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4962
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NC092FJU00255028
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輔仁大學
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食品營養學系
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舊
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學
491445102
號
研
究
生 郭怡君
(
中
)
研
究
生
(
英
)
論
文
名
稱 瘦素與免疫的相關性：綜論
(
中
)
論
文
名
稱 The relationship of leptin and immunity: An overview
(
英
)
其
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指
導
教
授 吳文勉 博士
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學
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學 92
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出
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文 中文
別
關
鍵
字 肥胖 營養不良 leptin 免疫反應
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中
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關
鍵
字
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英
)
摘
要
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中
)
摘
要
(
肥胖（obesity）儼然是全世界普遍存在的健康問題，與許多慢性疾病之罹患有密切關係，近幾年的研
態消耗，也就是熱量消耗大於由食物攝取所提供之熱量；而當leptin的濃度減少（如飢餓或厭食）時，
leptin濃度減少，並伴隨著細胞主導之免疫力減弱，感染機會增加。Ob/ob基因突變老鼠所模擬之厭食
adaptive immunity）反應皆較正常體位者低下，適當減輕體重後，免疫反應可恢復的較為正常。現代
，即可達到體重減輕及維持良好免疫力，這對大眾的健康而言是非常恰當的。
英
)
論
文
目
次
中文摘要…………………………………………………………………Ⅰ 英文摘要…………………………
……………………………………………………………………Ⅵ 縮寫表……………………………………
………………………………………………3 第二節 適應性免疫反應………………………………………
……………….……..……9 第三章 何謂肥胖…………………………………………………………12 第
………………………………………………….14 3.2.2 體脂肪率……………………………………………
…………………………………………………….18 3.3.2 肥胖與代謝………………………………………
…………………………………………………...32 3.4.2 Leptin對調節食慾與食物攝取的相關作用………
………………………………………………………..41 4.1.1 遺傳型肥胖動物體內之免疫調節機制………
…………………..57 第二節 Leptin對 ob/ob 老鼠胸腺細胞之影響………………………….70 第三節 Lep
自然殺手細胞………………………………………………….77 第四節 Leptin與發炎的相關性…………
影響…………………………….…..104 第六章 結論…………………………………………………………
參
考
文
獻
第七章 參考文獻 中華民國行政院衛生署（1998）中華民國行政院衛生署公告第三次全國營養調查結
婷、張瑛韶、潘文涵（1998）台灣地區居民體位及肥胖狀況。國民營養現況： 1993-1996國民營養健
（2002）肥胖者體重下降對血清瘦體激素濃度和胰島素抗性的影響。中華民國營養學會雜誌27： 101
29-52。 鄭淑妃、周美惠、林明芳（1999）糖尿病控制展新迎姿千禧。醫院藥學雜誌16： 6-11。 Wo
Flier JS (1996) Role of leptin in the neuroendocrine response to fasting. Nature 382: 250-252. Arend WP, M
thiazolidinediones. Trends Endocrinol Metab 14: 137-145. Astrup A, Ryan L, Grunwald GK, Storgaard M, S
S, Attoub S, Kermorgant S, Laigneau JP, Bortoluzzi MN, Moizo L, Lehy T, Guerre-Millo M, Le Marchand-B
respond to lipogenic hormones. J Biol Chem 271: 13939-13942. Bailie MB, Standiford TJ, Laichalk LL, Cof
activities. J Immunol 157: 5221-5224. Banks WA, Kastin AJ, Huang W, Jaspan JB and Maness LM (1996) L
JP, Maachi M, Van Nhieu JT, Jardel C, Bruckert E, Grimaldi A, Robert JJ, Capeau J and Hainque B (2002) A
Bailon PS, Kim H, Lai CF and Tartaglia LA (1996) The full-length leptin receptor has signaling capabilities
625-655. Berg AH, Combs TP and Scherer PE (2002) ACRP30/adiponectin: an adipokine regulating glucose
JAMA 287: 1706-1709. Bouret SG, Draper SJ and Simerly RB (2004) Trophic action of leptin on hypothalam
Cardiovascular Health Study. Correlations with baseline clinical and demographic characteristics. Am J Epid
and endocrine hypothesis. Physiol rev 59: 719-809. Bruun JM, Lihn AS, Verdich C, Pedersen SB, Toubro S,
Chobaz-Peclat V, Morard C, Martinez-Soria E, Talabot-Ayer D and Gabay C (2002) Leptin signaling deficie
obesity. Drugs 57: 883-904. Carel RS and Eviatar J (1985) Factors affecting leukocyte count in healthy adult
Res. 5: 30-35. Casabiell X, Pineiro V, Peino R, Lage M, Camina J, Gallego R, Vallejo LG, Dieguez C and C
Clin Endocrinol Metab 83: 2149-2155. Cason J, Ainley CC, Wolstencroft RA, Norton KR and Thompson RP
RK (1991) Nutrition and immunity: lessons from the past and new insights into the future. Am J Clin Nutr 53
Lacorte JM, Basdevant A, Bougneres P, Lebouc Y, Froguel P and Guy-Grand B (1998) A mutation in the hu
Knopp RH and Kahn SE (2002) The concurrent accumulation of intra-abdominal and subcutaneous fat expla
of insulin activities by leptin. Science 274: 1185-1188. Coleman DL (1973) Effects of parabiosis of obese wi
KP (1969) Effects of parabiosis of normal with genetically diabetic mice. Am J Physiol 217: 1298-1304. Com
adipocyte-specific secretory protein adiponectin. Diabetes 52: 268-276. Considine RV, Sinha MK, Heiman M
334: 292-295. Coppack SW (2001) Pro-inflammatory cytokines and adipose tissue. Proc Nutr Soc 60: 349-3
disease. Diabetes Rev 7: 23-38. Doring H, Schwarzer K, Nuesslein-Hildesheim B and Schmidt I (1998) Lept
postmenopausal women. Maturitas 42: 219-223. Ebihara K, Ogawa Y, Masuzaki H, Shintani M, Miyanaga F
lipoatrophic diabetes. Diabetes 50: 1440-1448. Emilsson V, Liu YL, Cawthorne MA, Morton NM and Daven
(1996) Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 274: 1704-
radioimmunoanalysis in patients with morbid obesity and anorexia nervosa after therapeutic intervention. Re
R136-R142. Faggioni R, Jones-Carson J, Reed DA, Dinarello CA, Feingold KR, Grunfeld C and Fantuzzi G
Keogh JM, Lawrence E, Agwu C, Sanna V, Jebb SA, Perna F, Fontana S, Lechler RI, DePaoli AM and O’Ra
Kralisch S, Klier M, Lossner U, Bluher M, Klein J and Paschke R (2003) Adiponectin gene expression and s
C57BL/Ks-dt+ mouse. Discrepancies between in vitro and in vivo immunological assays. J Clin Invest 61: 2
47: 1757-1762. Flier JS (1998) Lowered leptin slims immune response. Nat Med 4: 1124-1125. Finer N (200
proopiomelanocortin pathway. Proc Natl Acad Sci U S A 98: 4233-4237. Frederich RC, Hamann A, Anderso
and Girandola RN (1983) Physique, body composition, and psychological characteristics of competitive fem
physiology. Nutr Rev 60: S1-S14. Friedman JM and Leibel RL (1992) Tackling a weighty problem. Cell 69:
Gabay C, Dreyer M, Pellegrinelli N, Chicheportiche R and Meier CA (2001) Leptin directly induces the secr
adrenal axis. Ann N Y Acad Sci 917: 647-657. Gainsford T, Willson TA, Metcalf D, Handman E, McFarlane
Skoda RC (1997) The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-depend
brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels. J Clin Invest 99:
coronary, cancer, and all-cause mortality. JAMA 254: 1932-1937. Grinspoon S, Gulick T, Askari H, Landt M
Obesity: internal medicine, obstetric and gynecological problems related to overweight. Panminerva Med 36
DeFronzo RA (1992) Effect of insulin on oxidative and nonoxidative pathways of free fatty acid metabolism
Schulz KD (2000) The influence of menopause and body mass index on serum leptin concentrations. Eur J E
Natl Acad Sci U S A 94: 8878-8883. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D
(1997) Long-term influence of different postmenopausal hormone replacement regimens on serum lipids and
Hasty AH, Shimano H, Osuga J, Namatame I, Takahashi A, Yahagi N, Perrey S, Iizuka Y, Tamura Y, Amem
mice lacking both leptin and the low density lipoprotein receptor. J Biol Chem 276: 37402-37408. He Y, Che
Coleman DL (1977) Laboratory animals exhibiting obesity and diabetes syndromes. Metabolism 26: 59-99. H
controlled, dose-escalation trial. JAMA 282: 1568-1575. Hickey MS, Israel RG, Gardiner SN, Considine RV
A, Ikuse T, Asano M and Iwakura Y (2000) Development of chronic inflammatory arthropathy resembling rh
Metab Disord 24: S23-S27. Hotamisligil GS, Arner P, Atkinson RL and Spiegelman BM (1997) Differential
tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Inves 95: 240
sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 50: 1126-1133. Howard JK
Invest 104: 1051-1059. Isse N, Ogawa Y, Tamura N, Masuzaki H, Mori K, Okazaki T, Satoh N, Shigemoto M
(2002) Immunomodulatory actions of leptin. Mol Cell Endocrinol 194: 1-7. Kanaley JA, Sames C, Swisher L
activity, age, and menopausal status. Metabolism 50: 976-982. Kelley DS, Daudu PA, Branch LB, Johnson H
Moon YS and Sul HS (2001) A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differ
Life Sci 62: 1243-1250. Kimura M, Tanaka S, Yamada Y, Kiuchi Y, Yamakawa T and Sekihara H (1998b) D
3249-3253. Klein A, Zhadkewich M, Margolick J, Winkelstein J and Bulkley G (1994) Quantitative discrimi
arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity. J Clin Invest 108: 1533-15
Immunology 2thed. W.H. Freeman and Company. New York. Kyzer S, Binyamini J, Chaimoff C and Fishm
B and Ylikorkala O (2001) Comparison between 1 year oral and transdermal oestradiol and sequential noreth
postobese individuals. Am J Clin Nutr 62: 735-739. Lean ME and James WP (1988) Metabolic effects of iso
catecholamines in response to insulin in trained and non-trained subjects. Metabolism 31: 453-456. Lee FY,
Montez JM, Carroll KM, Darvishzadeh JG, Lee JI and Friedman JM (1996) Abnormal splicing of the leptin
fat diet. Biochem Biophys Res Commun 289: 564-567. Levin N, Nelson C, Gurney A, Vandlen R and de Sau
Tanaka S, Tataranni PA, Knowler WC and Krakoff J (2002) Adiponectin and development of type 2 diabete
factor receptor. Cell 61: 351-359. Lord G (2002) Role of leptin in immunology. Nutr Rev 60: S35- S38. Lord
Matarese G, Howard JK, Bloom SR and Lechler RI (2002) Leptin inhibits the anti-CD3-driven proliferation
Noble PW, Lane MD and Diehl AM (1998) Leptin regulates proinflammatory immune responses. FASEB J
Gingerich RL, Santiago JV, Klein S, Smith CH and Landt M (1996) Radioimmunoassay of leptin in human p
associated cells. J Clin Invest 104: 1041-1050. Maes HH, Neale MC and Eaves LJ (1997) Genetic and enviro
expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db lo
measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1: 1155-1161. M
MA and Mahmoud AA (1978) Impairment of cell-mediated immunity in mutation diabetic mice (db/db). J Im
relationships. Obes Rev 2: 131-140. Martin-Romero C, Santos-Alvarez J, Goberna R and Sanchez-Margalet
level as an indicator to predict the clinical efficacy of troglitazone in patients with type 2 diabetes mellitus. D
IFN-gamma-induced expression of the T cell-active CXC chemokines IP-10, Mig, and I-TAC in human endo
leptin: leptin as a novel placenta-derived hormone in humans. Nat Med 3: 1029-1033. Matarese G (2000) Le
Balancing susceptibility to infection and autoimmunity: a role for leptin? Trends Immunol 23: 182-187. Mer
by in situ hybridization. tu hybridization. FEBS Lett 387: 113-116. Messinis IE, Kariotis I, Milingos S, Kolli
Milingos S, Zikopoulos K, Kollios G, Seferiadis K and Lolis D (1998) Leptin concentrations in the follicular
stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415: 339-343. Mohamedinsulin resistance and type 2 diabetes. Trends Endocrinol Metab 11: 212-217. Moore SI, Huffnagle GB, Che
Decreased mitogen response of splenic lymphocytes in obese Zucker rats is associated with the decreased ex
expression in mice with bacterial peritonitis is partially regulated by tumor necrosis factor alpha. Infect Imm
Coakley EH, Field AE, Colditz G and Dietz WH (1999) The disease burden associated with overweight and
Arch Gen Psychiatry 55: 995-1000. Nieman DC, Henson DA, Nehlsen-Cannarella SL, Ekkens M, Utter AC,
Rainwater MK (1996) Immune response to obesity and moderate weight loss. Int J Obes Relat Metab Disord
Nova E, Gomez-Martinez S, Morande G and Marcos A (2002) Cytokine production by blood mononuclear c
metabolic covariates. J Clin Endocrinol Metab 81: 3909-3913. Ouchi N, Kihara S, Arita Y, Nishida M, Mats
suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macro
Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity. J Biol Chem 278: 9073-9085. Pal
Publishing, Elsevier Science Ltd. Pedersen BK, Helge JW, Richter EA, Rohde T and Kiens B (2000) Trainin
gene product on body weight regulation in ob/ob mice. Science 269: 540-543. Phillips MS, Liu Q, Hammond
and Horvath TL (2004) Rapid rewiring of arcuate nucleus feeding circuits by leptin. Science 304: 110-115. P
infection and leucocyte function. J Med Microbiol 44: 277-283. Polack E, Nahmod VE, Emeric-Sauval E, Be
Waeber G, Castillo E, Mosimann F, Thorens B and Gaillard RC (1998) Leptin inhibits directly glucocorticoi
selectively impair insulin action on glucose production. J Clin Invest 111: 225-230. Ranganathan S, Maffei M
insulin resistance in human disease (syndrome X): an expanded definition. Annu Rev Med 44: 121-131. Roit
Relationship to insulin resistance. J Clin Inves 97: 1111-1116. Santos-Alvarez J, Goberna R and Sanchez-Ma
O’Rahilly S (2001) Resistin / Fizz3 expression in relation to obesity and peroxisome proliferator-activated re
women. Med Sci Sports Exerc 30: 1666-1671. Scarpace PJ, Metheny M, Pollock BH and Tumer N (1997) Le
production and cell-mediated immunity in anorexia nervosa. Clin Exp Immunol 79: 62-66. Schutz Y, Tremb
Baskin DG (1996) Identification of targets of leptin action in rat hypothalamus. J Clin Invest 98: 1101-1106.
Nowak IA and Mooney RA (2002) Interleukin-6 induces cellular insulin resistance in hepatocytes. Diabetes
insulin resistance in hepatocytes. J Biol Chem 278: 13740-13746. Shears P (1991) Epidemiology and infectio
depletion of tissues. Proc Natl Acad Sci U S A 94: 4637-4641. Shimomura I, Hammer RE, Ikemoto S, Brow
Papapetropoulos A, Sessa WC, Madge LA, Schechner JS, Schwabb MB, Polverini PJ and Flores-Riveros JR
Endocrinology 138: 3374-3379. Spranger J, Kroke A, Mohlig M, Bergmann MM, Ristow M, Boeing H and P
Stephens TW, Basinski M, Bristow PK, Bue-Valleskey JM, Burgett SG, Craft L, Hale J, Hoffmann J, Hsiung
532. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS and Lazar M
AJ (1996) Current views on obesity. Am J Med 100: 230-236. Stunkard AJ, Harris JR, Pedersen NL and Mc
antitumor effects of murine natural killer cells in vitro and in vivo. Neuroimmunomodulation 10: 169-176. S
factor and interleukin-3 on monocytes. Am J Hematol 75: 179-189. Sweetnam PM, Thomas HF, Yarnell JW
Chan CK, Bulkley GB and Klein AS (1996) Role of reactive oxygen metabolites in murine peritoneal macro
obesity: suppressed but reversible lymphocyte responsiveness. Int J Obes Relat Metab Disord 17: 631-636. T
347-354. Tanaka S, Isoda F, Yamakawa T, Ishihara M and Sekihara H (1998) T lymphopenia in genetically o
Smutko JS, Mays GG, Woolf EA, Monroe CA and Tepper RI (1995) Identification and expression cloning o
10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothelia
domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc Natl Acad Sc
oxidation or in thermogenesis? Int J Obes Relat Metab Disord 16: 953-957. Tremblay A, Despres JP, Maheu
and Doucet E (2000) Obesity: a disease or a biological adaptation? Obes Rev 1: 27-35. Tremblay A, Doucet
(1989) Metabolic characteristics of postobese individuals. Int J Obes 13: 357-366. Tucker LA and Kano MJ
rebound. Int J Obes Relat Metab Disord 21: 811-817. Van Gaal LF, Wauters MA, Mertens IL, Considine RV
and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS). Circu
Wallenius K, Wallenius V, Sunter D, Dickson SL and Jansson JO (2002b) Intracerebroventricular interleukin
muscle and fat. Nature 393: 684-688. Wang MY, Zhou YT, Newgard CB and Unger RH (1996) A novel lept
expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gam
2483. Westerterp-Plantenga MS, Lejeune MP, Nijs I, van Ooijen M and Kovacs EM (2004) High protein inta
Wing RR and Jeffery RW (1995) Effect of modest weight loss on changes in cardiovascular risk factors: are
effector mechanisms in obese subjects. Am J Med 75: 91-96. Yang SQ, Lin HZ, Lane MD, Clemens M and D
Matsuzawa Y, Chao CL, Chen CL, Tai TY and Chuang LM (2001) Weight reduction increases plasma levels
Augmented production of tumor necrosis factor-alpha in obese mice. Clin Immunol Immunopathol 75: 51-56
Ueyama Y, Froguel P, Kimura S, Nagai R and Kadowaki T (2003) Globular adiponectin protected ob/ob mic
RJ (2001) High-dose leptin activates human leukocytes via receptor expression on monocytes. J Immunol 16
(1996) Down-regulation of the expression of the obese gene by an antidiabetic thiazolidinedione in Zucker d
Nature 372: 425-432. Zhao Y, Sun R, You L, Gao C and Tian Z (2003) Expression of leptin receptors and re
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