中国微米纳米技术学会纳米科学技术分会第三届年会暨 2014 全国纳米生物与医学学术会议-四川成都
多功能纳米药物及核酸载体
帅心涛*
中山大学化学与化学工程学院、中山医学院，邮编: 510275; 电话: 020- 84110365; 传真: 020- 84112245; Email: shuaixt@mail.sysu.edu.cn
基于高分子的药物及基因传输纳米载体是目前非常热门的研究领域。我们制备了多种用于药物和基
因或 siRNA 传输的聚合物纳米载体，通过在载体结构中引入分子靶向配体例如单链抗体、叶酸等获得了
对 T 细胞、肿瘤细胞等的主动靶向传输。同时，通过在纳米载体内负载核磁共振显像（MRI）试剂，可
以无创伤地检测药物和基因的靶向化输送效率。
Figure 1. Formation of MRI-visible targeting polyplex.
参考文献
1.
2.
3.
T. M. Allen, P. R. Cullis, Science, 2004, 303, 1818-1821.
N. Nasongkla, X. Shuai, H. Ai, J. Gao, Angew. Chem. Int. Ed., 2004, 43, 6323-6327.
G. Chen, W. Chen, X. Shuai et al, Biomaterials, 2009, 30, 1962-1970.
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中国微米纳米技术学会纳米科学技术分会第三届年会暨 2014 全国纳米生物与医学学术会议-四川成都
Bio-inspired synthesis and self-assembly of unique functional
inorganic nanostructures, nanocomposites and their
applications
Shu-Hong Yu*
Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale,
Department of Chemistry, University of Science and Technology of China, Hefei 230026, Tel.: +86-551-3603040;
Fax: +86-551-3603040, China. E-mail: shyu@ustc.edu.cn
Development of new methodologies for synthesis and self-assembly of unique functional nanostructures and
nanocomposites has been of significance to access new materials with unique functionalities. Herein, we will
report several facile synthetic protocols for one-pot controlled synthesis of several kinds of unique inorganic
nanomaterials and hybrids under mild solution conditions, in which simple organic molecules, surfactant or low
molecular weight polymers have been used. The high quality nanobuilding blocks we discussed include ultrathin
nanowires, nanoplates, and magnetic nanoparticles, new hybrid semiconducting nanobelts/nanowires, conducting
nanocables and nanotubes, and carbon-based nanostructures. Especially, we report that periodic ordered
mesostructures of hydrophilic ultrathin nanowires can be produced by Langmuir-Blodgett technique. The
mesostructures of ultrathin Te nanowire films show reversibly switched photoelectric properties. In addition, a
series of layered double hydroxides (LDH) micro/nano-platelets reinforced free-standing, strong, transparent, and
functional layered organic-inorganic hybrid films can be fabricated based on layer-by-layer (LBL) assembly
technique using series of LDH micro/nano-platelets as building blocks. These assembled structures based on bioinspired approaches will find potential applications in different fields.
Figure 1. Free-standing, strong, transparent, and functional layered organic-inorganic hybrid films
References
1.
2.
3.
4.
5.
J. W. Liu, J. H. Zhu, C. L. Zhang, H. W. Liang, S. H. Yu, J. Am. Chem. Soc. 2010, 132, 8945–8952.
H. B. Yao, H. Y. Fang, Z. H. Tan, L. H. Wu, S. H. Yu, Angew. Chem. Int. Ed. 2010, 49, 2140-2145.
M. J. Hu, Y. Lu, S. Zhang, S. R. Guo, B. Lin, M. Zhang, S. H. Yu, J. Am. Chem. Soc. 2008, 130, 11606-11607.
H. B. Yao, M. R. Gao, S. H. Yu, Nanoscale 2010, 2, 323-334.
M. R. Gao, W. H. Xu, H. B. Yao, S. H. Yu, Adv. Mater. 2010, 22, 1977-1981.
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