3rd Symposium on the Neurovirology and Neuroimmunology of Schiozphrenia and Bipolar Disorder October, 1997 DESCRIPTION OF THE STANLEY NERUOPATHOLOYG PROGRAM E. Fuller Torrey, Scientific Director, Stanley Foundation INDIVIDUAL VARIATIONS OF PROTEIN SPECIES AND LEVELS IN HUMAN FRONTAL CORTICES: A PRELIMINARY STUDY OF PROTEIN VARIATIONS BETWEEN MENTALLY ILL AND UNAFFECTED INDIVIDUALS Nancy L. Johnson, Johns Hopkins University, Stanley Laboratory VIRAL AND VIRUS-ASSOCIATED RNA TRANSCRIPTS ARE DIFFERENTIALLY EXPRESSED IN THE BRAINS OF INDIVIDUALS WITH SCHIZOPHRENIA AND BIPOLAR DISORDER Frances Yee, Johns Hopkins University, Stanley Laboratory SERIAL ANALYSIS OF GENE EXPRESSION OF BRAIN TISSUE FROM INDIVIDUALS WITH SCHIZOPHRENIA AND BIPOLAR DISORDER Yeping Sun, Johns Hopkins University, Stanley Laboratory EPIDEMIOLOGIC CORRELATES OF INTERLEUKIN-2 RECEPTOR IN POSTMORTEM CSF AND SERA OF INDIVIDUALS WITH SCHIZOPHRENIA AND BIPOLAR DISORDER Linda D. Bobo, Johns Hopkins University, Stanley Laboratory SPINOPHILIN: ALTERATIONS IN A POSTSYNAPTIC MARKER IN SCHIZOPHRENIA Indra Dé, Johns Hopkins University, Stanley Laboratory PCR METHODS FOR DIFFERENTIAL DISPLAY OF RETROVIRAL LTR SEQUENCES USING tRNA BINDING SITES AND DNA BINDING MOTIFS OF TRANSCRIPTION FACTORS AS PRIMERS Raphael P. Viscidi, Johns Hopkins University, Stanley Laboratory PROTEIN KINASE C SIGNALING CASCADE AND BIPOLAR DISORDER: THERAPEUTIC IMPLICATIONS Husseini K. Manji, Molecular Pathophysiology Program, WSU School of Medicine HERPES SIMPLEX VIRUS LATENT INFECTION OF THE CENTRAL NERVOUS SYSTEM Richard B. Tenser, Penn State University College of Medicine IDENTIFICATION OF A HERPES SIMPLEX VIRUS GENETIC ELEMENT INVOLVED NEUROVIRULENCE Jeng-Yang Ling, University of Arkansas for Medical Science SYSTEMIC INFECTION ALTERS NEUROTROPHIC FACTOR mRNA Johns H. Gilmore, Department of Psychiatry, University of North Carolina School of Medicine APOPTOSIS IN THE CNS OF TMEV-INFECTED SLJ MICE Emilia L. Oleszak, Fels Institute for Cancer Research and Molecular Biology and Department of Biochemistry and Neurology, Temple University School of Medicine CATHECHOLAMINERGIC TRANSMISSION DURING NEWCASTLE DISEASE VIRUS INFECTION IN CHICKS Valluru Lokantha, Department of Zoology, Sri Unkateswara University MODULATION OF CNS GENE EXPRESSION BY MOOD STABILIZING AGENTS Husseini K. Manji, Molecular Pathophysiology Program, WSU School of Medicine GENE EXPRESSION DISCOVERY SYSTEM (GEDSSM): A FLUORESCENT DIFFERENTIAL DISPLAY METHODOLOGY FOR RAPID EXPRESSION SURVEY AND ANALYSIS OF NEARLY ALL GENES Babak Azad, SRA Technologies, Inc GENOMIC DIFFERENTIAL DISPLAY: AN ALTERNATIVE TO POSITIONAL CLONING Cassandra Smith, Boston University, Center for Advanced Biotechnology and Departments of Biomedical Engineering, Biology and Pharmacology ANALYSIS OF BRAIN PROTEINS BY 2-DIMENSIONAL ELECTROPHORESIS N. Leigh Anderson, Large Scale Biology WHAT EPIDEMIOLOGY CAN TELL ABOUT MULTIPLE SCLEROSIS John F. Kurtzke, Neuroepidemiology Section, Neurology Service, VAMC, Washington DC PRENATAL INFECTION AND AFFECTIVE DISORDERS: A TALE OF TWO VIRUSES Alan S. Brown, New York State Psychiatric Institute SEASONAL INFLUENCES ON FIRST ADMISSIONS OF SCHIZOPHRENIA AND AFFECTIVE DISORDER IN AN IRISH NATIONAL SAMPLE Mark Clarke, Stanley Researach Unit, Cluain Mhuire Family Centre, St. John of God Adult Psychiatric Services CHARACTERIZATION OF RETROVIRAL SEQUENCES ISOLATED FROM MNOZYGOTIC TWINS DISCORDANT FOR SCHIZOPHRENIA USING REPRESENTATIONAL DIFFERENCE ANALYSIS (RDA) Shiva M. Singh, Molecular Genetics Unit, Department of Zoology, The University of Western Ontario EPIDEMIC STEALTH VIRUS INFECTION W. John Martin, Center for Complex Infectious Diseases POSSIBLE ANTIBODY CROSS-REACTIVITY BETWEEN RETROVIRAL AND BRAIN ANTIGENS Darrenn J. Hart, Department of Psychiatry and Neurology, Tulane University EPILEPSY AND SCHIZOPHRENIA: ALTERNATIVE RESPONSES TO BRAIN INJURY, INFECTION OR MALDEVELOPMENT: ARE EVER LARGER SAMPLE SIZES AND METANALYSES MUDDYING THE WATER? Janice R. Stevens, Oregon Health Sciences University CORRELATION OF IL-2 RECEPTOR LEVELS IN CSF OF INDIVIDUALS WITH SCHIZOPHRENIA, BIPOLAR DISORDER, UNIPOLAR DEPRESSION OR NORMAL CONTROLS WITH IMMUNOHISTOCHEMICAL LOCALIZATION IN THE BRAIN Maree Webster, Stanley Foundation Research Program, NIMH Neuroscience Center IDENTICAL T-CELL RECEPTOR TRANSCRIPTS ARE CLONALLY EXPANDED IN CNS OF THEV-INFECTED MICE WITH EARLY ACULTE & LATE CHRONIC DEMYELINATING DISEASE Emelia L. Oleszak, Fels Institute for Cancer Research and Molecular Biology and Department of Biochemistry and Neurology, Temple University School of Medicine BORNA DISEASE VIRUS INFECTION: PATHOGENESIS, DISEASE AND DIAGNOSIS IN EXPERIMENTALLY AND NATURALLY INFECTED SPECIES Lothar Stitz, Institute for Vaccines, Federal Research Center for Virus Diseases of Animals, Tjbingen, Germany DETECTION AND SEQUENCE ANALYSIS OF BORNA DISEASE VIRUS P24 RNA FROM PERIPHERAL BLOOD MONONUCLEAR CELLS OF PATIENTS WITH MAJOR DEPRESSION AND SCHIZOPHRENIA Yasuhide Iwata Department of Microbiology and Neuropshchiatry, Fukushima Medical College, Japan BORNA DISEASE VIRUS GENOMES IN AUTOPSY BRAIN SAMPLES FROM CONTROL AND SCHIZOPHRENIA IN JAPAN Kazuhiko Ikeda, Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry NUCLEAR TARGETING ACTIVITY ASSOCIATED WITH THE AMINOTERMINUS OF BORNA DISEASE VIRUS NUCLEOPROTEIN Masahiko Kishi, Institute of Immunological Science, Hokkaido University, Japan NUCLEAR LOCALIZATION OF THE PROTEIN FROM THE ORFx1 OF THE BORNA DISEASE VIRUS Tahir H. Malik, Department of Biosciences, Salem-Teikyo University EVOLUTION OF THE IMMUNE RESPONSE IN THE CENTRAL NERVOUS SYSTEM FOLLOWING INFECTION WITH BORNA DISEASE VIRUS Carolyn G. Hatalski, Laboratory for Neurovirology, University of California-Irvine HUMORAL IMMUNITY IN THE CENTRAL NERVOUS SYSTEM OF RATS INFECTED WITH BORNA DISEASE VIRUS Mady Hornig, Laboratory for Neurovirology, University of California-Irvine T CELL RESPONSE TO BORNA VIRUS IN PSYCHIATRIC PATIENT Koji Fukuda, Department of Microbiology and Neuropsychiatry, Fukushima Medical College, Japan THE QUAGMIRE OF BDV DIAGNOSTIC TESTS Kathryn M. Carbone, Laboratory of Pediatrics and Respiratory Viral Diseases, FDA CHILDHOOD C.N.S. INFECTIONS AND ADULT ONSET PSYCHOSIS Peter Jones, University of Nottingham WHAT WE KNOW ABOUT THE EPIDEMIOLOGY OF SCHIZOPHRENIA AND BIPOLAR DISORDER E. Fuller Torrey, Scientific Director, Stanley Foundation POSTERS Identification of Differentially Expressed Messages From The Postmortem Brains of Schizophrenic and Bipolar Individuals Nancy L. Johnston, Stanley Neurovirology Laboratory, Johns Hopkins University Correlation of Epidemilogic and Pathologic Variables with IL-2 Cytokine, IL-2 Receptor and Quinolinic Acid Levels of Individuals with Schizophrenia, Bipolar Disorder, Unipolar Depression or Normal Controls Jose D. Paltan-Ortiz, NIMH Neuroscience Center, Stanley Foundation Research Program Soluble Interleukin-2 Receptor Levels in Families of Patients With Schizophrenia Fiona Gaughran, Department of Psychiatry, United Medical and Dental School of St. Guys and Thomas’ Inducible-Nitric Oxide Synthase (iNOS) and Nitrotyrosine Are Found In Acute But Not In Chronic Multiple Sclerosis Lesions Emilia L. Oleszak, Fels Institute for Cancer Research and Molecular Biology and Department of Biochemistry and Neurology, Temple University School of Medicine Postnatal Herpes Simplex Virus Type 1 Encephalitis Affects Adults Sensorimotor Gating Function in Rats Jorgen A. Engel, Department of Pharmacology, Goteborg University CMV Infection Lorraine Brando, Stanley Neurovirology Laboratory, Johns Hopkins University School of Medicine Calcium-Channel Dysfunction in Hippocampal Neurons Induced by Mumps Virus Infection Krister Kristensson, Stanley Foundation European Research Center, Dept. Neuroscience, Karolinska Institute Hytothalamus-Hypophysis Pathology in Young Suicide Victims Z. Srebo, Department of Biology, Collegium Medicum, Jagiellonian University Schizotypy and Leadership: A Contrasting Model for the Deficit Symptoms: A Role for Sex Hormonal Dysgenesis? A.G. Alias, Chester Mental Health Center Schizophrenia, Affective Disorders and Infantile Autism: Ultrastructural Alterations in Platelets Sequndo Mesa, Psychiatric Hospital of Havana Stiff-Man Syndrome: Results of Interview and Psychologic Testing John L. Black, Mayo Foundation, Mayo Clinic