2ND SYMPOSIUM ON THE NEUROVIROLOGY AND NEUROIMMUNOLOGY
OF SCHIZOPHRENIA AND BIPOLAR DISORDER
NOVEMBER, 1996
OVERVIEW OF THE STANLEY LABORATORY PROGRAM – DO WE
REALLY THINK THAT INFECTIONS CAN CAUSE HUMAN PSYCHIATRIC
DISEASES
Robert Yolken, Stanley Laboratory, Johns Hopkins University, Baltimore, MD
VIRL AND VIRUS-RELATED RNA TRANSCRIPTS ARE DIFFERENTIALLY
EXPRESSED IN THE BRAINS OF INDIVIDUALS WITH SCHIZOPHRENIA
Frances Yee, Stanley Laboratory, Johns Hopkins University, Baltimore, MD
CORRELATION OF SCHIZOPHRENIA AND BIPOLAR DISORDER WITH
CYTOKINE AND CYTOKINE RECEPTORS IN VENTRICULAR FLUIDS AND
POSTMORTEM BRAIN TISSUE
Linda Bobo, Stanley Laboratory, Johns Hopkins University, Baltimore, MD
MEASURMENT OF RNA FROM 89 POSTMORTEM HUMAN BRAINS: A
MULTIVARIATE STATISTICAL ANALYSIS OF PRE- AND POST-MORTEM
EFFECTS ON THE YIELDS OF GAPdH AS MEASURED BY RT-PCR
Nancy Johnston, Stanley Laboratory, Johns Hopkins University, Baltimore, MD
DETECTION OF VIRAL PARTICLES IN GLIAL CELLS INOCULATED WITH
BRAIN TISSUE FROM INDIVIDUALS WITH SCHIZOPHRENIA AND
BIPOLAR DISEASE
Indre Dé, Stanley Laboratory, Johns Hopkins University, Baltimore, MD
SERIAL ANALYSIS OF GENE EXPRESSION OF HUMAN BRAIN TISSUE
Yeping Sun, Stanley Laboratory, Johns Hopkins University, Baltimore, MD
GENOMIC DIFFERENTIAL DISPLAY ENRICHED FOR RETROVIRAL LTR
SEQUENCE
Raphael P. Viscidi, Stanley Laboratory, Johns Hopkins University, Baltimore, MD
MOLECULAR BIOLOGY OF ALZHEIMER’S DISEASE
Sangram S. Sisodia, Department of Pathology and Neurosciences, Johns Hopkins
University, Baltimore, MD
GENETICS OF HUNTINGTON’S DISEASE: LESSONS FOR PSYCHIATRY
Christopher Ross, Department of Psychiatry, Johns Hopkins University, Baltimore, MD
TRYPANSOMA BRUCEI DYSREGULATES THE MAMMALIAN CIRCADIAN
CLOCK
Krister s. Kristensson, Department of Neurosciences, Karolinska Institute, Stockholm,
Sweden
CYTOMEGALOVIRUS AND POST-TRANSPLANT ARTERIOSCLEROSIS
Lorraine Jones-Brando, Stanley Laboratory, Johns Hopkins University, Baltimore, MD
VIROLOGICAL ASPECTS OF NEUROPATHOGENESIS OF HIV-1 DISEASE
Shizuku Sei, National Cancer Institute, National Institutes of Health, Bethesda, MD
DNA POLYMORPHISM AND SUSCEPTIBILITY TO ENVIRONMENTALLY
ACQUIRED CREUTZFELDT-JAKOB DISEASE
Laris Cervenakova, Laboratory of the Central Nervous System Studies, National
Institutes of Health, Bethesda, MD
ASSOCIATION OF HHV-6 AND MULTIPLE SCLEROSIS
Steven Jacobson, Neuroimmunology Branch, National Institutes of Health, Bethesda,
MD
HIGHER FREQUENCY OF HUMAN HERPESVIRUS-6 (HHV-6) ANTIBODY IN
CEREBRAL SPINAL FLUIDS AND SERA FROM MULTIPLE SCLEROSIS
PATIENTS
Dharam V. Ablashi, Georgetown University Medical School, Washington DC
MEASLES VIRUS INVASION THROUGH LIMBIC STRUCTURES IN MICE
WITH DISRUPTED GENE FOR THE TRANSPORTER ASSOCIATED WITH
ANTIGEN PRESENTATION
Erling Norrby, Microbiology and Tumor Biology Center, Karolinska Institutet,
Stockholm, Sweden
PSYCHOSIS AFTER PRENATAL EXPOSURE TO RUBELLA
Alan S. Brown, NYS Psychiatric Institute/Columbia University, New York, NY
RATES OF FLU-LIKE ILLNESS IN PATIENTS WITH AFFECTIVE
DISORDERS
Mady Hornig-Rohan, University of Pennsylvania, University Science Center Depression
Research Unit, Philadelphia, PA
INSTABILITY OF SCMV-DERIVED STEALTH VIRAL GENOME
W. John Martin, Center for Complex Infectious Diseases, Rosemead, CA
PANDAS: IS THERE A NEW “SPECIES” OF PEDIATRIC
NEUROPSYCHIATRIC DISORDERS?
Susan Swedo, National Institutes of Mental Health, Bethesda, MD
THE IMMUNE RESPONSE IN THE DISRUPTION OF HIPPOCAMPAL GABA
CIRCUITS FOLLOWING NEONATAL INFECTION WITH LYMPHOCYTIC
CHORIOMENINGITIS VIRUS (LCMV)
Brad D. Pearce, Emory University School of Medicine, Department of Psychiatry,
Atlanta, GA
EVIDENCE OF DIFFERENCES IN IMMUNE FUNCTION IN OLDER &
YOUNGER SCHIZOPHRENIC PATIENTS: IS THIS AGE OR A FUNCTION OF
SEVERITY OF ILLNESS
Mark H. Rapaport, University of California San Diego, Department of Psychiatry,
LaJolla, CA
ANTIBODIES TO NEURAL TISSUE PROTEINS IN SCHIZOPHRENIC
PATIENTS
Pinkas Sirota, Abarbanel Mental Health Center, Bat-Yam Felsenstein Medical Institute,
Bat-Yam, Israel
THE ROLE IF IMMUNE MEASURES IN PSYCHOSIS AND STRESS
SENSITIVITY IN SCHIZOPHRENIA
Daniel P. van Kammen, Department of Veterans Affairs, Medical Center, Pittsburgh, PA
THE ROLE OF CYTOKINES IN UNTREATED AND TREATED CHILDHOOD
ONSET SCHIZOPHRENIA
Barbara B. Mittleman, NIMH, Unit on Neuroimmunology, Behavioral Pediatrics Section,
Child Psychiatry Branch, Bethesda, MD
INTERLEUKIN-6 SENSITIZES RATS TO THE LOCOMOTOR-ACTIVATING
EFFECTS OF AMPHETAMINE
Steve Zalcman, Concordia University, Department of Psychiatry, Montreal, Canada
PPARδ AND ITS POTENTIAL INVOLVEMENT IN SCHIZOPHRENIA
Guoqiang Xing, National Institute of Mental Health, Bethesda, MD
DETECTION AND QUANTIATION OF GENOMIC DIFFERENCES IN
MICROSATELLITES OF MONOZYGOTIC TWINS
Cassandra L. Smith, Boston University, Departments of Biomedical Engineering,
Biology and Pharmacology, Boston, MA
CHARACTERIZATION OF DISEAE PROCESSES AND PHARMACEUTICAL
MECHANISMS THROUGH QUANTITATIVE HIGH-THROUGHPUT 2-D
ELECTROPHORESIS
N. L. Anderson, Large Scale Biology Corporation, Rockville, MD
A NEW PCR-BASED DNA FINGERPRINTING METHOD: AFLP
Jhy-Jhu Lin, Life Technologies (GIBCO/BR), Gaithersburg, MD
DO THE ANATOMY AND COURSE OF SCHIZOPHRENIA ASSIST IN THE
SEARCH FOR ETIOLOGY?
Janice R. Stevens, Oregon Health Sciences University, Department of Psychiatry,
Portland, OR
BORNA DISEASE VIRUS IN PSYCHIATRIC DISEASE
Kathryn Carbone, FDA, Laboratory of Pediatric & Respiratory Viral Diseases, Bethesda,
MD
BORNA DISEASE VIRUS IN HUMANS
Juan C. de la Torre, The Scripps Research Institute, LaJolla, CA
BORNA DISEASE VIRUS SEROLOGY IN A FIRST EPISODE
SCHIZOPHRENIA COHORT
Royce W. Waltrip II, Maryland Psychiatric Research Center, Baltimore, MD
PREVALENCE OF BORNA DISEASE VIRUS RNA IN PERIPHERAL BLOOD
MONONUCLEAR CELLS FROM PATIENTS WITH AFFECTIVE DISORDERS
Masahiko Kishi, Hokkaido, University Institute of Immunological Science, Section of
Bacterial Infection, Sapporo, Japan
IS ACTIVE BORNA DISEASE VIRUS INFECTION REALLY A CONTRIBUTOR
TO HUMAN PSYCHIATRIC DISORDERS?
D. Craig Hooper, Thomas Jefferson University, Center for Neurovirology, Department of
Microbiology and Immunology, Philadelphia, PA
NEURAL DEVELOPMENT PATTERNS IN RATS INFECTED WITH BORNA
DISEASE VIRUS AS NEONATES
Joanne M. Pyper, Johns Hopkins University School of Medicine, Division of
Comparative Medicine, Baltimore, MD
THE MOLECULAR BIOLOGY AND GENETICS OF PRION DISEASES: A
JOURNEY FROM HERESY TO ORTHODOXY
Stanley B. Prusiner, University of California San Francisco, Department of Neurology,
San Francisco, CA
WHERE HAVE WE BEEN AND WHERE ARE WE GOING: RISK FACTORS
AND FUTURE DIRECTIONS
E. Fuller Torrey, Guest Researcher, NIMH Neuroscience Center, Washington DC
POSTERS
SUSCEPTIBILITY OF HUMAN MACROPHAGES TO CORONAVIRUS OC43
Arlene Collins, SUNY, Department of Microbiology, Buffalo, NY
INVESTIGATION OF INSERTIONAL MUTAGENESIS OF “RETROID”
ELEMENTS IN THE HUMAN GENOME WITH REFERENCE TO
SCHIZOPHRENIA
Paromita Deb, The University of Western Ontario, Department of Zoology, London,
Ontario, Canada
NEONATAL INFECTION INCREASES NEUROTROPHIC FACTOR mRNA
John H. Gilmore, University of North Carolina School of Medicine, Department of
Psychiatry, Chapel Hill, NC
THE INCIDENCE AND PREVALENCE OF BIPOLAR AFFECTIVE DISORDER
IN JAMAICA
Frederick W. Hickling, Psychotherapy Associates, Connoley House, Kingston, Jamaica
COMPARISON OF cDNA LIBRARIES FROM THE BRAINS OF NORMAL AND
SCHIZOPHRENIC INDIVIDUALS SHOW THAT AN UNUSUALLY HIGH
NUMBER OF NOVEL SEQUENCES ARE PRESENT IN THE BRAIN OF THE
SCHIZOPHRENIC INDIVIDUAL
Nancy Johnston, Johns Hopkins University, Stanley Neurovirology Laboratory,
Baltimore, MD
THE APPLICATION AND ADAPTATION OF REPRESENTATIONAL
DIFFERENCE ANALYSIS IN THE EVALUATION OF RETROVIRAL
HYPOTHESIS FOR SCHIZOPHRENIA
Timothy A. Klempan, The University of Western Ontario, Department of Zoology,
London, Ontario, Canada
A PILOT STUDY OF CYTOKINE AND SOLUBLE INTERLEUKIN-2
RECEPTOR LEVELS IN SYMPTOMATIC BIPOLAR PATIENTS
Mark H. Rapaport, University of California San Diego, Department of Psychiatry,
LaJolla, CA
EFFECTS OF HTLV-1 VIRUS, IFN- AND QUIN PRECURSORS ON QUIN
RESPONSE IN CULTUED HUMAN MONOCYTES AND MACROPHAGES
Chettemgere Venkateshan, LCNSS, NINDS, NIH, Bethesda, MD