Supplemental Table S1. Adrenal-related hormone levels in pregnant
and non-pregnant women
Concentration in nonConcentration during
pregnant women
pregnancy (third trimester)
CRH
0.77-2.5 pmol/l
Rises by 1000-fold 1
ACTH
2.2-13.3 pmol/L
Circulating maternal ACTH is
(10-60 pg/ml)
increased above nonpregnancy levels, but still
remains within the normal
range2
Total plasma cortisol
276-690 nmol/L
2-to-3-fold elevation3,4
(10-25 µg/dL)
Free plasma cortisol
140-700 nmol/L
2-to-4-fold elevation5,6,7,8
(5-25 µg/dL)
Salivary cortisol
7-20 nmol/L
More than 2 fold elevation8,9
(253 – 717 ng/dL)
11-deoxycorticosterone
<303 pmol/L
2 fold during the first
(DOC)
trimester to 10-fold in the
third trimester10,11
11-deoxycortisol
7-18 nmol/L
2-fold increase12
17-OH progesterone
Follicular phase :
Up to 84 nmol/L13
< 2.4 nmol/L (<80 ng/dL)
Luteal phase: <8.6
nmol/L (<285 ng/dL)
Progesterone
17βEstradiol
Estrone
Estriol
Plasma renin activity
Aldosterone
DHEA-S
<0.64-51 nmol/L
(<0.2-16 ng/mL )
depending on the
menstrual cycle phase
147-1835 pmol/L
(40-500 pg/ml)
depending on the
menstrual cycle phase
111-740 pmol/L
(3-20 ng/dL)
depending on the
menstrual cycle phase
0.01-0.05 nmol/L
0.003-0.016 ng/ml
(depending on the
menstrual cycle phase)
6.4-44.8 pmol/L/min
(0.5-3.5 ng/mL/h)
221-831 pmol/L
(8-30 ng/dL)
Up to 10-15 fold elevation
above luteal phase levels 14
22-110 nmol/L15
(6-30 ng/mL)
7.4-111 nmol/L15
(200-3000 ng/dL)
34.67-104 nmol/L15
(10-30 ng/mL)
3-to-7-fold increase14,16,17
5-to-7-fold elevation during
the 1st trimester; up to 1020fold elevation at the 38th
week12,18,19
0.8-6.5 µmol/L13
18-29 years:
1.14-8.63 µmol/L
(0.44-3.32 µg/mL)
Levels decline with aging
Supplemental TableS1. Reference values in non pregnant normal women and during the third trimester of
pregnancy.
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