Job Title: - Jobs - University of Nottingham

advertisement
UNIVERSITY OF NOTTINGHAM
RECRUITMENT ROLE PROFILE FORM
Job Title:
Research Fellow (Medicinal Chemistry) – Fixed term
School:
School of Pharmacy
Salary:
£28,132 to £30,728 per annum depending on skills and experience
Hours of Work:
Full-time, 36¼ hours per week
Contract Status:
This post will be offered on a fixed-term contract for a period of 12 months.
Location:
School of Pharmacy, Centre for Biomolecular Sciences, University Park
Responsible to:
Prof Peter Fischer
Job Outline:
To work in a multidisciplinary team to (a) carry out structure-based ligand design through docking
and other techniques (b) optimise potency, selectivity, and pharmaceutical properties of selected
compounds, and (c) participate in the biological evaluation of project compounds and interact and
coordinate research activities with internal and external project collaborators
Main Duties and Responsibilities:
 Iterative design of kinase inhibitor compounds through structure-based medicinal chemistry
using traditional SAR methods, as well as receptor- and ligand-focussed docking and alignment
studies
 Design of synthetic routes to molecules of interest
 Preparation and purification of compounds
 Contribution to the biological evaluation of project compounds
 Interaction and coordination of research activities with external project collaborators
 Presentation of results at internal and external meetings
 Preparation and presentation of progress reports and contributing to scientific publications
 Assistance in the supervision of undergraduate and postgraduate students
 Organisation and assistance in general laboratory duties such as ordering of reagents,
equipment maintenance, and laboratory housekeeping
 Active contribution to group meetings by e.g. problem solving, suggestions, etc.
Person Specification:
Qualifications/
Education
Skills/Training
Experience
Essential
 A good first degree
 PhD (or equivalent) in medicinal
chemistry or a closely related
discipline.
 Excellent skills in organic synthesis
& medicinal heterocyclic chemistry
 Expertise in NMR, LC-MS and HPLC
and other analytical techniques
 Familiarity with biochemical and
cell-based assays and molecular
pharmacology
 Excellent problem solving abilities
 Good communication skills
 Write high quality reports and
papers for publication
 Present work effectively to a
variety of professional and
academic audiences at meetings
Desirable
 Drug discovery and
(industrial) working
experience






Structure-activity relationship
analysis
Computational medicinal
chemistry and drug design
Hands-on experience with
biochemical and cell-based
assays and molecular
pharmacology
Enzyme inhibitor discovery;
Patent production
Peer-reviewed publication
and presentations at peerreviewed conferences and
and conferences

Personal Attributes






meetings
Excellent information
technology and computing
skills
Strong commitment to the study
of medicinal chemistry
Flexible, independent working
Integrity
Ability to work well in a
multidisciplinary team
Ability to work to deadlines and
prioritise tasks
Proactive and dedicated approach
Due to the requirements of the UK Border and Immigration Agency, applicants who are not UK or
EEA nationals and whose immigration status entitles them to work without restriction in the UK will
be considered on an equal basis with UK and EEA nationals. Other non-UK or non-EEA nationals
whose employment will require permission to work subject to a resident labour market test may
only be considered if there are no suitable UK or EEA national candidates for the post. Please visit
http://www.ukba.homeoffice.gov.uk/ for more information.
Informal enquiries should be addressed to Prof P M Fischer, tel 0115 846 6242 or Email
[email protected] Please note that applications sent directly to this email address
cannot be accepted.
Please quote ref. SCI/008714.
Download