Curriculum Vitae
RICHARD PASCHAL COCHRAN, M.D.
PERSONAL DATA
Office Address:
Maui Memorial Medical Center
221 Mahalani St
Wailuku, HI 96793
Home Address:
708 Noweo Place
Wailuku, HI 96793
Office Contacts:
(808) 242-2680 office
(808) 214-2691 cell
rcochran@hhsc.org e-mail
Home Contacts:
(808) 214-6168
Birthdate and Place:
January 9, 1952
Anderson, South Carolina
EDUCATION
College:
1970-1974
B.S., Premed
Davidson College; Davidson, North Carolina
Medical School:
1974-1978
M.D.
Emory University School of Medicine; Atlanta, Georgia
Post Graduate Training:
1985-1986
Chief Resident
Cardiovascular and Thoracic Surgery
University of Utah; Salt Lake City, Utah
1984-1985
Resident
Cardiovascular and Thoracic Surgery
University of Utah; Salt Lake City, Utah
R.P. Cochran, M.D.
Page 2
1983-1984
Chief Resident
General Surgery
University of Texas Health Science Center; Dallas, Texas
1981-1982
Surgical Research Fellowship
Transplant Immunology
University of Texas Health Science Center; Dallas, Texas
1979-1983
General Surgery Residency
University of Texas Health Science Center; Dallas, Texas
1978-1979
Internship, General Surgery
University of Texas Health Science Center; Dallas, Texas
POSITIONS HELD
2008-present
Director of Cardiovascular and Thoracic Surgery
Maui Memorial Medical Center
Wailuku, Hawaii
2002-2008
Medical Director of Cardiac Surgery
Central Maine Heart and Vascular Institute
Central Maine Medical Center, Lewiston, Maine
2006- present
Graduate Faculty, Mechanical Engineering
University of Maine, Orono, Maine
2007- present
Vice-President
Superior Surgical Solutions
Auburn, Maine
1998-2002
Professor and Chair
Division of Cardiothoracic Surgery
University of Wisconsin; Madison, Wisconsin
1995-1998
Associate Professor
Division of Cardiothoracic Surgery
University of Washington; Seattle, Washington
1990-1995
Assistant Professor
Division of Cardiothoracic Surgery
University of Washington; Seattle, Washington
1986-1990
Assistant Professor
Division of Thoracic and Cardiovascular Surgery
University of Texas Southwestern Medical School; Dallas, Texas
R.P. Cochran, M.D.
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1981-1984
Instructor, Surgery
Physicians’ Assistant Program
University of Texas Health Science Center; Dallas, Texas
HOSPITAL POSITIONS HELD
2008-present
Maui Memorial Medical Center
2002-2008
Central Maine Medical Center, Lewiston, Maine
1998-2002
University of Wisconsin Hospital and Clinics, Madison, Wisconsin
1998-2002
William S. Middleton Memorial Veterans Affairs Hospital,
Madison, Wisconsin
1990-1998
University of Washington Medical Center, Seattle, Washington
1990-1998
Harborview Medical Center, Seattle, Washington
1990-1998
Veterans Affairs Hospital, Seattle, Washington
1995-1996
Chief, Cardiothoracic Surgery
Veterans Affairs Medical Center, Seattle, Washington
1987-1990
Children’s Medical Center of Dallas, Dallas, Texas
1987-1990
St. Paul Medical Center, Dallas, Texas
1986-1990
Parkland Memorial Hospital, Dallas, Texas
1986-1990
Medical Director, Cardiovascular and Thoracic Intensive Care Unit
Parkland Hospital; Dallas, Texas
1986-1990
Veterans Administration Medical Center; Dallas, Texas
R.P. Cochran, M.D.
Page 4
BOARD CERTIFICATIONS
1979
1985
1994
2002
1987
1996
1996
1996
2004
FLEX
American Board of Surgery – #30633
American Board of Surgery Recertification
American Board of Surgery Recertification (exp 07/2015)
American Board of Thoracic Surgery – #4493
American Board of Thoracic Surgery Recertification
American Board of Thoracic Surgery Recertification (exp 12/2107)
Surgical Critical Care, American Board of Surgery – # 1507
Surgical Critical Care, American Board of Surgery (exp 10/2017)
CURRENT LICENSES TO PRACTICE
Maine
Hawaii
Wisconsin
Washington
Utah
Texas
#016119
#MD-13921
#40092
#27949
#84-172067-1205
#F3849
Valid since 11/01/02
Valid since 08/01/02
Valid since 08/28/98
Valid since 01/09/90
Valid since 01/31/84
Valid since 05/31/79
PROFESSIONAL ORGANIZATIONS
Association for Academic Surgery
American Heart Association
American Society for Artificial Internal Organs
Fellow, American Association of Thoracic Surgeons
Fellow, American College of Chest Physicians
Fellow, American College of Cardiology
Fellow, American College of Surgeons
Henry Harkins Surgical Society
International Association for Cardiac Biological Implants
International Society for Heart and Lung Transplantation
Le Club Mitrale
Pacific Coast Surgical Association
Parkland Surgical Society
Seattle Surgical Society
Society of Critical Care Medicine
Society for Heart Valve Disease
Society of Thoracic Surgeons
Surgeons As Educators
Maine State Medical Association
Western Thoracic Surgical Association
Expires 01/31/12
Expires 01/31/10
Expires 10/31/11
Expires 01/09/12
Expires 01/31/12
Expires 05/31/11
R.P. Cochran, M.D.
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AWARDS
Madison Area’s Best Doctors, Cardiothoracic Surgery, 2000, Madison Magazine
America’s Top Surgeons, Cardiothoracic Surgery, 2004-2005, Consumer Research
Council of America
TEACHING RESPONSIBILITIES
1993-1998
Chairman, Cardiothoracic Division Education Committee, University of
Washington–Seattle
• Devise overall educational program for Cardiothoracic Residents,
General Surgery Residents, Externs, and PA students
1993-1998
Director, Core Curriculum for Cardiothoracic Surgery Residency,
University of Washington–Seattle
• Weekly Teaching Rounds - General Surgery residents and externs
• Wednesday Cath Conference and Grand Rounds
• Saturday Conference (Didactic Lectures, Current Journal Club,
Selected Readings)
1994-1998
Co-Director, Biomedical Engineering Journal Club, University of
Washington–Seattle
1994-2002
Editor, Selected Readings in Cardiothoracic Surgery “Classics in CardioThoracic Surgery”
Student Mentorship
Medical Students–Primary Mentor
1.
Ann Branchaud, M.D., School of Medicine, University of Washington–Seattle, Advisor,
Medical Student Research: Cardiac Surgery in Octogenarians, 8/95-3/98.
2.
Wendy Norris, M.D., School of Medicine, University of Washington–Seattle, Advisor,
Medical Student Research: Replacement of Pharmacologic Potassium Supplement with
Potassium-Rich Substitutes, 6/95-3/98.
Doctoral Students–Supervisory Committee Member
3.
Karyn S. Kunzelman, Ph.D., Doctoral Degree in Biomedical Engineering, University of
Texas Southwestern Medical Center–Dallas, Dissertation Title: Engineering Analysis of
Mitral Valve Structure and Function, 8/86-4/91.
4.
Jane Grande, Ph.D., Doctoral Degree in Bioengineering, University of Washington– Seattle,
Dissertation Title: The Aortic Root–Aortic Valve Relationship in the Normal, Diseased, and
Surgically Repaired States, 10/91-4/98.
5.
David Quick, B.S., Doctoral Degree in Bioengineering, University of Wisconsin– Madison,
Dissertation Research: Mitral Valve Remodeling, 9/98-5/01.
R.P. Cochran, M.D.
Page 6
6.
Dan Einstein, B.S., Doctoral Degree in Bioengineering, University of Washington– Seattle,
Thesis Research: Modal Analysis of Heart Sounds, 1/97-11/02.
Master’s Students–Committee Member
7.
Matthew Reimink, Master’s Degree in Bioengineering, University of Washington–Seattle,
Thesis Title: Evaluation of Mitral Valve Ring Annuloplasty, 10/93-6/96.
8.
David Quick, B.S., Master’s Degree in Mechanical Engineering, University of Washington–
Seattle, Thesis Title: Mitral Valve Response to Cardiac Ischemia Induced Stress Changes:
Implications to Valve Repair and Replacement Design, 1/95-5/98.
9.
Adam Berman, B.S., Master’s Degree in Mechanical Engineering, University of
Washington– Seattle, Thesis Research: Stress Patterns in Thoracic Aneurysms–A Finite
Element Model, 10/96-10/98.
10. Mario Tapia, B.S., Master’s Program, Mechanical Engineering, University of Washington–
Seattle, Thesis Research: Combined Mechanical and Fluid Modeling of the Mitral Valve:
11/96-12/99.
11. Jeff Kasalko, M.S., Master’s Degree in Biomedical Engineering, University of Wisconsin–
Madison, Thesis Research: The Biaxial Properties of Porcine Ascending Aortic Wall Tissue,
10/98-5/01.
12. Laura Kranendonk, M.S., Master’s Degree in Biomedical Engineering, University of
Wisconsin–Madison, Thesis Research: Effect of Shear Stress and Binding Substrate on
Endothelial Cell Adhesion, 9/99-5/01.
13. Kelley Dwyer, B.S., Master’s Degree in Biomedical Engineering, University of Wisconsin–
Madison, Thesis Research: Regurgitation Dependent Collagen Concentration in Ovine
Mitral Valves, 9/99-8/01.
14. Kristina Jensen, B.S., Master’s Program, Biomedical Engineering, University of Wisconsin–
Madison, Thesis Research: Quantitative Histologic Analysis of Mitral Valve Tissue, 1/006/02.
15. Talya Reilly, B.S., Master’s Program, Biomedical Engineering, University of Wisconsin–
Madison, Thesis Research: Biaxial Properties of Photofixed Pericardium, 8/01-8/02.
R.P. Cochran, M.D.
Page 7
Additional Educational Responsibilities
1991-1998
Co-Director, Division of Cardiothoracic Surgery Continuing Medical
Education, University of Washington–Seattle
Annual Visiting Scholar Program and Research Forum
Tirone David, M.D., “The Stentless Porcine Valve, A Realistic Alternative?” May
1992
Hermes Grillo, M.D., “Neoplasms of and in the Airway,” May 1993
Andrew Wechsler, M.D., “Revascularization for Ischemic Cardiomyopathy: The
Dilemma of Mitral Regurgitation,” May 1994
Hillel Laks, M.D., “Unifocalization and Definitive Repair for Pulmonary Atresia with
Multiple Aorta to Pulmonary Collaterals,” May 1995
James L. Cox, M.D., “Evolution of the Relationship between Cardiologist and Cardiac
Surgeons,” May 1996
D. Craig Miller, M.D., “Endovascular Stent/Graft Repair for Patients with Descending
Thoracic Aortic Aneurysms–Mid-Term Results of a Grand Clinical
Experiment,” May 1997
Mark B. Orringer, M.D., “Modern Concepts in the Treatment of Esophageal
Perforation,” May 1998
Educational Forums
Patrick Perrier, M.D., Albert Krause, M.D., “Comparison of the European and U.S.
Experiences with the New Carpentier-Edwards Pericardial Valve,” November
1991
Thomas Salerno, M.D., “Myocardial Protection: Retrograde Continuous Warm
Blood Cardioplegia,” February 1992
“Risk Stratification in Cardiac Surgery”–Washington and Oregon CT Surgeons,
December 1992.
Carlos Duran, M.D., “Cardiac Valve Reconstruction,” November 1993
Manuel J. Antunes, M.D., “Mitral Valve Surgery,” April 1993
Invited speakers, “The Mitral Valve: Concepts and Controversies,” August 1996
R.P. Cochran, M.D.
Page 8
SPECIAL NATIONAL RESPONSIBILITIES
1994-1998
Chairman, American Heart Association (Washington Chapter) Committee
for Establishment of Guidelines in “Indications for Valvular Heart
Surgery”
1996-2002
Membership Committee, Western Thoracic Surgical Association
SPECIAL LOCAL RESPONSIBILITIES
University of Washington Medical Center
1992-1998
1992-1998
1993-1995
1996-1997
1997-1998
1996-1998
1996-1998
Quality Assurance Committee
Cardiac Effectiveness Group
Early Extubation Task Force
Operations Improvement in the Surgical Specialties Center, Steering
Committee, and Track Care Task Force
Transfusion Practices Committee
Cardiovascular Services Committee
Surgeon Implant Evaluation Committee
University of Washington Department of Surgery
Chairman, Departmental Quality Assurance Committee
University of Wisconsin
1998-2002
1998-2002
Surgical Education Committee
Surgery Executive Council
R.P. Cochran, M.D.
Page 9
RESEARCH FUNDING
Peer Reviewed Funding
1.
Principal Investigator, Improved Thromboresistance for Circulatory Assist Devices,
American Heart Association, Texas Affiliate, 7/1/86-6/30/88, $49,903.
2.
Principal Investigator, Noninvasive Evaluation of Cardiac Transplantation, University of
Texas Health Science Center, Institutional Grant, 9/1/86-8/31/87, $6,000.
3.
Consultant, Protection from Air Embolism with Perfluorocarbons in Cardiopulmonary
Bypass, American Society for Extracorporeal Technology, 1/1/93-12/31/93, $11,000 (Bruce
Spiess, PI).
4.
Co-Investigator, Biomechanical Determinants of Aortic Valve Function, Whitaker
Foundation, 9/1/94-12/31/96, $119,171 (KS Kunzelman, PI).
5.
Co-Investigator, Effects of Fluid Dynamics and Surgical Alterations on Mitral Valve
Function in a Computer Model, American Heart Association, Washington Affiliate, 7/1/956/30/97, $62,344 (KS Kunzelman, PI).
6.
Consultant, Effect of Shear Stress on Cellular/Material Interactions; Flow Cell Model
Development and Expansion, National Science Foundation, 10/1/96-6/30/01, $309,487. (Part
of an Engineering Research Center Grant: University of Washington Engineered
Biomaterials), (KS Kunzelman, PI).
7.
Co-Investigator, Biomechanical Determinants of Aortic Valve Function, San Diego
Supercomputer Center, 4/1/97-3/31/98, 625 Service Units, (KS Kunzelman, PI).
8.
Principal Investigator, Mitral Valve Regurgitation Induces Structural Changes, National
Institutes of Health RO1, Heart Lung and Blood Institute, 7/1/97-6/30/01, $1,244,702.
9.
Co-Investigator, Biomechanical Determinants of Aortic and Mitral Valve Function, San
Diego Supercomputer Center, 4/1/98-3/31/99, 4000 Service Units, (KS Kunzelman, PI).
10. Co-Investigator, T-tubules and L-type Ca2+ Channels in Heart Failure, National Institutes of
Health, 7/1/99-6/30/04, $1,807,354, (M Wolf, PI).
11. Co-Investigator, Effect of Endothelial Cell Integrin Engagement on Protection from
Apoptosis Under Conditions of Shear Stress, American Heart Association Northland
Affiliate, 7/1/99-6/30/02, $90,000, (KS Kunzelman, PI).
12. Principal Investigator, Coupled Fluid/Structure Analysis of Aortic Valve Function,
Department of Surgery Grant, University of Wisconsin-Madison, 4/1/00-10/31/01, $47,643.
13. Co-Investigator, Translational Program in Cardiovascular Science, National Institutes of
Health, Training Grant, 7/1/01-6/30/06, $1,321,130, (R Moss, PI)
R.P. Cochran, M.D.
Page 10
14. Principal Investigator, Prevention and/or Correction of Ischemic Mitral Regurgitation, UW
Medical Foundation, 10/1/01-9/30/02, $68,017.
15. Principal Investigator, Mitral Valve Repair with the Zeus Surgical Robotics System, UW
Medical Foundation, 10/1/01-9/30/02, $44,869.
16. Co-Investigator, Aortic Valve and Root Evaluation – Model Development and Validation,
UW Medical Foundation, 10/1/01-9/30/02, $175,358, (KS Kunzelman, PI).
17. Sub-contractor, Rapidly Exchangeable Bioprosthetic Heart Valve, National Institutes of
Health SBIR grant, 1/1/03-12/31/03, $212,063 (I Vesely, PI).
18. Co-Investigator, Aortic Valve and Root Function: A Coupled Fluid-Structure Model,
American Heart Association, 1/1/03-12/30/04, $130,000, (KS Kunzelman, PI)
19. Sub-contractor, Biocompatibility of Rapidly Exchangealble Heart Valve, National Institutes
of Health SBIR grant, 9/1/03-12/31/03, $212,063 (I Vesely, PI).
20. Co-Investigator, Percutaneous Mitral Valve Repair: A Validated Fluid-Structure Interaction
Model, National Institutes of Health RO1, 8/1/09-6/30/14, $2,995,516, (KS Kunzelman, PI).
Other Funding
1.
Co-Investigator, Evaluation of Perfluorocarbon Emulsion Use in Cardiopulmonary Bypass,
Hemagen, Inc., 12/1/92-11/30/94, $32,000 (Bruce Spiess, PI).
2.
Principal Investigator, Randomized Clinical Trial of Large Diameter Vascular Grafts,
CarboMedics, Inc., 8/1/93-12/31/95, $23,070.
3.
Co-Investigator, Evaluation of Perfluorocarbons in Protection from Cerebral Air Embolism,
Hemagen, Inc., 1/1/94-12/31/95, $240,000 (Bruce Spiess, PI).
4.
Co-Investigator, Toronto Stentless Porcine Valve Clinical Investigation, St. Jude Medical
Inc., 6/1/94-12/31/97, $100,000 (Edward D. Verrier, PI).
5.
Principal Investigator, Echocardiographic Evaluation of St. Jude Valves, St. Jude Medical
Inc., 6/1/94-12/31/96, $15,500.
6.
Co-Investigator, Evaluation of Aortic Compliance after Implantation of Toronto Stentless
Porcine Valves, St. Jude Medical, Inc., 7/1/96-6/30/98, $69,772 (KS Kunzelman, PI).
7.
Principal Investigator, Randomized Trial of Complement Inhibition during Cardiopulmonary
Bypass, Alexion Pharmaceutical, 1/1/01-12/31/02.
8.
Principal Investigator, Robotic Mammary Takedown Clinical Trial, Computer Motion,
5/1/02-4/30/02, $75,000.
9.
Principal Investigator, Aortic Valve Operative Outcomes in Marfan Patients Study, 1/1/0612/31/07, $20,000.
R.P. Cochran, M.D.
Page 11
BIBLIOGRAPHY
ARTICLES IN REFEREED JOURNALS
(** Indicates that first author was a graduate student or resident under my direct supervision)
1.
Cochran RP, McGough EC. Bovine pericardium: A source of pulmonary venous obstruction
in the mustard procedure. Ann Thor Surg. 1987;44:552-553.
2.
Rosenfeld J, Cochran RP, Abraham M, Hillis LD, Taylor AL. False inferior
pseudoaneurysm: 2D and Doppler echocardiographic findings. J Amer Soc of Echocardiogr.
1988;1:351-353.
3.
Cochran RP, Kunzelman KS. Cryopreservation does not alter antigenic expression of aortic
allografts. J Surg Res. 1989;46:597-599.
4.
Goff DR, Purdue GF, Cochran RP, Hunt JL. Cardiac disease and the burn patient. J Burn
Care and Rehabil. 1990;11:305-307.
5.
**Kunzelman KS, Cochran RP. Mechanical properties of basal and marginal mitral valve
chordae tendineae. ASAIO Transactions. 1990;36:M405-M408.
6.
Landreneau RJ, Horton JW, Cochran RP. Splanchnic blood flow response to intra-aortic
balloon pump assist of hemorrhagic shock. J Surg Res. 1991;51:281-287.
7.
Cochran RP, Kunzelman KS. Comparison of the viscoelastic properties of suture vs. porcine
mitral valve chordae tendineae. J Card Surg. 1991;6:508-513.
8.
Cochran RP, Kunzelman KS, Chuong CJ, Sacks MS, Eberhart RC. Non-destructive analysis
of mitral valve collagen fiber orientation. ASAIO Transactions. 1991;37:M447-M448.
9.
Cochran RP, Horton JW, Landreneau RJ, Verrier ED. Myocardial blood flow alterations in
response to intra-aortic balloon counterpulsation in a canine hemorrhagic shock model. Surg
Forum. 1991;XLII:290-292.
10. Whitten CW, Latson TW, Cochran RP, Elmore JC, Griffin JD. ST segment elevation during
cardiac electrophysiologic surgery. Anesthesiology. 1991;75:161-163.
11. Kunzelman KS, Cochran RP. Stress/strain characteristics of porcine mitral valve tissue:
parallel vs. perpendicular collagen orientation. J Card Surg. 1992;7:71-78.
12. Kunzelman KS, Cochran RP, Murphree SS, Ring WS, Verrier ED, Eberhart RC.
Differential collagen structure in the mitral valve and its relation to biomechanical behavior.
J Heart Valve Dis. 1993;2: 236-244.
13. Kunzelman KS, Cochran RP, Chuong CJ, Ring WS, Verrier ED, Eberhart RC. Finite
element analysis of mitral valve pathology. J Long Term Eff Med Implants. 1993;3:161-179.
R.P. Cochran, M.D.
Page 12
14. Kunzelman KS, Cochran RP, Chuong CJ, Ring WS, Verrier ED, Eberhart RC. Finite
element analysis of the mitral valve. J Heart Valve Dis. 1993;2:326-340.
15. Grande KJ, Kunzelman KS, Cochran RP, David TE, Verrier ED. Porcine aortic leaflet
arrangement may contribute to clinical xenograft failure. ASAIO J. 1993;39:918-922.
16. Shen I, Kunzelman KS, Vocelka CR, Verrier ED, Cochran RP. Working model for
evaluating lung transplant preservation methods. Am Col Surgeons Surg Forum.
1993;XLIV:306-308.
17. Kunzelman KS, Grande KJ, David TE, Cochran RP, Verrier ED. Aortic valve and root
relationships: Impact on surgical repair. J Thor Card Surg. 1994;1:162-170.
18. Forbes AD, Wood DE, Cochran RP, Munkenbeck F, Schmidt R, Verrier ED. Schwannoma
of the left atrium: Diagnostic evaluation and surgical resection. Ann Thor Surg. 1994;57:743746.
19. Kunzelman KS, Cochran RP, Verrier ED, Eberhart RC. An anatomic basis for mitral valve
modeling. J Heart Valve Dis. 1994;3:491-496.
20. Vocelka C, Spiess B, Soltow L, Thomas R, Gohra H, Akimoto H, Rothnie C, Kunzelman K,
Verrier E, Cochran RP. A perfluorocarbon emulsion prime additive improves the electroencephalogram and cerebral blood flow at the initiation of cardiopulmonary bypass in swine.
J Am Soc ExtraCorp Tech. 1995;27:6-10.
21. Cochran RP, Kunzelman KS, Eddy AC, Hofer BO, Verrier ED. Modified conduit
preparation creates a pseudo-sinus in aortic valve sparing procedure for ascending aortic
aneurysm. J Thorac Cardiovasc Surg. 1995;109:1049-1058.
22. Reimink SM, Kunzelman KS, Verrier ED, Cochran RP. The effect of anterior chordal
replacement on mitral valve function and stresses. ASAIO Transactions. 1995;41:M754M762.
23. Verrier ED, Wright IH, Cochran RP, Spiess BD. Changes in cardiovascular surgical
approaches to achieve early extubation. J Cardiothorac Vasc Anesth. 1995;9(suppl 5):10-15.
24. Chandler WL, Fitch JCK, Wall MH, Verrier ED, Cochran RP, Soltow LO, Spiess BD.
Individual variations in the fibrinolytic response during and after cardiopulmonary bypass.
Thromb Haemost. 1995;74:1293-1297.
25. Kunzelman KS, Reimink MS, Verrier ED, Cochran RP. Replacement of mitral valve
posterior chordae tendineae with expanded polytetrafluoroethylene suture: A finite element
study. J Card Surg. 1996;11:136-145.
26. Whitten CW, Allison PM, Latson TW, Ivy R, Burkhardt D, Gulden RH, Cochran RP.
Evaluation of laboratory coagulation and lytic parameters resulting from autologous whole
blood transfusion during primary aortocoronary artery bypass grafting. J Clinical Anesth.
1996;8:229-235.
R.P. Cochran, M.D.
Page 13
27. Reimink MS, Kunzelman KS, Cochran RP. The effect of chordal replacement suture length
on function and stresses in repaired mitral valves: A finite element study. J Heart Valve Dis.
1996;5:365-375.
28. Spiess BD, Cochran RP. Perfluorocarbon emulsions and cardiopulmonary bypass: A
technique for the future. J Cardiothorac Vasc Anesth. 1996;10:83-90.
29. Cochran RP, Kunzelman KS. Discrepancies between marked dimensions of prosthetic
valves and sizers. J Card Surg. 1996;11:318-324.
30. Every NR, Maynard C, Cochran RP, Martin J, Weaver WD. Characteristics, management,
and outcome of patients with acute myocardial infarction treated with bypass surgery. Circ.
1996;94(suppl)II81-II86.
31. Cochran RP, Kunzelman K, Vocelka C, Soltow L, Thomas R, Akimoto H, Spiess B.
Perfluorocarbon emulsion in the cardiopulmonary bypass prime reduces tneurologic injury.
Ann Thor Surg. 1997;63:1326-1332.
32. Quick DW, Kunzelman KS, Kneebone J, Cochran RP. Collagen synthesis is upregulated in
sheep mitral valves subject to altered stress. ASAIO J. 1997;43:181-186.
33. Kunzelman KS, Reimink MS, Cochran RP. Annular dilatation increases stress in the mitral
valve and delays coaptation: A finite element computer model. Cardiovasc Surg. 1997;5:427434.
34. Van Norman GA, Gernsheimer T, Chandler WL, Cochran RP, Spiess BD. Indicators of
fibrinolysis during cardiopulmonary bypass after exogenous antithrombin III administration
for acquired antithrombin III deficiency: A case report. J Cardiothorac Vasc Anesth.
1997;11:760-763.
35. Herren JI, Kunzelman KS, Vocelka CR, Cochran RP, Spiess BD. Horseradish peroxidase as
a histologic indicator of mechanisms of retinal vascular damage and protection with
perfluorocarbons following massive air embolism. Stroke. 1997;28:2025-2030.
36. Kunzelman KS, Reimink MS, Cochran RP. Flexible versus rigid ring annuloplasty for
mitral valve annular dilation: A finite element model. J Heart Valve Dis. 1998;7:108-116.
37. Rand RP, Cochran RP, Aziz SA, Hofer BO, Allen MA, Kunzelman KS, Verrier ED.
Prospective trial of catheter irrigation and muscle flaps for sternal wound infections. Ann
Thor Surg. 1998;65:1046-1049.
38. Rosoff JD, Soltow LO, Vocelka CR, Schmer G, Chandler WL, Cochran RP, Kunzelman
KS, Spiess BD. A Second generation perfluorocarbon (perfluorodichlorooctane) does not
increase complement activation in ex vivo extracorporeal bypass experiments. J
Cardiothorac Vasc Anesth. 1998;12:397-401.
39. Grande KJ, Cochran RP, Reinhall PG, Kunzelman KS. Stress variations in the human aortic
root and valve: The role of anatomic asymmetry. Ann Biomed Eng. 1998;26:534-545.
R.P. Cochran, M.D.
Page 14
40. Kunzelman KS, Reimink MS, Cochran RP. Variations in annuloplasty ring and sizer
dimensions may alter outcome in mitral valve repair. J Card Surg. 1998;12:322-329.
41. Herren JI, Kunzelman KS, Vocelka CR, Cochran RP, Spiess BD. Angiographic and
histologic evaluation of porcine retinal vascular damage and protection with perfluorocarbons
following massive air embolism. Stroke. 1998;21:2396-2403.\
42. Lee AS, Lawrence O, Scatena M, Giachelli C, Cochran RP, Kunzelman KS. Extracellular
matrix proteins enhance the adhesion and NF-kB activation of endothelial cells subjected to
shear stress. Am Col Surgeons Surg Forum. 1998;49:294-296.
43. Spiess BD, Vocelka CR, Cochran RP, Soltow L, Chandler WL. Heparin-coated bypass
circuits suppress the release of tissue plasminogen activator during normothermic coronary
artery bypass graft surgery. J Cardiothorac Vasc Anesth. 1998;12(3):299-304.
44. Cochran RP, Kunzelman KS. Effect of papillary muscle position on mitral valve function:
relationship to mitral homografts. Ann Thor Surg. 1998;66(Suppl): S155-161.
45. Kunzelman KS, Quick DW, Cochran RP. Altered collagen concentration in mitral valve
leaflets: Biochemical and finite element analysis. Ann Thor Surg. 1998;66(Suppl): S198-205.
46. Grande KJ, Cochran RP, Reinhall PG, Kunzelman KS. Mechanisms of aortic valve
incompetence in aging: a finite element model. J Heart Valve Dis.1999;8(2):149-156.
47. Davis CL, Kausz AT, Zager RA, Kharasch ED, Cochran RP. Acute renal failure after
cardiopulomonary bypass is related to decreased serum ferritin levels. J Am Soc Nephrol.
1999; 10(11):2396-402.
48. Kunzelman KS, Linker DT, Sai S, Miyake-Hull C, Quick DM, Thomas R, Rothnie C,
Cochran RP. Acute mitral valve regurgitation created in sheep using echocardiographic
guidance. J Heart Valve Dis, 1999;8(6)637-643.
49. Quick DW, Kunzelman KS, Cochran RP. Quantitative histologic analysis of the mitral valve
anterior leaflet: ischemic alterations and implications for valve replacement designs. In:
Farkas DL, Leif RC, Tromberg BJ, eds. Optical Diagnostics of Living Cells. SPIE Vol 3604.
Bellingham, WA: SPIE-The International Society for Optical Engineering. 1999;118-128.
50. Grande KJ, Cochran RP, Reinhall P, Kunzelman KS. Mechanisms of aortic valve
incompetence: A finite element model of aortic root dilatation. Ann Thorac Surg. 2000;
69:1851-7.
51. Grande KJ, Cochran RP, Reinhall P, Kunzelman KS. Re-creation of sinuses is important for
aortic valve-sparing: A finite element study. J Thor Cardiovasc Surg,2000;119:753-763.
52. Cochran RP, Kunzelman KS. Methods of pseudo-sinus creation in an aortic valve sparing
operation for aneurysmal disease. J Card Surg. 2000;15:428-433.
53. Grande KJ, Cochran RP, Reinhall P, Kunzelman KS. Finite element analysis of aortic valve
sparing: Influence of graft shape and stiffness. IEEE Trans Biome Eng, 2001:48(6):647-59.
R.P. Cochran, M.D.
Page 15
55. Grande KJ, Cochran RP, Reinhall P, Kunzelman KS. Mechanism of aortic valve
incompetence: Finite element modeling of Marfan syndrome. J Thor Cardiovasc Surg,
2001;122:946-954.
56. Nicosia M, Cochran R, Reinhall P, Einstein D, Kunzelman K. A Coupled fluid-structure
model of the aortic valve and root. J Heart Valve Dis, 2003; 12:781-9.
57. Nicosia M, Kasalko J, Einstein D, Cochran R, Kunzelman K. Biaxial material properties of
the porcine aortic wall. J Heart Valve Dis, 2002; 11(5):680-6.
58. Cochran RP, Starkey TD, Panos AL, Kunzelman KS. Ambulatory intra-aortic balloon pump
use as bridge to transplant. Ann Thorac Surg, 2002; 74(3):746-51.
59. Einstein DR, Reinhall P, Nicosia M, Cochran RP, Kunzelman KS. Dynamic finite element
implementation of nonlinear, anisotropic hyperelastic biological membranes. Comp Meth
Biomech Biomed Eng, 2003; 6(1):33-44.
60. Norris W, Kunzelman KS, Bussell S, Rohweder L, Cochran RP. Potassium
Supplementation, Diet vs. Pills: A Prospectively Randomized Trial in Post-Operative Cardiac
Surgery Patients. Am J Clin Nutrition, 2004; 125:404-9.
61. Einstein D, Reinhall P, Kunzelman K, Cochran RP: Hemodynamic determinants of the mitral
valve closure sound: a finite element study. IEEE Med Biol Eng Comp, 2004; 42(6):832-46.
62. Quick DW, Kunzelman KS, Hata M, Hegge JO, Rahko PS, Weigel RL, Cochran RP: Effect
of infarction and ACE inhibitors on the mitral valve. J Ariz-Nev Acad Sci ,2004; 37(2): 94-99.
63. Einstein D, Reinhall P, Kunzelman K, Cochran RP: Nonlinear finite element analysis of the
mitral valve. J Heart Valve Dis. 2005; (3):376-85.
64. Einstein D, Reinhall P, Kunzelman K, Cochran RP: The relationship of normal and abnormal
microstructural proliferation to the mitral valve closure sound: J Biomech Eng. 2005;
127(1):134-47.
65. Brown JR, Cochran R, Dacey LJ, Ross CS, Kunzelman KS, Dunton RF, Braxton JH,
Charlesworth DC, Clough, RA, Helm RE, Leavitt BJ, MacKenzie TA, O'Connor GT,
Perioperative increases in serum creatinine are predictive of increased 90-day mortality
following cardiac surgery, Circulation, 2006;114 :I409-I413.
66. Kunzelman KS, Einstein D, Cochran RP: Fluid structure interaction models of the mitral
valve: Function in normal and pathologic states. Philos Trans R Soc Lond B Biol Sci. 2007;
362(1484):1393-406.
67. Brown JR, Cochran RP, Leavitt BJ, Dacey LJ, Ross CS, MacKenzie TA, Kunzelman KS,
Kramer RS, Hernadez F, Helm RE, Westbrook BM, Dunton RF, Malenka DJ, O’Connor GT.
Multivariable prediction of renal insufficiency developing after cardiac surgery. Circ
2007;11;116(11 Suppl):I139-43.
R.P. Cochran, M.D.
Page 16
68. Brown JR, Cochran RP, MacKenzie TA, Furnary AP, Kunzelman KS, Ross CS, Langner
CW, Charlesworth DC, Leavitt BJ, Dacey LJ, Helm RE, Braxton JH, Clough RA, Dunton RF,
O'Connor GT. Long-term survival after cardiac surgery is predicted by estimated glomerular
filtration rate. Ann Thorac Surg. 2008;86(1):4-11.
69. O'Connor GT, Olmstead EM, Nugent WC, Leavitt BJ, Clough RA, Weldner PW,
Charlesworth DC, Chaisson K, Sisto D, Nowicki ER, Cochran RP, Malenka DJ
Appropriateness of coronary artery bypass graft surgery performed in northern New England.
2008:51(24):2323-8.
70. Likosky DS, Dacey LJ, Baribeau YR, Leavitt BJ, Clough R, Cochran RP, Quinn R, Sisto
DA, Charlesworth DC, Malenka DJ, MacKenzie TA, Olmstead EM, Ross CS, O'Connor GT.
Long-term survival of the very elderly undergoing coronary artery bypass grafting Ann
Thorac Surg. 2008; 85(4):1233-7.
71. Schievano S, Kunzelman K, Nicosia M, Cochran R, Khambadkone S, Einstein D,
Kunzelman K, Bonhoeffer P: Percutaneous Mitral Valve Dilatation: Single Balloon versus
Double Balloon – A Finite Element Analysis. J Heart Valve Dis, 2009;18(1):28-34.
72. Einstein DR, DelPin F, Jiao X, Kuprat AP, Carson JP, Kunzelman KS, Cochran RP,
Guccione JM, Ratclifee MB. Fluid-structure interactions of the mitral valve and left heart:
Comprehensive strategies, past, present, and future. Comm Num Meth Eng. Accepted 2009,
pre-print available.
73. Leavitt BJ, Baribeau YR, DiScipio AW, Ross CS, Quinn RD, Olmstead EM, Sisto D, Likosky
DS, Cochran RP, Clough RA, Boss RA Jr, Kramer RS, O'Connor GT; Northern New
England Cardiovascular Disease Study Group. Outcomes of patients undergoing concomitant
aortic and mitral valve surgery in northern New England. Circ 2009; 120(11 Suppl):S127-33.
74. Likosky DS, Sorensen MJ, Dacey LJ, Baribeau YR, Leavitt BJ, DiScipio AW, Hernandez F
Jr, Cochran RP, Quinn R, Helm RE, Charlesworth DC, Clough RA, Malenka DJ, Sisto DA,
Sardella G, Olmstead EM, Ross CS, O'Connor GT. Long-term survival of the very elderly
undergoing aortic valve surgery. Circulation. 2009; 120(11 Suppl):S155-62
BOOK CHAPTERS
1. Cochran RP, Kunzelman KS. Aortic valve sparing in aortic root disease. In: Karp D, Laks H,
Wechsler AS, eds. Advances in Cardiac Surgery. Vol. 8. St. Louis, Mo: Mosby-Year Book,
Inc.; 1996:81-107.
2. Kunzelman KS, Cochran RP. Computer models. In: Troidl H, Spitzer WO, McPeek B,
Mulder DS, McKneally MF, Wechsler AS, eds. Surgical Research: Basic Principles and
Clinical Practice. 3rd ed. New York, NY: Springer-Verlag, Inc.; 1997:453-470.
R.P. Cochran, M.D.
Page 17
3. Kunzelman KS, Cochran RP. Hemi-homograft replacement of the mitral valve: A finite
element model. In: Huysmans HA, David TE, Westaby S, eds. Stentless Bioprostheses.2nd ed.
Oxford, England: Isis Medical Media, Ltd., 1999:31-38.
4. Cochran RP, Verrier ED. Valvular heart disease: The surgical approach. In: Otto CM, ed.
Valvular Heart Disease. Philadelphia, Pa: Saunders Co. 1999:151-178.
5. Cochran RP, Kunzelman KS. Valve sparing operations for aortic annulo-ectasia. In: Franco
K, Verrier ED, eds., Advanced Therapy in Cardiac Surgery. 1st ed. Hamilton, Ontario,
Canada: B.C. Decker Inc 1999:280-291.
6. Cochran RP, Panos AL. Coronary Artery Bypass Surgery. In: Douglas PS, ed. Women and
Heart Disease. Philadelphia, Pa: Saunders Co. 2002:372-382.
7. Cochran RP, Kunzelman KS. Valve sparing operations for aortic annulo-ectasia. In: Franco
K, Verrier ED, eds., Advanced Therapy in Cardiac Surgery. 2nd ed. Hamilton, Ontario,
Canada: B.C. Decker Inc 2003:311-322.
OTHER PUBLICATIONS
1. **Kunzelman KS, Cochran RP, Chuong CJ, Eberhart RC. Engineering analysis of mitral
valve repair. In: Digest of Papers, 6th Southern Biomedical Engineering Conference.
1987:12-13.
2. **Kunzelman KS, Sacks MS, Cochran RP, Eberhart RC. Mitral valve leaflet collagen
distribution by laser analysis. In: Digest of Papers, 7th Southern Biomedical Engineering
Conference. 1988;82-85.
3. **Kunzelman KS, Cochran RP, Eberhart RC. Mechanical properties of mitral valve chordae
tendineae. In: Digest of Papers, 7th Southern Biomedical Engineering Conference. 1988:8081.
4. Huo HH, Tsai CC, Tunstall A, Cochran RP, Eberhart RC. Albumin affinity and
thromboresistance of poly (C16) alkyl sulfone. In: Digest of Papers, 7th Southern Biomedical
Engineering Conference. 1988:77-79.
5. Cochran RP, Mattox KL. Blunt chest injury after horizontal deceleration. Postgraduate
General Surgery. 1990;2(3):143-146.
6. Cochran RP, Rohrich RJ. Repair of sternal dehiscence using a harrington compression
system [letter to the editor]. Ann Thorac Surg. 1990;49:853-854.
7. Cochran RP, Kunzelman KS, Vocelka CR, Akimoto H, Thomas R, Soltow LO, Spiess BD.
Macroscopic bubbles from dissolved nitrogen during CPB–Reply. Ann Thor Surg.
1998;54:1527.
R.P. Cochran, M.D.
Page 18
MANUSCRIPTS SUBMITTED
ABSTRACTS
1.
Cochran RP, Douglas DS. Renal function during cardiopulmonary bypass is not affected by
low dose dopamine administration; Texas Medical Association, May 1989.
2.
Barth MJ, Cochran RP. Conservative utilization of subxyphoid exploration in penetrating
thoracic trauma. Western Thoracic Surgical Association; June 1989, Monterey, Calif.
3.
Ring WS, Cochran RP, Nikaidoh H, Johnson NA, Braunlin EA, Fixler DE. Mechanical
circulatory support following orthotopic heart transplantation in infants. J Heart & Lung
Trans. 1991;(Suppl), January/February.
4.
Gulden RH , Whitten CW, Latson T, Lipton JM, Cochran RP, Elmore JC. Radiant heat
reduces requirement for vasodilator drugs after cardiopulmonary bypass. Anesth Analg.
1991;72:S95.
5.
Cochran RP, Horton JW, Landreneau RJ, Verrier ED. Myocardial blood flow alterations in
response to intra-aortic balloon counterpulsation in a canine hemorrhagic shock model.
American College of Surgeons Surgical Forum Proceedings.
6.
Grande KJ, Kunzelman KS, Cochran RP, David TE, Verrier ED. Porcine aortic valve leaflet
dimensions. ASAIO Abstracts, May 1992;33.
7.
Vocelka C, Cochran RP, Kunzelman KS, Verrier ED. Extracorporeal circuit for evaluation
of lung preservation techniques. ASAIO abstracts, May 1992;61.
8.
Kunzelman KS, Cochran RP, Chuong CJ, Ring WS, Verrier ED, Eberhart RC. Finite
element modeling of the mitral valve. Proceedings: Biomedical Engineering Society National
Meeting, October 1992;G4.6.
9.
Kunzelman KS, Grande KJ, Cochran RP, David TE, Verrier ED. MRI analysis of the aortic
valve. ASAIO Abstracts, May 1993;28.
10. Grande KJ, Kunzelman KS, Cochran RP, David TE, Verrier ED. Comparative anatomy of
the aortic valve and root: finite element model development. ASAIO abstracts, May 1993;28.
11. Kunzelman KS, Cochran RP, Chuong CJ, Ring WS, Verrier ED, Eberhart RC. Mitral valve
function: A finite element study. American College of Surgeons, Washington State Chapter
Annual Meeting, June 1993.
12. Cochran RP, Eddy AC, Hofer BO, Kunzelman KS, Verrier ED. The aortic valve sparing
operation (David procedure) for aortic incompetence and ascending aneurysm of the aorta.
R.P. Cochran, M.D.
Page 19
The University of Washington Experience. American College of Surgeons, Committee on
Medical Motion Pictures, October 1993.
13. Grande KJ, Kunzelman KS, Cochran RP, Nelson JA, David TE, Verrier ED. Finite element
model of the aortic valve and root. biomedical engineering society. Proceedings, 1993;22.
14. Kunzelman KS, Cochran RP, Verrier ED. Replacement of mitral valve chordae tendineae
with polytetrafluoroethylene suture–A finite element analysis. Society of Thoracic Surgeons,
February 1994.
15. Burdge EC, Kunzelman KS, Schmidt R, Verrier ED, Cochran RP. Digital analysis of mitral
valve microstructure. American Society for Artificial Internal Organs, April 1994.
16. Vocelka C, Spiess B, Soltow L, Thomas R, Gohra H, Akimoto H, Rothnie C, Kunzelman KS,
Verrier ED, Cochran RP. Effects of a perfluorocarbon emulsion prime additive on EEG at
the initiation of cardiopulmonary bypass in swine. American Society of Extracorporeal
Technology, April 1994.
17. Kunzelman KS, Burdge EC, Schmidt R, Verrier ED, Cochran RP. Digital analysis of mitral
valve microstructure. International Symposium Cardiac Bioprostheses proceedings, p. 208.
18. Cochran RP, Eddy AC, Hofer BO, Kunzelman KS, Verrier ED. Modified conduit
preparation creates a pseudo-sinus in aortic valve sparing procedure for ascending aortic
aneurysm. Western Thoracic Surgical Association proceedings, p. 56.
19. Cochran RP, Kunzelman KS, Vocelka CR, Akimoto H, Gohra H, Soltow L, Spiess BD:
Perfluorocarbon is protective as a prime, but not as a treatment for massive air embolus
during cardiopulmonary bypass. The Brain and Cardiac Surgery proceedings, September
1994.
20. Spiess BD, Cochran RP, Kunzelman KS, Vocelka CR, Soltow L, Thomas B, Akimoto H,
Gohra H, Rothnie CL. Cerebral protection from massive air embolism with a perfluorocarbon emulsion prime addition for cardiopulmonary bypass. Anesthesiology. 1994;81: A566.
21. Cochran RP, Wright IH, Kunzelman KS, Anton WR, Verrier ED. Alterations in anesthesia
and analgesia significantly reduces ventilator times in post-operative heart patients. Pacific
Coast Surgical Association, Seattle, Wash, February 1995.
22. Rand RP, Cochran RP, Aziz SA, Hofer BO, Allen MA, Verrier ED. Prospective trial of
catheter irrigation and muscle flaps for sternal wound infections. Pacific Coast Surgical
Association, Seattle, Wash, February 1995.
23. Spiess BD, Soltow LO, Wright IH, Gillies BS, Cochran RP, Aziz S, Hofer BO, Verrier ED.
Thromboelastography reflects the hypocoagulable status of acadesine. Society of
Cardiovascular Anesthesiologists Annual Meeting, Philadelphia, Pa, May 1995.
24. Stephens K, Lupinetti M, Cochran RP, Hofer B, Aziz S, Verrier E. The Ross procedure:
emerging therapeutic option for aortic valve disease. Seattle Surgical Society Annual
Scientific Program, Seattle, Wash, January 1996.
R.P. Cochran, M.D.
Page 20
25. Quick DW, Kunzelman KS, Kneebone J, Cochran RP. Collagen synthesis is upregulated in
sheep mitral valves subject to altered stress. ASAIO J. 1996;42:29.
26. Reimink MS, Kunzelman KS, Cochran RP. The effect of replacement suture length on the
function and stresses of repaired mitral valves: A finite element study. ASAIO J. 1996;42:29.
27. Kunzelman KS, Reimink MS, Cochran RP. Annular dilatation increases stress in the mitral
valve and delays coaptation: A finite element computer model. European Society of
Cardiovascular Surgeons, September 1996, Venice, Italy.
28. Cochran RP, Kunzelman KS, Zwink T, Linker DT. Hemodynamic performance of standard
St. Jude vs. St. Jude HP aortic prostheses. American Heart Association, November 1996.
29. Rosoff JD, Soltow LO, Vocelka CR, Schmer G, Chandler WL, Cochran RP, Kunzelman
KS, Spiess BD. second generation perfluorocarbon (perfluorodichlorooctane) does not
increase complement activation in ex vivo extracorporeal bypass experiments. Society of
Cardiovascular Anesthesiologists, 1996.
30. Kunzelman KS, Reimink MS, Cochran RP. Rigid ring annuloplasty restores near normal
stresses and coaptation in the mitral valve: A finite element model. American College of
Cardiology, March 1997.
31. Kunzelman KS, Cochran RP. Hemi-homograft replacement of the mitral valve: A finite
element model. Stentless Bioprosthetics Meeting, April 1997, Noordwijk, The Netherlands.
32. Cochran RP, Kunzelman KS. Effect of papillary muscle position on mitral valve stresses
and function: Relationship to mitral homografts. VII International Symposium–Cardiac
Bioprostheses, June 1997, Barcelona, Spain.
33. Quick DW, Kunzelman KS, Eyre DR, Cochran RP. Regional collagen content of mitral
valve leaflets: Impact on prosthetic design and impact of altered thickness or tissue stiffness
on mitral valve stresses and coaptation. VII International Symposium–Cardiac Bioprostheses,
June 1997, Barcelona, Spain.
34. Grande KJ, Cochran RP, Reinhall P, Kunzelman KS. Regional variations in aortic root and
valve stresses in a finite element model. International Society for Artificial Organs, Annual
Meeting, Providence, RI, July 1997.
35. Grande KJ, Cochran RP, Reinhall P, Kunzelman KS. Dacron root replacement alters aortic
valve stresses: Finite element modeling. Cardiovascular Medicine, Surgery; Science, and
Mechanics, June 1997, Washington, DC.
36. Berman A, Cochran RP, Johansen K, Elger DF, Blacketter DF, Kunzelman KS. Thoracic
aortic aneurysms have increased rupture risk vs. abdominal aortic aneurysms: A finite
element analysis. Biomedical Engineering Society, October 1997, San Diego, Calif.
37. Grande KJ, Cochran RP, Reinhall P, Kunzelman KS. Altered valve stresses in Osteogenesis
imperfecta. Biomedical Engineering Society, October 1997, San Diego, Calif.
R.P. Cochran, M.D.
Page 21
38. Quick DW, Kunzelman KS, Cochran RP. Regional collagen content of mitral valve
posterior leaflets: Impact on prosthetic valve design. Parker H Petit Institute for
Bioengineering, Georgia Institute of Technology, Prosthetic Heart Valves: Future
Technologies, Hilton Head, SC, February 1998.
39. Grande KJ, Cochran RP, Kunzelman KS. Variations in aortic root sinus dimensions:
Implications for stentless bioprostheses. Parker H Petit Institute for Bioengineering, Georgia
Institute of Technology, Prosthetic Heart Valves: Future Technologies, Hilton Head, SC,
February 1998.
40. Kunzelman KS, Cochran RP. Pericardial patch repair of mitral valve leaflet perforation:
Clinical case and finite element computer model. Third World Congress of Biomechanics
Sapporo, Japan, August 1998.
41. Carter YM, Allen, MD, Cochran RP. The renaissance of the human mitral valve homograft.
8th Annual Scientific Symposium of the Society of Black Academic Surgeons, Washington,
DC, April 17, 1998.
42. Grande KJ, Cochran RP, Reinhall PG, Kunzelman KS. Influence of aging on aortic root and
valve function. ASAIO J. 1998;44:17.
43. Cochran RP, Austin R, Kunzelman KS, Curtis W, Verrier ED. Repair of ascending aortic
transection. American College of Surgeons. Committee on Motion Pictures, Orlando, Fla,
October 1998.
44. Lee AS, Lawrence O, Scatena M, Giachelli C, Cochran RP, Kunzelman KS. Extracellular
matrix proteins enhance the adhesion and NDal cells subject to
shear stress. American College of Surgeons, Orlando, Fla, October 1998.
45. Quick DW, Kunzelman KS, Cochran RP. Quantitative histologic analysis of the mitral
valve. Annual Meeting of the International Society for Optical Engineering. Presented,
January 1998.
46. Love RB, Cornwell RD, Welter DL, Canver CC, Cochran RP, Meyer KC. Extended human
lung preservation with UW solution. American Lung Association/American Thoracic Society
International Conference, San Diego, Calif, accepted, April 23-28, 1999.
47. Einstein D, Kunzelman KS, Thomas R, Rothnie C, Cochran RP. Non-invasive determination of mitral valve acoustic properties: A proposed method to determine tissue
alterations due to disease. World Congress on Heart Valve Disease, January 1999.
48. Kunzelman KS, Tapia M, Cochran RP. Computer modeling for evaluation of surgical
intervention for cardiac valvular disease. World Congress on Heart Valve Disease, January
1999.
49. Kunzelman KS, Linker DT, Sai S, Miyake-Hull C, Quick D, Thomas R, Rothnie C, Cochran
RP. A sheep model for acute mitral regurgitation using echocardiographic guidance. World
Congress on Heart Valve Disease, January 1999.
R.P. Cochran, M.D.
Page 22
50. Cochran RP, Raikar G, Kunzelman KS. Right atrial myxoma arising from the coronary
sinus and presenting emergently. American College of Surgeons. October 2000.
51. Einstein D, Kunzelman KS, Reinhall PG, Cochran RP. Dynamic finite element
implementation of a nonlinear, anisotropic, pseudo-elastic formulation for cardiac valve
tissue. World Congress on Medical Physics and Biomedical Engineering, Chicago, July
2000.
52. Kunzelman KS, Cochran RP. Computer modeling for evaluation of cardiac valvular
function. World Congress on Medical Physics and Biomedical Engineering, Chicago, July
2000.
53. Cochran RP, Kunzelman KS. Biomechanics in cardiac surgery: Evolution from “macro” to
“micro”. World Congress on Medical Physics and Biomedical Engineering, Chicago, July
2000.
54. Quick DW, Kunzelman KS, Cochran RP. Biomechanics of surgery: Analysis of physical
loads and fatigue potential. World Congress on Medical Physics and Biomedical
Engineering, Chicago, July 2000.
55. Dwyer K, Kunzelman K, Quick D, Jensen K, Cochran R. Age dependent procollagen
expression in human mitral valves. World Society Cardiothoracic Surgeons Congress,
Vancouver, BC, August 2000.
56. Jensen K, Kunzelman K, Quick D, Dwyer K, Cochran R. Regurgitation dependent cellular
nuclei presence in human mitral valves. World Society Cardiothoracic Surgeons Congress,
Vancouver, BC, August 2000.
57. Quick D, Kunzelman K, Rahko P, Hata M, Jensen K, Dwyer K, Hegge J, Cochran R.
Regurgitation dependent heat shock expression in Ovine Mitral Valves. World Society
Cardiothoracic Surgeons Congress, Vancouver, BC, August 2000.
58. Cochran R, Love R, Woolley D, Sollinger H, Kunzelman KS. Success of combined
heart/kidney transplantation. 2nd International Meeting of the Onassis Cardiac Surgery
Center, Athens, Greece, December 2000.
59. Quick D, Kunzelman K, Hata M, Hegge J, Rahko P, Cochran R. Effect of ACE Inhibitors
on Mitral Valve Heat Shock Protein and Procollagen Expression following Myocardial
Infarction. 2nd International Meeting of the Onassis Cardiac Surgery Center, Athens, Greece,
December 2000.
60. Kasalko J, Kunzelman K, Nicosia M, Einstein D, Cochran R. Biaxial material properties of
the porcine aortic wall. Society for Heart Valve Disease Annual Meeting, London, England,
June 2001.
61. Nicosia M, Cochran R, Reinhall P, Einstein D, Kunzelman K. Coupled fluid-structure
model of the aortic valve and root. Society for Heart Valve Disease Annual Meeting, London,
England, June 2001.
R.P. Cochran, M.D.
Page 23
62. Nicosia M, Cochran RP, Kunzelman KS. A coupled fluid-structure finite element model of
the aortic valve and root. Prosthetic Heart Valve Workshop, Hilton Head, SC, March, 2002.
63. Einstein D, Kunzelman K, Reinhall P, Nicosia M, Cochran RP. Finite element
implementation of a structural constitutive equation for aortic valve tissue. Society for
Industrial and Applied Mathematics, Boston, MA, March 2002.
64. Einstein DR, Reinhall P, Nicosia MA, Kunzelman KS, Cochran RP. Finite element
implementation of a structural model for aortic valve tissue. World Congress Biomechanics,
Calgary, Canada, July 2002.
65. Jensen KT, Kunzelman KS, Dwyer KW, Quick DW, Cochran RP. Regional differences in
cellular densities in human and ovine mitral valves. World Congress Biomechanics, Calgary,
Canada, July 2002.
66. Nicosia MA, Cochran RP, Kunzelman KS. Coupled fluid-structure finite element modeling
of the aortic valve and root. Biomedical Engineering Society Annual Meeting, Houston, TX,
October 2002.
67. Weigel T, Quick D, Kunzelman K, Johnson C, Cochran R. Robotic lung resection with Zeus
in a pig model. Society of American Gastrointestinal Endoscopic Surgeons Annual Meeting,
Los Angeles, CA, March, 2003.
68. Kunzelman KS, Quick DW, Weigel TL, Klos SS, Cochran RP. Effects of surgeon
experience on the surgical robotics learning curve. Society of American Gastrointestinal
Endoscopic Surgeons Annual Meeting, Los Angeles, CA, March, 2003.
69. Nicosia MA, Cochran RP, Einstein DR, Kunzelman KS. Coupled fluid-structure finite
element modeling of the aortic root and valve. Maine Biological and Medical Sciences
Symposium, Bar Harbor, Maine, April 2003.
70. Einstein DR, Kunzelman KS, Reinhall PG, Nicosia MA, Cochran RP. Nonlinear fluidcoupled computational model of the mitral valve. Society for Heart Valve Disease, Paris,
France, July 2003.
71. **Einstein DE, Kunzelman KS, Reinhall PG, Nicosia MA, Cochran RP. Functional and
dysfunctional proliferation in the mitral Valve: A computational study of the relationship of
tissue integrity to MR and S1. World Congress on Medical Physics and Biomedical
Engineering, Sydney, Australia, April 2003.
72. Brown JR, Cochran RP, Dacey LJ, Ross CS, Kunzelman KS, Dunton RF, Braxton JH,
Charlesworth DC, Clough RA, Helm RE, Leavitt BJ, MacKenzie TA, O’Connor.
Perioperative increases in serum creatinine are predicitive of increased 90-day mortality
following cardiac surgery. American Heart Association Annual Meeting, Dallas, Texas,
November 2005.
73. Baribeau YR, Leavitt BJ, Braxton H, Nugent WC, Cochran RP, Hernandez FH, Helm RE,
Dunton RF, Olmstead EM, O’Connor GT, Malenka DJ. Long-term survival following
R.P. Cochran, M.D.
Page 24
coronary artery bypass graft surgery is related to completeness of revascularization.
American Heart Association Annual Meeting, Dallas, Texas, November 2005.
74. Brown JR, Cochran RP, Leavitt BJ, Ross CS, MacKenzie TA, Kunzelman KS, Kramer RS,
Hernandex F, Helm RE, Westbrook BM, Dunton RF, O’Connor GT Decision Support for
Coronary Revascularization, American College of Cardiology Annual Meeting, presented,
March 2006.
75. Brown JR, Cochran RP, Leavitt BJ, Ross CS, MacKenzie TA, Kunzelman KS, Kramer RS,
Hernandex F, Helm RE, Westbrook BM, Dunton RF, O’Connor GT. Multivariate prediction
of renal insufficiency developing after cardiac surgery. American Heart Association,
presented, Nov 2006.
76. Brown JR, Cochran RP, Dacey LJ, Ross CS, Kunzelman KS, Dunton RF, Braxton JH,
Charlesworth DC, Clough RA, Helm RE, Leavitt BJ, MacKenzie TA, O’Connor GT.
Glomerular filtration rate after cardiac surgery is predictive of 90-day mortality. American
Association of Thoracic Surgery, presented, May 2006.
77. Schievano S, Nicosia M, Cochran RP, Khambadkone S, Einstein DR, Bohfoeffer P,
Kunzelman KS. Percutaneous Mitral Valve Dilatation: Single Balloon Versus Double
Balloon – A Finite Element Analysis, Society for Heart Valve Disease, New York, NY
presented June 2007.
ABSTRACTS SUBMITTED
PRESENTATIONS
National/International Presentations as Invited Faculty Participant
1.
Cochran RP, Kunzelman KS. “Mitral Valve Structure and Function in Normal, Diseased,
and Surgically Repaired States.” Carpentier’s Club Mitrale, Paris, France, December 1995.
2.
Cochran RP. “Anatomy and Physiology of the Aortic Root.” Toronto SPV Valve: State of
the Art in Bioprosthetic Valve Technology Symposium, Prague, Czech Republic, October
1996.
3.
Cochran RP. “Anatomy and Physiology of the Aortic Root.” Toronto SPV Valve:
Implantation Training Seminar, Sunnybrook Medical Center, Toronto, Ontario, Canada,
January 1997.
4.
Cochran RP. “Aortic Root Pathology; Rationale for Stentless Valves.” Toronto SPV Valve
Implantation Symposium, SJM Institute, St. Jude Medical, Inc., Dallas, Tex, December 1997.
R.P. Cochran, M.D.
Page 25
5.
Cochran RP. “Range of Surgical Options for Valvular Heart Disease.” Cleveland, Ohio,
October 12, 1998.
6.
Cochran RP. “Innovations in Aortic Valve Surgery.” Kansas City, Mo, May 4, 1999
7.
Kunzelman KS, Cochran RP. “Mitral Valve Structure and Function – Computer and
Animal Models.” International Forum on Ischemic Mitral Valve Regurgitation, Nice, France,
March, 1999.
8.
Cochran RP. “Aortic Root Surgery”, Society of Cardiovascular Anesthesiologists,
Breckenridge, Colorado, March, 2000.
9.
Kunzelman KS, Cochran RP. “Mitral Valve Physiology – Computer and Animal Models.”
International Forum on Ischemic Mitral Valve Regurgitation, Santa Barbara, California,
October, 2000.
10. Cochran RP. “Does the Aortic Base Require Support?”, International Valve Symposium,
Missoula, Montana, August, 2001.
11. Kunzelman KS, Cochran RP, "Finite Element Analysis of Ischemic Mitral Regurgitation:
Impact on Left Ventricle and Correlation to Sheep Model", Symposium on Ischemic Mitral
Valve Regurgitation, Dearborn, Michigan September, 2001.
12. Kunzelman KS, Cochran RP. “Finite Element Analysis of Ischemic Mitral Regurgitation:
Impact on Left Ventricle and Correlation to Sheep Model", Symposium on Emerging
Alternatives vs. Traditional Treatments, Orlando, Florida, October, 2001.
13. Kunzelman KS, Cochran RP. “Mitral Valve Physiology and Reconstruction”, Wisconsin
Perfusion Society, Madison, Wisconsin, April 2002.
14. Cochran RP. “Aortic Root Pathology: Rationale for Stentless Valves”, Cleveland Clinic
Symposium on Aortic Valve Disease, Cleveland, Ohio, October, 2002.
15. Cochran RP. “Range of Surgical Options for Aortic Regurgitation”, Cleveland Clinic
Symposium on Aortic Valve Disease, Cleveland, Ohio, October, 2002.
National/International Presentations by Peer Review
1.
Cochran RP. “Subclavian Artery Injuries: Choosing the Right Incision.” Southwestern
Surgical Congress, San Diego, Calif, April 26-29, 1987.
2.
Cochran RP. “Cryopreservation Does Not Alter Antigenic Expression of Aortic Allografts.”
Annual Meeting, Association of Academic Surgeons–Salt Lake City, Utah, November 1988.
3.
Cochran RP. “Comparison of the Viscoelastic Properties of Suture vs. Porcine Mitral Valve
Chordae Tendineae.” V International Symposium, Cardiac Bioprostheses, Avignon, France,
May 1992.
R.P. Cochran, M.D.
Page 26
4.
Cochran RP. “The Aortic Valve Sparing Operation (David Procedure) for Aortic
Incompetence and Ascending Aneurysm of the Aorta. The University of Washington
Experience.” American College of Surgeons, Committee on Medical Motion Pictures, San
Francisco, Calif, October 1993.
5.
Cochran RP. “Modified Conduit Preparation Creates a Pseudo-Sinus in Aortic Valve
Sparing Procedure for Ascending Aortic Aneurysm.” Western Thoracic Surgical Association
Annual Meeting, Squaw Creek, Calif, June 1994.
6.
Cochran RP, Kunzelman KS, Vocelka CR, Akimoto H, Gohra H, Soltow L, Spiess BD.
“Perfluorocarbon is Protective as a Prime, But Not as a Treatment for Massive Air Embolus
During Cardiopulmonary Bypass.” The Brain and Cardiac Surgery, Key West, Fla,
September 1994.
7.
Cochran RP. “Alterations in Anesthesia and Analgesia Significantly Reduces Ventilator
Times in Postoperative Heart Patients.” Pacific Coast Surgical Association, Seattle, Wash,
February 1995.
8.
Cochran RP, Kunzelman KS, Zwink T, Linker DT. “St. Jude HP vs. Standard Valves.”
American Heart Association, New Orleans, La, November 1996.
9.
Cochran RP, Kunzelman KS. “Effect of Papillary Muscle Position on Mitral Valve Stresses
and Function: Relationship to Mitral Homografts.” VII International Symposium–Cardiac
Bioprostheses, presented, Barcelona, Spain, June 1997.
Regional/Local Meetings
1.
Cochran RP. “Cardiac Transplantation: First Year Experience at the University of Utah
Medical Center.” Parkland Hospital Surgical Society, Dallas, Tex, May 16, 1986.
2.
Cochran RP. “Cardiac Transplantation.” Thoracic Surgery Grand Rounds–University of
Texas Health Science Center, Dallas, Tex, November 8, 1986.
3.
Cochran RP. “Superior Vena Cava Syndrome: A Single Stage Surgical Approach.” North
Texas Chapter of the American College of Surgeons Meeting, Dallas, Tex, March 6, 1987.
4.
Cochran RP. “Utilization of Ventricular Assist Devices and Total Artificial Heart. Baylor
University Medical Center Heart Center, Roberts Hospital, Dallas, Tex, June 1987.
5.
Cochran RP. “The Aortic Valve Sparing Operation (David Procedure) for Aortic
Incompetence and Ascending Aneurysm of the Aorta.” Seattle Surgical Society Annual
Meeting, Seattle, Wash, January 1993.
R.P. Cochran, M.D.
Page 27
6.
Cochran RP. “Innovations in Aortic Surgery.” Cardiology in the Gorge, Stevenson, Wash,
August 1994.
7.
Cochran RP. “Trauma.” Grand Rounds, Emmanuel Hospital, Portland, Ore, September
1995.
8.
Cochran RP. “Thoracic Aorta Rupture.” What’s New in General Surgery–University of
Washington Continuing Medical Education, Seattle, Wash, September 1996.
9.
Cochran RP. “New Approach to Valve Surgery.” Cardiology Grand Rounds, University of
Washington, Seattle, Wash, April 1997
10. Cochran RP. “A Clinician’s Perspective: What I Need to Know to Optimally Treat Patients
with Thoracic Injuries.” Trauma Radiology 97 Course, Seattle, Wash, August 1997.
11. Cochran RP. “CABG: Surgical Implications.” Cardiology Tutorial, University of
Washington, Seattle, Wash, August 1997.
12. Cochran RP. “Valve Surgery–1998.” Department of Surgery Grand Rounds, University of
Wisconsin, Madison, Wis, November 4, 1998.
13. Cochran RP. “Update on Heart Transplantation.” Douglas T. Miller Symposium on Organ
and Tissue Donation, Wisconsin Dells, Wis, April 30, 1999.
14. Cochran RP. “Creating a First Class Cardiac Surgical Program”, Central Maine Medical
Center, All Boards Retreat, Dixville Notch, New Hampshire, October, 2002.
15. Cochran RP. “Creating a First Class Cardiac Surgical Program”, Community Forum,
Lewiston, Maine, November 2002.
16. Cochran RP. “Creating a First Class Cardiac Surgical Program”, Regional Management
Retreat, Central Maine Medical Center, Lewiston, Maine, November 2002.
17. Cochran RP. “Creating a First Class Cardiac Surgical Program”, Rumford Community
Forum, Rumford, Maine, January, 2003.
18. Cochran RP. “Creating a First Class Cardiac Surgical Program”, Bridgton Hosptial Grand
Rounds, Bridgton, Maine, January, 2003..
19. Cochran RP, “Aortic Root Option”, Surgical Grand Rounds, University of California San
Francisco, California, March, 2003.
20. Cochran RP, “Mitral Valve Structure and Function”, Joint Radiology and Biomedical
Engineering Conference, University of California San Francisco, California, March, 2003.
21. Cochran RP. “Coronary and Cardiac Surgery”, St. Andrew’s Hospital Grand Rounds,
Boothbay Harbor Maine, March, 2003.
R.P. Cochran, M.D.
Page 28
22. Cochran RP. “ CABG: The Operation”, 1st Annual Cardiovascular Conference, Sunday
River, Maine, Feb, 2004.
23. Cochran RP. “ CABG: Where Are We in Off Pump Surgery?”, 1st Annual Cardiovascular
Conference, Sunday River, Maine, Feb, 2004.
24. Cochran RP. “ When to Refer Valvular Heart Disease Patients”, 1st Annual Cardiovascular
Conference, Sunday River, Maine, Feb, 2004.
25. Cochran RP. “ Aortic Valve Disease - What’s New?”, 2nd Annual Cardiovascular
Conference, Bethel Maine, Feb, 2005.
26. Cochran RP. “ Mitral Valve Repair vs. Replacement”, 2nd Annual Cardiovascular
Conference, Bethel Maine, Feb, 2005.
27. Cochran RP. “ Minimally Invasive Surgery”, 2nd Annual Cardiovascular Conference,
Bethel Maine, Feb, 2005
28. Cochran RP. “Evaluation for valvular heart disease”, 3rd Annual Cardiovascular Conference
(Heart Disease, A Family Affair), Bethel Maine, Mar 2006
29. Cochran RP. “Surgical options for aortic valve and aneurysm disease”, 3rd Annual
Cardiovascular Conference (Heart Disease, A Family Affair), Bethel Maine, Mar 2006.
Poster Presentations
1.
Cochran RP, Snyder WH. “Subclavian Artery Injuries: Choosing the Right Incision.”
Southwestern Surgical Congress, San Diego, Calif, April 26-29, 1987.
2.
Barth MJ, Cochran RP, Dierks EJ. “The Pectoralis Major Muscle Flap in Neck Base
Reconstructive Problems: A Combined Approach.” North Texas Surgical Society–Dallas,
Tex, March 1989.
3.
Cochran RP, Kunzelman KS. “Cryopreservation Does Not Alter Antigenic Expression of
Aortic Allografts.” Association of Academic Surgeons–Annual Meeting, Salt Lake City,
Utah, November 1988.
4.
Kunzelman KS, Sacks MS, Cochran RP, Eberhart RC. “Collagen Fiber Orientation in the
Mitral Valve.” Sigma XI Poster Competition, University of Texas Southwestern Medical
Center at Dallas, Dallas, Tex, March 1990.
5.
Grande KJ, Kunzelman KS, Cochran RP, David TE, Verrier ED. “Porcine Aortic Valve
Leaflet Dimensions.” American Society for Artificial Internal Organs–38th Annual Meeting,
Nashville, Tenn, May 1992.
R.P. Cochran, M.D.
Page 29
6.
Kunzelman KS, Grande KJ, Cochran RP, David TE, Verrier ED. “MRI Analysis of the
Aortic Valve.” American Society for Artificial Internal Organs–39th Annual Meeting, New
Orleans, La, April 1993.
7.
Kunzelman KS, Cochran RP, Verrier ED. “Replacement of Mitral Valve Chordae
Tendineae with Polytetrafluoroethylene (ePTFE) Suture–A Finite Element Study.” Society of
Thoracic Surgeons, February 1994.
8.
Reimink MS, Kunzelman KS, Cochran RP. “Replacement of Anterior Mitral Valve Chordae
Tendineae with Expanded Polytetrafluoroethylene Suture: A Finite Element Study.” Chordal
Replacement Symposium, presented, San Diego, Calif, May 1996.
9.
Quick DW, Kunzelman KS, Kneebone J, Cochran RP. “Collagen Synthesis is Upregulated
in Sheep Mitral Valves Subject to Altered Stress.” ASAIO Annual Conference, Washington,
DC, May 1996.
10. Reimink MS, Kunzelman KS, Cochran RP. “The Effect of Replacement Suture Length on
the Function and Stresses of Repaired Mitral Valves: A Finite Element Study.” ASAIO
Annual Conference, Washington, DC, May 1996.
11. Grande KJ, Cochran RP, Reinhall PG, Kunzelman KS. “Influence of Aging on Aortic Root
and Valve Function.” ASAIO Annual Conference, New York, NY, April 1998.
Revised April 9, 2010