Ingmar Skoog
Ten most important publications (IS)
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Skoog I, Nilsson L, Palmertz B, Andreasson L-A, Svanborg A. (1993) A populationbased study of dementia in 85-year-olds. New Engl J Med; 328:153-158
Skoog I. (1996) Sex and Swedish 85-year-olds. New Engl J Med;334:1140-1141
Skoog I, Lernfelt B, Landahl S, Palmertz B, Andreasson L-A, Nilsson L, Persson
G, Odén A, Svanborg A. (1996) A 15-year longitudinal study on blood pressure and
dementia. Lancet;347:1141-1145.
Waern M, Beskow J, Runeson B, Skoog I. (1999) Suicidal feelings in the last year of
life in elderly people who commit suicide. Lancet;354:917-918
Waern M, Beskow J, Runesson B, Skoog I. (1996) High rate of antidepressant
treatment in elderly suicides. Brit Med J;313:1118.
Waern M, Rubenowitz E, Runeson B, Skoog I, Wilhelmson K, Allebeck P. (2002)
Burden of illness and suicide in elderly people: a case-control study. Brit Med
J;324:1355-57.
Steffens DC, Skoog I, Norton MC, Hart AD, Tschanz JT, Plassman BL, Wyse BW,
Welsh-Bohmer KA, Breitner JC. (2000) Prevalence of depression and its treatment in
an elderly population: the Cache County study. Arch Gen Psychiatry;57:601-7.
Skoog G, Skoog I. (1999) A 40-year follow-up of patients with obsessive-compulsive
disorder. Arch Gen Psychiatr;56:121-127.
Ostling S, Skoog I. (2002) Psychotic symptoms and paranoid ideation in a
nondemented population-based sample of the very old. Arch Gen Psychiatry;59:53-59.
Gustafson D, Rothenberg E, Blennow K, Steen B, Skoog I. (2003) An 18-year followup of overweight and risk of Alzheimer disease. Arch Intern Med.;163:1524-8
Peer-reviewed publications 2003-2007 (IS)
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Heijer T, Skoog I, Oudkerk M, de Leeuw FE, de Groot JC, Hofman A, Breteler
MM. (2003) Association between blood pressure levels over time and brain atrophy in
the elderly. Neurobiol Aging;24:307-13.
Gustafson D, Rothenberg E, Blennow K, Steen B, Skoog I. (2003) An 18-year followup of overweight and risk of Alzheimer disease. Arch Intern Med.;163:1524-8.
Skoog I, Davidsson P, Aevarsson O, Vanderstichele H, Vanmechelen E, Blennow K.
(2003) Cerebrospinal Fluid Beta-Amyloid 42 Is Reduced before the Onset of Sporadic
Dementia: A Population-Based Study in 85-Year-Olds. Dement Geriatr Cogn
Disord;15:169-76
Steffens DC, Norton MC, Hart AD, Skoog I, Corcoran C, Breitner JC (2003) Cache
County Study Group. Apolipoprotein E genotype and major depression in a community
of older adults. The Cache County Study. Psychol Med;33:541-7
Gislason TB, Sjogren M, Larsson L, Skoog I. (2003) The prevalence of frontal variant
frontotemporal dementia and the frontal lobe syndrome in a population based sample of
85 year olds. J Neurol Neurosurg Psychiatry;74:867-71
Guo X, Matousek M, Sonn U, Skoog I, Björkelund C, Steen B. (2003) A longitudinal
study on changes of movement performance and their relation to medical conditions in a
female population followed from age 70 to 78. Arch Gerontol Geriatr;36:127-140.
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Lithell H, Hansson L, Skoog I, Elmfeldt D, Hofman A, Olofsson B, Trenkwalder P,
Zanchetti A (2003) For the SCOPE Study Group. The Study on Cognition and
Prognosis in the Elderly (SCOPE): principal results of a randomized double-blind
intervention trial. J Hypertens;21:875-886
Erkinjuntti T, Skoog I, Lane R, Andrews C. (2003) Potential long-term effects of
rivastigmine on disese progression may be linked to drug effects on vascular changes in
Alzheimer brains. Int J Clin Pract;57:756-760.
Liebetrau M, Steen B, Skoog I. (2003) Stroke in 85-year-olds. Prevalence, incidence,
risk factors and relation to mortality and dementia. Stroke;34:2617-2622
Östling S, Andreasson L-A, Skoog I. (2003) Psychotic symptoms and basal ganglia
calcification in a population-based sample of 85-year-olds. Int J Geriatr Psychiatry.; 18:
983-7.
Lernfelt B, Samuelsson O, Skoog I, Landahl S. (2003) Changes in drug treatment in
the elderly between 1971 and 2000. Eur J Clin Pharmacol; 59: 637-44.
Lissner L, Skoog I, Andersson K, Beckman N, Sundh V, Waern M, Zylberstein DE,
Bengtsson C, Bjorkelund C. (2003) Participation bias in longitudinal studies:
experience from the Population Study of Women in Gothenburg, Sweden.Scand J Prim
Health Care.;21:242-7.
Linden T, Skoog I, Fagerberg B, Steen B, Blomstrand C. (2004) Cognitive
impairment and dementia 20 months after stroke. Neuroepidemiology; 23:45-52
Östling S, Johansson B, Skoog I. (2004) Cognitive test performance in relation to
psychotic symptoms and paranoid ideation in non-demented 85-year-olds. Psychol
Med;34:443-450
Gustafson D, Steen B, Skoog I. (2004) Body mass index and white matter lesions in
elderly women. An 18-year longitudinal study. Int Psychogeriatr;16:327-36
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Tschanz JT, Corcoran C, Skoog I, Khachaturian AS, Herrick J, Hayden KM,
Welsh-Bohmer KA, Calvert T, Norton MC, Zandi P, Breitner JC (2004) Cache
County Study Group. Dementia: the leading predictor of death in a defined elderly
population: the Cache County Study. Neurology.;62:1156-62.
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Degl'Innocenti A, Elmfeldt D, Hofman A, Lithell H, Olofsson B, Skoog I,
Trenkwalder P, Zanchetti A, Wiklund I. (2004) Health-related quality of life during
treatment of elderly patients with hypertension: results from the Study on COgnition and
Prognosis in the Elderly (SCOPE). J Hum Hypertens.;18:239-45.
Liebetrau M, Steen B, Hamann GF, Skoog I. (2004) Silent and symptomatic infarcts
on cranial computerized tomography in relation to dementia and mortality. A populationbased study in 85-year-olds. Stroke; 35:1816-20
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Lithell H, Hansson L, Skoog I, Elmfeldt D, Hofman A, Olofsson B, Trenkwalder P,
Zanchetti A (2004) For the SCOPE Study Group. The Study on Cognition and
Prognosis in the Elderly (SCOPE): outcomes in patients not receiving add-on therapy
after randomization. J Hypertens;22:1-8.
Gustafson D, Lissner L, Bengtsson C, Björkelund C, Skoog I. (2004) A 24-year
follow-up of body mass index and cerebral atrophy. Neurology;63:1876-81.
Papademetriou V, Farsang C, Elmfeldt D, Hofman A, Lithell H, Olofsson B, Skoog
I, Trenkwalder P, Zanchetti A, for the SCOPE Study Group. (2004) Stroke Prevention
with the AT1-receptor Blocker Candesartan in Elderly Patients with Isolated Systolic
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Hypertension: The Study on COgnition and Prognosis in the Elderly (SCOPE). J Am Coll
Cardiol.;44:1175-80
Börjesson Hansson A, Edin E, Gislason T, Skoog I. (2004) The prevalence of
dementia in 95-year-olds. Neurology.;63:2436-8
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Braam AW, Delespaul P, Beekman ATF, Deeg DJH, Pérès K, Dewey M, Kivelä S-L,
Lawlor BA, Magnusson H, Meller I, Prince MJ, Reischies FM, Roelands M, Saz P,
Schoevers RA, Skoog I, Turrina C, Versporen A, Copeland JRM. (2004) National
context of healthcare, economy and religion and the association between disability and
depressive symptoms in older Europeans: results from the EURODEP concerted action.
Eur J Ageing;1:26-36.
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Copeland JR, Beekman AT, Braam AW, Dewey ME, Delespaul P, Fuhrer R,
Hooijer C, Lawlor BA, Kivela SL, Lobo, A, Magnusson H, Mann AH, Meller I,
Prince MJ, Reischies F, Roelands M, Skoog I, Turrina C, Devries MW, Wilson KC..
(2004) Depression among older people in Europe: the EURODEP studies. World
Psychiatry, 3:45-9
Liebetrau M, Hamann GF, Skoog I. (2005) White matter lesions as a risk factor for
stroke and dementia. Nervenarzt Jun;76(6):708-15
Claesson L., Lindén T, Skoog I, Blomstrand C. (2005) Cognitive impairment after
stroke - impact on activities of daily life and costs of care for elderly people.
Cerebrovasc Dis;19:102-109.
Rosengren A, Skoog I, Gustafson D, Wilhelmsen L. (2005) Body mass index, other
cardiovascular risk factors, and hospitalization for dementia. Arch Intern Med;165:321-6.
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Braam AW, Prince MJ, Beekman ATF, Delespaul P, Dewey ME, Geerlings SW,
Kivelä S-L, Lawlor BA, Magnusson H, Meller I, Pérès K, Reischies FM, Roelands
M, Schoevers RA, Saz P, Skoog I, Turrina C, Versporen A, Copeland JRM. (2005)
Physical health and depressive symptoms in older Europeans: results from EURODEP.
Brit J Psychiatry;187:35-42.
Lindén T, Samuelsson H, Skoog I, Blomstrand C. (2005) Visual neglect and cognitive
impairment in elderly patients late after stroke. Acta Neurol Scand;111:163-8.
Mielke MM, Zandi PP, Sjögren M, Gustafson D, Östling S, Steen B, Skoog I. (2005)
High total cholesterol levels in late-life associated with a reduced risk of dementia.
Neurology;64:1689-95.
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Skoog I, Lithell H, Hansson L, Elmfeldt D, Hofman A, Olofsson B, Trenkwalder P,
Zanchetti A, for the SCOPE Study Group. (2005) Effect of baseline cognitive function
on cognitive and cardiovascular outcomes: Study on COgnition and Prognosis in the
Elderly (SCOPE) – a randomized double-blind trial. Am J Hypertens.;18:1052-9.
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Trenkwalder P, Elmfeldt D, Hofman A, Lithell H, Olofsson B, Papademetriou V,
Skoog I, Zanchetti A. (2005) The Study on COgnition and Prognosis in the Elderly
(SCOPE) - major CV events and stroke in subgroups of patients. Blood Press.;14:31-37.
Sacuiu S, Sjogren M, Johansson B, Gustafson D, Skoog I. (2005) Prodromal cognitive
signs of dementia in 85-year-olds using four sources of information. Neurology. Dec
27;65(12):1894-900.
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Björkelund C, Bondyr-Carlsson D, Lapidus L, Lissner L, Mansson J, Skoog I,
Bengtsson C. (2005) Sleep Disturbances in Midlife Unrelated to 32-Year Diabetes
Incidence: The prospective Population Study of Women in Gothenburg. Diabetes Care
2005;28:2739-44.
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Mitnitski A, Skoog I, Song X, Waern M, Ostling S, Sundh V, Steen B, Rockwood
K. (2006) A vascular risk factor index in relation to mortality and incident dementia.
European Journal of Neurology, 13:514-21.
Mitnitski A, Song X, Skoog I, Broe GA, Cox JL, Grunfeld E, Rockwood K. (2006)
Relative fitness and fraility in elderly men and women in developed countries, in relation
to mortality. J Am Ger Soc, 53:2184-2189
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Norton MC, Skoog I, Franklin LM, Corcoran C, Tschanz JAT, Zandi PP, Breitner
JCS, Welsh-Bohmer KA, Steffens DC (2006) for the Cache County Investigators.
Gender Differences in the Association between Religious Involvement and Depression:
The Cache County (Utah) Study. Journals of Gerontology: Psychological Sciences,
61:129-136.
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Norton M.C., Skoog I., Toone L., Corcoran C., Tschanz J.T., Lisota R.D., Hart
A.D., Zandi P.P., Breitner J.C.S., Welsh-Bohmer, K.A, Steffens, D.C. (2006) Threeyear Incidence of First-Onset Depressive Illness in a Population Sample of Older Adults.
The Cache County Study. American Journal of Geriatric Psychiatry, 14:237-245.
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Mielke MM, Zandi PP, Sjögren M, Blennow K, Gustafson D, Sjögren M, Skoog I.
(2006) Low serum potassium in mid-life associated with descreased CSF Ab (1-42) in
late-life. Alzheimer's Disease and Associated Disorders, 20:30-36.
Rockwood K, Mitnitski A, Song X, Steen B, Skoog I. (2006) Long-term risks of death
and institutionalisation of elderly people in relation to deficit accumulation at age 70. J
Am Ger Soc, 54:975-9..
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Khachaturian AS, Zandi PP, Lyketsos CG, Hayden KM, Skoog I, Norton MC,
Tschanz JT, Mayer LS, Welsh-Bohmer KA, Breitner JCS (2006) for the Cache
County Study Group. Anti-Hypertensive Medication Use and Incident Alzheimer's
Disease. The Cache County Study. Arch Neurol, 63:686-92
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Guo X, Sjögren K, Waern Margda, Lissner L, Bengtsson C, Björkelund C, Östling
S, Skoog I. (2005) Midlife Lung Function and Incidence of Alzheimer’s disease: a 29year Longitudinal Study in Women. Neurobiol Aging, 28:343-50.
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Guo X, Pantoni L, Simoni M, Gustafson D, Bengtsson C, Palmertz B, Skoog I.
(2006) Midlife respiratory function related to white matter lesions and lacunar infarcts in
late life: The Prospective Population Study of Women in Gothenburg, Sweden. Stroke,
37:1658-62.
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Henningsson S, Annerbrink K, Olsson M, Allgulander C, Andersch S, Sjödin I,
Gustafson D, Skoog I, Norrback K, Adolfsson R, Eriksson E, Westberg L. (2006)
The Arg441His polymorphism in the tryptophan hydroxylase 2 gene in Sweden. Am J
Med Genet B Neuropsychiatr Genet., 144B:816-817
Ostling, S. Pálsson, S. Skoog, I. (2007) The incidence of first-onset psychotic symptoms
and paranoid ideation in a representive population sample followed from age 70 to 90
years. Relation to mortality and later development of dementia. Int J Geriatr Psychiatry,
22:520-8
Gustafson D, Skoog I, Rosengren L, Zetterberg H, Blennow K. (2007) Ab42 and Ttau in cerebrospinal fluid predict cognitive decline and dementia in a population-based
sample Cerebrospinal fluid Ab42 concentration may predict cognitive decline in elderly
women. J Neurol Neurosurg Psychiatry, 78:461-4
Mitnitski A, Bao L, Skoog I, Rockwood K. (2007) A cross-national study of transitions
in deficit counts in two birth cohorts: Implications for modeling ageing. Experimental
Gerontology, 42:241-6
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Linden L, Blomstrand C, Skoog I. (2007) Depressive disorders after 20 months in
elderly stroke patients. A case-control study. Stroke, 38:1860-3.
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Wengreen HJ, Munger RG, Corcoran CD, Zandi P, Hayden KM., Fotuhi M, Skoog
I, Norton MC, Tschanz JA, Breitner JCS, Welsh-Bohmer KA. (2007) Antioxidant
intake and cognitive function of elderly men and women: The Cache County Study. J
Nutr Health Aging, 11:230-7.
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Simonsen A.H, McGuire J, Podust V.N, Davies H, Minthon L, Skoog I, Andreasen
N, Wallin A, Waldemar G, Blennow K. (2007) Identification of a Novel Panel of
Cerebrospinal Fluid Biomarkers for Early Stage Alzheimer’s Disease. Neurobiol Aging
(in press)
Gudmundsson P, Skoog I, Waern M, Blennow K, Palsson S, Gustafson D. (2007)
The relationship between cerebrospinal fluid biomarkers and depression in elderly
women Am J Ger Psychiatr (in press).
Wancata J, Börjesson-Hansson A, Östling S, Sjögren K, Skoog I. (2007) Diagnostic
criteria influence dementia prevalence. Am J Geriatr Psychiatry (in press)
Börjesson-Hansson A, Gustafson D, Skoog I. (2007) Five-year survival after age 95.
Relation to dementia and cognitive function. The Göteborg 95+ Study. Neurology (in
press)
Östling S, Börjesson-Hansson A, Skoog I. (2007) Psychotic symptoms and Paranoid
Ideation in a Population-based sample of 95-year-olds. Am J Geriatr Psychiatry (in
press)
Gustafson D, Karlsson C, Skoog I, Rosengren L, Lissner L, Blennow K. (2007) Midlife adiposity factors relate to blood brain barrier integrity in late-life. J Int Med (in press)
Guo X, Skoog I, Idrizbegovic E, Pantoni L, Simoni M, Rosenhall U. (2007) Hearing
loss and cortical atrophy in a population-based study on non-demented women. Age
Ageing (in press)
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Norton, M.C.,Singh, A., Skoog, I., Corcoran, C., Tschanz, J.T., Zandi, P.P.,
Breitner, J.C.S., Welsh-Bohmer, K.A., & Steffens, D.C. (2007) Church Attendance
and New Episodes of Major Depression in a Community Study of Older Adults. The
Cache County Study. Journals of Gerontology: Psychological Sciences (in press).
Books/Invited reviews 2003-2007 (IS)
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Skoog I. (2003) Highs or lows of blood pressure: a cause of Alzheimer’s disease? Lancet
Neurology; 2: 334.
Skoog I, Gustafson D. (2003) Hypertension, hypertension-clustering factors and
Alzheimer's disease. Neurol Res.;25:675-80
Skoog I, Gustafson D. Vascular Disorders and Alzheimer’s Disease. In: Bowler JV,
Hachinski V (eds) (2003) Vascular Cognitive Impairment. Preventable Dementia.
Oxford University Press. Oxford New York: 260-271.
Marcusson J, Blennow K, Skoog I, Wallin A. (2003) Alzheimers sjukdom och andra
kognitiva sjukdomar Liber.
Skoog I. (2003) Hypertension and cognition. Int Psychogeriatr. 2003;15:139-46.
Skoog I. (2004) Psychiatric epidemiology of old age: the H70 study - the NAPE Lecture
2003. Acta Psychiatr Scand.;109:4-18.
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Skoog I, Gustafson D. (2004) Evolutionary rather than revolutionary progress in
dementia. Lancet Neurol. Jan; 3:17
Skoog I. (2004) Subcortical vascular dementia. Clinical Neuropsychologist ;18 :4-5.
Skoog I, Gustafson D, Sjögren M. (2004) Vascular factors and Alzheimer’s Disease. In
Gauthier, Cummings, Scheltens. Alzheimer's Disease and Related Disorders Annual
2004. London, Martin Dunitz Publisher:21-46.
Skoog I, Aevarsson O. (2004) Epidemiology of vascular dementia in Europe. In:
O’Brien J, Ames D, Gustafson L, Folstein M, Chiu E. Cerebrovascular Disease,
Cognition and Dementia 2nd Edition. Martin Dunitz Ltd, London; 35-48
Andrews G., Poulton R, Skoog I (2005) Life-time risk of depression: restricted to a
minority or waiting for most? Brit J Psychiatry 187:495-496
Skoog I, Gustafson D. (2006) Lessons learned from primary prevention trials in
dementia. In: Rockwood K, Gauthier S (eds) Trial Designs and Outcomes in Dementia
Therapeutic Research. Taylor & Francis, Abingdon, 189-211.
Chui H, Skoog I. (2006) Advances in Vascular Cognitive Impairment 2005. Stroke,
37:323-5.
Sjögren M, Mielke M, Gustafson D, Zandi P, Skoog I. (2006) Cholesterol and
Alzheimer's disease-is there a relation? Mech Ageing Dev, 127:138-47
Skoog I. (2006) Commentary on The NIH Cognitive and Emotional Health Project:
Report of the Critical Evaluation Study Committee. Alzheimer's & Dementia, 2:89-90.
Skoog I, Gustafson D. (2006) Update on hypertension and Alzheimer’s Disease.
Neurological Research, 28:605-11
Skoog I. (2006) Vascular Dementia. In: Pathy MSJ, Sinclair AJ, Morley JE. Principles
and Practice of Geriatric Medicine. 4th Edition. John Wiley & Sons Ltd, Chichester,
1103-1110.
Skoog I. (2007) Clinical Diagnosis and management of Alzheimer’s Disease. N Engl J
Med, 357: 725-726.
Skoog I. (2007) Sexuality in old age In: Lewin B, Træen B (eds) Sexology in Context.
Fagbokforlaget (in press)
Skoog I. (2007) Mental Disorders associated with aging. In: Heggenhougen K (ed)
Encyclopedia of Public Health. Elsevier, Oxford. (in press)