Name…………. Class……………… Plymstock School Physics Department Module G485.4 Medical Imaging student booklet © science-spark.co.uk 2010 Page 1 of 49 Lesson 44 notes – X-Rays Objectives (a) describe the nature of X-rays; (b) describe in simple terms how X-rays are produced; Outcomes Be able to describe the what X-Rays are and their typical wavelengths/frequencies/energy Be able to describe how X-Rays were discovered Be able to describe how X-Rays are produced Be able to use equations to describe the energy needed in production of X-Rays. X-Ray Production X-Ray Discovery •1895 •Wilhelm Roentgen, Professor of Physics in Worzburg, Bavaria •Accident – he was investigating cathode rays through partially evacuated tubes •Black paper cover •But fluorescent screen showed images Hand mit Ringen (Hand with Rings): print of Wilhelm Röntgen's first "medical" X-ray, of his wife's hand, taken on December 22, 1895 © science-spark.co.uk 2010 Page 2 of 49 © science-spark.co.uk 2010 Page 3 of 49 Lesson 44 questions – X-Rays Name………………………………. Class…………… ( /14)…..%……… ALL 1. In an X-ray tube, the efficiency of conversion of the kinetic energy of the electrons into X-rays is 0.15%. (i) Calculate the power required in the electron beam in order to produce X-rays of power 18 W. power =..................................................... W [2] (ii) Calculate the velocity of the electrons if the rate of arrival of electrons is 7.5 × 1017 s–1. Relativistic effects may be ignored. velocity =............................................. . m s–1 [2] © science-spark.co.uk 2010 Page 4 of 49 (iii) Calculate the p.d. across the X-ray tube required to give the electrons the velocity calculated in (ii). p.d. = ........................................................ V [3] [Total 7 marks] 2. The figure below shows a simplified X-ray tube. Explain briefly, with reference to the parts labelled C and A, • how X-rays are generated • the energy conversions that occur. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. [Total 7 marks] © science-spark.co.uk 2010 Page 5 of 49 Lesson 45 notes – X-Ray interaction Objectives (c) describe how X-rays interact with matter (limited to photoelectric effect, Compton Effect and pair production); (d) define intensity as the power per unit cross-sectional area; (e) select and use the equation I = I0 e−μx to show how the intensity I of a collimated Xray beam varies with thickness x of medium; Outcomes Be able to describe the wave nature of X-Rays Be able to describe the particle nature of X-Rays Be able to describe 3 predominant reasons for attenuation Be able to carry out an experiment that models how the intensity of X-Rays attenuates through materials. Be able to select and use the equation I = I0 e−μx to show how the intensity I of a collimated X-ray beam varies with thickness x of medium Wave Properties X-Rays are part of the EM Spectrum and so can be reflected, refracted and diffracted. © science-spark.co.uk 2010 Page 6 of 49 Particle nature of X-Rays The reason that intensity goes down when X-Rays pass through materials (Attenuation) is because of the following: Photoelectric effect Pair production Compton Effect Photoelectric effect Photon energy is absorbed by electrons. The electrons move into higher energy levels. As they move back down they emit photons of light depending on how far they have moved. If they absorb enough energy (depending on the work function Φ of the element) they are emitted from the atom as a photo-electron E=Φ+KEmax hf= Φ+½mv2 Pair Production X-Ray photon absorbed by a nucleus. Producing a positron and an electron. Positron unstable and breaks down into two photons. Can occur when the X-Ray photon energy is greater than 1.02 MeV, but really only becomes significant at energies around 10 MeV. Most X-Ray tubes work at P.Ds of less than 100000V (0.625eV). Explanation An electron or positron have a mass of 0.00055u. 1u is equivalent to 931MeV (since 1 u = 1.661 x 10-27 kg E calculated using Einstein’s equation E=mc2) (check you can calculate this). So to produce a positron and an electron we must have energy of 2x0.00055x931MeV=1.02meV. © science-spark.co.uk 2010 Page 7 of 49 Compton Effect Also called Compton Scattering. It happens when the X-Ray photon is not completely absorbed by the electron like in the photoelectric effect. It’s just deflected off course. This changes energy of photon and therefore wavelength. Explanation of equation E = hf = hc/λ E = mec2 = hc/λ So λ = h/mec At θ=0 all X-Ray photon energy absorbed (photoelectric effect occurs) θ=90 impossible (no energy absorbed) Intensity Intensity = Power / Cross sectional Area Attenuation We have discussed the causes of attenuation. Now we look at it mathematically: I = I0 e−μx μ is the attenuation coefficient for a particular material, I the intensity and x is the thickness of the material. e.g: for medical X-Rays, μ is: © science-spark.co.uk 2010 Page 8 of 49 vacuum, 0 Flesh, 100m-1 Bone, 300m-1 The distance for halving the intensity is called the half-value thickness. © science-spark.co.uk 2010 Page 9 of 49 Lesson 45 questions – X-Ray Interaction Name………………………………. Class…………… ( /27)…..%……… ALL 1. An average person in the UK will have at least 30 X-ray photographs taken in their lifetime. In order to take an X-ray photograph, the X-ray beam is passed through an aluminium filter to safely remove low energy X-ray photons before reaching the patient. (a) Suggest why it is necessary to remove these low energy X-rays. ........................................................................................................................ ........................................................................................................................ [1] SOME (b) The average linear attenuation coefficient for X-rays that penetrate the aluminium is 250 m–1. The intensity of an X-ray beam after travelling through 2.5 cm of aluminium is 347 W m–2. Show that the intensity incident on the aluminium is about 2 × 105 W m–2. [3] © science-spark.co.uk 2010 Page 10 of 49 (c) The X-ray beam at the filter has a circular cross-section of diameter 0.20 cm. Calculate the power of the X-ray beam from the aluminium filter. Assume that the beam penetrates the aluminium filter as a parallel beam. power = .................................................... W [2] [Total 6 marks] MOST 2. Fig. 1 shows data for the intensity of a parallel beam of X-rays after penetration through varying thicknesses of a material. intensity / MW m–2 thickness / mm 0.91 0.40 0.69 0.80 0.52 1.20 0.40 1.60 0.30 2.00 0.23 2.40 0.17 2.80 Fig. 1 © science-spark.co.uk 2010 Page 11 of 49 (a) On Fig. 2 plot a graph of transmitted X-ray intensity against thickness of absorber. 1.0 0.8 0.6 intensity / MW m –2 0.4 0.2 0 0 1.0 2.0 3.0 thickness / mm Fig. 2 [3] (b) (i) Find the thickness that reduces the intensity of the incident beam by one half. thickness = …………….. mm [1] © science-spark.co.uk 2010 Page 12 of 49 (ii) Use your answer to (b)(i) to calculate the linear attenuation coefficient μ. Give the unit for your answer. = …………….. unit ……… [4] [Total 8 marks] ALL 3. In order to take an X-ray photograph, the X-ray beam is passed through an aluminium filter to remove low energy X-ray photons before reaching the patient. (a) Suggest why it is necessary to remove these low-energy X-rays. ........................................................................................................................ ........................................................................................................................ [1] © science-spark.co.uk 2010 Page 13 of 49 SOME (b) The average linear attenuation coefficient for X-rays that penetrate the aluminium is 250 m–1. The intensity of an X-ray beam after travelling through 2.5 cm of aluminium is 347 W m–2. Show that the intensity incident on the aluminium is about 2 × 105 W m–2. [3] (c) The X-ray beam at the filter has a circular cross-section of diameter 0.20 cm. Calculate the power of the X-ray beam emerging from the aluminium filter. Assume that the beam penetrates the aluminium filter as a parallel beam. power = ............................ W [2] © science-spark.co.uk 2010 Page 14 of 49 ALL (d) The total power of X-rays generated by an X-ray tube is 18W. The efficiency of conversion of kinetic energy of the electrons into X-ray photon energy is 0.15%. (i) Calculate the power of the electron beam. power = ..................... W [2] (ii) Calculate the velocity of the electrons if the rate of arrival of electrons is 7.5 × 1017 s–1. Relativistic effects may be ignored. velocity = ..................... m s–1 [2] © science-spark.co.uk 2010 Page 15 of 49 (iii) Calculate the p.d. across the X-ray tube required to give the electrons the velocity calculated in (ii). p.d.= ........................ V [3] [Total 13 marks] © science-spark.co.uk 2010 Page 16 of 49 Lesson 46 notes – X-Ray imaging Objectives (f) describe the use of X-rays in imaging internal body structures including the use of image intensifiers and of contrast media (HSW 3, 4c and 6); (g) explain how soft tissues like the intestines can be imaged using barium meal; (h) describe the operation of a computerized axial topography (CAT) scanner; (i) describe the advantages of a CAT scan compared with an X-ray image (HSW 4c, 6). Outcomes Be able to describe how X-Rays can be used in the imaging of internal body structures in 2D and 3D using computerised axial tomography. Be able to describe the advantages of a CAT scan compared with an X-ray image (HSW 4c, 6). Be able to explain how soft tissues like the intestines can be imaged using barium meal. Use of X-Rays in diagnosis X-Rays are very penetrating and can pass through the body. They are absorbed more by dense materials such as bone (so they are useful for checking the skeleton) and particularly metal. Because X-Rays can damage cells we need to minimise exposure by: only using X-Rays when necessary, shielding other parts of the body, focussing the X-Rays, using short exposure times. CAT scans Multiple X-Ray images can be combined to give 3D images This is called a CAT scan. Computerised Axial Tomography (tomos – Greek for slice) The scans are put together to form the images using computers. © science-spark.co.uk 2010 Page 17 of 49 The fan shaped X-Rays slice through the parts of the body and are detected using fluorescent material whose sparks of light are detected by CCDs that you might find in a digital camera. Advantages of CAT Scans over normal X Rays A major advantage of CT is its ability to image bone, soft tissue and blood vessels all at the same time. Unlike conventional x-rays, CT scanning provides very detailed images of many types of tissue as well as the lungs, bones, and blood vessels. CT examinations are fast and simple; in emergency cases, they can reveal internal injuries and bleeding quickly enough to help save lives. CT imaging provides real-time imaging, making it a good tool for guiding minimally invasive procedures such as needle biopsies and needle aspirations of many areas of the body, particularly the lungs, abdomen, pelvis and bones. The dose of radiation is low because of the sensitivity of the sensors. Barium Meal The gastrointestinal tract, like other soft-tissue structures, does not show up very well on X-Rays. Barium salts are radio opaque, (they show clearly on a radiograph). If barium is swallowed before radiographs are taken, the barium within the oesophagus, stomach or duodenum shows the shape of the lumina of these organs. Liquid suspensions of barium sulfate are non-toxic and they usually have a chalky taste that can be disguised by adding flavours. A barium meal usually takes less than an hour. The patient ingests gas pellets and citric acid to expand the stomach. Then about about 709mL of Barium is ingested. The patient may move or roll over to coat the stomach and oesophagus in barium. Following these preparations, an x-ray is taken. © science-spark.co.uk 2010 Page 18 of 49 Lesson 46 questions – X-Ray Imaging Name………………………………. Class…………… ( /26)…..%……… SOME 1. Full-body CT scans produce detailed 3-D information about a patient and can identify cancers at an early stage in their development. (a) Describe how a CT scan image is produced, referring to the physics principles involved. ........................................................................................................................ ........................................................................................................................ ........................................................................................................................ ........................................................................................................................ ........................................................................................................................ ........................................................................................................................ ........................................................................................................................ ........................................................................................................................ ........................................................................................................................ ........................................................................................................................ [7] (b) State and explain two reasons why full-body CT scans are not offered for regular checking of healthy patients. ........................................................................................................................ ........................................................................................................................ ........................................................................................................................ ........................................................................................................................ [3] [Total 10 marks] © science-spark.co.uk 2010 Page 19 of 49 2. Describe the use of a contrast medium, such as barium, in the imaging of internal body structures. Your answer should include • how an image of an internal body structure is produced from an X-ray beam • an explanation of the use of a contrast medium • examples of the types of structure that can be imaged by this process. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. [Total 8 marks] © science-spark.co.uk 2010 Page 20 of 49 3. The figure below shows a cross-section of a radiographic detector which uses fllm and intensifying screens. Describe how an image of an internal body structure may be produced using X-ray film. Within your answer you should include details of the use and advantages of an intensifying screen. X-ray photons plastic coating intensifying screen film intensifying screen metal backing ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. [Total 8 marks] © science-spark.co.uk 2010 Page 21 of 49 Lesson 47 notes – Radioactive tracers and the Gamma Camera Objectives (a) describe the use of medical tracers like technetium-99m to diagnose the function of organs; (b) describe the main components of a gamma camera; (c) describe the principles of positron emission tomography (PET); Outcomes Be able to describe the use of medical tracers like technetium-99m to diagnose the function of organs; Be able to describe the main components of a gamma camera; Be able to describe the principles of positron emission tomography (PET); Use of gamma radiation in diagnosis - Tracer techniques A source of gamma radiation is injected or ingested and moves around the body collecting in the region of interest. The gamma rays given off are detected outside the body and the location is determined. Technetium-99m Technetium-99m (m means metastable since it has a comparatively long half life compared to a lot of other gamma emitters). It is used as a radioactive tracer. It is well suited to the role because it emits readily detectable 140 keV gamma rays, and its half-life is 6.01 hours (meaning that about 94% of it decays to technetium-99 in 24 hours). Technetium-99 decays almost entirely by beta decay. © science-spark.co.uk 2010 Page 22 of 49 Gamma Cameras © science-spark.co.uk 2010 Page 23 of 49 PET Scans While a CT scan provides anatomical detail (size and location of the tumour, mass, etc.), a PET scan provides metabolic detail (cellular activity of the tumour, mass, etc.). Combined PET/CT is more accurate than PET and CT alone. This is a whole-body PET acquisition, showing abnormality in the region of the stomach. Normal physiological isotope uptake is seen in the brain, renal collection systems and bladder. Radionuclides used are typically isotopes with short half-lives. Examples are: carbon-11 (~20 min), nitrogen-13 (~10 min), oxygen-15 (~2 min), and fluorine-18 (~110 min). These radionuclides are incorporated into compounds normally used by the body such as glucose, water or ammonia These labelled compounds are known as radiotracers. PET technology can be used to trace the biologic pathway of any compound. © science-spark.co.uk 2010 Page 24 of 49 How PET Scans work © science-spark.co.uk 2010 Page 25 of 49 Lesson 48 notes – Radioactive tracers and the Gamma Camera Objectives (d) outline the principles of magnetic resonance, with reference to precession of nuclei, Larmor frequency, resonance and relaxation times; (e) describe the main components of an MRI scanner; (f) outline the use of MRI (magnetic resonance imaging) to obtain diagnostic information about internal organs (HSW 3, 4c and 6a); (g) describe the advantages and disadvantages of MRI (HSW 4c & 6a); Outcomes Be able to describe what MRI scans are used for and the advantages and disadvantages of them. Be able to describe the principles of MRI. Be able to describe the main components of an MRI scanner. MRI Basics The Angular momentum of an electron makes a magnet (The strength of which is given by “magnetic moment, μ”.) The Nuclei of atoms have a spin and associated magnetic moments just like electrons, except that the magnetic moments are 1000-10000 times smaller. Each different type of atom has different moment, or “nuclear fingerprint”. By looking at nucleus spin flip transitions, we can identify different types of atoms but this nuclear spin spectroscopy (“nuclear magnetic resonance”, NMR) will also work in a solid, including living tissue. Can use NMR to measure distribution of H atoms in human body, and chemical environment = “magnetic resonance imaging, MRI”. Larmor Frequency, Resonance and Relaxation time A spinning disc of charge has angular momentum. Produces magnetic dipole moment, µ. ------------------When a proton is in a magnetic field it experiences a torque and so it precesses with a certain frequency called the Larmor Frequency. The Larmor frequency depends on the magnetic moment, µ,and the magnetic flux density, B but is in the range of radio frequencies. If a radio wave at the Larmor frequency is absorbed by a proton it will flip on it axis – changing energy state. © science-spark.co.uk 2010 Page 26 of 49 Over time it will flip back to the lower energy state and as it does so will emit a radio wave that can be detected. The time it takes to flip back is called the relaxation time. Magnetic resonance imaging. (MRI) Detects the density of H atoms throughout body. There is more H than anything else, and its magnetic moment is the biggest of common stuff. Different tissues have different molecules = different number of H atoms. H atoms--tiny magnets MRI Scanner © science-spark.co.uk 2010 Page 27 of 49 How to look at details in a particular location The magnetic field is made different across body weak at one end and strong at the other. This uses the magnetic field dependence of resonance. 1.0 T 1.1 T BLE B BRE x © science-spark.co.uk 2010 Page 28 of 49 © science-spark.co.uk 2010 Page 29 of 49 Advantages and disadvantages Advantages No ionising radiation Image quality is excellent Can tell the difference between different tissues Radio waves pass through all materials (except metal) easily No side effects known Disadvantages No metal can be scanned and so no pins etc allowed in machine Machines very expensive Machines sensitive to radio waves in the machine Scans take a long time © science-spark.co.uk 2010 Page 30 of 49 Lesson 48 questions – MRI Name………………………………. Class…………… ( /6)…..%……… ALL 1. Discuss briefly the advantages and disadvantages of scanning using MRI techniques. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. [Total 6 marks] © science-spark.co.uk 2010 Page 31 of 49 Lesson 49 notes – Non-invasive techniques Objectives (h) describe the need for non-invasive techniques in diagnosis (HSW 6a); (i) explain what is meant by the Doppler effect; Outcomes Be able to describe the need for non-invasive techniques in diagnosis (HSW 6a); Be able to explain what is meant by the Doppler effect; Endoscopes An endoscope is a bundle of fibre optic cables that can be used to see inside a patient without having to cut them open! Light is shone down the cables that reflects off the part of the body that is being examined and back up to the eyepiece by total internal reflection. Each fibre optic cable is one pixel of the image – so the more there are the better the image quality. They can be used to examine lungs, intestines, stomach etc. © science-spark.co.uk 2010 Page 32 of 49 With a small incision keyhole surgery is also made possible with the use of this technology. Ultrasound and the Doppler effect Ultrasound is any frequency above 20000Hz. It can also be used for non-invasive imaging and is especially useful where ionising radiation may be particularly dangerous. Ultrasound uses the Doppler effect to help image moving blood flow so an explanation of the Doppler effect follows: Moving sound produces high frequency in font and low frequency behind. Remember c=fλ If a wave of frequency f and a speed c moves with a speed v then since T=1/f, in this time it has moved a distance v/f. The wave is being caught up with its source and so: λ’=(c-v)/f f’=c/λ’=cf/(c-v) © science-spark.co.uk 2010 Page 33 of 49 Lesson 50 notes – Ultrasound Objectives (a) describe the properties of ultrasound; (b) describe the piezoelectric effect; (c) explain how ultrasound transducers emit and receive high-frequency sound; (d) describe the principles of ultrasound scanning; (e) describe the difference between A-scan and B-scan; (f) calculate the acoustic impedance using the equation Z = ρc; (g) calculate the fraction of reflected intensity using the equation I = (Z2-Z1)2 Ir (Z2+Z1)2 (h) describe the importance of impedance matching; (i) explain why a gel is required for effective ultrasound imaging techniques. Outcomes Be able to describe the properties of ultrasound; Be able to describe the piezoelectric effect; Be able to explain why a gel is required for effective ultrasound imaging techniques. Be able to explain how ultrasound transducers emit and receive high-frequency sound; Be able to describe the principles of ultrasound scanning; Be able to describe the difference between A-scan and B-scan; Be able to calculate the acoustic impedance using the equation Z = ρc; Be able to describe the importance of impedance matching; Be able to calculate the fraction of reflected intensity using the equation I = (Z2-Z1)2 Ir (Z2+Z1)2 © science-spark.co.uk 2010 Page 34 of 49 Ultrasound Ultrasound is a sound that has a higher frequency than our ears can hear. Other animals have different ranges. Uses of Ultrasound in Medicine •Ultrasound is used for examining soft tissue inside the body. •Parts of the body that may be examined include muscles and unborn babies. •Blood flow can also be monitored using ultrasound. A Scan 1-dimensional, distance only. © science-spark.co.uk 2010 Page 35 of 49 B Scan – creates a picture Piezo crystals Piezo crystals create electricity when they are squashed but if they are given an electrical impulse they will vibrate and create sounds that can be amplified and used in ultra sonograms. © science-spark.co.uk 2010 Page 36 of 49 © science-spark.co.uk 2010 Page 37 of 49 •From previous lesson we had: •f’=c/λ’=cf/(c-v) •So if it appears to go twice the distance in the same time we get: •f’=c/λ’=cf/(c-2v) © science-spark.co.uk 2010 Page 38 of 49 Acoustic impedance At a boundary, part of the initial intensity is transmitted, and part is reflected. It is important to try and match the impedance by using gel to get as much ultrasound to be transmitted instead of being reflected straight off the surface. •The acoustic impedance is given by: •Z = v ( - density; v-speed of sound in material) •It is used to find the fraction of the intensity refracted at a boundary of different materials. •Ir = (Z2-Z1)2 I0 (Z2+Z1)2 © science-spark.co.uk 2010 Page 39 of 49 Lesson 50 questions – Ultrasound Name………………………………. Class…………… ( /44)…..%……… SOME 1. The quality of ultrasound images in increasing at a phenomenal pace, thanks to advances in computerised imaging techniques. The computer technology is sophisticated enough to monitor and display tiny ultrasound signals from a patient. The ratio of reflected intensity to incident intensity for ultrasound reflected at a boundary is related to the acoustic impedance Z1 of the medium on one side of the boundary and the acoustic impedance Z2 of the medium on the other side of the boundary by the following equation. reflected intensity (Z 2 Z1 ) 2 incident intensity (Z 2 Z1 ) 2 (a) State two factors that determine the value of the acoustic impedance. ........................................................................................................................ ........................................................................................................................ [2] (b) An ultrasound investigation was used to identify a small volume of substance in a patient. It is suspected that this substance is either blood or muscle. During the ultrasound investigation, an ultrasound pulse of frequency of 3.5 × 106 Hz passed through soft tissue and then into the small volume of unidentified substance. A pulse of ultrasound reflected from the front surface of the volume was detected 26.5 μs later. The ratio of the reflected intensity to the incident intensity, for the ultrasound pulse reflected at this boundary was found to be 4.42 × 10–4. The table below shows data for the acoustic impedances of various materials found in a human body. medium air blood water brain tissue soft tissue bone muscle © science-spark.co.uk 2010 acoustic impedance Z/ kg m–2 s–1 4.29 × 102 1.59 × 106 1.50 × 106 1.58 × 106 1.63 × 106 7.78 × 106 1.70 × 106 Page 40 of 49 (i) Use appropriate data from the table above to identify the unknown medium. You must show your reasoning. medium = ..................................................... [4] (ii) Calculate the depth at which the ultrasound pulse was reflected if the speed of ultrasound in soft tissue is 1.54 km s–1. depth = .................................................. cm [2] (iii) Calculate the wavelength of the ultrasound in the soft tissue. wavelength = ............................................m [2] [Total 10 marks] © science-spark.co.uk 2010 Page 41 of 49 MOST 2. Describe the principles of the production of a short pulse of ultrasound using a piezoelectric transducer. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. [Total 5 marks] 3. The diagram below shows a trace on a cathode-ray oscilloscope (CRO) of an ultrasound reflection from the front edge and rear edge of a foetal head. 20 s The CRO timebase is set to 20 s cm–1. The speed of ultrasound in the foetal head is 1.5 × 103 m s–1. © science-spark.co.uk 2010 Page 42 of 49 (i) Calculate the size of the foetal head. size = ................................................... cm [4] (ii) State and explain what would be seen on the CRO screen if gel had not been applied between the ultrasound transducer and the skin of the mother. ........................................................................................................................ ........................................................................................................................ ........................................................................................................................ ........................................................................................................................ ........................................................................................................................ ........................................................................................................................ [3] [Total 7 marks] 4. Explain how ultrasound is produced using a piezoelectric crystal such as quartz. ................................................................................................................................. ................................................................................................................................. ................................................................................................................................. [Total 2 marks] © science-spark.co.uk 2010 Page 43 of 49 5. Quartz is a compound of silicon and oxygen. Each silicon atom is attached to four oxygen atoms. See Fig. 1 below. Each oxygen atom carries a negative charge. The silicon atom carries a positive charge. – oxygen ion silicon ion – – – – – – + + – – E-field – – – + Fig. 1 (i) + + + + + + Fig. 2 On Fig. 2, draw possible positions for the negatively-charged oxygen ions when an electric field is applied in the direction shown. The central silicon ion and one oxygen ion have been drawn in for you. [1] (ii) Use your answer to (i) to explain why a single crystal of quartz is piezoelectric. ........................................................................................................................ ........................................................................................................................ [1] [Total 2 marks] © science-spark.co.uk 2010 Page 44 of 49 SOME 6. (a) Acoustic impedance Z is the product of the density of a medium and the speed of ultrasound v. The fraction f of ultrasound reflected at a boundary between two media of acoustic impedances Z1 and Z2 is given by the equation f= (Z 2 Z1 ) 2 (Z 2 Z1 ) 2 medium density / kg m–3 ultrasound velocity v / m s–1 air 1.299 330 skin 1075 1590 coupling medium 1090 1540 bone 1750 4080 Fig. 1 (i) Use the data in Fig. 1 to find the fraction f of ultrasound reflected at an air-skin boundary. f = ........................... [2] © science-spark.co.uk 2010 Page 45 of 49 MOST (ii) Hence explain the need for a coupling medium in ultrasound imaging. ............................................................................................................... ............................................................................................................... ............................................................................................................... ............................................................................................................... [2] (b) Fig. 2 is a CRO display showing the reflected ultrasound signal from the front edge F and the rear edge R of a bone. The time-base setting is 1.0 × 10–5 s cm–1. F R 1 cm 1 cm 1.0 × 10–5 s Fig. 2 © science-spark.co.uk 2010 Page 46 of 49 Using appropriate data from Fig. 1 and Fig. 2, calculate the thickness of the bone. thickness = ........................................... cm [4] [Total 8 marks] 7. The ratio of reflected intensity to incident intensity for ultrasound reflected at a boundary is related to the acoustic impedance Z1 of the medium on one side of the boundary and the acoustic impedance Z2 of the medium on the other side of the boundary by the following equation. reflected intensity (Z 2 Z1 ) 2 incident intensity (Z 2 Z1 ) 2 (a) State the two factors that determine the value of the acoustic impedance. ........................................................................................................................ ........................................................................................................................ [2] © science-spark.co.uk 2010 Page 47 of 49 (b) An ultrasound investigation was used to identify a small volume of substance in a patient. It is suspected that this substance is either blood or muscle. During the ultrasound investigation, an ultrasound pulse of frequency 3.5 × 106 Hz passed through soft tissue and then into the small volume of unidentified substance. A pulse of ultrasound reflected from the front surface of the volume was detected 26.5 μs later. The ratio of the reflected intensity to incident intensity for the ultrasound pulse reflected at this boundary was found to be 4.42 × 10–4. The table below shows data for the acoustic impedances of various materials found in a human body. (i) medium acoustic impedance Z /kg m–2 s–1 air 4.29 × 102 blood 1.59 × 106 water 1.50 × 106 brain tissue 1.58 × 106 soft tissue 1.63 × 106 bone 7.78 × 106 muscle 1.70 × 106 Use appropriate data from the table to identify the unknown medium. You must show your reasoning. medium = ............................ [4] © science-spark.co.uk 2010 Page 48 of 49 (ii) Calculate the depth at which the ultrasound pulse was reflected if the speed of ultrasound in soft tissue is 1.54 km s–1. depth = ...................... cm [2] (iii) Calculate the wavelength of the ultrasound in the soft tissue. wavelength = ............................... m [2] [Total 10 marks] © science-spark.co.uk 2010 Page 49 of 49