姚伟娟，理学博士
副教授
联系方式：
电话：82802419
Email：weijuanyao@bjmu.edu.cn
主要学习及工作经历：
1993.9-1997.7
河北师范大学数学系，数学
学士
1997.9-2002.7
北京大学医学部生物物理系，生物物理学
博士
2003.6-2007.2
美国加州大学圣地亚哥分校生物工程系
博士后
2007.2-2008.8
美国加州大学圣地亚哥分校，医疗系
助理研究员
2008.8-至今
北京大学医学部生理与病理生理学系
副教授
主要学术任职：
中国生物物理学会第九届生物力学与生物流变学专业委员会委员
第七届北京生物医学工程学会生物力学专业委员会委员（2009-2012）
获奖情况：
2008 奥地利维也纳，CTEPH Workshop, Scientific Award
2008 美国加州圣地亚哥，实验生物学会议（Experimental Biology），美国解剖学家学会
AAA 最佳博士后海报报告奖和旅行奖
2006 美国加州大学圣地亚哥分校生物工程系，客座讲师
2005 加州大学系统生物工程会议，旅行奖
2004 北京大学，优秀博士论文三等奖
基金来源：
教育部博士点新教师基金，教育部留学回国人员启动基金，国家自然科学基金青年基金，
国家自然科学基金面上项目
论文：
1. Wen Z, Xie, J, Guan Z, Sun D, Yao W, Chen K, Yan Z, Mu Q. A study of hemorheological
behavior in patients with Alzheimer’s disease at the early stages. Clinc. Hemorheol. Microcirc.
22: 261-266, 2000.
2. Wen Z, Yao W, Xie L, Yan Z, Chen K, Ka W, Sun D. Influence of neuraminidase on the
characteristics of microrheology of red blood cells. Clin. Hemorheol. Microcirc. 23: 51-57, 2000.
3. Wen Z, Xie L, Yao W, Chen K, Ka W, Chien S. Effects of 60Co irradiation on hemorheological
characteristics in rabbits. Clin. Hemorheol. Microcirc. 25:75-81, 2001.
4. Yao W, Wen Z, Yan Z, Sun D, Ka W, Xie L, Chien S. Low viscosity ektacytometery and its
validation tested by flow chamber. J. Biomech. 34: 1501-1509, 2001.
5. Wang J, Sun D, Yao W, Zeng Z, Yan Z, Wen Z. Biophysical and biorheological studies on the
hematopoietic precursor cells at different stages. Science China 45: 421-428, 2002.
6. Xie L, Sun D, Yao W, Ka W, Wen Z. Study on microrheological characteristics of reticulocyte in
vivo. Science China 45: 50-56, 2002.
7. Yao W, Liang Y, Chen K, Xie L, Sun D, Wang X, Wen Z, Chien S. Changes of biophysical
behaviour of K562 cells for p16 gene transfer. Clin. Hemorheol. Microcirc. 27: 177-183, 2002.
8. Yao W, Chen K, Wang X, Xie L, Wen Z, Yan Z, Chien S. Influence of TRAIL gene on
biomechanical properties of the human leukemia cell line Jurkat. J. Biomech. 35: 1659-1663,
2002.
9. Xie L, Gu L, Yan Z, Yao W, Sun D, Wen Z. The microrheological changes in the course of
erythrocyte senescence after phynylhydrazine injection. Clin. Hemrheol. Microcirc. 28: 5-11,
2003.
10. Gu L, Yao W, Wan ZY, Xie L, Sung DG, Li D, Zeng Z, Wen ZY. Effects of TFAR19 gene on
the growth and biorheological properties of mouse erythroleukemia cell line MEL. Science China
46: 293-301, 2003.
11. Yao W, Gu L, Sun D, Ka W, Wen Z, Chien S. Wild type p53 gene causes reorganization of
cytoskeleton and therefore the impaired deformability and difficult migration of murine
erythroleukemia Cells. Cell Motil. Cytoskel. 56: 1-12, 2003.
12. Sun D, Wang J, Yao W, Gu L, Wen Z, Chien S. Tumorigenesis of murine erythroleukemia cell
line transfected with exogenous p53 gene. Clin. Hemorheol. Microcirc. 30: 117-126, 2004.
13. Chen K, Li D, Jiang Y, Yao W, Wang X, Wei X, Gao J, Xie L, Yan Z, Wen Z, Chien S.
Influence of TRAIL gene on biophysical cell line Jurkat. Cell Res. 2004; 2:161-168.
14. Xie L, Jiang Y, Yao W, Gu L, Sun D, Ka W, Wen Z, Chien S. Studies on the biomechanical
properties of maturing reticulocytes. J. Biomech. 39: 530-535, 2006.
15. Makino A, Prossnitz ER, Bunemann M, Wang JM, Yao W, Schmid-Schönbein GW. G proteincoupled receptors serve as mechanosensors for fluid shear stress in neutrophils. Am. J. Physiol.
Cell Physiol. 290: 1633-1639, 2006.
16. Zhang Y, Yao W, Zeng Z, Wang X, Sun D, Ka W, Zhou S, He D, Wen Z, and Chien S.
Exogenous wild-type p53 gene improved survival of nude mice injected with murine
erythroleukemia cell line through amelioration of hemorheological changes. Microcirculation 14:
155-166, 2007.
17. Yao W, Nathanson J, Lian I, Gage FH, Sung LA. Mouse erythrocyte tropomodulin in the brain
reported by lacZ knocked-in downstream from the E1 promoter. Gene Expr. Pattern. 8(1): 36-46,
2007.
18. Ogawa A, Firth AL, Yao W, Rubin LJ, Yuan, JX-J. Prednisolone inhibits PDGF-induced nuclear
translocation of NF-B in human pulmonary artery smooth muscle cells. Am. J. Physiol. Lung
Cellul. Mol. Physiol. 295: L648-L657, 2008.
19. Xu M, Remillard CV, Sachs BD, Makino A, Platoshyn O, Yao W, Dillmann WH, Akassoglon K,
Yuan JX-J. p75 neurotrophin receptor regulates agonist-induced pulmonary vasoconstriction. Am.
J. Physiol. Heart Circ. Physiol. 295: H1529-H1538, 2008.
20. Yao W, Sung LA. Specific expression of E-Tmod (Tmod1) in horizontal cells: implication in
neuronal cell mechanics and glaucomatous retina. Mol. Cellul. Biomech. 6: 71-82, 2009.
21. Yao W, Firth AL, Sacks RS, Ogawa A, Auger WR, Fedullo PF, Madani MM, Lin GY,
Sakakibara N, Thistlethwaite PA, Jamieson SW, Rubin LJ, Yuan JX-J. Identification of putative
endothelial progenitor cells (CD34+CD133+Flk-1+) in endarterectomized tissue of patients with
chronic thromboembolic pulmonary hypertension. Am. J. Physiol. Lung Cell. Mol. Physiol.
296:L870-L878, 2009.
22. Zeng Z*, Yao W*(co-first author), Xu X, Xu G, Long J, Wang X, Wen Z, Chien S.
Hepatocellular carcinoma cells deteriorate the biophysical properties of dendritic cells. Cell
Biochem. Biophys. 55:33–43, 2009.
23. Ogawa A, Firth AL, Yao W, Madani MM, Kerr KM, Auger WR, Jamieson SW, Thistlethwaite
PA, Yuan JX-J. Inhibition of mTOR attenuates store-operated Ca2+ entry in cells from
endarterectomized tissues of patients with chronic rhromboembolic pulmonary hypertension. Am.
J. Physiol. Lung Cell. Mol. Physiol. 297: L666-L676, 2009.
24. Wang X, Chen X, Tang Z, Yao W, Liu X, Wang X, Ka W, Sun D, He D, Wen Z, Chien S.
Ryanodine Receptor 1 Mediates Ca2+ Transport and Influences the Biomechanical Properties in
RBCs. J. Biomech. 42(16): 2774-2779, 2009.
25. Chen D, Yao W, Zhang X, Han X, Qu X, Ka W, Sun D, Wu X, Wen Z. Effects of Gekko sulfated
polysaccharide–protein complex on human hepatoma SMMC-7721 cells: Inhibition of
proliferation and migration. J. Ethpharm. 127: 702-708, 2010.
26. Zhang X, Yao W, Chen D, Jia B, Sun D, Ka W, He D, Wang X, Wen Z. Acute dichlorvos
poisoning induces hemorheological abnormalities in rabbits via oxidative stress. Clin. Hemorheol.
Microcirc. 44: 207-216, 2010.
27. Xu X, Zeng Z, Yao W, Wang X, Sun D, Ka W, Zhang Y, Wang X, Chen X, Zha Y, Sun L, Xie L,
Wen Z, Chien S. Biomechanical alterations of dendritic cells by co-culturing with K562 CML
cells and their potential role in immune escape. J. Biomech. 43: 2339-2347, 2010.
28. Firth AL*, Yao W*(co-first author), Remillard CV, Ogawa A, Yuan JX-J. Upregulation of Oct-4
isoforms in pulmonary artery smooth muscle cells from patients with pulmonary arterial
hypertension. Am. J. Physiol. Lung Cell. Mol. Physiol. 298:L548-L557, 2010.
29. Firth AL, Yao W, Ogawa, A, Madani MM, Lin GL, Yuan JX-J. Multipotent mesenchymal
progenitor cells are present in endarterectomized tissues from patients with chronic
thromboembolic pulmonary hypertension. Am. J. Physiol. Cell Physiol. 298:C1217-C1225, 2010.
30. Yao W, Sung LA. Erythrocyte tropomodulin isoforms with and without the N-terminal actinbinding domain. J. Biol. Chem. 285: 31408-31417, 2010.
31. Wang X, Chen D, Zhang X, Jia B, Xie L, Sun D, Ka W, Yao W*, Wen Z*. Biorheological
changes of dendritic cells at the different differentiation stages.Clin. Hemorheol. Microcirc. 46:
265-273, 2010.
32. Du Y, Yao W, Qian Y, Han M, Wen Z, Ma L. Hemorheological changes in patients with livingdonor renal transplantation. Clin. Hemorheol. Microcirc. 47(3):199-209, 2011.
33. Zhang Y, Chen X, Xu X, Wang X, Wang X, Yuan G, Sun D, Ka W, He D, Wen Z, Yao W*.
Knockdown of hTERT alters biophysical properties of K562 cells resulting in decreased
migration rate in vitro. Cell Biochem. Biophys. 2011 Aug 11. [Epub ahead of print]
34. Chen D, Zhang X, Du Y, Jia B, Ka W, Sun D, Yao W*, Wen Z*. Effects of Gekko Sulfated
Polysaccharide–Protein Complex on the defective biorheological characters of dendritic cells
under tumor microenvironment. Cell Biochem. Biophys. 2011 Sep 13. [Epub ahead of print]
35. Yao W, Mu W, Zeifman A, Lofti M, Remillard CV, Makino A, Perkins DL, Garcia JGN, Yuan
JX-J, Zhang W. Fenfluramine-induced gene dysregulation in human pulmonary artery smooth
muscle and endothelial cells. Pulmonary Circulation, 1(3): 405-418, 2011.
章节
Firth AL, Yao W, Yuan JX-J. Identification of adult stem and progenitor cells in pulmonary vasculature.
Page 621-636. In: Textbook of Pulmonary Vascular Disease, edited by Yuan JX-J, Garcia JGN, Hales CA,
Stuart R, Archer SL, West JB. New York, NY: Springer, 2011.
综述
1. 张晓兰，文宗曜，姚伟娟*. F-actin 慢生长端的盖帽蛋白: 红细胞原肌球调节蛋白. 生理科学进
展, 42(1): 27-31, 2011.
摘要
1. Yao W, Lian I, Katz B, Sung LA. Splice variants and alternative promoters of erythrocyte
tropomodulin in erythroid cells under mechanical regulation. The 6th Annual UC Systemwide
Bioengineering Symposium, Santa Cruz, CA, 2005.
2. Sung LA, Yao W. Splice variants and alternative promoters of erythrocyte tropomodulin in
erythroid cells under mechanical regulation. The 12th International Conference of Biorheology
and the 5th International Congress on Clinical Hemorheology, Chongqing, China, 2005.
3. Yao W, Lian I, Sung LA. The expression pattern of erythrocyte tropomodulin in mouse brain
reported by the knocked-in lacZ gene. FASEB 19: A794, 2005.
4. Yao W, Sacks RS, Ogawa A, Firth AL, Auger WR, Madani M, Sakakibara N, Thistlethwaite PA,
Jamieson SW, Rubin LJ, and Yuan JX-J. Structural changes of the pulmonary vasculature in
patients with chronic thromboembolic pulmonary hypertension: role of progenitor cells.
American Thoracic Society, Toronto, Canada, 2008.
5. Yao W, Firth AL, Ogawa A, Yuan JX-J. Enhanced expression of pluripotency gene Oct-4 in
pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial
hypertension. Experimental Biology, San Diego, CA, 2008.
6. Yao W, Sung LA. Specific expression of E-Tmod (Tmod1) in horizontal cells of the retina.
Experimental Biology, San Diego, CA, 2008.
7. Firth AL, Yao W, Dao C, Yuan JX-J. Functional voltage dependent potassium channels are
present in human embryonic stem cells. International Society for Stem Cell Research Annual
Meeting, Pennsylvania, PA, 2008.
8. Yao W, Zhang X, Song J. The mechanical regulations of tropomodulin1 in the remodeling of
cytoskeleton in erythrocyte maturation. 17 Interantional Biophysical Congress, Beijing, China,
2011.