Long Essay suggested Titles for 2010-2011 Department of Physiology & Biochemistry 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. 43. 44. 45. 46. Genotype-phenotype correlation in APC gene mutation in FAP The PTEN gene in growth and differentiation The intestinal microbiome Tissue transglutaminase Mitochondrial Inheritance and the Central Nervous System Maternal Inheritance of Congenital Heart Diseases Neurofibromatosis Chromosomal Deletion Syndromes Trisomies and Monosomies in Genetics Genetics and Neural Tube Defects Genomic Imprinting Diabetes Mellitus Bipolar Disorder and Heredity Epigenetics in Cancer Heredity of Addison's disease Amyloidosis Celiac Disease and Multifactorial Inheritance Genetic Markers in Molecular Medicine Genetics of Duchenne Muscular Dystrophy Reactive Oxygen Species and Autoimmune Diseases Parkinson’s Disease Multiple Sclerosis Biological and medical importance herbal supplements. Vitamin deficiency and food supplements. The use of umbilical stem cells. Adult Stem Cells Transplantation Dying to Sleep: Prions & Fatal Familial Insomnia Before Sperm meets Egg: The physiology of attraction, courtship and love- making The ends have arrived: Telomeres, Telomerase and their impact on medicine Life of the Extremes: Deep Sea Diving, High Altitude and Space Physiology Building the Spliceosome: what can go wrong? Building the Ribosome: what can go wrong? Nuclear Bodies Functions of small and large non-coding RNA Neurodegenerative Disorders Electrical Activity of the Heart Cellular Structure and Function of the heart Cardiac Function Vascular Function Neurohumoral Control of the Heart and Circulation Organ Blood Flow Exchange Function of the Microcirculation Cardiovascular Integration and Adaptation Pathophysiology of Dopamine systems Pathophysiology of Serotonin systems Nitric Oxide in Parkinson’s disease 47. 48. 49. 50. 51. 52. 53. 54. 55. 56. 57. 58. 59. 60. 61. 62. 63. 64. 65. 66. 67. 68. 69. 70. 71. 72. 73. 74. 75. 76. 77. 78. 79. 80. 81. 82. 83. 84. 85. 86. 87. 88. 89. 90. 91. 92. 93. Nitric Oxide in Drug addiction Role of diet in neurodegenerative disorders Role of diet in psychiatric disorders Basal ganglia Absence Epilepsy Nicotine addiction Sleep The Physiological Basis of Anti-Coagulation The Stem Cells of Blood Normal and Abnormal Haemoglobins. Inflammatory Cytokines The Two Faces of Oxygen Nutrition and Haematology New Aspects of Iron Pathophysiology. The Developmental Physiology of Haemoglobin The Endothelium. New Aspects of Immunology. Molecular virology Ubiquitin and/or the Proteasome Molecular Chaperones Metal Homeostasis Autoimmune Disease Collagens and Disease G Proteins Cyclases and/or Phosphodiesterases Heat Shock response Genetically engineered human therapeutic proteins Opsins and vision Carcinogens Effect of oxidative stress on vasculature Diabetic retinopathy Multiple sclerosis and vitamin D The biochemistry of Amyotrophic lateral sclerosis The insulin receptor and insulin resistance Essential fatty acids The molecular biology of metastasis Role of carbonic anhydrase in tumour cells Gene therapy of the musculoskeletal system Movement Disorders Drugs of Abuse Psychiatric Disorders Genetic Basis of CNS Disorders Plasticity Pain Learning and Memory Emotions Reward 94. 95. 96. 97. 98. 99. 100. 101. 102. 103. 104. 105. 106. 107. 108. 109. 110. 111. 112. 113. 114. 115. 116. 117. 118. 119. 120. 121. 122. 123. 124. The pathophysiology of retinal pigmentosa Management of raised intracranial pressure Pathophysiology of diabetic neuropathy Brain edema Regulation of cerebral blood flow Brain signalling of nitric oxide Cerebellar circuitry Cerebellar malformations Brain imaging modalities Positron emission tomography Neuroendocrine control of body weight Hormonal regulation of glucose homeostasis The interface between the autoimmune system and the endocrine system The physiology of hormone-receptor interactions and hormone resistance syndromes Cell cycle regulation, oncogenes and tumorigenesis in the endocrine system Mitochondrial ion channels – novel therapeutic target Calcium uptake mechanisms of mitochondria CNS regulation of glucose homeostasis Molecular mechanisms of ischemic cerebral oedema Parkinson’s disease and tea Amyotrophic Lateral Sclerosis – recent advances Islet inflammation in type 2 diabetes Potassium ion movement in the inner ear The mammalian urine concentrating mechanism – recent advances Hypertonic stress in the kidney Pathogenesis of Preeclempsia Endocrine and metabolic disorders of the adrenal glands. Inherited kidney disorders. Cancers and epigenetics