactions to drugs show in vivo polarized patterns of cytokine expression depending on the
chronology of the clinical reaction. J Allergy Clin Immunol 2000;106(4):769-76.
Matés JM, Pérez-Gómez C, Olalla L, Segura JM, Blanca M. Allergy to drugs: antioxidant enzymic activities, lipid
peroxidation and protein oxidative damage in human blood. Cell Biochem Funct 2000;18(2):77-84.
Matés JM, Pérez-Gómez C, Blanca M. Chemical and biological activity of free radical 'scavengers' in allergic
diseases. Clin Chim Acta 2000;296(1-2):1-15.
Romano A, Torres MJ, Quaratino D, Di Fonso M, Perrone MR, Viola M, Venuti A, Blanca M. Diagnostic evaluation
of delayed hypersensitivity to systematically administered drugs. Allergy 1999;54:23-7.
Blanca M, Torres MJ, Mayorga C, Romano A, Perez-Inestrosa E, Suau R. In vitro methods for quantifying IgE
antibodies to betalactams. Allergy 1999;54:8-12.
Leyva L, Torres MJ, Posadas S, Blanca M, Besso G, O'Valle F, del Moral RG, Santamaría LF, Juárez C.
Anticonvulsant- induced toxic epidermal necrolysis: monitoring the immunologic response. J Allergy Clin Immunol
2000;105(1 Pt 1):157-65.
Romano A, Quaratino D, Venemalm L, Torres MJ, Venuti A, Blanca M. A case of IgE-mediated hypersensitivity to
ceftriaxone. J Allergy Clin Immunol 1999;104(5):1113-4.
Torres MJ, Mayorga C, Pamies R, Rodriquez JL, Juarez C, Romano A, Blanca M. Immunologic response to
different determinants of benzylpenicillin, amoxicillin, and ampicillin. Comparison between urticaria and
anaphylactic shock. Allergy 1999;54(9):936-43.
Fernandez J, Blanca M, Soriano V, Sanchez J, Juarez C. Epidemiological study of the prevalence of allergic
reactions to Hymenoptera in a rural population in the Mediterranean area. Clin Exp Allergy 1999;29(8):1069-74.
Brugnolo F, Annunziato F, Sampognaro S, Campi P, Manfredi M, Matucci A, Blanca M, Romagnani S, Maggi E,
Parronchi P. Highly Th2-skewed cytokine profile of beta-lactam-specific T cells from nonatopic subjects with
adverse drug reactions. J Immunol 1999;163(2):1053-9.
Matés JM, Segura JM, Pérez-Gómez C, Rosado R, Olalla L, Blanca M, Sánchez-Jiménez FM. Antioxidant
enzymatic activities in human blood cells after an allergic reaction to pollen or house dust mite. Blood Cells Mol
Dis 1999;25(2):103-9.
Bolzacchini E, Consonni V, Gramatica P, Meinardi S, Orlandi M, Rindone B, Todeschini R, Blanca M, Mayorga C.
Toward an in vitro test for the diagnosis of allergy to penicillins. Synthesis, characterization, and use of betalactam and beta-lactam metabolite poly-L-lysines which recognize human IgE antibodies. Bioconjug Chem
1999;10(3):332-7.
Blanca M, Torres MJ, García JJ, Romano A, Mayorga C, de Ramon E, Vega JM, Miranda A, Juarez C. Natural
evolution of skin test sensitivity in patients allergic to beta-lactam antibiotics. J Allergy Clin Immunol 1999;103(5 Pt
1):918-24.
Leyva L, Torres MJ, Posadas S, Luque I, Gonzalez L, Blanca M, Juarez C, Santamaria LF. Preferential expression
of the skin- homing receptor CLA in peripheral T lymphocytes from patients with drug-allergic reactions. Int Arch
Allergy Immunol. 1999;118(2-4):355-7.
Torres MJ, Gonzalez FJ, Corzo JL, Giron MD, Carvajal MJ, Garcia V, Pinedo A, Martinez-Valverde A, Blanca M,
Santamaria LF. Circulating CLA+ lymphocytes from children with atopic dermatitis contain an increased
percentage of cells bearing staphylococcal-related T-cell receptor variable segments. Clin Exp Allergy
1998;28(10):1264-72.
Blanca M, Canto G, Lopez C, Romano A, Fernandez J, Garcia JC, Juste S, Marti E, Martinez I. The connection
between basic research and clinical practice. Clin Exp Allergy 1998;28:87-91.
Torres MJ, Mayorga C, García JJ, Romano A, Juarez C, Blanca M. New aspects in betalactam recognition. Clin
Exp Allergy 1998;28:25-8.
González FJ, Leyva L, Posadas S, Luque I, Blanca M, Santamaría L, Juarez C. Participation of T lymphocytes in
cutaneous allergic reactions to drugs. Clin Exp Allergy 1998;28:3-6.
Coleman JW, Blanca M. Mechanisms of drug allergy. Immunol Today 1998;19(5):196-8.
Romano A, Quaratino D, Venuti A, Venemalm L, Mayorga C, Blanca M. Selective type-1 hypersensitivity to
cefuroxime. J Allergy Clin Immunol 1998;101(4 Pt 1):564-5.
Romano A, Torres MJ, Fernandez J, Vega JM, Mayorga C, Garcia J, Blanca M. Allergic reactions to ampicillin.
Studies on the specificity and selectivity in subjects with immediate reactions. Clin Exp Allergy 1997;27(12):142531.
Blanca M, Torres MJ, Girón M, Corzo JL, Martínez-Valverde A. Successful administration of cytarabine after a
previous anaphylactic reaction. Allergy 1997;52(10):1009-11.
Fernandez M, Barceló M, Muñoz C, Torrecillas M, Blanca M. Anaphylaxis to thiamine (vitamin B1). Allergy
1997;52(9):958-60.
Gonzalez FJ, Carvajal MJ, del Pozo V, Lahoz C, Santamaria L, Blanca M, Juarez C. Erythema multiforme to
phenobarbital: involvement of eosinophils and T cells expressing the skin homing receptor. J Allergy Clin Immunol
1997;100(1):135-7.
Gonzalez FJ, Carvajal MJ, Leiva L, Juarez C, Blanca M, Santamaria LF. Expression of the cutaneous lymphocyteassociated antigen in circulating T cells in drug-allergic reactions. Int Arch Allergy Immunol 1997;113(1-3):345-7.
Torres MJ, Gonzalez FJ, Mayorga C, Fernandez M, Juarez C, Romano A, Blanca M. IgG and IgE antibodies in
subjects allergic to penicillins recognize different parts of the penicillin molecule. Int Arch Allergy Immunol
1997;113(1-3):342-4.
Terrados S, Blanca M, Justicia JL, Moreno F, Mayorga C. The presence of latex can induce false-positive skin
tests in subjects tested with penicillin determinants. Allergy 1997;52(2):200-4.
Garcia JJ, Blanca M, Moreno F, Vega JM, Mayorga C, Fernandez J, Juarez C, Romano A, de Ramon E.
Determination of IgE antibodies to the benzylpenicilloyl determinant: a comparison of the sensitivity and specificity
of three radio allergo sorbent test methods. J Clin Lab Anal 1997;11(5):251-7.
Romano A, Blanca M, Mayorga C, Venuti A, Gasbarrini G. Immediate hypersensitivity to penicillins. Studies on
Italian subjects. Allergy 1997;52(1):89-93.
Blanca M, Carmona MJ, Moreno F, Mayorga C, Garcia J. Selective immediate allergic response to penicillin V.
Allergy 1996;51(12):961-3.
Miranda A, Blanca M, Vega JM, Moreno F, Carmona MJ, García JJ, Segurado E, Justicia JL, Juarez C. Crossreactivity between a penicillin and a cephalosporin with the same side chain. J Allergy Clin Immunol
1996;98(3):671-7.
Blanca M, Garcia J, Vega JM, Miranda A, Carmona MJ, Mayorga C, Moreno F, Juarez C. Anaphylaxis to
penicillins after non- therapeutic exposure: an immunological investigation. Clin Exp Allergy 1996;26(3):335-40.
Torres MJ, Blanca M, Fernandez J, Esteban A, Moreno F, Vega JM, Garcia J. Selective allergic reaction to oral
cloxacillin. Clin Exp Allergy 1996;26(1):108-11.
Blanca M. Allergic reactions to penicillins. A changing world? Allergy 1995;50(10):777-82.
Fernandez M, Warbrick EV, Blanca M, Coleman JW. Activation and hapten inhibition of mast cells sensitized with
monoclonal IgE anti-penicillin antibodies: evidence for two-site recognition of the penicillin derived determinant.
Eur J Immunol 1995;25(9):2486-91.
Moreno F, Blanca M, Mayorga C, Terrados S, Moya M, Pérez E, Suau R, Vega JM, García J, Miranda A, et al.
Studies of the specificities of IgE antibodies found in sera from subjects with allergic reactions to penicillins. Int
Arch Allergy Immunol 1995;108(1):74-81.
Terrados S, Blanca M, Garcia J, Vega J, Torres MJ, Carmona MJ, Miranda A, Moya M, Juarez C, Fernandez J.
Nonimmediate reactions to betalactams: prevalence and role of the different penicillins. Allergy 1995l;50(7):563-7.
Torres MJ, Garcia JJ, del Caño Moratinos AM, Rondón C, Blanca M. Fixed drug eruption induced by mepivacaine.
J Allergy Clin Immunol 1995;96(1):130-1.
Moreno F, Blanca M, Fernandez J, Ferrer A, Mayorga C, del Caño A, Aguilar F, Juarez C, Garcia J. Determination
of inflammatory markers in allergic reactions to drugs. Allergy Proc 1995;16(3):119-22.
Fernandez J, Blanca M, Moreno F, Garcia J, Segurado E, del Cano A, Aguilar F. Role of tryptase, eosinophil
cationic protein and histamine in immediate allergic reactions to drugs. Int Arch Allergy Immunol 1995;107(13):160-2.
Mayorga C, Obispo T, Jimeno L, Blanca M, Moscoso del Prado J, Carreira J, Garcia JJ, Juarez C. Epitope
mapping of beta- lactam antibiotics with the use of monoclonal antibodies. Toxicology 1995;97(1-3):225-34.
Sanchez F, Blanca M, Fernandez J, Miranda A, Terrados A, Torres MJ, Del Cano A, Garcia JJ, Juarez C.
Comparative study between European and American species of Polistes using sera from European sensitized
subjects. Clin Exp Allergy 1995;25(3):281-7.
Blanca M. The contribution of the side chain of penicillins in the induction of allergic reactions. J Allergy Clin
Immunol 1994;94(3 Pt 1):562-3.
Sanchez F, Blanca M, Miranda A, Carmona MJ, Garcia J, Fernandez J, Torres MJ, Rondon MC, Juarez C.
Comparison of Vespula germanica venoms obtained from different sources. Int Arch Allergy Immunol
1994;104(4):385-9.
Vega JM, Blanca M, García JJ, Carmona MJ, Miranda A, Pérez-Estrada M, Fernández S, Acebes JM, Terrados S.
Immediate allergic reactions to amoxicillin. Allergy 1994;49(5):317-22.
Blanca M, Vega JM, Garcia J, Miranda A, Carmona MJ, Juarez C, Terrados S, Fernandez J. New aspects of
allergic reactions to betalactams: crossreactions and unique specificities. Clin Exp Allergy 1994;24(5):407-15.
Blanca M. Allergic reactions to beta-lactams. Allergol Immunopathol (Madr) 1994;22(3):107-8.
Panzani R, Blanca M, Sánchez F, Juarez C. Sensitivity to European wasps in a group of allergic patients in
Marseille: preliminary results. J Investig Allergol Clin Immunol 1994;4(1):42-6.
Carmona MJ, Blanca M, Garcia A, Fernandez S, Burgos F, Miranda A, Vega JM, Garcia J. Intolerance to
piroxicam in patients with adverse reactions to nonsteroidal antiinflammatory drugs. J Allergy Clin Immunol
1992;90(6 Pt 1):873-9.
Blanca M, Mayorga C, Perez E, Suau R, Juarez C, Vega JM, Carmona MJ, Perez-Estrada M, Garcia J.
Determination of IgE antibodies to the benzyl penicilloyl determinant. A comparison between poly-L-lysine and
human serum albumin as carriers. J Immunol Methods. 1992 Aug 30;153(1-2):99-105.
Juarez C, Blanca M, Miranda A, Sanchez F, Carmona MJ, Avila MJ, Fernandez S, Fernandez J, Terrados S.
Specific IgE antibodies to vespids in the course of immunotherapy with Vespula germanica administered to
patients sensitized to Polistes dominulus. Allergy 1992;47(4 Pt 1):299-302.
Fernández J, Rodes F, Marti J, Blanca M. Wasp sting anaphylaxis as a cause of death: a case report. Allergol
Immunopathol 1992;20(1):40-1.
Blanca M, Mayorga C, Sanchez F, Vega JM, Fernandez J, Juarez C, Suau R, Perez E. Differences in serum IgE
antibody activity to benzylpenicillin and amoxicillin measured by RAST in a group of penicillin allergic patients.
Allergy 1991;46(8):632-8.
Müller U, Mosbech H, Blaauw P, Dreborg S, Malling HJ, Przybilla B, Urbanek R, Pastorello E, Blanca M, Bousquet
J, et al. Emergency treatment of allergic reactions to Hymenoptera stings. Clin Exp Allergy 1991;21(3):281-8.
Vega JM, Blanca M, García JJ, Miranda A, Carmona MJ, García A, Moya MC, Sanchez F, Terrados S. Tolerance
to aztreonam in patients allergic to beta-lactam antibiotics. Allergy 1991;46(3):196-202.
Blanca M, Garcia F, Miranda A, Carmona MJ, Garcia J, Fernandez J, Terrados S, Vega JM, Juarez C.
Determination of IgE antibodies to Polistes dominulus, Vespula germanica and Vespa crabro in sera of patients
allergic to vespids. Allergy 1991;46(2):109-14.
Vega JM, Blanca M, Carmona MJ, Garcia J, Claros A, Juarez C, Moya MC. Delayed allergic reactions to betalactams. Four cases with intolerance to amoxicillin or ampicillin and good tolerance to penicillin G and V. Allergy
1991;46(2):154-7.
Blanca M, Vega JM, Perez E, Carmona MJ, Miranda A, Terrados S, Fernandez J, Suau R. Determination of
specific IgE antibodies to benzylpenicillin and amoxicillin in sera from patients allergic to beta-lactams. Int Arch
Allergy Appl Immunol 1991;94(1-4):376.
Blanca M, Vega JM, Garcia J, Carmona MJ, Terados S, Avila MJ, Miranda A, Juarez C. Allergy to penicillin with
good tolerance to other penicillins; study of the incidence in subjects allergic to beta-lactams. Clin Exp Allergy
1990;20(5):475-81.
Blanca M, Vega JM, Garcia JJ, Carmona MJ, Miranda A. Immediate hypersensitivity reactions to penicillin and
related antibiotics. Clin Exp Allergy 1989;19(5):556-8.
Blanca M, Perez E, Garcia JJ, Miranda A, Terrados S, Vega JM, Suau R. Angioedema and IgE antibodies to
aspirin: a case report. Ann Allergy 1989;62(4):295-8.
Blanca M, Fernandez J, Miranda A, Terrados S, Torres MJ, Vega JM, Avila MJ, Perez E, Garcia JJ, Suau R.
Cross-reactivity between penicillins and cephalosporins: clinical and immunologic studies. J Allergy Clin Immunol
1989;83(2 Pt 1):381-5.
Blanca M, Perez E, Garcia J, Miranda A, Fernandez J, Vega JM, Terrados S, Avila M, Martin A, Suau R.
Anaphylaxis to amoxycillin but good tolerance for benzyl penicillin. In vivo and in vitro studies of specific IgE
antibodies. Allergy 1988;43(7):508-10.
Blanca M, Miranda A, Fernandez J, Terrados S, Vela JM, Vega JM, Gonzalez JJ, Juarez C. Allergic reactions to
vespids: comparison of sensitivities to two species in a Mediterranean area. Clin Allergy 1988;18(1):21-7.
Blanca M, Boulton P, Brostoff J, Gonzalez-Reguera I. Studies of the allergens of Olea europea pollen. Clin Allergy
1983;13(5):473-8.
PARTICIPATIONS AND/OR COMUNICATIONS TO INTERNATIONAL MEETINGS (updated from 2002 till
2007)
Fernández T, Mayorga C, Cornejo-García J, Torres M, Rondon C, Andreu J, Doña I, Blanca M. TÍTULO: Study of
cytokine and chemokine expression in patients with allergic delayed reactions to drugs.:
CONGRES: XXVI Congress of the European Academy of Allergology and Clinical Immunology.
Göteborg (Sweden). 2007.
Cornejo-García J, Torres M, FernándezT, Mayorga C, Carballo M, Hernan I, Antunez C, Blanca M. TÍTULO:
Cytokine and transcriptions factors expression in PBMCs and T cell subpopulations from patients with immediate
and delayed allergic drug reaction.
CONGRES: XXVI Congress of the European Academy of Allergology and Clinical Immunology.
Göteborg (Sweden). 2007.
Rondón C, López S, R-Pena R, Mayorga C, Torres MJ, Antúnez C, Romero JJ, Cornejo- García JA, Doña I,
Blanca M. Allergic and idiopathic rhinitis: differences in the nasal flow cytometry.
CONGRES: XXV Congress of the European Academy of Allergology and Clinical Immunology.
Viena (Austria). 2006.
Fernández TD, Cornejo-García JA, Martín E, Mayorga C, López S, R-Pena R, Doña I, Valenzuela M, RodríguezBada JL, Torres MJ, Blanca M. TÍTULO: DRESS to Phenytoin: Role of T cells.
CONGRES: XXV Congress of the European Academy of Allergology and Clinical Immunology.
Viena (Austria). 2006.
AUTORES/AS: Mayorga C, Fernández TD, Torres MJ, Martín E, Rodriguez-Bada JL, Antunez C, Blanca- López
N, Canto G, Cornejo-García JA, Blanca M.
Survival analysis of in viro tests in patients with hypersensitivity reactions to amoxicillin.
CONGRES: XXV Congress of the European Academy of Allergology and Clinical Immunology.
Viena (Austria). 2006.
Cornejo-Garcia JA, Martin E, Fernandez TD, Mayorga C, Lopez S, R-Pena R, Doña I, Rodriguez-Bada JL, Blanca
M. Response in a Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) to Phenytoin in both
Peripheral Blood and Skin.
CONGRES: 62th Annual Meeting of the American Academy of Allergy, Asthma and Immunology.
Miami (FL, USA). 2006.
Martin E, Cornejo-Garcia JA, R-Pena R, Fernandez TD, Lopez S, Mayorga C, Torres MJ, Antunez C, Valenzuela
M, Blanca M.
Non-immediate Reaction to Iodine Contrast Media.
CONGRES: 62th Annual Meeting of the American Academy of Allergy, Asthma and Immunology.
Miami (FL, USA). 2006.
Fernández TD, Torres MJ, Mayorga C, Martín E, Rodriguez-Bada JL, Antunez C, Blanca N, Cornejo-García JA,
Blanca M.
Rate of negativization of the basophil activation test (Basotest) and RAST in patients with immediate allergic
reactions to amoxicillin.
CONGRES: 62th Annual Meeting of the American Academy of Allergy, Asthma and Immunology.
Miami (FL, USA). 2006.
R-Pena R, López S, Mayorga C, Antúnez C, Torres MJ, Cornejo-García JA, Fernandez TD, Blanca M. TÍTULO:
Role of Dendritic Cells in the Induction of Tolerant and Effector T Lymphocytes-Mediated Responses to
Amoxicillin.
CONGRES: 62th Annual Meeting of the American Academy of Allergy, Asthma and Immunology.
Miami (FL, USA). 2006.
Canto G, Rodriguez-Bada JL, Mayorga C, Torres MJ, R-Pena R, Antunez C, Cornejo-Garcia JA, Fernandez T,
Blanca M.
Influence of a boosting in the recognition and specificity of IgE antibodies in patients with immediate allergic
reaction to betalactams.
CONGRES: 61th Annual Meeting of the American Academy of Allergy, Asthma and Immunology.
San Antonio (TX, USA). 2005.
: Cytokine production patterns in immediate, accelerated and delayed cutaneous reactions to drugs. TÍTULO:
Mayorga C, Cornejo-García JA, Antúnez C, R-Pena R, Fernández T, Torres MJ, Juárez C, Blanca M.
TIPO DE PARTICIPACIÓN: Poster.
CONGRES: 61th Annual Meeting of the American Academy of Allergy, Asthma and Immunology.
San Antonio (TX, USA). 2005.
The anti-inflammatory effect of corticosteroids interferes with the in vitro diagnosis of allergic reactions to these
drugs.
R-Pena R, Torres MJ, Canto G, Mayorga C, Antunez C, Cornejo-Garcia JA, Fernandez C, Blanca M.
CONGRES: 61th Annual Meeting of the American Academy of Allergy, Asthma and Immunology.
San Antonio (TX, USA). 2005.
Torres MJ, Mayorga C, Leyva L, Antúnez C, Cornejo-García JA, Fernández T, Blanca M.
Allergic reactions to macrolides: diagnostic role of lymphocyte transformation test (LTT).
CONGRES: XXIV Congress of the European Academy of Allergology and Clinical Immunology
Munich (Alemagne). : 2005.
R-Pena R, Torres MJ, Canto G, Mayorga C, Antúnez C, Cornejo-García JA, Fernández C, Blanca M. TÍTULO:
Interferences of corticosteroids used in vitro tests for diagnosing allergic reactions to these drugs.
CONGRES: XXIV Congress of the European Academy of Allergology and Clinical Immunology
Munich (Alemagne). : 2005.
Robles S, Fuentes MS, Rodríguez-Bada JL, Torres MJ, Mayorga C, Fernández TD, R- Pena R, Antúnez C,
Cornejo-García JA, Blanca M.
A case of anaphylaxis after mare ́s milk ingest with good tolerance to other milks.
CONGRES: XXIV Congress of the European Academy of Allergology and Clinical Immunology
Munich (Alemagne). : 2005.
Fernández TD, Cornejo-García JA, Mayorga C, Antúnez C, Torres MJ, R-Pena R, López MS, Juárez C, Blanca M.
T cell markers in peripheral blood and skin in delayed cutaneous reactions to drugs.
CONGRES: XXIV Congress of the European Academy of Allergology and Clinical Immunology
Munich (Alemagne). : 2005.
Mayorga, C.; Cornejo-García, J. A.; Antúnez, C.; R-Pena, R.; Fernández, T.; Torres, M. J.; Juárez, C.; Blanca, M.
Comparisons of intracellular protein and mRNA expression of cytokine production in cutaneous reactions to drugs.
CONGRES: XXIV Congress of the European Academy of Allergology and Clinical Immunology
Munich (Alemagne). : 2005.
Canto, G.; Rodriguez-Bada, J. L.; Mayorga, C.; Torres, M. J.; R-Pena R, Antunez C, Cornejo-Garcia JA,
Fernandez T, Blanca M.
Study of the boosting effect in the pattern recognition of IgE antibodies to betalactams. TIPO DE
PARTICIPACIÓN: CONGRES: XXIV Congress of the European Academy of Allergology and Clinical Immunology
Munich (Alemagne). : 2005.
Mayorga, C.; R-Pena, R.; Antúnez, C.; Cornejo-García, J. A.; Fernández, T.; Torres, M. J.; Blanca, M. TÍTULO:
Description of the in vivo and in vitro diagnostic methods available in adverse reactions. TIPO DE
PARTICIPACIÓN: Poster.
II International Meeting: Allergic reactions to drugs. Advances and new perspectives.
Palma de Mallorca (Spain). 2004.
R-Pena, R.; Antúnez, C.; Mayorga, C.; Torres, M. J.; Cornejo-García, J. A.; Fernández, T.; Rodríguez-Bada, J. L.;
Blanca, Specific immunological mechanisms involved in allergic reactions to drugs.
II International Meeting: Allergic reactions to drugs. Advances and new perspectives.
Palma de Mallorca (Spain). 2004.
Antúnez, C.; Cornejo, J. A.; Fernández, T.; Rodríguez-Bada, J. L.; R-Pena, R.; Mayorga, C.; Torres, M. J.; Blanca,
M. In vitro techniques used in the monitorization of an adverse reaction (acute episode and resolution).
II International Meeting: Allergic reactions to drugs. Advances and new perspectives.
Palma de Mallorca (Spain). 2004.
Canto, G.; Rodríguez-Bada, J. L.; Mayorga, C.; Torres, M. J.; R-Pena, R.; Antúnez, C.; Cornejo-García, J. A.;
Fernández, T.; Blanca,
Study of the boosting effect in the pattern recognition of IgE antibodies to betalactams. TIPO DE
PARTICIPACIÓN:
CONGRES: Drug Hypersensitivity Meeting.
Berna (Suiza). AÑO: 2004.
AUTORES/AS: Torres, M. J.; Mayorga, C.; Leyva, L.; Antúnez, C.; Cornejo-García, J. A.; Fernández, T.;
Rodríguez-Pena, R.; Blanca, M. TÍTULO: The role of the lymphocyte transformation test (LTT) in the diagnosis of
allergic reactions to macrolides.
CONGRES: Drug Hypersensitivity Meeting.
Berna (Suiza). AÑO: 2004.
Torres, M. J.; Padial, A.; Fuentes, M. S.; Mayorga, C.; Rodríguez, R.; Fernández, T.; Cornejo-García, J. A.;
Robles, S.; Blanca, M.The role of skin and drug provocation tests in the diagnosis of patients with non-immediate
allergic reactions to betalactams.
CONGRES: XXIII Congress of the European Academy of Allergology and Clinical Immunology. LUGAR DE
Ámsterdam (Holanda). AÑO: 2004.
Cornejo-García, J. A.; Mayorga, C.; Torres, M. J.; Antúnez, C.; Matés, J. M.; Fuentes, M. S.; Blanca, M.; Juárez,
C. Differences in antioxidant enzyme activity in adverse drug reactions. TIPO DE PARTICIPACIÓN: Poster.
CONGRES: XXIII Congress of the European Academy of Allergology and Clinical Immunology.
Ámsterdam (Holanda). AÑO: 2004.
Antúnez, C.; Torres, M. J.; Corzo, J. L.; Mayorga, C.; Vera, A.; Cornejo-García, J. A.; Fernández, T.; Jurado, A.;
Blanca, M. TÍTULO: Evaluation of cytokine production, activation marker and homing receptors in children with
atopic dermatitis and atopic bronchial asthma.
CONGRES: XXIII Congress of the European Academy of Allergology and Clinical Immunology. LUGAR DE
Ámsterdam (Holanda). AÑO: 2004.
Mayorga, C.; Corzo, J.L.; Antúnez, C.; Torres, M.J.; Cornejo-García, J.A.; R Santos, Jurado, A.; Blanca, M.
TÍTULO: Comparison Of Immunological Changes Induced By Sublingual And Subcutaneous Specific
Immunotherapy In Children With Allergic Respiratory Disease.
CONGRES: 61th Annual Meeting of the American Academy of Allergy, Asthma and Immunology. LUGAR DE San
Francisco (CA, USA). 2004.
Cornejo-García, J.A.; Torres, M.J.; Mayorga, C.; Antúnez, C.; Blanca, M.; Matés, J.M.; Juárez, C. Differences in
Antioxidant Enzyme Activity in Adverse Drug Reactions.
TIPO DE PARTICIPACIÓN: Poster.
CONGRES: 61th Annual Meeting of the American Academy of Allergy, Asthma and Immunology. LUGAR DE San
Francisco (CA, USA). 2004.
Antúnez, C.; Torres, M.J.; Mayorga, C.; Corzo, J.L.; Vera, A.; Cornejo-García, J.A.; A Jurado, A.; Blanca, M.
Evaluation of Cytokine Production, Activation Marker and Homing Receptors in Children with Atopic Dermatitis
and Atopic Bronchial Asthma.
CONGRES: 61th Annual Meeting of the American Academy of Allergy, Asthma and Immunology. LUGAR DE San
Francisco (CA, USA). 2004.
Torres, M.J.; Mayorga, C.; Padial, A.; Antúnez, C.; Cornejo-García, J.A.; Rodríguez- Bada, J.L.; Blanca, M. Role
Of The Basophil Activation Test (BASOTEST) In The Diagnosis Of Immediate Allergic Reactions To Betalactams.
61th Annual Meeting of the American Academy of Allergy, Asthma and Immunology. LUGAR DE San Francisco
(CA, USA). 2004.
Antúnez, C.; Santos, R.; Corzo, J.L.; Cornejo-García, J.A.; Mayorga, C.; Torres, M.J.; Jurado, A.; Blanca, M. Early
immunological changes induced by sublingual and subcutaneous specific immunotherapy in children with allergic
respiratory disease.
CONGRES: XXII Congress of the European Academy of Allergology and Clinical Immunology. Paris (France).
2003.
Cornejo-García, J.A.; Torres, M.J.; Mayorga, C.; Romano, A.; Fernández, J.; Sánchez, E.; Padial, A.; Blanca, M.
Intradermal and skin patch test evaluation in non-immediate allergic reactions to penicillins. TIPO DE
PARTICIPACIÓN: Poster.
CONGRES: XXII Congress of the European Academy of Allergology and Clinical Immunology. Paris (France).
2003.
Blanca, M.; Torres, M.J.; Mayorga, C.; Moya, M.C.; Rodríguez-Bada, J.L.; Antúnez, C.; Cornejo-García, J.A.;
Juárez, C.: Allergological study can induce a skin test resensitization in patients with immediate allergic reactions
to betalactams.
CONGRES: XXII Congress of the European Academy of Allergology and Clinical Immunology. Paris (France).
2003.
Cornejo-García, J.A.; Juárez, C.; Antúnez, C.; Torres, M.J.; Sánchez, E.; Álvarez, J., Blanca, M.; Mayorga, C.
Immediate, accelerated and delayed cutaneous reactions to drugs induced different expression in peripheral T cell
markers.
CONGRES: XXII Congress of the European Academy of Allergology and Clinical Immunology. Paris (France).
2003.
Moya, M.C.; Cornejo-García, J.A.; Antúnez, C.; Torres, M.J.; Mayorga, C.; Rodríguez- Bada, J.L.; Romano, A.;
Blanca, M: Boosting effect in patients allergic to betalactams. Evaluation of IgE antibody specificity. TIPO DE
CONGRES: XXII Congress of the European Academy of Allergology and Clinical Immunology. Paris (France).
2003.
Mayorga, C.; Cornejo-García, J.A.; Torres, M.J.; Antúnez, C.; Posadas, S.; Bellón T.; Blanca, M.; Juárez,
Differences in the antioxidant enzyme activity (catalase) and lymphocyte markers in patients with drug allergic
reactions.
CONGRES: XXII Congress of the European Academy of Allergology and Clinical Immunology. Paris (France).
2003.
Blanca, M.; Moya, C.; Rodríguez-Bada, J.L.; Torres, M.J.; Cornejo-García, J.A.; Antúnez, C.; Romano, A. G.;
Mayorga, C. Study of IgE antibody specificity to penicillin after a boosting process in patients allergic to
betalactams.
CONGRES: 60th Anniversary Meeting American Academy of Allergy, Asthma and Immunology.
Denver (CO, USA). 2003.
Torres, M.J.; Fernández, J.; Mayorga, C.; Sánchez, E.; Padial, A.; Cornejo-García, J.A.; Romano, A. G.; Blanca,
M. Diagnosing non-immediate reactions to betalactams: intradermal and skin patch testing standardization.
CONGRES: 60th Anniversary Meeting American Academy of Allergy, Asthma and Immunology.
Denver (CO, USA). 2003.
Moya, M.C.; Torres, M.J.; Cornejo-García, J.A.; Mayorga, C.; Antúnez, C.; Rodríguez- Bada, J.L.; Blanca, M.;
Juárez, C. Skin test resensitization after allergological study in patients with immediate allergic reactions to
betalactams.
CONGRES: 60th Anniversary Meeting American Academy of Allergy, Asthma and Immunology.
Denver (CO, USA). 2003.
Cornejo-García, J.A.; Torres, M.J.; Mayorga, C.; Antúnez, C.; Bellón, T.; Posadas, S.; Blanca, M.; Juárez, C.
Involvement of T cells and the reactive oxygen species in patients with allergic reactions to drugs.
CONGRES: 60th Anniversary Meeting American Academy of Allergy, Asthma and Immunology.
Denver (CO, USA). 2003.
Juárez, C.; Cornejo-García, J.A.; Antúnez, C.; Torres, M.J.; Mayorga, C.; Álvarez, J.; Sánchez, E.; Blanca, M.
Expresión of different markers in peripheral blood from subjects with immediate, accelerated, and delayed
cutaneous reactions to drugs.
CONGRES: 60th Anniversary Meeting American Academy of Allergy, Asthma and Immunology.
Denver (CO, USA). 2003.
Posadas, S.; Torres, M.J.; Leyva, L.; Mayorga, C.; Cornejo-García, J.A.; Sánchez, E.; Bellón, T.; Fernández, J.;
Blanca, M. TÍTULO: Cytokine profiles and cytotoxic markers in toxic epidermal necrolysis treated with and without
corticoids.
CONGRES: 60th Anniversary Meeting American Academy of Allergy, Asthma and Immunology.
Denver (CO, USA). 2003.
Corzo, J.L.; García-Martín, F.J.; Vera, V.; Mayorga, C.; Torres, M.J.; González, L.; Cornejo-García, J.A.; Jurado,
a.; Blanca, M. Toxic epidermal necrolysis induced by lamotrigine in a child: rapid recovery after high dose
intravenous immunoglobulin treatment.
CONGRES: 58th Annual Meeting American Academy of Allergy, Asthma and Immunology.
New York (USA). AÑO: 2002.
Cornejo-García, J. A.; Corzo, J. L.; Torres, M. J; García-Martín, F. J.; Vera, A.; Mayorga, C.; González, L.; Gámez,
F.; Jurado, F.; Blanca, Reversal of toxic epidermal necrolysis after the early administration of a single high dose of
intravenous gammaglobulin.
CONGRESS: Congress of the European Academy of Allergology and Clinical Immunology. LUGAR DE
CELEBRACIÓN: Nápoles (Italia). AÑO: 2002.
NUMBER OF PHD DIRECTED: 16