1
TABLE S3
TUMOR-SUPPRESSOR GENE
Official Symbol
Official Full Name
EGLN1/ PHD2
egl nine homolog 1
PRTFDC1
phosphoribosyl
transferase
domain containing 1
UV radiation resistance
associated gene
tumor suppressor candidate
3
UVRAG
TUSC3
Fold
(treated
/Control)
6,23
Gene Ontology Biological Process
(http://www.ebi.ac.uk/GOA/)
Component
Oxidoreductase activity, acting on single donors with
incorporation of molecular oxygen, incorporation of two
atoms of oxygen, response to hypoxia, associated with HIF-1
Hypoxanthine phosphoribosyltransferase activity, transferase
activity, nucleoside metabolic process.
DNA repair.
Cytosol
4,00
Protein amino acid N-linked glycosylation via asparagine, this
gene is a candidate tumor suppressor gene
Integral to membrane
membrane
Fold
(treated
/Control)
4,72
Gene Ontology Biological Process
(http://www.ebi.ac.uk/GOA/)
Component
G-protein coupled receptor protein signaling pathway, signal
transduction
Protein kinase activity, I-kappaB kinase/NF-kappaB cascade,
inflammatory response, signal transduction
Phosphoinositide phospholipase C activity, receptor signaling
protein activity, activation of MAPK activity, cell proliferation,
cytoskeleton organization and biogenesis, regulation of cell
growth.
Inactivation of MAPK activity, regulation of signal
transduction
Plasma membrane
Gene Ontology Biological Process
(http://www.ebi.ac.uk/GOA/)
Component
5,28
4,86
Cytoplasm
Cytoplasm
SIGNAL TRANSDUCTION
Official Symbol
Official Full Name
Gpr103
G protein-coupled receptor
103
interleukin-1 receptorassociated kinase 2
phospholipase C, epsilon 1
IRAK2
PLCE1
SPRED2
sprouty-related,
domain containing 2
EVH1
9,65
4,14
4,29
Cell surface
Golgi apparatus
Golgi membrane
Membrane
METABOLISM
Official Symbol
Official Full Name
ADH6
Alcohol dehydrogenase 6
Fold
(treated
/Control)
4,00
Ethanol
oxidation,
metabolic
process,
electron
carrier
Cytoplasm
2
MSRA
methionine sulfoxide
reductase A
4,00
PLA2G4E
phospholipase A2, group IVE
6,73
PRTFDC1
phosphoribosyl
transferase
domain containing 1
5,28
activity, oxidoreductase activity
oxidoreductase
activity,
protein-methionine-S-oxide
reductase activity, methionine metabolic process, response to
oxidative stress. MSRA gene on chromosome 8p might
possess metastasis suppressor activity in HCC.
calcium ion binding, hydrolase activity, phospholipase A2
activity, lipid catabolic process
hypoxanthine phosphoribosyltransferase activity, transferase
activity, nucleoside metabolic process, possible tumorsuppressor gene
Cytoplasm, membrane
Cytoplasm
IMMUNE RESPONSE
Official Symbol
Official Full Name
BRDG1 / STAP-1
signal transducing adaptor
family member 1
CCDC110
coiled-coil domain containing
110
Fc fragment of IgG, low
affinity IIIa, receptor (CD16a)
major
histocompatibility
complex, class I, C
major
histocompatibility
complex, class I, C
major
histocompatibility
complex, class II, DQ beta 1
major
histocompatibility
complex, class II, DR alpha
interferon,
alpha-inducible
protein 6
killer cell immunoglobulinlike receptor, two domains,
long cytoplasmic tail, 1
leucine-rich repeats and
immunoglobulin-like
domains 1
T cell receptor associated
transmembrane adaptor 1
FCGR3A
HLA-C
HLA-C
HLA-DQB1
HLA-DRA
IFI6
KIR2DL1
LRIG1
TRAT1
Fold
(treated
/Control)
6,06
Gene Ontology Biological Process
(http://www.ebi.ac.uk/GOA/)
Component
Cytoplasm
8,51
humoral immune response, transmembrane receptor protein
tyrosine kinase signaling pathway, intracellular signaling
cascade
Cellular and humoral immune responses
5,28
Receptor activity, immune response
Plasma membrane
8,00
MHC class I receptor activity, immune response
Membrane
6,96
Immune response
4,00
MHC class II receptor activity, immune
MHC class I protein
complex
integral to membrane
11,31
MHC class II receptor activity, immune response.
4,00
Anti-apoptosis, immune response, negative regulation of
caspase activity
HLA-C specific inhibitory MHC class I receptor activity,
immune response
6,50
Nucleus
MHC class II protein
complex
Membrane, mitochondrion
Integral to plasma
membrane
5,66
Protein binding
Integral to membrane
4,29
Immune response
Pasma membrane
3
CELL PROLIFERATION, GROWTH FACTOR ACTIVITY
Official Symbol
Official Full Name
CDKN1C
cyclin-dependent
kinase
inhibitor 1C (p57, Kip2)
latent transforming growth
factor beta binding protein 4
nephroblastoma
overexpressed gene
LTBP4
NOV
Fold
(treated
/Control)
6,50
5,06
4,29
Gene Ontology Biological Process
(http://www.ebi.ac.uk/GOA/)
Component
Cyclin-dependent protein kinase inhibitor activity, cell cycle
arrest, negative regulation of cell proliferation
Growth factor activity
Nucleus
Growth factor activity, insulin-like growth factor binding, cell
adhesion, chemotaxis, cell survival
Extracellular region
Cellular_component
TRANSCRIPTION COACTIVATOR ACTIVITY, TRANSCRIPTION FACTOR ACTIVITY
Official Symbol
Official Full Name
ELF2
FRYL
ZHX2
E74-like factor 2
FRY-like
zinc fingers and homeoboxes
2
Fold
(treated
/Control)
5,66
4,69
4,23
Gene Ontology Biological Process
(http://www.ebi.ac.uk/GOA/)
Component
Transcription activator activity, transcription factor activity
Regulation of transcription, DNA-dependent, transcription
Sequence-specific DNA binding, transcription factor activity,
negative regulation of transcription, DNA-dependent
Nucleus
Nucleus
Nucleus
Gene Ontology Biological Process
(http://www.ebi.ac.uk/GOA/)
Component
4,47
4,59
Oligopeptide transport, calcium-dependent cell-cell adhesion,
It is associated with hepatocellular carcinoma
Cytoskeletal protein binding
calcium-dependent cell-cell adhesion
Integral to plasma
membrane
Cytoskeleton
Integral to plasma
membrane
Integral to membrane
Membrane
STRUCTURAL MOLECULE, CELL ADHESION
Official Symbol
Official Full Name
CDH17
MSN
NLGN1
cadherin 17, LI
(liver-intestine)
moesin
neuroligin 1
PCDH10
PCDH9
protocadherin 10
protocadherin 9
7,46
6,06
Cell adhesion, calcium ion binding
Cell adhesion, homophilic cell adhesion
Official Full Name
Fold
(treated
Gene Ontology Biological Process
(http://www.ebi.ac.uk/GOA/)
cadherin
Fold
(treated
/Control)
6,50
CELL DEATH
Official Symbol
Component
4
IFI6
NGFR
TRAF3IP3
interferon,
alpha-inducible
protein 6
nerve growth factor receptor
(TNFR superfamily, member
16)
TRAF3 interacting protein 3
/Control)
4,00
4,59
Anti-apoptosis, immune response, negative regulation of
caspase activity
Death receptor activity, nerve growth factor binding,
apoptosis
Membrane, mitochondrion
Integral to plasma
membrane, cytoplasm,
nucleus
Integral to membrane
7,46
Proapoptotic effect
Fold
(treated
/Control)
4,06
Gene Ontology Biological Process
(http://www.ebi.ac.uk/GOA/)
Component
ATPase activity, coupled to transmembrane movement of
substances
Protein transport, vesicle docking during exocytosis
Integral to membrane
Cell adhesion. The protein encoded by this gene is a major
structural protein of the bone matrix.
Protein binding
Extracellular region
OTHERS
Official Symbol
Official Full Name
ABCC12
ATP-binding cassette, subfamily C member 12
exocyst complex component
4
integrin-binding sialoprotein
EXOC4
IBSP
LRRC4
PARP10
SORBS2
9,85
10,93
Cytoplasm
leucine rich repeat
containing 4
poly (ADP-ribose) polymerase
family, member 10
4,59
Membrane
4,38
NAD+ ADP-ribosyltransferase activity, transferase activity,
transferring glycosyl groups
Cytoplasm
Nucleus
sorbin and SH3 domain
containing 2
25,81
Protein binding, cytoskeletal adaptor activity
Nucleus
Actin cytoskeleton