The Sweet Stevia Science

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NOW e-newsletter
December 5, 2003
The Sweet Stevia Science
By Allison Tannis, BSc, MSc
Nutritionist, Puresource Natural Products
With the current epidemic of obesity there is a need to find alternatives to white
sugar. Stevia is a naturally sweet, all-natural herb that has a number of reasons why it is
the healthier alternative. Scientific studies are limited on stevia; however, it’s important
to investigate them as they highlight some great features of stevia that makes it an ideal
choice for many diseases such as diabetes, hypertension and cancer.
Stevia is from the leaves of Stevia rebaudiana. It’s a sweet substance that can be
easy used in place of sugar (i.e. ¼ to ½ tsp of stevia for 1 cup of sugar), but it does not
cause the same detrimental effects as sugar in the body. Therefore, diabetics may find
stevia to be beneficial as it offers a sweet taste, but does not result in a sharp increase in
blood sugar. In fact, science suggests that stevia may stimulate insulin production from
the beta-cells of the pancreas, and appears to increase glucose tolerance (i.e. antihyperglycemic effects). Therefore, stevia is an obvious choice for diabetics for both its
great taste, and its healthy benefits.
People who suffer from high blood pressure may also benefit from the use of
stevia. A number of studies have noted stevia’s ability to reduce hypertension. However,
the most convincing evidence comes from Chan et al. 2000. This multi-centered, double
blind, placebo controlled human trial was on hypertensive men. They received about 750
mg of stevia each day for a month. The results indicated that stevia is an antihypertensive and is well tolerated in humans. Therefore, stevia may reduce hypertension.
Some studies suggest that stevia may also have anti-cancer, anti-microbial and
anti-viral properties. These aspects of stevia are not yet strongly supported by scientific
literature, which is to be expected as the first study noting these properties was reported
just six years ago.
The safety of stevia has always been a debate. One study noted that in an Ames
test there was some toxicity seen; however, this does not represent the effect of stevia in
human metabolism. As some studies suggest that it may have negative aspects, others
have found it to be safe. More importantly, stevia has been used extensively in North
America for 20 years without one reported overdose, or toxicity, nor have the human
trials that have supplemented with stevia. The information to date indicates that stevia
appears to be safe.
Stevia is known as a natural sweetener. However, science suggests that it needs to
be considered as a beneficial natural product for diabetics, patients with high blood
pressure and perhaps as an anti-cancer and anti-microbial. Stay tuned to research in
coming years as the science may soon unveil the true health potential of stevia.
References:
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Absorption and metabolism of glycosidic sweeteners of stevia mixture and their
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Hubler MO, Bracht A, Kelmer-Bracht AM. Influence of stevioside on hepatic glycogen
levels in fasted rats. Res Commun Chem Pathol Pharmacol. 1994 Apr;84(1):111-8.
Curi R, Alvarez M, Bazotte RB, Botion LM, Godoy JL, Bracht A. Effect of Stevia
rebaudiana on glucose tolerance in normal adult humans. Braz J Med Biol Res.
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Jeppesen PB, Gregersen S, Poulsen CR, Hermansen K. Stevioside acts directly on
pancreatic beta cells to secrete insulin: actions independent of cyclic adenosine
monophosphate and adenosine triphosphate-sensitive K+-channel activity. Metabolism.
2000 Feb;49(2):208-14.
Jeppesen PB, Gregersen S, Rolfsen SE, Jepsen M, Colombo M, Agger A, Xiao J,
Kruhoffer M, Orntoft T, Hermansen K. Antihyperglycemic and blood pressure-reducing
effects of stevioside in the diabetic Goto-Kakizaki rat. Metabolism. 2003 Mar;52(3):3728.
Yasukawa K, Kitanaka S, Seo S. Inhibitory effect of stevioside on tumor promotion by
12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. Biol
Pharm Bull. 2002 Nov;25(11):1488-90.
Chan P, Tomlinson B, Chen YJ, Liu JC, Hsieh MH, Cheng JT. A double-blind placebocontrolled study of the effectiveness and tolerability of oral stevioside in human
hypertension. Br J Clin Pharmacol. 2000 Sep;50(3):215-20.
Jeppesen PB, Gregersen S, Alstrup KK, Hermansen K. Stevioside induces
antihyperglycaemic, insulinotropic and glucagonostatic effects in vivo: studies in the
diabetic Goto-Kakizaki (GK) rats. Phytomedicine. 2002 Jan;9(1):9-14.
Lee CN, Wong KL, Liu JC, Chen YJ, Cheng JT, Chan P. Inhibitory effect of stevioside
on calcium influx to produce antihypertension. Planta Med. 2001 Dec;67(9):796-9.
Takahashi K, Matsuda M, Ohashi K, Taniguchi K, Nakagomi O, Abe Y, Mori S, Sato N,
Okutani K, Shigeta S. Analysis of anti-rotavirus activity of extract from Stevia
rebaudiana.
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ombuoside from Stevia triflora. Ann Pharm Fr. 1997;55(6):262-8.
Klongpanichpak S, Temcharoen P, Toskulkao C, Apibal S, Glinsukon T. Lack of
mutagenicity of stevioside and steviol in Salmonella typhimurium TA 98 and TA 100. J
Med Assoc Thai. 1997 Sep;80 Suppl 1:S121-8.
Pezzuto JM, Compadre CM, Swanson SM, Nanayakkara D, Kinghorn AD. Metabolically
activated steviol, the aglycone of stevioside, is mutagenic. Proc Natl Acad Sci U S A.
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