UNIVERSITY OF NOTTINGHAM RECRUITMENT ROLE PROFILE FORM Job Title: Research Fellow (Medicinal Chemistry) – Fixed term School: School of Pharmacy Salary: £28,132 to £30,728 per annum depending on skills and experience Hours of Work: Full-time, 36¼ hours per week Contract Status: This post will be offered on a fixed-term contract for a period of 12 months. Location: School of Pharmacy, Centre for Biomolecular Sciences, University Park Responsible to: Prof Peter Fischer Job Outline: To work in a multidisciplinary team to (a) carry out structure-based ligand design through docking and other techniques (b) optimise potency, selectivity, and pharmaceutical properties of selected compounds, and (c) participate in the biological evaluation of project compounds and interact and coordinate research activities with internal and external project collaborators Main Duties and Responsibilities: Iterative design of kinase inhibitor compounds through structure-based medicinal chemistry using traditional SAR methods, as well as receptor- and ligand-focussed docking and alignment studies Design of synthetic routes to molecules of interest Preparation and purification of compounds Contribution to the biological evaluation of project compounds Interaction and coordination of research activities with external project collaborators Presentation of results at internal and external meetings Preparation and presentation of progress reports and contributing to scientific publications Assistance in the supervision of undergraduate and postgraduate students Organisation and assistance in general laboratory duties such as ordering of reagents, equipment maintenance, and laboratory housekeeping Active contribution to group meetings by e.g. problem solving, suggestions, etc. Person Specification: Qualifications/ Education Skills/Training Experience Essential A good first degree PhD (or equivalent) in medicinal chemistry or a closely related discipline. Excellent skills in organic synthesis & medicinal heterocyclic chemistry Expertise in NMR, LC-MS and HPLC and other analytical techniques Familiarity with biochemical and cell-based assays and molecular pharmacology Excellent problem solving abilities Good communication skills Write high quality reports and papers for publication Present work effectively to a variety of professional and academic audiences at meetings Desirable Drug discovery and (industrial) working experience Structure-activity relationship analysis Computational medicinal chemistry and drug design Hands-on experience with biochemical and cell-based assays and molecular pharmacology Enzyme inhibitor discovery; Patent production Peer-reviewed publication and presentations at peerreviewed conferences and and conferences Personal Attributes meetings Excellent information technology and computing skills Strong commitment to the study of medicinal chemistry Flexible, independent working Integrity Ability to work well in a multidisciplinary team Ability to work to deadlines and prioritise tasks Proactive and dedicated approach Due to the requirements of the UK Border and Immigration Agency, applicants who are not UK or EEA nationals and whose immigration status entitles them to work without restriction in the UK will be considered on an equal basis with UK and EEA nationals. Other non-UK or non-EEA nationals whose employment will require permission to work subject to a resident labour market test may only be considered if there are no suitable UK or EEA national candidates for the post. Please visit http://www.ukba.homeoffice.gov.uk/ for more information. Informal enquiries should be addressed to Prof P M Fischer, tel 0115 846 6242 or Email [email protected] Please note that applications sent directly to this email address cannot be accepted. Please quote ref. SCI/008714.