Spec. study ULTRASOUND, Page 1 Postgraduate specialized study: ULTRASOUND IN OBSTETRICS AND GYNAECOLOGY DESCRIPITON This postgraduate program is designed to train physicians in ultrasound diagnostic in obstetrics and gynecology. The goal of the study is to enable students for ultrasound practice. Ultrasound as a separate subject before graduation on the Medical School does not exist, although it is integrated in diagnosis and therapy procedures in almost every branch of medicine. Therefore, this program is the only possible way of organized education that enables students to get appropriate theoretical and practical knowledge in this field. Licensure for independent practice with ultrasound is issued by the state authorities (Chamber of Physicians, Ministry of Health....). The study consists of six basic (obligatory) subjects and the choice of seven elective topics, where the candidate should choose three. Basic topics are: - Basic science (physics and technology) - Ultrasound in infertility - Ultrasound in gynecology - Ultrasound in obstetrics - Ultrasound and breast - Medical statistics TOTAL 286 hours (42,9 ECTS) Elective topics are (3 should be chosen): - Ultrasound and menopause - Application of 3D and 4D ultrasound - Ultrasound in neonatology - Early Human development - Interventional ultrasound in O&G - Ultrasound in adolescence - Echocardiography TOTAL 120 hours (18 ECTS) The course lasts one academic year, offering 406 hours and equivalent in 60.9 ECTS. The program consists of lectures, seminars and practical work, with the point on practical work (more than 50% of the program). After completing full training program, the candidate is completely capable of working in all diagnostic and therapeutic procedures involving ultrasound equipment in obstetrics and gynecology. There are identical studies on Croatian and English language. Organizers University of Zagreb, Medical School, Sveti Duh Hospital Duration of the study 1 academic year 2 semesters Necessary requirements recognized diploma of completed undergraduate education, resident or specialist of O & G, license If some of the candidates do not complete the program within the defined period of time for study, they can continue in the next academic year. In these circumstances, they have to attend all missing lectures and pass the separate exams and final exam. Practical experience assessment Log book Spec. study ULTRASOUND, Page 2 Practical experience 100 examinations under supervision in gynae including early pregnancy 100 examinations in obstetrics Description of 30 slučajeva with image on 1 A4 page Minimum 15 fetal malformations and 15 gynae cases Study leader: Ratko Matijevic, MD, PhD, MRCOG Spec. study ULTRASOUND, Page 3 The content of main subjects BASIC ULTRASOUND (PHYSICS AND TECHNOLOGY) Subject leader: Prof. Jasminka Kraljević, PhD Semester: I Hours: lectures 8, seminars 8, practical work 16 (ECTS: 4.8) Content: Definition of ultrasound wave (wave modes, wavelength, frequency, propagation speed, frequency). Interaction of waves with matter (reflection, refraction, scattering, absorption, attenuation). Relation of phenomena in the time and frequency domains. Ultrasound transducer, ultrasound beam, focusing methods, ultrasound probes. Principle of echography (ultrasound scanner). Resolution (methods of manipulation of resolution and sensitivity, optimum scanner adjustment). Ultrasound contrasts. Harmonic imaging. 3D scanners. Tissue characterization, artifacts. Ultrasound measurements and errors. The Doppler effect. Doppler instrumentation. Limitations of various Doppler systems. Measurement errors and scanner adjustment. Ultrasound therapy systems. Safety of ultrasound and possible sources of hazard. Scanner specification. Price - performance relation. Collaborator: TBA Literature: 1. B. Breyer, Ž. Andreic: Basic principles of ultrasonic imaging. In: Handbook of ultrasound in obstetrics and gynecology, A. Kurjak, ed. CRC Press, Boca Raton, USA, 1990 2. S.B. Barnett, G. Kossoff: Safety of diagnostic ultrasound, Parthenon Publishing, London-New York, 1998 3. J.B. Fowlkes, C.K. Holland: Mechanical bio effect from diagnostic ultrasound; AIUM Consensus Statements, Journal of Ultrasound in Medicine, 19, 2000 Evaluation: written MCQ examination ULTRASOUND AND INFERTILITY Subject leaders: Ass.prof. Biserka Funduk Kurjak, MD, PhD, Prof. Veljko Vlaisavljević, MD, PhD Semester: I Hours: lectures 12, seminars 8, practical work 16 (ECTS: 5.4) Content: Basic principles of human reproduction. Menstrual cycle. Ultrasound monitoring of the ovarian and endometrial changes in spontaneous cycles. Abnormalities of the menstrual cycle. Uterine causes of infertility. Uterine anomalies: diagnosis and treatment. Ultrasound monitoring of ovarian and endometrial changes in stimulated cycle. Ovarian causes of infertility. Polycystic ovarian syndrome. Tubal causes of infertility. The role of ultrasound and Doppler in performing interventional procedures in human reproduction. Hysterosonosalpingography using echo enhancing contrast and color Doppler ultrasound. The role of ultrasound in “in vitro” fertilization and other assisted conception techniques. Collaborators: Prof. Asim Kurjak, MD, PhD, Prof. A. Salihagić, MD,PhD, R. Bauman, MD, W Andonotopo, MD, PhD Literature: 1. S. Kupesic, A. Kurjak. Slide atlas in human reproduction, Parthenon Publishing, London-New York, 1997. 2. A. Kurjak, S. Kupesic: Video tape on transvaginal color Doppler in gynecology and infertility, Parthenon Publishing, London, 1997. 3. A. Kurjak, S. Kupesic: A slide atlas of three-dimensional ultrasound in gynecology and obstetrics. Parthenon Publishing Group, London-New York, 1998. 4. A. Kurjak, S. Kupesic: Color Doppler in obstetrics, gynecology and infertility. Art Studio Azinović-Medison, ZagrebSeoul, 1999 5. S. Kupesic, D. De Ziegler: Ultrasound and infertility. Parthenon Publishing, London-New York, 2000 6. A. Kurjak, F.A. Chervenak: Donald School Textbook of ultrasound in obstetrics and gynecology, Jaypee Brothers, New Delhi, 2003 Evaluation: practical exam – examination of the patients, description of the images and written MCQ exam Spec. study ULTRASOUND, Page 4 ULTRASOUND IN GYNAECOLOGY Subject leader: Prof. Asim Kurjak, MD, PhD Semester: I i II Hours: lectures 20, seminars 20, practical work 50 (ECTS: 13.5) Content: Ultrasound imaging of female reproductive system. Endometriosis. Pelvic inflammatory disease. Ectopic pregnancy. Intrauterine device. Benign and malignant uterine tumors. Benign and malignant ovarian tumors. Fallopian tube lesions. Differential diagnosis of pelvic masses. Interventional ultrasound in gynecology. Transperineal ultrasound. Low urinary tract. Gynecologic ultrasound in emergency room. Sonographic pearls and pitfalls. Color Doppler in gynecology, Normal blood flow. Uterine and ovarian blood flow changes during normal menstrual cycle, Blood flow changes in inflammatory processes, Angiogenesis and neovascularisation Doppler parameters of benign and malignant tumors of female genital tract. Collaborators: Prof. Ivica Zalud, MD, PhD, Ass.prof. M. Kopjar, MD, PhD, Bauman, MD, B Ujević MD, M Kerner MD, W Andonotopo MD,PhD, I Marton MD, Literature: 1. A. Kurjak et al: Slide atlas - gynecology, volume 2, Parthenon Publishing, London- New York 1994. 2. A. Kurjak: An atlas of transvaginal color Doppler: the current state of art (the encyclopedia of visual medicine series). Parthenon Publishing, London-New York, 1994. 3. A. Kurjak: Ultrasound and ovary (Progress in obstetrics and gynecological sonography series). Parthenon Publishing, London-New York, 1994. 4. R. Osmers, A. Kurjak: Ultrasound and the uterus (Progress in obstetrics and gynecological sonography series). Parthenon Publishing, London-New York, 1995. 5. I.E. Timor Tritsch, A. Kurjak: Ultrasound and the Fallopian tube (Progress in obstetrics and gynecological sonography series)., Parthenon Publishing, New-York- London, 1996. 6. A.C. Fleischer, A. Kurjak, S. Granberg: Ultrasound and the endometrium. (Progress in obstetrics and gynecological sonography series). Parthenon Publishing, London-New York, 1997. 7. A. Kurjak, S. Kupesic: A slide atlas of three-dimensional ultrasound in gynecology and obstetrics. Parthenon Publishing Group, London-New York, 1998. 8. A. Kurjak, S. Kupesic: An atlas of transvaginal color Doppler, Parthenon Publishing, London-New York, 2000 9. Kurjak A, Chervenak FA, Carrera JM. Donald School Atlas of fetal anomalies. Jaypee Brothers, New Delhi, 2007 10. Kurjak A, Bajo Arenas J. Donald School Textbook of transvaginal sonography. Jaypee Brothers New Delhi, 2005 Evaluation: practical exam – patient examination, description of images; written MCQ exam ULTRASAUND IN OBSTETRICS Subject leader: Prof. Snježana Škrablin - Kučić, MD, PhD, Ass.prof. Ratko Matijević, MD,PhD, MRCOG Semester: I and II Hours: lectures 20, seminars 20, practical work 50 (ECTS: 13.5) Content: Estimation of gestational age. Fetal dimensions in estimation of gestational age. Factors influencing fetal growth. Retarded and accelerated fetal growth. Ultrasound in estimation of the fetal growth. Ultrasound estimation of fetal weight and fetal maturity. Causes and classification of congenital anomalies. Ultrasound in detection of fetal anomalies (vaginal and abdominal approach). Normal fetal anatomy. Anomalies in first trimester of pregnancy. Anomalies of the cranium and its contents, neck, fetal face, spine, fetal chest, heart and great arteries, gastrointestinal and urogenital tracts, abdominal wall and skeletal system. Multiple anomalies. Fetal tumors. Nonimmune fetal hydrops. Polyhydramnios. Oligohydramnios. Genetic counselling. Most frequent syndromes. Mendelian modes of inheritance; multifactorial inheritance; chromosome abnormalities. The methods of antenatal diagnosis (CVS, early amniocentesis, cordocentesis, organ biopsy). Ultrasound markers and biochemical analysis in detection of risk fetuses. Fetal therapy. Medical legal aspects of antenatal diagnosis and fetal therapy. Rights of the fetus. Antenatal care. Influence of ultrasound on perinatal mortality. Development, growth and functions of placenta. Ultrasound estimation of early placentation. Embryology including normal and abnormal development and sonoembryology of major systems. Pathology of early pregnancy. Pathology of the placenta (placenta praevia, abruption of placenta, tumors). Ultrasound examination of placenta. The role of amniotic fluid. Ultrasound examination Spec. study ULTRASOUND, Page 5 of amniotic fluid volume. Spontaneous abortion and premature delivery. Transvaginal sonography of the cervix. The role of ultrasound in diabetic pregnancy, EPH-gestosis, multiple pregnancy, RH-immunization. Ultrasound in the treatment of fetal haemolytic disease. Survey of fetus in pregnancy and delivery. Ultrasound in estimation of fetal condition. Fetal activity. Fetal behaviour. Trophoblastic disease and magnetic resonance imaging. Collaborators: Prof. A. Kurjak, MD,PhD, Prof. Višnja Latin, MD, PhD, Prof. Zarko Alfirević, MD, PhD, Prof. Frank Chervenak, MD, PhD, D. Habek, MD, PhD, W Andonotopo, MD,PhD, M. Kos,MD,PhD, T. Hafner,MD,MSc, B.Mišković, MD,MSc, I Marton MD, PhD Literature: 1. A. Kurjak: An atlas of ultrasonography in obstetrics and gynecology, ed. A. Kurjak, Parthenon Publishing, LondonNew Jersey, USA, 1992. 2. A. Kurjak: A slide atlas of ultrasound in obstetrics. Parthenon Publishing, London- New York, 1994. 3. A. Kurjak: Textbook of perinatal medicine. Parthenon Publishing, London-New York, 1998. 4. A. Kurjak, F.A. Chervenak: Donald School Textbook of ultrasound in obstetrics and gynecology, Jaypee Brothers, New Delhi, 2003 5. K.H. Nicolaides, N.J. Sebire, J.M. Snijders. The 11-14-week scan. Parthenon Publishing, New York-London, 1999 6. G. Pilu, K.H. Nicolaides. Diagnosis of fetal abnormalities: The 18-23 weeks scan. Parthenon Publishing, New YorkLondon, 1999. 7. Kurjak A, Chervenak FA, Carrera JM. Donald School Atlas of fetal anomalies. Jaypee Brothers, New Delhi, 2007 9. Kurjak A, Bajo Arenas J. Donald School Textbook of transvaginal sonography. Jaypee Brothers New Delhi, 2005 Evaluation: practical exam – patient examination, description of images; writen MCQ exam ULTRASOUND AND BREAST Subject leader: Prof. Boris Brkljačić, MD, PhD Semester: I Hours: lectures 6, seminars 4, practical work 12 (ECTS: 3.3) Content: Anatomy of the breast. The methods of breast examination: clinical, mammography, ultrasound and other methods. Inflammations. Benign and malignant masses. Collaborators: E. Pichler, MD, PhD, Prof B.Breyer,PhD, Prof. V. Šeparović, MD, PhD, E. Čepulic, MD,MSc Literature: 1. E. Tohno, D.O. Cosgrove, J.P. Sloane: Ultrasound diagnosis of breast disease Churchill Livingstone, New York, 1994 2. E. Pichler: Sonography of breast tumors. Acta Clin Croat 1997;36:169-72 3. S.Heywang-Kobruner: Diagnostic breast imaging: mamography, senography, MRI and interventional procedures. Thieme, Stuttgart-New York, 1997 4. H. Madjar: The practice of breast ultrasound: Techniques, findings, differential diagnosis. Thieme, Stuttgart-New York, 2000 5. Fact sheet on breast cancer: www.at.com/ref_lib/br/fact_sheet.html Evaluation: practical exam – patient examination, description of images; writen MCQ exam MEDICAL STATISTICS Subject leader: Prof.Davor Ivanković, PhD Semester: I Hours: lectures 4, seminars 6, practical work 6 (ECTS: 2.4) Content: Characteristics and peculiarities of statistical data analysis models (experimental design, quasiexperimental design, population surveys, organization functioning). Sampling. Confidence interval. Validity tests of diagnostic procedures, ROC analysis. Risk estimation. Standardization. General linear model. Space reduction. Discriminant analysis. Time series analysis. Quality of health care assessment. Critical analysis of statistical analytical procedures and conclusions applied in selected papers published in medical journals. Collaborators: Prof.S. Vuletic,PhD Z. Sonicki, MD,MSc Literature: Spec. study ULTRASOUND, Page 6 1. E.H. Shortliffe, L.E. Perreault: Medical informatics. Computer applications in health care. Addison-Wesley Publishing Company, Reading, Massachusetts, 1990 2. E. Coiera: Guide to medical informatics, the Internet and Telemedicine. Chapman & Hall Medica, London, 1997. 3. J. van Bemmel, M.A. Musen: Handbook of medical informatics. Houten, Bohn Staflen Van Loghum, 1997. Evaluation: oral exam Spec. study ULTRASOUND, Page 7 Elective subjects ULTRASOUND AND MENOPAUSE Subject leader: Prof. Asim Kurjak, MD, PhD; Ass.prof. Biserka Funduk Kurjak, MD, PhD Semester: II Hours: lectures 10, seminars 5, practical work 25 (ECTS: 6,0) Content: Ultrasound assessment of the uterus and ovaries in perimenopausal and postmenopausal period. Transvaginal color Doppler in the assessment of circulatory changes during the menopause. Role of ultrasound in the assessment of the postmenopausal patients with vaginal bleeding. Ultrasound and Doppler findings of endometrial hyperplasia, endometrial polyps and endometrial carcinoma. Detection and staging of endometrial carcinoma by different forms of ultrasound. Adnexal lesions in postmenopausal period. Ultrasound and Doppler assessment of the patients receiving hormonal replacement therapy. Ultrasound and Doppler changes in uterine morphology and circulation in patients undergoing tamoxifen treatment. Role of ultrasound in the assessment of urogynecological disorders. The use of transperineal ultrasound in postmenopausal patients. Collaborators: Prof. Veljko Vlaisavljević, MD, PhD, R. Bauman, MD, B Ujevic MD, M Kerner MD Literature: 1. A. Kurjak i suradnici: An atlas of ultrasonography in obstetrics and gynecology, Parthenon Publishing, London-New York, 1992. 2. A. Kurjak i suradnici: Slide atlas - gynecology, volume 2, Parthenon Publishing, London-New York 1994. 3. A. Kurjak: An atlas of transvaginal color Doppler: the current state of art (the encyclopedia of visual medicine series). Parthenon Publishing, London-New York, 1994. 4. A. Kurjak: Ultrasound and ovary (Progress in obstetrics and gynecological sonography series). Parthenon Publishing, London-New York, 1994. 5. R. Osmers, A. Kurjak: Ultrasound and the uterus (Progress in obstetrics and gynecological sonography series). Parthenon Publishing, London-New York, 1995. 6. I.E. Timor Tritsch, A. Kurjak: Ultrasound and the Fallopian tube (Progress in obstetrics and gynecological sonography series)., Parthenon Publishing, New-York- London, 1996. 7. A.C. Fleischer, A. Kurjak, S. Granberg: Ultrasound and the endometrium. (Progress in obstetrics and gynecological sonography series). Parthenon Publishing London-New York, 1997. 8. A. Kurjak, M. Kos: Temelji ultrazvuène dijagnostike u ginekologiji i porodništvu. Art Studio Azinoviæ, Zagreb, 1998. 9. A. Kurjak, S. Kupesic: An atlas of transvaginal color Doppler, Parthenon Publishing, London-New York, 2000 10. S. Kupesic: Color Doppler and 3D ultrasound in gynecology, infertility and obstetrics, Jaypee Brothers, New Delhi, 2003 11. Kurjak A, Bajo Arenas J. Donald School Textbook of transvaginal sonography. Jaypee Brothers New Delhi, 2005 Evaluation: practical exam – patient examination, description of images; written MCQ exam APPLICATION OF 3D AND 4D ULTRASOUND Study leader: Prof. Asim Kurjak, MD, PhD Semester: II Hours: lectures 10, seminars 5, practical work 25 (ECTS: 6,0) Content: Basic principles and physics of three-dimensional ultrasound. Threedimensional power Doppler ultrasound. Uterine cavity and myometrium assessed by three-dimensional ultrasound. Uterine anomalies. Role of threedimensional ultrasound in the diagnosis of the intracavitary lesions (submucous leiomyoma, endometrial polyps, intrauterine synechiae). Role of three-dimensional ultrasound in the assessment of infertility. Assessment of the IUD location by three-dimensional ultrasound. Role of three-dimensional ultrasound in detection of endometrial carcinoma. Staging of endometrial carcinoma by three-dimensional and power Doppler ultrasound. Ovarian lesions assessed by 3D and power Doppler ultrasound. Three-dimensional power Doppler improves detection of the malignant pelvic tumors. Three-dimensional ultrasound of benign and malignant lesions of the Fallopian tube assessed by threedimensional ultrasound. Three-dimensional ultrasound and power Doppler hysterosonosalpingography. Assessment of urogynecological disorders by three-dimensional multiplanar imaging. Three-dimensional sonoembryology. Spec. study ULTRASOUND, Page 8 Gestational sac volume assessed by three-dimensional ultrasound. Volume and vascularity of the yolk sac assessed by three-dimensional and power Doppler ultrasound. Pathology of early pregnancy (missed abortion, blighted ovum) assessed by three-dimensional ultrasound. Ultrasound markers for chromosomopathies assessed by multiplanar imaging and surface rendering. Fetal malformations (abnormalities of the fetal brain and spinal cord, face, heart and great arteries, lungs, diaphragm, gastrointestinal and urogenital tracts, abdominal wall and skeletal system) assessed by three-dimensional ultrasound. Normal and abnormal fetal face assessed by three-dimensional ultrasound. Multiple fetal malformations. The role of three-dimensional power Doppler in the assessment of fetal and placental circulation. Three-dimensional ultrasound improves the accuracy in performing ultrasonically guided procedures. Fetal behaviour and fetal physiology Collaborators: Prof. B. Breyer,PhD, Prof. I Žalud, MD, PhD, Prof. Aida Salihagić, MD, PhD, M. Stanojević,MD,PhD, W Andonotipo, MD, PhD, R. Bauman,MD, T. Hafner,MD,Msc Literature: 1. A. Kurjak, S. Kupesic: Slide atlas of three-dimensional ultrasound in gynecology and obstetrics. Parthenon Publishing, London-New York, 1998 2. A. Kurjak: Three-dimensional power Doppler in obstetrics and gynecology. Parthenon Publishing, New YorkLondon, 1999 3. A. Kurjak, S. Kupesic: Clinical application of 3D sonography. Parthenon Publishing, London-New York, 2000 4. A. Kurjak, S. Kupesic: An atlas of transvaginal color Doppler. Parthenon Publishing, London-New York, 2000 5. S. Kupesic, D. De Ziegler: Ultrasound and infertility. Parthenon Publishing, London-New York, 2000 6. A. Kurjak, D. Jackson: An atlas of three- and four-dimensional sonography in obstetrics and gynecology. Parthenon Publishing, London-New York, 2004 7. Kurjak A, Chervenak FA, Carrera JM. Donald School Atlas of fetal anomalies. Jaypee Brothers, New Delhi, 2007 8. Kurjak A, Bajo Arenas J. Donald School Textbook of transvaginal sonography. Jaypee Brothers New Delhi, 2005 9. Kurjak A, Azumendi G. Fetus in three dimensions Informa, London 2007 Evaluation: images description and writen MCQ exam ULTRASOUND IN NEONATLOGY Subject leader: M. Stanojević, MD, PhD Semester: II, Hours: lectures 10, seminars 5, practical work 25 (ECTS: 6,0) Content: The use of ultrasound in neonatal surgery. Ultrasound in diagnosis of hip displasia. Hypoxic-ishemic brain damage in pre-term and term neonates. Periintraventricular hemorrhage in pre-term babies. Intracranial malformations. Intracranial ultrasound in early diagnosis of neurodevelopmental handicap in children with perinatal brain damage. Transcranial Doppler in newborns. Collaborators: Prof. Vlatka Bošnjak Mejaški, MD, PhD Literature: 1. H.W. Taeusch, R.A. Ballard: Avery’s disease of the newborn. W.B. Saunders Company, Philadelphia-LondonToronto-Montreal-Sidney-Tokyo, 1998 2. G.B. Merenstein, S.I. Gardner: Handbook of neonatal intensive care. Mosby-Year Book, Inc., 1998 3. J.O. Haller: Textbook of neonatal ultrasound. Parthenon Publishing, New York- London, 1997 4. A.Q. Fischer, J.C. Anderson, R.M. Shuman, W. Stinson: Pediatric neurosonography. Clinical, tomographic and neuropathological correlates. A Willey Medical Publication, New York-Chicester-Brisbane-Toronto-Singlapore, 1985 Evaluation: images description and writen MCQ exam EARLY HUMAN DEVELOPMENT Subject leader: Prof. Ljiljana Kostović-Knežević, MD,PhD Semester: II Hours: lectures 10, seminars 5, practical work 25 (ECTS: 6,0) Content: Human embryo before ultrasound visualization. Embryo staging according to morphological features. Spec. study ULTRASOUND, Page 9 Key events and morphogenetic processes during embryogenesis. Differentiation of the tissues and organ primordia. Molecular basis of early development: network of gene cascades, inductive and suppressive events during cellular and tissue differentiation. Experimental mammalian models in understanding of early normal and abnormal human development. Etiopathogenetic factors involved in abnormal embryo development. Isolation and application of embryonic stem cells in experimental models. Collaborators: Prof. D. Ježek, MD,PhD, Prof. S. Gajović, MD, PhD, D. Mitrečić, MD, PhD Literature: 1. Langman’s Medical Embryology, ed. Sadler TW. 10th edition. Williams and Wilkins,Baltimore-Sidney, 2006. 2. Human Embryology,ed. Larsen WJ. 3th edition, Churchill Livingstone, New York Edinburg London Philadelphia 3. Donald School Atlas of Clinical Application of Ultrasound in Obstetric & Gynecology, ed. Carrera JM, Kurjak A. 1th edition. Jaypee Brothers Medical Publishers (P) Ltd 2006. 4. Donald School Textbook of Ultrasound in Obstetric & Gynecology, ed. Kurjak A. Chervenak FA. 1th edition. Jaypee Brothers Medical Publishers (P) Ltd 2004. Evaluation: oral exam INTERVENTIONAL ULTRASUND IN OBSTETRICS AND GYNAECOLOGY Subject leader: Ass.prof. R Matijević, MD,PhD, MRCOG Semester: II Hours: lectures 10, seminars 5, practical work 25 (ECTS: 6,0) Content:: Introduction to interventional ultrasound (procedure and principles of the ultrasonically guided puncture, prerequisites, equipment, safety precautions). Handling of aspirated materials (fine-needle aspiration cytology, preparation of the smear, cytological evaluation of the smear, fine-needle histological sampling, microscopic evaluation of benign and malignant lesions). Puncture of gynecologicalmasses (selection of the patients, indication, technique of the ultrasonically guided puncture in gynecology, follow-up of the patients). Ultrasonically guided aspiration of human oocytes (equipment, indications, in vitro fertilization and embryotransfer). Intrauterine diagnostic procedures (chorion biopsy, early and late amniocentesis, fetal blood sampling, heart puncture, puncture of the umbilical vein, skin biopsy, puncture of fetal cysts). Multifetal pregnancy reduction. Collaborators: Prof. A. Kurjak,MD,PhD, Prof. Snjezana Skrablin Kučić, MD, PhD, Prof. Žarko Alfirevic, MD, PhD, D Habek, MD, PhD, R. Bauman, MD, B. Mišković,MD,MSc, T. Hafner, MD,MSc Literature: 1. A. Kurjak et al: An atlas of ultrasonography in obstetrics and gynecology, Parthenon Publishing, London-New York, 1992. 2. A. Kurjak et al: Slide atlas - gynecology, volume 2, Parthenon Publishing, London- New York 1994. 3. A. Kurjak: An atlas of transvaginal color Doppler: the current state of art (the encyclopedia of visual medicine series). Parthenon Publishing, London-New York, 1994. 4. M.I. Evans, C.H. Rodeck. Ultrasound and fetal therapy. Parthenon Publishing, New York-London, 2000 5. A. Kurjak, M. Kos: Temelji ultrazvuène dijagnostike u ginekologiji i porodništvu. Art Studio Azinoviæ, Zagreb, 1998. 6. A. Kurjak, S. Kupesic: A slide atlas of three-dimensional ultrasound in gynecology and obstetrics. Parthenon Publishing Group, London-New York, 1998. 7. S. Weiner, A. Kurjak. Interventional ultrasound. Parthenon Publishing, New York- London, 1999 8. A. Kurjak, S. Kupesic: An atlas of transvaginal color Doppler, Parthenon Publishing, London-New York, 2000 9. S. Kupesic, D. De Ziegler: Ultrasound and infertility. Parthenon Publishing, London-New York, 2000 10.Donald School Atlas of Clinical Application of Ultrasound in Obstetric & Gynecology, ed. Carrera JM, Kurjak A. 1th edition. Jaypee Brothers Medical Publishers (P) Ltd 2006. 11. Donald School Textbook of Ultrasound in Obstetric & Gynecology, ed. Kurjak A. Chervenak FA. 1th edition. Jaypee Brothers Medical Publishers (P) Ltd 2004. Evaluation: images description and writen MCQ exam Spec. study ULTRASOUND, Page 10 ECHOCARDIOGRAPHY Study leaders: Prof. Ivo Malčić, MD,PhD, Milan Stanojević, MD,PhD Semester: II Hours: lectures 10, seminars 5, practical work 25 (ECTS: 6,0) Content: Normal echocardiographic imaging. Doppler method in echocardiography. Echocardiography in mitral and aortic valve disease. Echocardiographic diagnosis of intracardiac masses. Echocardiography in pericardial diseases. Transesophageal and interventional echocardiography. Specific features of echocardiography in children. Congenital cardiac diseases with right-left shunt. Two-dimensional Doppler echocardiography. Congenital cardiac diseases with left-right shunt. Valvular heart disease and cardiomyopathies. Collaborators: Prof.B. Marinović,MD,PhD, Prof. Ivo Čikeš, MD,PhD, U.Marton, MD, MSc Literature: 1. I. Čikeš: Echocardiography in cardiac interventions. Kluwer Academic Publishers, Boston-Dordrecht-London, 1989 2. J.R.T.C. Roelandt, G.R. Sutherland, S. Iliceto, D.T. Linker, eds. Cardiac ultrasound. Churchill Livingstone, Edinburgh-London-Madrid-Melbourne-New York- Tokyo, 1993 3. H. Feigenbaum. Echocardiography, 5th ed. Lea & Febiger, Philadelphia- Baltimore-Hong Kong-London-MunichSidney-Tokyo, 1994 Evaluation: oral exam ULTRASOUND IN ADOLESECNECE Subject leader: Ass.Prof. Biserka Funduk-Kurjak, MD, PhD Semester: II Hours: lectures 10, seminars 5, practical work 25 (ECTS: 6,0) Content: Transabdominal and transperineal ultrasound in pediatric and adolescent patients. Anatomy of gynecological structures in childhood and adolescency. Menstrual cycle disorders. Primary and secondary amenorrhea. Functional ovarian cysts. Gynecologic tumors in childhood and adolescency: diagnosis, follow-up and management. Menstrual disorders: role of ultrasound and Doppler findings. Oral contraception: ultrasound assessment of the uterus and ovaries. Collaborators: R. Bauman, MD, M Kerner, MD Literature: 1. J.C. Anderson: Gynecologic imaging. Churchill Livingstone, New York, 1999 2. S.R. Goldstein, I.E. Timor-Tritsch: Ultrasound in gynecology. Churchill Livingstone, New York, 1995 3. A. Kurjak, S. Kupesic: An atlas of transvaginal color Doppler. Parthenon Publishing, London-New York, 2000 4. A. Kurjak i suradnici: Slide atlas - gynecology, volume 2, Parthenon Publishing, London-New York 1994. 5. A. Kurjak: An atlas of transvaginal color Doppler: the current state of art (the encyclopedia of visual medicine series). Parthenon Publishing, London-New York, 1994. 6. A. Kurjak, S. Kupesic: A slide atlas of three-dimensional ultrasound in gynecology and obstetrics. Parthenon Publishing Group, London-New York, 1998. 7. A. Kurjak, S. Kupešiæ, M. Kos: Ultrazvuk u klinièkoj medicini, Art Studio Azinoviæ, Zagreb, 2000. 8. A. Kurjak, S. Kupesic: An atlas of transvaginal color Doppler, Parthenon Publishing, London-New York, 2000 9. A. Kurjak, F.A. Chervenak: Donald School Textbook of ultrasound in obstetrics and gynecology, Jaypee Brothers, New Delhi, 2003 Evaluation: images description and oral exam Spec. study ULTRASOUND, Page 11 Table 1. The list of basic and elective subjects with ECTS ULTRASOUND IN OBSTETRICS AND GYNECOLOGY Hours ECTS First and second trimester Basic subjects BASIC SCIENCS (PHYSICS AND TECHNOLOGY) ULTRASOUND AND INFERTILITY ULTRASOUND IN GYNECOLOGY ULTRASOUND IN OBSTETRICS ULTRASOUND AND BREAST MEDICAL STATISTICS Total 32 90 36 90 22 16 286 4.8 13.5 5.4 13.5 3.3 2.4 42.9 40 40 40 40 40 40 40 120 6 6 6 6 6 6 6 18 ELECTIVE SUBJECTS 286 120 42.9 18 TOTAL FOR STUDY 406 60.9 Second semester Elective subjects (three should be chosen) ULTRASOUND AND MENOPAUSE APPLICATUION OD 3D AND 4D ULTRASOUND IN O & G ULTRASOUND IN NEONATOLOGY EARLY HUMAN DEVELOPMENT INTERVENTIONAL ULTRASOUND IN O & G ECHOCARDIOGRAPHY ULTRASOUND IN ADOLESCENCE Total (for 3 subjects) BASIC SUBJECTS