BMRC TRANSLATIONAL CLINICAL RESEARCH PARTNERSHIP
BIOMEDICAL RESEARCH COUNCIL
TRANSLATIONAL CLINICAL RESEARCH (TCR)
PARTNERSHIP GRANT CALL 2010
Grant Application Form
CLOSING DATE: 17 September 2010, 5pm
IMPORTANT: EVERY SECTION AND FIELD MUST BE COMPLETED.
PLEASE
INDICATE ‘NA’ WHERE A PARTICULAR SECTION OR FIELD IS NOT APPLICABLE.
INCOMPLETE APPLICATIONS WILL BE REJECTED.
Application must be submitted by the above closing date.
Also submit one duly signed original hardcopy to BMRC through your Office of
Research to:
Biomedical Research Council
20 Biopolis Way, Centros, #08-01
Singapore 138668
Tel: 68266111 Fax: 64789580
E-mail: chua_yee_cheng@a-star.edu.sg
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This document contains THIRTEEN (13) separate sections.
Please complete ALL sections.
Please use Font: Arial 10 pt, SINGLE spacing for your text
SECTION
I.
II.
DESCRIPTION
DESCRIPTIVE TITLE AND SCIENTIFIC ABSTRACT OF PROPOSED RESEARCH
PROJECT
DETAILS OF CO-PRINCIPAL INVESTIGATORS (Co-PIs) AND COLLABORATORS
III.
MAIN OBJECTIVES OF PROPOSED RESEARCH AND BRIEF DESCRIPTION OF
PROJECT
IV.
VALUE OF THE COLLABORATION
V.
POTENTIAL APPLICATIONS/EXPLOITATION
VI.
DESCRIPTION OF PLANS FOR INTERACTION AMONG PERSONNEL INVOLVED
IN THE COLLABORATION
VII.
WORK CONTRIBUTION OF TEAM MEMBERS
VIII.
CURRICULUM VITAE
IX.
BUDGET OUTLINE & JUSTIFICATIONS
X.
MILESTONES AND PERFORMANCE INDICATORS
XI.
OTHER SUPPORT
XII.
SUGGESTED NAMES OF INTERNATIONAL REVIEWERS
XIII.
DECLARATION BY CO-PRINCIPAL INVESTIGATORS AND ENDORSEMENT BY
HOST INSTITUTION
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I.
DESCRIPTIVE TITLE AND SCIENTIFIC ABSTRACT OF PROPOSED RESEARCH PROJECT
Applicants to add in appropriate number of boxes.
Proposal Title of
Research Project:
Scientific Abstract of Research Project :
 List specific aims, hypotheses, methodology and approach of the research proposal
 Do NOT exceed 300 words
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II. DETAILS OF CO-PRINCIPAL INVESTIGATORS (Co-PIs) AND COLLABORATORS

The Lead Investigator should be nominated from one of the co-PIs in this project. His role will
be to coordinate research activities carried by research team. He will make presentations and
submit progress and scientific reports on behalf of the research team.

The Co-PIs will be the persons who leading and managing a particular aspect of the
collaborative effort.
A. Lead Investigator and Co-PIs
LEAD INVESTIGATOR
(Title, name and research institution, email
address and contact no.)
BMRC CO- PI :
(Title, name and research institution, email
address and contact no.)
BMRC CO- PI :
(Title, name and research institution, email
address and contact no.)
NON-A*STAR CLINICAL CO-PI:
(Title, name and research institution, email
address and contact no. )
NON-A*STAR CLINICAL CO-PI:
(Title, name and research institution, email
address and contact no. )
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B. Collaborators (to include Industry collaborators)
1.
Title and name
Affiliation (i.e. Dept, Faculty and Home
Institution/Organization)
Email address and contact no.
Postal Address
Role in proposed project
2.
Title and name
Affiliation (i.e. Dept, Faculty and Home
Institution/Organization)
Email address and contact no.
Role in proposed project
3.
Title and name
Affiliation (i.e. Dept, Faculty and Home
Institution/Organization)
Role in proposed project
4.
Title and name of researcher
Affiliation (i.e. Dept, Faculty and Home
Institution/Organization)
Role in proposed project
5.
Title and name
Affiliation (i.e. Dept, Faculty and Home
Institution/Organization)
Role in proposed project
6.
Title and name
Affiliation (i.e. Dept, Faculty and Home
Institution/Organization)
Role in proposed project
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III. MAIN OBJECTIVES OF PROPOSED RESEARCH AND DESCRIPTION OF PROJECT
 List main objectives in order of priority.
 Describe the project clearly and succinctly
 Describe the main methodology and innovative approaches.
 Please do NOT exceed ten (10) pages for this section.
Aim
.
Hypothesis
Methodology
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IV. VALUE OF THE COLLABORATION
Demonstrate how the research could not be done without the joint inputs of all the co-PIs in this
research team for the full term of the project.
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V. POTENTIAL APPLICATIONS/EXPLOITATION
State clearly the likely applications of the work (technological, social, scientific, and economic) and
when these applications are likely to occur.
Technological –
Social –
Scientific –
Economic –
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VI. DESCRIPTION OF PLANS FOR INTERACTION AMONG PERSONNEL INVOLVED IN THE
COLLABORATION
 Briefly describe the plans for interaction among the team member(s) and with industry
collaborators in achieving the research objectives.
 Include a qualitative description of the team member(s)’ commitment to the project.
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VII. WORK CONTRIBUTION OF TEAM MEMBERS
Provide the expected percentage effort within the project, as well as within his/her other work
commitments for the Co-PIs and Collaborator(s).
Name
Role in project (e.g.
Co-PIs and
Collaborators)
Institution
% effort within
project1
Total
100%
% effort within
own work
commitments2
1
NOTE: Represents percentage effort spent by the team members in the project relative to his/her other team
members. The total in this column must add up to 100%.
2 NOTE: Represents percentage effort spent by the team members on this project out of total work commitments
(eg. other grants, other teaching and administrative responsibilities, clinical work, etc).
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VIII. CURRICULUM VITAE
In no more than 1 page per team member, please provide the following information on all the CoPrincipal Investigators and Collaborator(s):








Name
Current position and past employment history (Please provide full details, eg, joint
appointments, percentage of time spent in Singapore every year, if applicable)
Academic qualifications (indicate institution’s name and year degree awarded)
Latest 10 publications
Patents held (related or unrelated to study)
Recent awards (Scientific awards)
Current and previous support from A*STAR/BMRC/NMRC/NRF or other sources
Research outcomes from other grants (e.g. publications, patents, awards, etc.)
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IX. BUDGET OUTLINE & JUSTIFICATIONS
Instruction:
A. State the estimated funding required for the proposed research under each of the co-PIs for
categories listed in the table below. Add or delete depending on the number of co-PIs.
1. BMRC Co-PI’s Budget
Manpower (EOM)
Qualifications
No
Year 1($)
Year 2($)
Year 3($)
Total ($)
No
Year 1($)
Year 2($)
Year 3($)
Total ($)
Year 1($)
Year 2($)
Year 3($)
Total ($)
Year 1($)
Year 2($)
Year 3($)
Total ($)
Research Fellow
Research Assistant
Research Nurse
Laboratory
Technician
Others (Please
specify)
EOM Sub-total
Equipment (please state)
Capped at a total of $100k
Equipment Subtotal
Other Operating Expenses (OOE)
Materials & Consumables
(Capped at $35k/Research Personnel/year)
Animal Cost
Conferences
Maintenance
Publications
Others (please state)
OOE- Overseas Travel
(This is capped at $6k/year and includes
overseas conference travel & overseas travel
for purposes directly related to the research
project)
OOE Subtotal3
GRAND TOTAL
3
OOE Subtotal should include that of OOE and OOE- Overseas Travel expenses.
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2. BMRC Co-PI’s Budget
Manpower (EOM)
Qualifications
No
Year 1($)
Year 2($)
Year 3($)
Total ($)
No
Year 1($)
Year 2($)
Year 3($)
Total ($)
Year 1($)
Year 2($)
Year 3($)
Total ($)
Year 1($)
Year 2($)
Year 3($)
Total ($)
Research Fellow
Research Assistant
Research Nurse
Laboratory
Technician
Others (Please
specify)
EOM Sub-total
Equipment (please state)
Capped at a total of $100k
Equipment Subtotal
Other Operating Expenses (OOE)
Materials & Consumables
(Capped at $35k/Research Personnel/year)
Animal Cost
Local Conferences
Maintenance
Publications
Others (please state)
OOE- Overseas Travel
(This is capped at $6k/year and includes
overseas conference travel & overseas travel
for purposes directly related to the research
project)
OOE Subtotal4
GRAND TOTAL
4
OOE Subtotal should include that of OOE and OOE- Overseas Travel expenses.
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3. Non-A*STAR Clinical Co-PI’s Budget
Manpower (EOM)
Qualifications
No
Year 1($)
Year 2($)
Year 3($)
Total ($)
No
Year 1($)
Year 2($)
Year 3($)
Total ($)
Year 1($)
Year 2($)
Year 3($)
Total ($)
Year 1($)
Year 2($)
Year 3($)
Total ($)
PI EOM5 (capped at
$100K)
Research Fellow
Research Assistant
Research Nurse
Laboratory
Technician
Others (Please
specify)
EOM Sub-total
Equipment (please state)
Capped at a total of $100k
Equipment Subtotal
Other Operating Expenses (OOE)
Materials & Consumables
(Capped at $35k/Research Personnel/year)
Animal Cost
Local Conferences
Maintenance
Publications
Others (please state)
OOE- Overseas Travel
Overseas Travel
(This is capped at $6k/year and includes
overseas conference travel & overseas travel
for purposes directly related to the research
project)
OOE Subtotal6
GRAND TOTAL
5
Co-PI needs to fulfil certain conditions in order to qualify for funding.
6 OOE
Subtotal should include that of OOE and OOE- Overseas Travel expenses.
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4. Non-A*STAR Clinical Co-PI’s Budget
Manpower (EOM)
Qualifications
No
Year 1($)
Year 2($)
Year 3($)
Total ($)
No
Year 1($)
Year 2($)
Year 3($)
Total ($)
Year 1($)
Year 2($)
Year 3($)
Total ($)
Year 1($)
Year 2($)
Year 3($)
Total ($)
PI EOM6 (capped at
$100K)
Research Fellow
Research
Assistant
Research Nurse
Laboratory
Technician
Others (Please
specify)
EOM Sub-total
Equipment (please state)
(Capped at a total of $100k)
Equipment Subtotal
Other Operating Expenses (OOE)
Materials & Consumables
(Capped at $35k/ResearchPersonnel/year)
Animal Cost
Local Conferences
Maintenance
Publications
Others (please state)
OOE- Overseas Travel
Overseas Travel
(This is capped at $6k/year and includes
overseas conference travel & overseas
travel for purposes directly related to the
research project)
OOE Subtotal7
GRAND TOTAL
6
Co-PI needs to fulfil certain conditions in order to qualify for funding.
7
OOE Subtotal should include that of OOE and OOE- Overseas Travel expenses.
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B. Provide the details and justifications why these items are critical for the success of the
research project:
 Proposed budget for PI EOM
 Equipment (where cap has exceeded $100k or if co-PIs wish to pool equipment budget to
purchase equipment
 OOE for consumables exceeding the cap of $35k/research officer hired in the grant/year;
animal costs and maintenance.
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X. MILESTONES AND PERFORMANCE INDICATORS
A. Propose detailed scientific milestones for the research proposal. These will be used to assess
the progress of the study. The progress of the project will be taken into consideration for
continued disbursements of funds.
Research
Milestones/
Deliverables
Q1
Year 1
Q2 Q3
Q4
Q1
Year 2
Q2 Q3
Q4
Q1
Year 3
Q2 Q3
Q4
BMRC Co- PI (1)
Milestone 1
Milestone 2
Etc.
BMRC Co- PI (2)
Milestone 1
Milestone 2
Etc.
Non-A*STAR Co-PI (1)
Milestone 1
Milestone 2
Etc.
*Please use shading for the time points
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Research
Milestones/
Deliverables
Q1
Year 1
Q2 Q3
Q4
Q1
Year 2
Q2 Q3
Q4
Q1
Year 3
Q2 Q3
Q4
Non-A*STAR Co- PI (2)
Milestone 1
Milestone 2
Etc.
Collaborator (1)
Milestone 1
Milestone 2
Etc.
Collaborators (2)
Milestone 1
Milestone 2
Etc.
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B. Indicate the final expected targets for proposed research project. Please state ‘NA’ where
indicator is not applicable.
Performance Indicators
Industry
Relevance
Indicators
R&D
collaboration
Outcomes
Number /
value
R&D projects with industry cash funding
Industry dollars received to fund R&D projects
( includes in-kind contribution )
Revenue from royalties and licensing agreements
Spin-off companies registered
New products/processes commercialised
Capability
Indicators
Training R&D
manpower for
industry
Developing
long term R&D
capability
Master’s research students trained
PhD students trained
Master’s research and PhD students trained and
spun out to local industry as RSEs8
Research staff spun out to local industry as RSEs
Post-doctoral (within 3 years of the PhD award)
researchers hired
Joint programs/projects with prestigious international
research organisations
Joint programs/projects with local universities
Invention disclosures
Proof-of-concept studies in man
Progress to Clinical trials
Kick-start clinical treatments/therapeutics
Patents filed/granted/licensed/commercialized
Papers published in international journals
(To state impact factor)
Presentations at international conferences
External awards for research at international level
8
RSE: Research Scientist and Engineer
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XI. OTHER SUPPORT
Provide the following details for the grants currently held or being applied for by the Co-PIs.
A. Support from any industry partner(s)
Provide details on the funding/drug(s) or other resources provided by any participating industry
partner(s) for the applied grant.
Items Supported
Funding Source
Amount of Fund ($)
Support Period
(Year)
B. Grant Support
Provide the details for all currently held or applied grants by the Co-PIs. These include those
supported by / applied to BMRC, NMRC, Universities, Clusters and other public funding agencies.
Attach the scientific abstract of each grant listed below for Council’s reference.
Title of Research
Funding
Agency
Amount of Fund
Approved/
Received ($)
BMRC TRANSLATIONAL CLINICAL RESEARCH PARTNERSHIP
Balance
Available ($)
Support
Period
(Year)
Expiry
Date of the
grant
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XII. SUGGESTED NAMES OF INTERNATIONAL REVIEWERS
Suggest names of reviewers who may be suitable to review the proposed project, and state the
relationship with the PI(s). Reviewers who are co-authors with the PI(s) in publications are generally
not to be included. Note that reviewers must not have conflict of interest or involvement (direct and
indirect) with the proposed project. BMRC has the final discretion whether to select the suggested
reviewers for the evaluation of the grant proposal.
S/N
Title
Names of Reviewers
Details of contacts
(Please provide mailing address,
e-mail address, tel and fax numbers.)
Relationship to
Principal
Investigator
1
2
3
4
5
The application should not be sent to the following reviewers.
1)
2)
3)
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XIII A. DECLARATION BY CO-PRINCIPAL INVESTIGATORS
We declare that the facts stated in this application and the accompanying information are true and
that this is an original proposal. In signing the Grant Application, we UNDERTAKE, on any Grant
Award, to the following:
 Not send similar versions or part(s) of this proposal to other agencies for funding.
 Submit supporting documents of ethics approval obtained from the relevant Institutional
Review Board (IRB) and Animal Ethics Committee for studies involving human
subjects/human tissues or cells, and animal/animal tissues or cells respectively.
 Be actively engaged in the execution of the research and comply with all laws, rules and
regulations pertaining to animal and human ethics, including the Singapore Good Clinical
Practice guidelines.
 Ensure that BMRC’s funding is acknowledged in all publications.
 Ensure that all publications arising from research wholly or partly funded by BMRC will be
forwarded to BMRC.
 Co-operate with BMRC to develop interests in biomedical sciences among students and
teachers.
 Obtain approval from BMRC before engaging in any commercial activity that will exploit the
findings of the research funded by Council.
Signature
Date
Non-A*STAR Co-Principal
Investigator
Non-A*STAR Co-Principal
Investigator
BMRC Co-Principal Investigator
BMRC Co-Principal Investigator
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B. ENDORSEMENT BY HOST INSTITUTIONS
In signing the Grant Application, the Institution UNDERTAKES, on any Grant Award, to:
 Provide appropriate support during the grant period.
 Ensure that the funds provided are used for the appropriate purposes.
 Ensure that the study complies with all laws, rules and regulations pertaining to animal and
human ethics, including the Singapore Good Clinical Practice guidelines.
 Ensure that approval from BMRC has been obtained before engaging in any commercial
activity that will exploit the findings of the research funded by the Councils.
 Have in place code of practice for research integrity and procedures to deal with unethical
research practices.
Name and Signature
Date
Head/Director of Dept/Institution/
non-A*STAR (pls specify):
Head/Director of Dept/Institution/
non-A*STAR (pls specify):
Head/Director of BMRC RI (pls
specify):
Head/Director of BMRC RI (pls
specify):
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