Project acronym: ProteomeBinders
Project full title: A European Infrastructure of Ligand Binding Molecules against the
Human Proteome
Contract no.: 026008
Co-ordination Action
1.
Project summary
The objective of this proposal is to coordinate the establishment of a European resource infrastructure of binding
molecules directed against the entire human proteome. A major objective of the post-genome era is to detect,
quantify and characterise all relevant human proteins in tissues and fluids in health and disease. This effort
requires a comprehensive, characterised and standardised collection of specific ligand-binding reagents,
including antibodies, the most widely used such molecules, and in addition novel protein scaffolds, nucleic acid
aptamers, peptides and small chemical entitities. Currently there is no pan-European platform to coordinate
systematic development, resource management and quality control for these important reagents. This CA will
coordinate 26 European partners and two in the USA, several of which operate infrastructures or large-scale
projects in aspects including cDNA collections, protein production, polyclonal and monoclonal antibodies. They
provide a critical mass of leading expertise in binder technology, protein expression, binder applications and
bioinformatics. Many have close links to relevant SMEs, as founders or advisors. The CA will plan the
organisation of the resource, by integrating existing infrastructures, reviewing technologies and high-throughput
production methods, standardising binder-based tools and applications, assembling bioinformatics and
establishing a database schema for a central binders repository. The Proteome Binders resource is predicted to
have huge benefits for basic and applied research, impacting on healthcare, diagnostics, target discovery for drug
intervention and therapeutics. It will thus be of great advantage to the research and biotechnology communities.
In general terms, Europe is already well advanced in the technologies required and excellently placed to initiate
this large scale project. The CA will prepare the way for an application for the production phase of the
infrastructure under FP7.
2.
Project webpage: www.proteomebinders.org
3.
Start date: 1 March 2006
Duration: 48 months
1
4.
List of participants
Participant
number
Organisation
Short name
1
The Babraham Institute,
Cambridge, UK
BI
2
CNRS
CNRS
3
The Beatson Institute for Cancer Research, Glasgow, UK
BICR
4
Universite Victor Segalen - Bordeaux II, France
UBx2
5
Deutsches Krebsforschungszentrum
Heidelberg, Germany
DKFZ
6
European Molecular Biology Laboratory, Heidelberg, Germany
EMBL
7
GSF - Forschungszentrum fur Umwelt und Gesundheit, Neuherberg,
Germany
GSF
Gesellschaft fuer Biotechnologische Forschung mbH, Braunschweig,
Germany
GBF
Universitaet Kassel, Kassel, Germany
UNIK
8
9
Universitaet Konstanz, Konstanz, Germany
10
UKON
11
Kungliga Tekniska Hogskolan, Stockholm, Sweden
12
Akademisch Ziekenhuis Leiden,
The Netherlands
KTH
LUMC
Los Alamos National Laboratory,
13
New Mexico, USA.
LANL
14
Lunds Universitet
Lund, Sweden
ULUND
15
Max Planck Gesellschaft zur Foerderung der Wissenschaften E.V., (Institute
for Molecular Genetics, Berlin), Germany
MPG
2
17
Naturwissenschaftliches und Medizinisches Institut an der Universitaet
Tuebingen, Germany
NMI
University of Rijeka, Croatia
18
19
20
21
22
23
24
25
26
27
MEDRI
National University of Ireland Dublin, (University College, Dublin), Ireland
RZPD – Deutsches Ressourcenzentrum für Genomforschung, GMBH
Heidelberg, Germany
SomaLogic Inc., Boulder, Colorado 80301, USA
Technische Universitaet Carolo-Wilhelmina zu Braunschweig,
Braunschweig, Germany
Technische Universität München, Germany
Uppsala Universitet, Uppsala, Sweden
Vlaams Interuniversitair Instituut voor Biotechnologie
Zwijnaarde, Belgium
Valtion Teknillinen Tutkimuskeskus (VTT), Turku, Finland
The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
28
Universität Zurich,
Zurich, Switzerland
29
Ecole Nationale Supérieure d'Electronique, Informatique &
Radiocomunications de Bordeaux, Talence, France
3
UCD
RZPD
SomaLogic
TUBS
TUM
UU
VIB
VTT
Sanger
UNIZH
ENSEIRB