CURRICULUM VITAE
Ι.
ΙΙ.
Personal Details
Name:
Emmanouil (Manolis)
Surname:
Fousteris
Date of Birth:
16th May 1975
Home Address:
Roikou 2, 26442, Patras, Greece
Phone:
+302610969391
e-mail:
manolisf@upatras.gr
Education
Diploma in Pharmacy, University of Patras, Greece, July 2000.
M.Sc. in Pharmaceutical Chemistry, University of Patras, Greece, November 2002.
Ph.D. in Pharmaceutical Chemistry, University of Patras, Greece, March 2005.
III.
Professional Experience
03 - 2006  06 – 2007
Part-time Lecturer in Organic Chemistry and Medicinal Chemistry courses,
Department of Pharmacy, University of Patras, Greece.
Current Position
Lecturer in Medicinal Chemistry, Department of Pharmacy, University of Patras,
Greece.
IV.
Research Experience
01 - 1999  06 – 2000
Bachelor’s Thesis:
«Improvement of synthetic methodologies for the synthesis of nitrogen mustards
alkylating agents»
CURRICULUM VITAE
Research Supervisor: Assistant Prof. Dr S. Nikolaropoulos
Department of Pharmacy, University of Patras, Greece.
11 - 2000  12 - 2002
Master Thesis:
«S
Synthesis and biological evaluation of steroidal esters of 4-Methyl-3-bis(2chloroethyl)amino benzoic acid (4-Me-CABA)
Research Supervisor: Assistant Prof. Dr S. Nikolaropoulos
Department of Pharmacy, University of Patras, Greece.
09 - 2000  09 - 2002
Research Grant «Κ. Κaratheodori (No 2564), University of Patras, Greece.
«Development of New Anticancer Agents: Synthesis, conformational analysis (2D3D QSAR) and biological evaluation of chlorambucil’s steroidal esters and
derivatives of it»
Research Supervisor: Assistant Prof. Dr G. Pairas
Department of Pharmacy, University of Patras, Greece.
11 - 2002  09 - 2005
Research Grant «Κ. Κaratheodori (No 3013), University of Patras, Greece.
«Development of New Anticancer Agents: The role of the B steroidal ring in
antileukemic activity: Synthesis, conformational analysis (2D-3D QSAR) and
biological evaluation of chlorambucil’s steroidal esters and derivatives of it»
Research Supervisor: Assistant Prof. Dr S. Nikolaropoulos
Department of Pharmacy, University of Patras, Greece.
12 - 2002  06 - 2004
PhD Thesis entitled:
«Synthesis
of
novel
pyrrolocarbazole
analogs
of
aromatic
skeleton
of
indolocarbazole natural products as potential inhibitors of cell cycle enzymes»
Research Supervisor: Assistant Prof. Dr S. Nikolaropoulos
Department of Pharmacy, University of Patras, Greece.
10 - 2005  01-2006
Postdoctoral researcher in CNRS - Université de Reims Champagne-Ardenne,
Unité
Mixte
de
Recherche
No
6519-Réactions
Sélectives
et
Applications, “Catalyse” Group.
2
CURRICULUM VITAE
Research Supervisor: Dr Jacques Muzart, Research Director
Reims, France
02 - 2006  11-2007
Postdoctoral researcher in Laboratory of Medicinal Chemistry, Department of
Pharmacy, University of Patras, Greece.
Research Supervisor: Assistant Prof. Dr S. Nikolaropoulos
Department of Pharmacy, University of Patras, Greece.
11 - 2007 01-2009
Postdoctoral researcher in the Institute of Organic Chemistry, Department of
Chemistry and Mineralogy, University of Leipzig, Germany.
Research Supervisor: Prof. Dr. Athanassios Giannis
Referee in International Scientific Journals
1. Bioorganic & Medicinal Chemistry Letters (Bioorg. Med. Chem. Lett.)
IF=2.478
2. Anti-Cancer Drugs (Anti-Cancer Drug)
IF=1.907
V. Research Grants
09 - 2000  09 – 2002
Research Grant «Κ. Κaratheodori (No 2564), University of Patras, Greece.
«Development of New Anticancer Agents: Synthesis, conformational analysis (2D3D QSAR) and biological evaluation of chlorambucil’s steroidal esters and
derivatives of it»
Research Supervisor: Assistant Prof. Dr G. Pairas
Department of Pharmacy, University of Patras, Greece.
Postgraduate Fellowship
3
CURRICULUM VITAE
11 - 2002  09 – 2005
Research Grant «Κ. Κaratheodori (No 3013), University of Patras, Greece.
«Development of New Anticancer Agents: The role of the B steroidal ring in
antileukemic activity: Synthesis, conformational analysis (2D-3D QSAR) and
biological evaluation of chlorambucil’s steroidal esters and derivatives of it»
Research Supervisor: Assistant Prof. Dr S. Nikolaropoulos
Department of Pharmacy, University of Patras, Greece.
Postgraduate Fellowship
10 - 2006  12- 2007
Pythagoras II, Ministry of Education
«New tetrahydroindole derivatives: Synthesis, biological evaluation and structure
activity-relationship studies in the cardiovascular system»
Research
Coordinator:
Assistant
Prof.
Dr
S.
Nikolaropoulos
Department of Pharmacy, University of Patras, Greece.
Postdoctoral Fellowship
10 - 2008  12 – 2008
Marie Curie Actions, European Union-University of Leipzig, Leipzig, Germany
Σύμβαση Νo MRTN-CT-2004-512348, «Understanding the dynamics of cell
division», «Structuring the ERA»
Research Supervisor: Prof. Dr. Athanassios Giannis
Institut für Organische Chemie, Universität Leipzig, Germany
Postdoctoral Fellowship
12 - 2008  2010
DESMI 2008, Republic of Cyprus and the European Regional Development Fund
“Design, Synthesis and Biological Evaluation on Cardiovascular System of New
Selective Inhibitors of Soluble Guanyl Cyclase”,
Duration time: 2008-2010,
Research Coordinator: Associate Prof. Panayotis Koutentis
Research Scientist
4
CURRICULUM VITAE
2010  2012
Research Grant «Κ. Κaratheodori (C.109), University of Patras, Greece.
«Design, Synthesis and Biological Evaluation of Novel Pyrrolo- Indolo-azepinone
Derivatives as Potential Inhibitors of the Cyclin Dependent Kinase 1 (CDK1).
Research Coordinator: M. Fousteris
VI.
Teaching Experience
11 - 2000  09 – 2004
Teaching-assistant in the tutorial courses of Medicinal Chemistry, Organic
Chemistry and Synthetic Organic Chemistry,
Department of Pharmacy, University of Patras, Greece.
11 - 2000  09 – 2004
Teaching-assistant in the practical courses of Medicinal Chemistry and Synthetic
Organic Chemistry,
Department of Pharmacy, University of Patras, Greece.
01 - 2002  06 - 2003
Teaching-assistant in the practical courses of Genaral Chemistry,
Department of Material Sciences, University of Patras, Greece.
02 - 2006  11 – 2007
Assistant supervisor of MSc and PhD Theses,
Department of Pharmacy, University of Patras, Greece.
03 - 2006  06 – 2007
Part-time Lecturer in Organic Chemistry and Medicinal Chemistry courses,
Department of Pharmacy, University of Patras, Greece.
01 - 2009  today
Lecturer in Medicinal Chemistry and Synthetic Organic Chemistry courses,
Department of Pharmacy, University of Patras, Greece.
5
CURRICULUM VITAE
VII.
Teaching Activities
Undergraduate Courses
(Undergraduate Studies, Department of Pharmacy, University of Patras)
1. Co-instructor of the course “Synthetic Organic Chemistry”, Second Year of
Studies
20092. Co-instructor of the course “Medicinal Chemistry Ι”, Third Year of Studies
20093. Practical course “Synthetic Organic Chemistry ”, Second Year of Studies
20094. Practical course “Medicinal Chemistry I”, Second Year of Studies
20095. Practical course “Medicinal Chemistry IV”, Fourth Year of Studies
2009-
Postgraduate Courses
(Postgraduate Studies, Department of Pharmacy, University of Patras)
1. Co-instructor of the course (ΦΜ-Β02) “Organic Chemistry: Protective GroupsCombinatorial Chemistry ”
20092. Co-instructor of the course (ΦΜ-Β07) “Drug Design”
2009-
VIII. Fellowships and Prizes
1.
Postgraduated Fellow of the Research Grant «Κ. Κaratheodori, No 2564»
University of Patras, Greece, 1/9/2000-30/09/2002
2.
Postgraduated Fellow of the Programm “Interreg II, Greece-Italy”
University of Patras, Greece, 1/3/2001-30/4/2001
Universita degli Studi di Lecce, Italy, 1/6/2001-30/6/2001
6
CURRICULUM VITAE
3.
Award for the first academic year of postgratuated studies from the
National Foundation of Fellowships (IKY)
National Foundation of Fellowships, Greece, 2001
4. Postgraduated Fellow of the Research Grant «Κ. Κaratheodori, No 3013»
University of Patras, Greece, 1/11/2002-30/09/2004
IX.
Membership
Hellenic Society of Medicinal Chemistry
European Federation of Medicinal Chemistry
X.
Specific Skills
Languages
English (First Certificate in English, University of Cambridge)
French (Intermediate knowledge)
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CURRICULUM VITAE
XI.
Publications
1.
Manolis A. Fousteris, Anna I. Koutsourea, Evagelia S. Arsenou, Athanasios Papageorgiou,
Dionisis Mourelatos and Sotiris S. Nikolaropoulos:
Antileukemic and Cytogenetic Effects of Modified and non-Modified Esteric Steroidal
Derivatives of 4-Methyl-3-bis(2-chloroethyl)amino benzoic acid (4-Me-CABA)
Anticancer Research, 22, 2293-2300 (2002).
2.
Venetia Karayianni, Athanasios Papageorgiou, Eleftheria Mioglou, Zafeiroula Iakovidou,
Dionysios Mourelatos, Manolis Fousteris, Anna Koutsourea, Evaggelia Arsenou and Sotiris
Nikolaropoulos:
7-Keto hybrid steroidal esters of nitrogen mustard: cytogenetic and antineoplastic effects
Anticancer Drugs, 13, 637-643 (2002).
3.
Evaggelia S. Arsenou, Anna I. Koutsourea, Manolis A. Fousteris and Sotiris S.
Nikolaropoulos:
Optimization of the allylic oxidation in the synthesis of 7-keto-Δ5-steroidal substrates
Steroids, 68, 407-414 (2003).
4.
Venetia Karayanni, Eleftheria Mioglou, Zafeiroula Iakovidou, Dionisis Mourelatos, Manolis
Fousteris, Anna Koutsourea, Evaggelia Arsenou and Sotiris Nikolaropoulos:
A new approach for evaluating in vivo anti leukemic activity using the SCE assay: An
application of three newly synthesised anti-tumour steroidal esters
Mutation Research/Genetic Toxicology and Enviromental Mutagenesis, 535(1), 79-86 (2003).
5.
Anna I. Koutsourea, Evaggelia S. Arsenou, Manolis A. Fousteris and Sotiris S.
Nikolaropoulos:
Synthetic approaches for the synthesis of a cytostatic steroidal B-D bilactam
Steroids, 68, 659-666 (2003).
6.
E.S. Arsenou, M.A. Fousteris, A.I. Koutsourea and S.S. Nikolaropoulos:
7-Keto-.Δ5-Steroids: Key-Molecules Owning Particular Biological and Chemical Interest
Mini Reviews in Medicinal Chemistry, 3(6), 557-567 (2003).
7.
Manolis A. Fousteris, Anna I. Koutsourea, Evaggelia S. Arsenou, Leondios Leondiadis,
8
CURRICULUM VITAE
Sotiris S. Nikolaropoulos and Ioannis K. Stamos:
Pyrrolocarbazole analogs of aromatic skeleton of indolocarbazole natural products
Journal of Heterocyclic Chemistry, 41, 349-353 (2004).
8.
Evaggelia S. Arsenou, Manolis A. Fousteris, Anna I. Koutsourea, Athanasios Papageorgiou,
Venetia Karayianni, Eleftheria Mioglou, Zafiria Iakovidou, Dionysios Mourelatos and Sotiris
S. Nikolaropoulos:
The allylic 7-ketone at the steroidal skeleton is crucial for the antileukemic potency of
chlorambucil’s active metabolite steroidal esters
Anticancer Drugs, 15, 983-990 (2004).
9.
Agnes Kapou, Manolis A. Fousteris, Sotiris S. Nikolaropoulos, Maria Zervou, Simona G.
Grdadolnikc, Panagiotis Zoumpoulakis, Ioanna Kyrikou, Thomas Mavromoustakos:
2D NMR and conformational analysis of a prototype anti-tumour steroidal ester
Journal of Pharmaceutical and Biomedical Analysis, 38(3), 428-434 (2005).
10.
Athanasios Papageorgiou, Anna I. Koutsourea, Evagelia S. Arsenou, Manolis A. Fousteris,
Dionysios Mourelatos and Sotiris S. Nikolaropoulos:
Srtucture-antileukemic activity relationship study of B and D-ring modified and non-modified
steroidal esters of chlorambucil’s active metabolite
Anticancer Drugs, 16, 1075-1082, (2005).
11.
Manolis A. Fousteris, Anna I. Koutsourea, Sotiris S.Nikolaropoulos, Abdelkhalek Riahi,
Jacques Muzart:
Improved chromium-catalyzed allylic oxidation of Δ5-steroids with t-butyl hydroperoxide
Journal of Molecular Catalysis A: Chemical, 250, 70-74 (2006).
12.
Manolis A. Fousteris, Anna I. Koutsourea, Evaggelia S. Arsenou, Athanasios Papageorgiou,
Dionysios Mourelatos, Sotiris S.Nikolaropoulos:
Structure-anti-leukemic activity relationship study of B- and D-ring modified and nonmodified steroidal esters of chlorambucil
Anti-Cancer Drugs, 17, 511-519 (2006).
13.
Manolis Fousteris, Carole Chevrin, Jean Le Bras and Jacques Muzart:
Water-promoted iodocyclisation of 2-allylphenols
Green Chemistry, 8, 1–3, 2006.
9
CURRICULUM VITAE
14.
M.A. Fousteris, A.I. Koutsourea, E.S. Arsenou, C. Spyridonidou, D. Mourelatos and S.S.
Nikolaropoulos:
Rational design, synthesis and in vitro evaluation of three new alkylating steroidal esters
Medicinal Chemistry, 2, 569-576, 2006.
15.
M. A.Fousteris, A.Papageorgiou, E. S. Arsenou, A. I. Koutsourea, E. Karaberis, D.Mourelatos,
D. O. Onyango, S. S. Nikolaropoulos:
Antileukemic and Cytogenetic Activity by Triple Administration of Three Modified Steroidal
Derivatives of Nitrogen Mustards.
Chemotherapy, 53, 118-126, 2007.
16.
M. A.Fousteris, A.Papageorgiou, E. S. Arsenou, A. I. Koutsourea, D.Mourelatos, S. S.
Nikolaropoulos:
Structure-antileukemic activity relationship study of B- and D-ring modified and nonmodified
steroidal esters of 4-methyl-3-N,N-bis(2-chloroethyl)amino benzoic acid: a comparative study.
Anti-Cancer Drugs, 18, 997-1004, 2007.
17.
Manolis A. Fousteris, Athanasios Papakyriakou, Anna Koutsourea, Maria Manioudaki,
Evgenia Lampropoulou, Evangelia Papadimitriou, Georgios A.Spyroulias, Sotiris S
Nikolaropoulos:
Pyrrolo[2,3-a]carbazoles as Potential Cyclin Dependent Kinase 1 (CDK1) Inhibitors.
Synthesis, Biological Evaluation, and Binding Mode through Docking Simulations.
Journal of Medicinal Chemistry, 51, 1048-1052, 2008.
18.
Anna I. Koutsourea, Manolis A. Fousteris, Evagelia S. Arsenou, Athanasios Papageorgiou,
George N. Pairas, Sotiris S. Nikolaropoulos.
Rational design, synthesis, and in vivo evaluation of the antileukemic activity of six new
alkylating steroidal esters.
Bioorganic & Medicinal Chemistry,,16, 5207-5215, 2008.
19.
Anna I. Koutsourea, Manolis A. Fousteris, Evagelia S. Arsenou, Athanasios Papageorgiou,
George N. Pairas, Sotiris S. Nikolaropoulos:
Synthesis, in vivo antileukemic evaluation and comparative study of novel 5α-7-keto steroidal
esters of chlorambucil and its metabolite
In vivo, 22, 345-352, 2008
10
CURRICULUM VITAE
20.
Katerina Spyridonidou, Manolis Fousteris, Marazioti Antonia, Athanasia Chatzianastasiou,
Andreas Papapetropoulos, Sotiris Nikolaropoulos: Tricyclic indole and dihydroindole
derivatives as new inhibitors of soluble guanylate cyclase
Bioorganic & Medicinal Chemistry Letters, 19, 4810-4813, 2009.
21.
I. Karapidaki, A. Papageorgiou, , G. Geromichalos, M. Fousteris, I. Papaconstadinou, G.
Pairas, A. Koutsourea, D. Mourelatos, S. Nikolaropoulos, T. Lialiaris: Cytogenetic and
antineoplastic effects of modified steroidal alkylators
Genetic Testing and Molecular Biomarkers, 14, 93-97, 2010.
22.
F. Churruca, M. Fousteris, Y. Ishikawa, M. Von Wantoch Rekowski, C. Hounsou, T. Surrey,
A. Giannis: A novel approach to indoloditerpenes by nazarov photocyclization: Synthesis and
biological investigations of terpendole E analogues
Organic Letters 12, 2096-2099, 2010.
23.
M. A. Fousteris, U. Schubert, D. Roell, J. Roediger, N. Bailis, S. S. Nikolaropoulos, A.
Baniahmad, A. Giannis: 20-Aminosteroids as a novel class of selective and complete androgen
receptor antagonists and inhibitors of prostate cancer cell growth
Bioorganic and Medicinal Chemistry 18, 6960-6969, 2010.
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CURRICULUM VITAE
XII.
Publications in National Conferences
1.
6th Conference in Advanced Medicinal Chemistry
Thessaloniki, 28-29 May 1999
“Potential antileukemic agents: an improved method of synthesis of a steroidal b-d bilactam in
order to be used as biological carrier of nitrogen mustards”
A. Ι. Koutsourea, M. Α. Fousteris, E. S. Arsenou, G. N. Pairas and S. S. Nikolaropoulos.
2.
9th Hellenic Symposium of Medicinal Chemistry
Athens, 14-15 January 2000
“The role of 7-keto steroidal group in the antitumor activity and toxicity of steroidal esters
with four different alkylating agents ”
M. Fousteris, Ε. Αrsenou, Α. Κoutsourea, G. Pairas and S. Nikolaropoulos
3.
9th Hellenic Symposium of Medicinal Chemistry
Athens, 14-15 January 2000
“Synthesis and antitumor activity of steroidal esters of 4-Methyl-3-bis(2-chloroethyl)amino
benzoic acid (4-Me-CABA)”
Α. Κoutsourea, M. Fousteris, Ε. Αrsenou, , G. Pairas and S. Nikolaropoulos
4.
9th Hellenic Symposium of Medicinal Chemistry
Athens, 14-15 January 2000
“Optimization of the allylic oxidation -Δ5-steroids for the synthesis of steroidal B-ring
lactams”
Ε. Αrsenou, Α. Κoutsourea, M. Fousteris, G. Pairas and S. Nikolaropoulos
5.
7th Conference in Advanced Medicinal Chemistry
Thessaloniki, 18-20 May 2001
“Pyrrolocarbazole analogs of aromatic skeleton of indolocarbazole natural products”
Fousteris M., Koutsourea A., Arsenou E., Stamos I.and Nikolaropoulos S.
6.
7th Conference in Advanced Medicinal Chemistry
Thessaloniki,, 18-20 May 2001
“A new class of all-trans retinoic acid (ATRA) derivatives and their preliminary evaluation”
Arsenou E., Lagonicacos N., Fousteris M., Koutsourea A., Papageorgiou A. and
Nikolaropoulos S.
7th Conference in Advanced Medicinal Chemistry
Thessaloniki,, 18-20 May 2001
“Acyl chlorides reactivity toward amides in order to protect the hindered nitrogen atom of the
amidic group at steroidal D-lactams”
Koutsourea A., Fousteris M., Diplas A., Arsenou E., Pairas G. and Nikolaropoulos S.
7.
10.
10th Hellenic Symposium of Medicinal Chemistry
Athens, 25-26 January 2002
12
CURRICULUM VITAE
“A new route to the synthesis of the 3β-hydroxy-7α,17α-diaza-B,D-dihomo-5-androsten-7,17dione”
Α. Ι. Koutsourea, Ε. S. Arsenou, Μ. Α. Fousteris and S. S. Nikolaropoulos.
11.
10th Hellenic Symposium of Medicinal Chemistry
Athens, 25-26 January 2002
“In vivo and in vitro evaluation of the antitumor activity after the coadministration of two
nitrogen mustards homo-aza steroidal esters”
Ε. S. Arsenou, Μ. Α. Fousteris, D. Mourelatos, A. Papageorgiou and S. S Nikolaropoulos.
12.
10th Hellenic Symposium of Medicinal Chemistry
Athens, 25-26 January 2002
“Allylic oxidation of Δ5-steroids under phase transfer catalysis conditions”
Α. Ι. Koutsourea, Ε. S. Arsenou, Μ. Α. Fousteris and S. S Nikolaropoulos
13.
10th Hellenic Symposium of Medicinal Chemistry
Athens, 25-26 January 2002
“Synthesis of pyrrolocarbazole analogs of the aromatic skeleton of indolocarbazole natural
products using the Polyphosphoric Acid Trimethylsilyl Ester (PPSE) reagent”
Μ. Α. Fousteris, Ε. S. Arsenou, Α. Ι. Koutsourea, I. K. Stamos and S. S. Nikolaropoulos.
14.
24th National Congress of the Hellenic Biological Sciences Association
Eretria, Evoia, 23-26 May 2002
“Cytogenetic activity of simple and oxidized steroidal esteric derivatives of nitrogen
mustards. A comparative study”
Karagianni V., Arsenou E., Iakovidou Z., Fousteris M., Mioglou E., Koutsourea A., Diplas
A., Nikolaropoulos S and Mourelatos D.
15.
24th National Congress of the Hellenic Biological Sciences Association
Eretria, Evoia, 23-26 May 2002
“Antileukemic activity of an oxidized steroidal esteric derivative of 4-Methyl-3-N,N-bis(2chloroethyl)amino benzoic acid ”
Karagianni V., Arsenou E., Iakovidou Z., Koutsourea A., Mioglou E., Fousteris M.,
Lagonicacos N., Mourelatos D., and Nikolaropoulos S.
16.
24th National Congress of the Hellenic Biological Sciences Association
Eretria, Evoia, 23-26 May 2002
“Structure-activity relationship study of B-homo-aza-steroidal esters of alkylating agents”
Arsenou E., Karagianni V., Koutsourea A., Mioglou E., Fousteris M., Iakovidou Z., Koleti F.,
Nikolaropoulos S and Mourelatos D.
17.
8th Conference in Advanced Medicinal Chemistry
Thessaloniki, Greece, 18-20 April 2003
“Development of a modified method for the effective allylic oxidation of Δ5-steroids”
E. S. Arsenou, A. I. Koutsourea, M. A. Fousteris, A. Diplas and S. S. Nikolaropoulos.
13
CURRICULUM VITAE
18.
8th Conference in Advanced Medicinal Chemistry
Thessaloniki, Greece, 18-20 April 2003
“Preparation of a pyrroloazepine skeleton as precursor for the synthesis of novel
pyrrolocarbazole analogs”
M. A. Fousteris, A. I. Koutsourea, E. A. Arsenou, I. K. Stamos ans S. S. Nikolaropoulos.
19.
8th Conference in Advanced Medicinal Chemistry
Thessaloniki, Greece, 18-20 Απριλίου 2003
“New synthetic procedures for the preparation of a cytostatic B,D-bilactam”
A. I. Koutsourea, E. S. Arsenou, M. A. Fousteris, P. A. Papadimitriou, K. K. Spyridonidou
and S. S. Nikolaropoulos.
20.
8th Conference in Advanced Medicinal Chemistry
Thessaloniki, Greece,18-20 Απριλίου 2003
“In vivo and in vitro studies of the antileukemic activity of three modified steroidal
derivatives of nitrogen mustards after combined administration”
A. I. Koutsourea, M. A. Fousteris, E. S. Arsenou, P. A. Papadimitriou, A. Papageorgiou, D.
Mourelatos, V. Karayanni and S. S. Nikolaropoulos.
21.
11th Hellenic Symposium of Medicinal Chemistry
Patras, 23-24 January 2004
“Combined administration of three modified esteric steroidal derivatives of nitrogen mustards
and evaluation of the antileukemic and cytostatic activity ”
A. Koutsourea, E. Arsenou, M. Fousteris, K. Spyridonidou and S. Nikolaropoulos.
22.
11th Hellenic Symposium of Medicinal Chemistry
Patras, 23-24 January 2004
“Synthesis of a new pyrrolo[3,2-b]carbazoloquinone skeleton via Pd catalyzed oxidative
cyclization”
M. Fousteris, E. Arsenou, A. Koutsourea, I. Stamos and S. Nikolaropoulos.
23.
11th Hellenic Symposium of Medicinal Chemistry
Patras, 23-24 January 2004
“Effect of a retinoic acid analogue on cancer cells proliferation and angiogenesis”
Xountala M., Arsenou E., Nikolaropoulos S., Xatziapostolou M.., Fousteris M. and
Papadimitriou E.
24.
11th Hellenic Symposium of Medicinal Chemistry
Patras, 23-24 January 2004
“Effects of pyrrolocarbazole analogs of the aromatic skeleton of indolocarbazole natural
products on glioblastoma multiform cell-lines proliferation”
Manioudaki M., Fousteris M., Papadimitriou E. And Nikolaropoulos S.
25.
26th Scientific Congress, Hellenic Association of Biological Sciences
Volos, 27-30 May 2004
14
CURRICULUM VITAE
“Antileukemic and cytogenetic activity of a new modified nitrogen mustard steroidal ester:
A comparative study”
Mioglou E., Mourelatos D., Iakwvidou Z., Karapidaki E., Fousteris M., Koutsourea A.,
Arsenou E., Spyridwnidou A. and S. Nikolaropoulos.
26.
5th Conference Medicinal Chemisty: Drug Discovery and Design
Patras, Greece, 11-13 March 2004
“Pyrolocarbazole derivatives of the indolocarbazole framework of natural products and their
anti-proliferative action against glioblastoma multiform cell lines”
Manioudaki M, Fousteris M, Papadimitriou E, Nikolaropoulos S.
27.
9th Conference in Advanced Medicinal Chemistry
Thessaloniki, Greece, 20 and 21 May 2005
“On the protection of 2-carboxyethyl- pyrrole and 4,5,6,7-tetrahydroindole derivatives”
Fousteris Manolis, Onyango O. David, Koutsourea Anna, Arsenou Evagelia, Spyridonidou
Katerina and Nikolaropoulos Sotiris.
28.
9th Conference in Advanced Medicinal Chemistry
Thessaloniki, Greece, 20 and 21 May 2005
“Preparation of functionalized 2-carboxyethyl-4,5,6,7-tetrahydroindole derivatives as key
intermediates to the synthesis of modified pyrrolo[2,3-a]carbazole derivatives”
Fousteris Manolis, Onyango O. David, Koutsourea Anna, Arsenou Evagelia, Spyridonidou
Katerina and Nikolaropoulos Sotiris.
29.
9th Conference in Advanced Medicinal Chemistry
Thessaloniki, Greece, 20 and 21 May 2005
“The effect of B ring modification on the toxicity of D-lactamic steroidal esters of
chlorambucil and its analogues. A comparative study.”
Koutsourea Anna, Arsenou Evagelia, Onyango O. David, Fousteris Manolis, Lagonicacos
Nikos, Spyridonidou Katerina, Papageorgiou Athanasios and Nikolaropoulos Sotiris.
30.
9th Conference in Advanced Medicinal Chemistry
Thessaloniki, Greece, 20 and 21 May 2005
“Comparative study of the in vivo antineoplastic activity of B-ring lactamic androsten esters
of chlorambucil and its analogs”
Koutsourea Anna, Arsenou Evagelia, Onyango O. David, Fousteris Manolis, Lagonicacos
Nikos, Spyridonidou Katerina, Papageorgiou Athanasios and Nikolaropoulos Sotiris.
35.
9th Conference in Advanced Medicinal Chemistry
Thessaloniki, Greece, 20 and 21 May 2005
“Antileukemic and cytogenetic effects by 7-oxidized steroidal mesters of nitrogen mustards”
Mourelatos D., Iakovidou Z., Mioglou E., Karapidaki E., Koutsourea A., Fousteris M.,
Arsenou E. and Nikolaropoulos S.
36.
12th Hellenic Symposium of Medicinal Chemistry
Patras, 27-28 January 2006
15
CURRICULUM VITAE
“Study of interaction a new inhibitor with the active site of the enzyme CDK2, through
docking simulation”
Vlaxopoulos Georgios, Fousteris Manolis, Spyroulias Georgios, Nikolaropoulos Sotiris.
37.
12th Hellenic Symposium of Medicinal Chemistry
Patras, 27-28 January 2006
“Syntheis of new pyrroloazepinoindole skleton with potential inhibitory activity against protein
kinases”
Koutsandrea Eythimia, Fousteris M., Stamos I., Papagerorgopoulou A., Koutsourea A.,
Nikolaropoulos S.,
38.
12th Hellenic Symposium of Medicinal Chemistry
Patras, 27-28 January 2006
“Rational design, synthesis and antileukemic activity of six new alkylating steroidal esters”
Α.Ι. Koustsourea, Μ.Α. Fousteris, Ε.S. Arsenou, Α. Papagergiou, S.S. Nikolaropoulos.
39.
12th Hellenic Symposium of Medicinal Chemistry
Patras, 27-28 January 2006
“Synthesis and in vitro evaluation of the antileukemic activity of new steroidal esters of Nacetyl melphalan”
K. Spyridonidou, Manolis Fousteris, Anna Koutsourea, Dionisis Mourelatos, Eleni Dima,
Sotiris Nikolaropoulos.
40.
12th Hellenic Symposium of Medicinal Chemistry
Patras, 27-28 January 2006
“Design and Synthesis of modified pyrrolo[2,3-a]carbazole analogs.”
David O.Onyango, Stella Kokoli, Fotini Selasidi, Manolis Fousteris, Anna Koutsourea and
Sotiris Nikolaropoulos.
41.
12th Hellenic Symposium of Medicinal Chemistry
Patras, 27-28 January 2006
“Synthesis of new pyrroloazepinoindoles as structural analogs of known CDK inhibitors”
Manolis Fousteris, Stella Kokoli, Ioannis Stamos, David O.Onyango, Efthymia Koutsandrea,
Anna Koutsourea and Sotiris Nikolaropoulos.
42.
7th Conference Medicinal Chemisty: Drug Discovery and Design
Patras, Greece, 8-11 March 2006
“Synthesis of new pyrroloazepinoindole skeleton analogs with potential protein kinase
inhibitory activity”
Efthymia Koutsandrea, Manolis Fousteris, Stella Kokoli, David O.Onyango, Ioannis Stamos,
Anna Koutsourea and Sotiris Nikolaropoulos.
43.
7th Conference Medicinal Chemisty: Drug Discovery and Design
Patras, Greece, 8-11 March 2006
“Synthesis of new pyrroloazepinoindole analogs,with potential CDK inhibitory activity”
16
CURRICULUM VITAE
Stella Kokoli, Manolis Fousteris, Efthymia Koutsandrea, Andromaxi Papageorgopoulou,
Ioannis Stamos, Anna Koutsourea and Sotiris Nikolaropoulos.
44.
5th Hellenic Forum on Bioactive Peptides
Patras, Greece, 14-16 May 2006
“Study of interaction of ethyl 9-chloro-1H-pyrrolo[2,3-a]carbazole-2-carboxylate with the
active site of CDK2 and CDK1, through docking simulation.”
Georgios F. Vlachopoulos, Manolis Fousteris, Georgios A. Spyroulias and S. Nikolaropoulos.
45.
10th Conference in Advanced Medicinal Chemistry
Thessaloniki, Greece, 25 and 26 May 2007
“The role of the presence of Δ5-7-keto conjugated steroidal system on the antileukemic potency
of nitrogen mustard steroidal esters”
Koutsourea Anna, Spyridonidou Katerina, Fousteris Manolis, Dima Eleni, Evagelia Arsenou,
Papageorgiou Athanasios and Nikolaropoulos Sotiris.
46.
10th Conference in Advanced Medicinal Chemistry
Thessaloniki, Greece, 25 and 26 May 2007
“Novel pyrrolo[2,3-a]carbazole analogs as potential inhibitors of CDKs”
Fotini Selasidi, Manolis Fousteris, Michalis Batistatos, Stathis Spyropoulos, Katerina
Spyridonidou, Anna Koutsourea and Sotiris Nikolaropoulos.
47.
27th ESMEC-Urbino School of Medicinal Chemistry
Urbino, Italy, 1-6 July 2007
“Design and synthesis of modified Pyrrolo[2,3-α]carbazole analogs”
Manolis Fousteris, Katerina Spyridonidou, Anna Koutsourea and Sotiris Nikolaropoulos.
48.
13th Hellenic Symposium of Medicinal Chemistry
Athens, 14-15 March, 2008
“Molecular targeting of protein kinases: Design and synthesis of pyrroloazepinoindole analogs”
Koutsandrea E., Fousteris M., Syridonidou K., Koutsourea A., Nikolaropoulos S.
49.
13th Hellenic Symposium of Medicinal Chemistry
Athens, 14-15 March, 2008
“Design and synthesis of modified pyrrolo[2,3-a]carbazole analogs”
Spiropoulos E., Fousteris Μ., Spyridonidou K., Nikolaropoulos S.
50.
14th Hellenic Symposium of Medicinal Chemistry
Thessaloniki, 23-25 April, 2010
“New Tricyclic Indole and Dihydroindole Derivatives as Potential Inhibitors of Soluble
Guanylate Cyclase”
Aikaterini Anatoliti, Panoraia Choli, Vasiliki Politi, Manolis Fousteris, Andreas
Papapetropoulos and Sotiris Nikolaropoulos.
17
CURRICULUM VITAE
51.
52.
14th Hellenic Symposium of Medicinal Chemistry
Thessaloniki, 23-25 April, 2010
“Exploring the CDK1 Inhibitory Potency of the Pyrrolo[2,3-a]carbazole Skeleton”
Efstathios Spyropoulos, Andreas Montzolis, Athanasia Chatzianastasiou, Anna Koutsourea,
Athanasios Papakyriakou, Manolis Fousteris, Georgios Spyroulias Andreas Papapetropoulos
and Sotiris Nikolaropoulos.
.
14th Hellenic Symposium of Medicinal Chemistry
Thessaloniki, 23-25 April, 2010
“Third generation of antileukemic compounds: History, evaluation and future perspectives”
S. Nikolaropoulos, M. Fousteris, G. Pairas, C. Kamoutsis, E. Arsenou, A. Koutsourea, A.
Kapou and I. Papakonstantinou.
XIII. Publications in International Conferences
1.
EUROPEAN ASSOCIATION FOR CANCER RESEARCH
(EACR) XVI-2000
ANNUAL MEETING
Athos-Halkidiki-Hellas, 30 May-3 June 2000
“Potential Antitumor Agents: Esters of two 7-keto steroidal D-Lactams with two different
aromatic nitrogen mustards”.
A. Papageorgiou, L. Boutis, E. Chrysogelou, D. Mourelatos, E. Arsenou, M. Fousteris and S.
Nikolaropoulos.
2.
23rd Annual meeting. European Organization of Research and Treatment of Cancer
Pharmacology and Molecular Mechanisms PAMM
Copenhagen, Denmark, January 23-26, 2002
“Newly synthesized steroidal alkylating derivatives as promising antitumour drugs for clinical
trials?”
V. Karagianni, Ε. Mioglou, Ζ. Iakovidou, D. Mourelatos, Μ. Fousteris, Α. Koutsourea, Ε.
Arsenou and S. Nikolaropoulos.
3.
7th International Symposium on Predictive Oncology and Intervention Strategies
Nice, France, Februarry 7-10, 2004
“Anti-proliferative activity of pyrrolocarbazole analogues of the indolocarbazole skeleton of
natural products against glioblastoma multiform cell lines”
M A Fousteris, M E.Manioudaki, E. P. Papadimitriou, S. S. Nikolaropoulos.
4.
95th American Association for Cancer Research (AACR)
Orlando,Florida, USA, March 27-31, 2004
“Antileukemic activity of two newly synthesized steroidal derivatives of chlorambucil and its
active metabolite”
Sotiris S. Nikolaropoulos, Anastasios L. Boutis, Evaggelia S. Arsenou, Anna I. Koutsourea,
18
CURRICULUM VITAE
Manolis A. Fousteris, Dionisis Mourelatos, Venetia Karayianni, Athanasios Papageorgiou
Lazaros Boutis.
5.
7th International Conference of Anticancer Research
Corfu, October 25-30, 2004
“Cytogenetic effects of 7-oxidized steroidal esters of nitrogen mustards”
D. Mourelatos, E. Mioglou, Z. Iakovidou, A. Koutsourea, M. Fousteris, E. Arsenou and S.
Nikolaropoulos.
6.
Review of Clinical Pharmacology and Pharmacokinetics, Int. Ed., 18, 52-54, 2004
“SCEs and PRIs as indicators of structure-biological activity relationship of newly
synthesized steroidal esters”
D. Mourelatos, Z. Iakovidou, E. Mioglou, E. Karapidaki, A. Koutsourea, E. Arsenou, M.
Fousteris, S.Nikolaropoulos
7.
5th International Conference on Organic Chemistry for Young Scientists (InterYCOS
2009)
Saint-Petersburg, Russia June 22-25, 2009
“Towards The Total Synthesis of Terpendole E”
Churruca Fatima, Ishikawa Yuichi, Fousteris M., Giannis Athanassios.
8.
18th European Symposium on Quantitative Structure-Activity Relationships
Rhodes, Greece, September 19-24, 2010
“Optimization of pyrrolo[2,3-a]carbazoles as CDK1 inhibitors. Synthesis, Kinase Inhibitory
Activity, and Binding Mode Through Docking Simulations”
Efstathios Spyropoulos, Andreas Montzolis, Athanasia Chatzianastasiou, Athanasios
Papakyriakou, Manolis Fousteris, Georgios Spyroulias, Andreas Papapetropoulos and Sotiris
Nikolaropoulos.
19