Dr.Dalia Mahmoud Ghorab
Dr. Dalia Mahmoud Mohamed Ghorab
NATIONALITY
: Egyptian
DATE OF BIRTH
: 13-2-1968
MARITAL STATUS
: married, and having three kids.
PRESENT OCCUPATION:
Professor of Pharmaceutics and Pharmaceutical
Technology
Faculty of Pharmacy, Cairo University,
Cairo, Egypt.
PAST EXPERIENCE:
Consultant in Egyptian Patent office
Scientific Research Academy, Kasr el Eini street
Cairo, Egypt.(2002- 2005)
Visitor Lecturer at 6th October university (2003-2005) and
(2007-2009)
Academic Vice Dean in the International Academy for
Health Sciences (girls branch Al Hofouf, KSA) (2005-2007).
Visitor Ass. Prof. at ACU (Ahram Canadian University)
Academic year 2009/2010
Vice president of the Drug Manufacturing unit (DMU) faculty
of Pharmacy Cairo University (2012)
EDUCATION
2000-2002: Ph. D. of Pharmaceutical Sciences in Pharmaceutics from Faculty of
Pharmacy Cairo University
Thesis Advisor: Dr. Nadia Mohamed Moursi
Thesis Title: “Biopharmaceutical Studies on Certain Antihypertensive Drugs in
Controlled Release Delivery Systems”.
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Dr.Dalia Mahmoud Ghorab
1996-1999: Master, Pharmaceutics
Faculty of Pharmacy, Cairo University
Thesis Advisor: Dr. Nadia Mohamed Moursi
Thesis Title: “Studies on Controlled Release Calcium Channel Blockers in Solid
Dosage Forms”.
1985-1990: Bachelor of Pharmaceutical Sciences with general grade excellent
with honour degree Faculty of Pharmacy, Cairo University, Cairo, Egypt
(2000): Diploma in educational sciences from Cairo University.
(2005): Diploma in development of managerial skills from Cairo University.
(2005): Diploma in decision making and problems solving from Cairo University.
(2005): Diploma in modern teaching methods from Cairo University.
(2007): Diploma in scientific writing and international publishing from Cairo
University.
(2007):Diploma in syllabus and coarse designing from Cairo University.
(2007):Diploma in time management and work stress from Cairo University.
(2008):Diploma in Management of law and financial aspects from Cairo
University.
(2008):Diploma in conferences organization from Cairo University.
(2008):Diploma in E- learning from Cairo University.
(2009): Diploma in Research team management from Cairo University
(2010): Diploma in Credit hours systems from Cairo University
(2011): Diploma in Exam preparation and Student evaluation from Cairo
University
(2012): Diploma in Code of Ethics from Cairo University
RESEARCH ACTIVITIES AND EXPERIENCE
1996-1999: The objective of the master work was to control the release of
nicardipine hydrochloride (NCH) in order to maintain the drug plasma concentration
for a longer time. Solid dispersion, film coating of pellets and wet granulation
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Dr.Dalia Mahmoud Ghorab
techniques were applied for sustaining the release rate of (NCH). Attempts have
been made to design special delivery system for (NCH) so as to remain buoyant on
the stomach contents and increasing the gastric residence time of the drug. in vitro
evaluation of the prepared floating capsules in comparison to the commercially
available brand of (NCH) revealed the success of the new special design.
2000-2002: In the PHD work two antihypertensive drugs were introduced to control
their release through the formulation of floating systems. The first is furosemide, a
loop diuretic. The second is verapamil hydrochloride, a calcium channel blocker.
Formulation
of
furosemide
floating
capsules
was
achieved.
The
relative
bioavailability of the prepared capsules when compared to lasix tablets was found to
be 180.9%. Also floating microspheres of verapamil hydrochloride were prepared
and their relative bioavailability when compared to isopten retard was found to be
almost the same.
EXPERIENCE WITH EQUIPMENT AND SOFTWARE
Pharmaceutical Equipment
Release Testing Equipment
USP dissolution apparatus 1 and 2
Tablet disintegration apparatus
Coating pan, Manesty Machines.
Spectroscopic Equipment
HPLC
Ultraviolet/visible spectrophotometer
Computer Software
Internet user plus Microsoft Word, Microsoft Excel, Power
point, Chem Window.
Statistical software packages: SAS and JMP
Pharmacokinetic analysis software: Winnonlin
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Dr.Dalia Mahmoud Ghorab
PUBLICATIONS
1- N. M. Moursi, N. N. Afifi, D. M. Ghorab, “Study on the enhancement of
nicardipine hydrochloride dissolution at intestinal pH”, J. Drug Research Egypt
(NODCAR) Vol.24, (2002).
2- N. M. Moursi, N. N. Afifi, D. M. Ghorab, Y. El-Saharty, “Formulation and
evaluation of sustained release floating capsules of nicardipine hydrochloride”,
Die Pharmazie, 58(1): 38-43 (2003).
3- N. M. Moursi, N. N. Afifi, D. M. Ghorab, “Controlled release floating forms of
nicardipine hydrochloride”, Patent application No.7/ 2000 (2000010007).
4- N. M. Moursi, N. N. Afifi, D. M. Ghorab, “Preparation and biopharmaceutical
evaluation of floating capsules of furosemide” , Patent application No.1259/ 2002
(2002111259).(according to the GAT i.e for final compound).
5- N. M. Moursi, N. N. Afifi, D. M. Ghorab, “Preparation and biopharmaceutical
evaluation of floating capsules of furosemide” , Patent application No.1260/ 2002
(2002111260).( method of preparation).
6- Moursi, N M.; Afifi, N. N.; Ghorab, D. M. and El-Saharty, Y. S., “Improving
Bioavailability of Furosemide by Controlled Release Floating Granules in
Capsules Formulation”, Bull. Fac. Pharm. Cairo Univ. 41(3) (2003) 83.
7- N. M. Moursi, N. N. Afifi, D. M. Ghorab,"A Study on the Enhancement of
Nicardipine Hydrochloride Dissolution at Intestinal ph", J. Drug Res. Egypt: 24 (12), 21-28 (2002)
8- Ghorab, M. M., Ghorab, D. M., Ibrahim, H. K.,”Formulation and Evaluation of
Phenytoin -cyclodextrin Complexes”, Patent application No.625 / 2003
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Dr.Dalia Mahmoud Ghorab
(2003070625).
9- Ghorab, D. M., “Microballoons as a gastric retarding system for controlled
release nicardipine hydrochloride” Bull. Fac. Pharm. Cairo Univ. 42(1) (2004) 99.
10- Moursi, N M.; Afifi, N. N.; Ghorab, D. M. and El-Saharty, Y. S., “Floating
Microballoon
as
Controlled
Release
Delivery
System
for
Verapamil
Hydrochloride”, a poster had been presented in the Third Azhar International
Conference for Pharmaceutical and Biological Sciences held in December 2003.
11- Ghorab, D. M.,Taha, E. I. “Comparative Pharmacokinetics and Bioavailability of
Two Omeprazole preparations", in Bull. Fac. Pharm. Cairo Univ., 44(3) (2006)
111- 117.
12- Taha, E., Ghorab, D. M., Zaghloul, A. " Bioavailability assessment of vitamin A
self nano emulsified drug delivery systems in rats; a comparative study" Med.
Princ. Pract, 884,17, 26 (2007).
13- Ghorab, D. M., Ibrahim, H. M. "Phentoin sodium /betacyclodextrin inclusion
complexes preparation and evaluation" Bull. Fac. Pharm. Cairo univ. 45(1)
(2007) 105-113.
14- Ghorab, D. M., Ibrahim, H. M. "Formulation and biopharmaceutical evaluation of
gliclazide/ β- cyclodextrin complex" Bull. Fac. Pharm. Cairo univ. 45 (2) (2007).
15- Ghorab, D. M.," A randomized, open- label, two – period, crossover
bioavailability study of two oral brands of Atenolol in healthy volunteers" Bull.
Fac. Pharm. Cairo univ. 45 (2) (2007).
16- Moursi, N M., Mohamed, M. I., Ghorab, D. M., Teba, H. S., "Preparation,
Characterization and In-vitro Evaluation of Transdermal Drug Delivery System of
Ketorolac Tromethamine". a poster had been Published in the 13th conference of
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Dr.Dalia Mahmoud Ghorab
Scientific Association of Colleges of Pharmacy in the Arab World held in May
2010. In press.
17- Dalia Mahmoud Ghorab, Heba Ibrahim Abdallah, Preparation of Small Pool
Stabilized virus Inactivated, Factor VIII Concentrate in Resource Limited
Countries., journal of Pharmaceutical Process Development (3)( 2011).
Ghorab, D. M., Ibrahim, H., "Biopharmaceutical studies on certain plasma
products" a poster had been presented in the AAPS Conference of held in
November 2009.
18- Dalia M. Ghorab, Maha Mohamed Amin, Omnia M. Khowessah, Mina Ibrahim
Tadrous, Colon Targeted Celecoxib- loaded Eudragit S100- Coated poly ԐCaprolactone microparticles: Preparation, Characterization and in vivo evaluation
in rats, Drug Delivery 18(7): 523-535 (2011).
19- Ghorab D., Refai, H., Tag R., Preparation and Evaluation of Fenoterol
hydrobromide suppositories, Drug Discoveries and Therapeutics, 5(6) 311-318
(2011).
Ghorab, D. M. Refai , H., Abd El Rehem, R. T., “Formulation and Evaluation of
Fenoterol Suppositories” a poster had been presented in the 29 th Conference of
Pharmaceutical Sciences held in December 2004.
20- D.M.Ghorab, Ibrahim I.S., Industrialization of chewable sugar coated tablets of
Phytominadione β- cylodextrin complexes, Journal of Pharmaceutical research
and opininon, 2(10): 129-137 (2012)
21- Mearal A. Hussien, Howida K. Ibrahim and Dalia M.Ghorab, Sterile Lyophilized
Pantoprazol
Sesquihydrate:
Formulation
and
Manufacturing
Economics.
International Journal of Novel Drug Delivery Technology, 2(2): 276-282 (2012).
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Dr.Dalia Mahmoud Ghorab
22- N. M. Morsi, D.M. Ghorab, H.A.Badie, Bioadhesive Brain Targeted Nasal
Delivery of an Ant ischemic Drug, Int. J. Pharm. Biomed. Archieves. 3 (5) 11011110 (2012).
23- Elnawawy T. M., Swailem A.M., Ghorab D. M., Nour S. A., Floating tablets as a
controlled release stomach targeted drug delivery system of diltiazem
hydrochloride, Journal of Pharmaceutical research and opininon, 2(11), 173-183
(2012).
24- Tayseer El-nawawy, Abdel Monaem Swailem, Dalia Ghorab, Samia Nour,
Solubility Enhancement of Olmesartan by Utilization of Solid Dispersion and
Complexation Techniques, International Journal of Novel Drug Delivery
Technology,; in press (2012).
25- M. Moursy, Magdy. I. Mohamed, Dalia. M. Ghorab, Hoda. E. Teba. Permeation
Study of Transdermal Ketorolac Tromethamine (KT) Through Different
Membranes Published as a poster in the third coference of faculty of pharmacy
cairo university under the title of Good Pharmacy Practice held in 25-26 April
(2012)
26- Nadia M. Morsi, Dalia M. Ghorab, and Hany A. Badie, Brain targeted solid lipid
nanoparticles for brain ischemia: preparation and in vitro characterization,
Pharmaceutical development and technology,; Vol.18. (3): 735- 744 (2013).
TEACHING
Cairo University
Demonstrator (1993-1999)
Pharmaceutical Principles Laboratory and Industrial Pharmacy
Duties include assisting the students in dispensing different dosage form
prescriptions (such as solutions, suspension, ointments, emulsions, suppositories,
tablets and capsules). Assisting the students in understanding the designing of
different pharmaceutical equipment.
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Dr.Dalia Mahmoud Ghorab
Assistant Lecturer (2000-2002)
Duties include providing instruction to teaching assistants on laboratory
experiments and proper laboratory techniques in addition to monitoring students’
performance and ensuring implementation of safety regulations throughout the lab.
Lecturer (2002- 2007)
Visitor Lecturer in faculty of pharmacy 6th October university (2003-2008)
Courses lectured in include orientation to pharmacy and pharmacy history,
pharmaceutical dosage forms, liquid (solutions, suspensions, emulsions, colloids),
solid dosage forms (tablets, capsules), quality control, Pharmacokinetics, cosmetics
and legislation
Associate professor (2007- 2013)
Visitor associate professor in Alahram Canadian university ACU (2009-2010)
Courses lectured include Liquid dosage forms, Parentrals, Ophthalmic, statistics
Quality control and Industrial Pharmacy.
Teaching in the Clinical Pharmacy Program (faculty of Pharmacy, Cairo University)
Pharmaceutical dosage form 1 and Pharmacy legislation.
Professor (2013 till now)
PROFESSIONAL AFFILIATIONS
1991-till now
LANGUAGES
ADDRESS
Egyptian Association of Pharmaceutical Scientists
: English (excellent),
German (good),
French (good).
: Work: Faculty of Pharmacy, Cairo University, El-Kasr El-Eini
Street, 11562, Cairo, Egypt.
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Dr.Dalia Mahmoud Ghorab
* Residence: Building 47 A, Road 276, El-Maadi, Cairo, Egypt.
TELEPHONE No.: 00202/25193626 and mobile 0020122/3635022.
FAX No.: 00202/5320005
Email: dghorab@yahoo.com
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