The Effectiveness of the Life Skills Program IPSY for the Prevention of Adolescent Tobacco Use: Mediating Processes in the Area of Competencies Relevant within Peer Interactions Karina Weichold Friedrich Schiller University of Jena, Germany Martin J. Tomasik University of Zurich, Switzerland Rainer K. Silbereisen Friedrich Schiller University of Jena, Germany This study investigated the effectiveness of a Life Skills program with regard to tobacco use in early adolescence. The focus was on the mediating role of competencies relevant for successful interactions in the peer context (i.e., stability against groups, self-confidence, yielding to peer pressure), based on the expectation that peer influences represent a major risk factor for adolescent smoking behavior. The universal school-based Life Skills program IPSY (Information + Psychosocial Competence = Protection) aiming at combating adolescent tobacco and alcohol use was implemented and evaluated over four years (longitudinal quasiexperimental design with treatment and control group, and five measurement points; N = 2,464 students who participated in at least one of the five measurement occasions, age 10 at T1). Applying a growth curve modeling approach, results showed that participation in IPSY predicted a slower increase in tobacco use over time, suggesting a weak but significant intervention effect, compared to the control group. Moreover, increase in self-confidence and lower yielding to peer-pressure induced by IPSY mediated the program effects on tobacco use over time. Thus, program components focusing on these attributes seem to be particularly effective for the prevention of youth smoking by the IPSY program. Introduction The consumption of psychoactive substances such as tobacco is a widespread risk behavior during adolescence in many Western countries. In Germany, 32% of 12- to 17-year-olds report having smoked at least once in their life, and 6% of them consume cigarettes on a daily basis (BZgA, 2011). Because of negative health and adjustment outcomes associated with adolescent tobacco use during early and mid adolescence (Mathers, Toumbourou, Catalano, Williams, & Patton, 2006), effective preventive efforts against the initiation and age-typical increase in cigarette smoking during adolescence are urgently needed. Numerous prevention programs have attempted to influence the consumption of tobacco in young people by lowering the impact of risk factors and increasing the influence of protective factors. Additionally, prevention programs have aimed at supporting adolescents to learn skills needed to resolve developmental tasks appropriate to their age, such as gaining a high peer status or establishing first romantic relationships (see for summary Weichold, Bühler, & Silbereisen, 2008). This approach has been used particularly in universal prevention programs, designed to be implemented before adolescents begin to smoke and developed for unselected population groups, such as school classes. Among the various intervention programs, school-based Life Skills programs were the most effective ones to delay onset and to reduce the age-typical increases in frequency and amount of cigarette smoking, both short- and long-term (e.g., World Health Organization [WHO], 2002; Tobler et al., 2000). Life Skills programs focus on the promotion of general competences in the interpersonal (e.g., assertiveness, positive social relationships) and intrapersonal (e.g., critical thinking, self-esteem) domains. In addition, substance-specific skills and knowledge are conveyed (WHO, 1997). All this is supposed to support the resolution of every-day challenges adolescents have to face while striving for the solution of their age-related developmental tasks, such as establishing a status among their peers, and to reduce the likelihood of substance use as a pseudo-mature behavior (e.g., smoking to behave adult-like such as offering a cigarette to get in touch with someone) or a coping strategy (e.g., if adolescents fail to solve their developmental tasks; Weichold, Bühler, & Silbereisen, 2008). Based on the existing literature, however, it is still unclear by which specific mechanisms these programs are effective in the prevention of early tobacco use or, in other words, what mediating processes may explain positive program effects. Research on mediating mechanisms is important, because the identification of mediators is crucial for learning which components of prevention programs are effective in causing changes in substance use behaviors. Thereby existing programs can be optimized (MacKinnon, Taborga, & MorganLopez, 2002), and knowledge of the etiology of problem behaviors is cumulated. If the modification of a risk or protective factor via a quasi-experimental intervention program leads to a reduced increase in substance use over time then this factor is indeed meaningful in its influence and is a true causal agent. In addition, because changes in risk or protective factors usually precede the onset of problem behaviors, confidence about the direction of the effect increases. Finally, the design of evaluation studies including the comparison of a treatment vs. control group, both of which are equivalent before the intervention, provides strong evidence that the mediation effect is not caused by exogenous factors other than the intervention program (Howe, Reiss, & Yuh, 2002). Various theories and descriptions of associated risk factors try to explain adolescent tobacco use (see MacKinnon et al., 2002), thereby stressing the importance of peer influences on adolescent smoking behavior (Chassin, Presson, & Sherman, 1990; Kobus, 2003; Pandina, Johnson, & White, 2010). According to the Social Learning Theory (Akers, 1998), for instance, social processes (e.g., imitation within the peer group) and cognitive aspects (e.g., positive attitudes towards cigarette smoking) are important to initiate and maintain smoking. Behavior is learned by the observation of others, whereby peers (with frequent and close contact to the adolescent) as well as parents represent the most important role models. Once smoking is initiated, rewards such as physiological reactions or successful social interactions modify perceptions on smoking, and promote progress to more frequent and sustained consumption patterns. The Primary Socialization Theory (Oetting, Deffenbacher, & Donnermeyer, 1998) considers individual characteristics (e.g., personality, skills, self-esteem) and bonds to normative contexts, such as family or school, as antecedents of the self-selection into peer groups that show deviant behaviors such as smoking. Spending time with deviant peers, in turn, increases the likelihood to take over their norms and behavior styles in terms of socialization. Empirical studies support these theories by demonstrating peer variables as robust risk factors to explain adolescent smoking, for instance with regard to friendship homophily where selection and socialization processes can be observed (for summary Kobus, 2003). In particular for initiation of smoking during early and mid adolescence, peer smoking models and influences seem to be of major importance. Once smoking had occurred, adolescents increase their number of smoking friends (Chassin et al., 1990). In addition, studies focusing on peer-pressure and its role in the development of smoking imply that in a deviant peer context smoking becomes normative, and pressure to smoke is more subtle, rather than overt (e.g., smoking to be liked by others, to avoid social exclusion, to gain approval, or to facilitate social interactions; Nichter, Nichter, Vuckovic, Quintero, & Ritenbaugh,, 1997). In such situations, competencies and interpersonal skills, such as selfconfidence and assertiveness, are important for adolescents to resist to peer-influences and peer-pressure (Epstein, Griffin, & Botvin, 2000). Consequently, from a prevention perspective it seems particularly promising to target peer-related variables in order to prevent tobacco use in youth. Several prevention programs have indeed focused on the modification of risk and protective factors in the peer context (i.e., peer-influences or skills relevant to effectively interact with peers, refusal skills; see for summary Chassin et al., 1990). Among these, in particular programs based on the Social Influence and Life Skills approach, and especially those using interactive teaching methods such as role play or group discussions were effective, probably because they conveyed and practiced such skills as how to resist to passive or overt social pressure or role modeling in the peer context, or promoted enhanced positive self-perceptions (e.g., Lantz et al., 2000; Tobler et al., 2000). However, there have been only few evaluation studies focusing on mediating mechanisms in the area of peer influences. Cuijpers (2002), in reviewing the existing literature, reports that besides the promotion of skills and the increase in knowledge after participation, a reduction of peer influence in adolescents’ decision making processes was identified as a potential mediator of positive program effects on substance use. More specifically, studies from the 1990s showed that social acceptability, friends’ reactions to use (Botvin, G., Baker, Dusenbury, Botvin, L. & Diaz, 1995), perceived peer reactions to use (MacKinnon et al., 1993), or perceived acceptability of substance use (Donaldson, Graham, & Hansen, 1994) acted as mediators of program effects. Evidence for resistance skills towards the offer of substances as program mediator, in contrast, was rather weak (e.g., Hansen & McNeal, 1997; Wynn, Schulenberg, Maggs, & Zucker, 2000). More recent evaluation studies showed that perceived peer influence mediated the prevention program effects (Komro et al., 2001; Orlando, Ellickson, McCaffrey, & Longshore, 2005), so did normative beliefs of prevalence rates, friends’ consumption behavior and encouragement to use (Liu, Flay, & Aban Aya Investigators, 2009). Finally, Botvin and Griffin (2004) demonstrated the importance of Life Skills, such as assertiveness or self-confidence as mediators of program effects. The vast majority of studies on mediators of program effectiveness relied on U.S. samples; cultural differences (e.g., regarding prevalence rates in early adolescence, or acceptance of smoking in youth) may limit the transfer of U.S. findings to the European context. In addition, most studies in this field investigated samples in mid to late adolescence rather than early adolescence, while early adolescence seems to be a particularly important life period to substance use because most users in Europe initiate consumption at this time in the context of peers (BZgA, 2011), who are especially influential for smoking initiation (e.g., Chassin et al., 1990). Against this background, we aimed at investigating the role of competencies conducive to effective peer interactions (i.e., stability against groups, self-confident behavior), and yielding to peer-pressure in explaining the program effects of a Life Skills program on early adolescent smoking, investigated in a German context. Hypotheses This evaluation study based on the investigation of a longitudinal sample including treatment and control group, and had two goals. First, we examined the individual trajectories of tobacco use in adolescents between 10 and 14 years of age as a function of participation in a Life Skills program. Tobacco use was assessed in terms of the frequency of smoking in the last 30 days and we assumed that the frequency of smoking could be sufficiently well described by a linear growth model. As the Life Skills program was supposed to postpone substance use in early developmental stages and encourage a lower age-typical increase during adolescence, we hypothesized that students in the intervention group would report a significantly slower increase in smoking as compared to students in the control group (Hypothesis 1). The second and central goal of this study was to investigate possible mediating processes in the area of competencies relevant in the peer context that were responsible for the supposedly positive program effect. In other words, we were interested in describing the way in which the intervention status had an effect on tobacco use through the influence of theoretically selected mediating variables. As mediator variables we investigated conditions conducive to effective social interactions within the peer group: self-concept on stability against groups, knowledge about self-confident behavior, and yielding to peer-pressure. All three competencies reflect central learning goals of the program under investigation. We hypothesized that the three constructs represent significant mediators of the effects of the Life Skills program on tobacco use in early adolescence (Hypothesis 2). Method Sample The original sample consisted of N = 2,464 students who have participated on at least one of the five measurement occasions. At the first four measurement occasions, 61.7 to 68.7% of these students took part in the assessments. Participation, however, dropped to 56.2% at the fifth measurement occasion. From the full sample, 55.2% were in the intervention group and 44.8% in the control group. There were 49.3% boys and 50.7% girls with a mean age of M = 10.48 (SD = 0.64) years at pre-test. Approximately six out of ten participants attended the college-bound school track (i.e., Gymnasium) whereas the others attended the vocational school track (i.e., Regelschule). There were no significant differences between the intervention group and the control group at the pre-test on various background variables including the number of siblings, t(1629) = 1.15, p = .25), the subjective evaluation of the families’ financial standing, t(1649) = 1.11, p = .27, height, t(1653) = .68, p = .49, weight, t(1635) = 1.40, p = .16, and pubertal status in terms of self-reported growth of pubic hair, t(1619) = .91, p = .36. We found no significant group differences on initial substance use, i.e. frequency of tobacco use, t(1672) = .52, p = .61 and alcohol consumption at the last drinking occasion t(1655) = .96, p = .34, and one potential mediator variable, i.e., knowledge of self-confident behavior, t(1691) = .85, p = .39. However, students in the intervention group were younger (M = 10.44 years) compared to the control group (M = 10.54; t(1685) = 3.37, p < .01). Also, there were more boys in the intervention group (50%) as compared to the control group (44%; t(1690) = 2.33, p < .05). Furthermore, the students from the intervention group reported lower self concept of stability against groups (M = 3.90 vs. M = 4.04; t(1671) = 3.56, p < .01) and more yielding to peer pressure (M = 1.74 vs. M = 1.67; t(1634) = 2.08, p < .05) as compared to the students from the control group. Intervention IPSY (Information + Psychosocial Competence = Protection) is a universal school-based life skills program that aims to delay the onset and to reduce the normative increase in the consumption of alcohol and tobacco in early adolescence (Weichold, 2007). The program is based theoretically on the model for Life Skills education by the World Health Organization (WHO, 1997) and developmental psychological models on the aetiology of youth problem behavior, as well as empirical findings on risk and protective factors for substance misuse (e.g., Petraitis, Flay, & Miller, 1995). IPSY is a comprehensive program that combines the training of general, intra-personal and inter-personal life skills (e.g., self-awareness, coping strategies, assertiveness, or communication skills) with instruction on substance-specific skills (e.g., resistance to peers offering substances). In addition, knowledge concerning alcohol and tobacco use (e.g., accurate prevalence rates) is conveyed in an age-appropriate manner. Additionally, IPSY focuses on the promotion of positive school involvement, and structured leisure activities. The intervention primarily uses interactive methods (e.g., role plays, group discussion) that have been shown to be the most effective instruction technique in the context of prevention (see Tobler & Stratton, 1997). It is implemented by teachers who have been trained in a one-day facilitator workshop before each of the three program parts in grades 5, 6, and 7, and who use a comprehensive manual. Teachers are trained to be aware of the positive characteristics of each student and to work with positive reinforcement strategies in order to promote the acquisition of skills. Since IPSY is a primary prevention program, it is delivered to adolescents before they start to experiment with the use of substances. As the average age of substance use initiation in Germany is around 12 years, the program was developed for students in grade 5 (usually aged 10 to 11 years) with booster sessions in grades 6 and 7. The intervention in grade 5 consists of 15 basic lessons (10 à 90 minutes and 5 à 45 minutes) and there are seven booster lessons (4 à 90 minutes and 3 à 45 minutes) in grade 6 and 7 each in order to practice the learned skills within age-typical risk situations. Process evaluation was very satisfactory with regard to fidelity of implementation and acceptance by the students (see Weichold, 2007). Design This evaluation study used a quasi-experimental prospective intervention-control group design with five measurement occasions and school-wise assignment to the respective groups. Between pre-test (fall of 2003) and post-test (spring of 2004) there was an interval of approximately half a year. Three follow-up measurements were gathered within an interval of approximately one year each (spring of 2005 until spring of 2007). The study had to be approved by the Thuringian State Ministry of Culture and Education, and schools participated on a voluntary basis. A letter was sent from the Ministry to all 403 schools offering the two main tracks (Regelschule and Gymnasium) of the federal state of Thuringia inviting them to participate in a presentation by the research group on an intervention program against adolescent substance misuse. As schools have been receiving similar invitations on a regular basis, or may have been already involved in similar activities, the response rate was usually rather low and only 40 schools accepted the invitation. Reasons given for participation varied and included, among others, a general interest in intervention programs, specific interest in substance misuse at schools, and the enhancement of school prestige. During the presentation, teachers were introduced to the general framework of the IPSY program and to the rules of participation which included cooperation in an evaluation study. They were then asked to decide together with the school’s principal whether they wanted to implement the program in their schools, and whether they would be willing to take part in the evaluation study. At the end 23 schools out of 40 were selected at random to form the intervention group for the evaluation study. Control schools were recruited at random from the remaining 363 schools of the state. Finally, 21 schools agreed to form the control group. One-third of them had already participated in interventions in the past and, interestingly, the share was the same among our intervention schools. The IPSY program was implemented as part of the regular school curriculum. Parents were informed in the run-up to the project via program presentations and letters. They were then asked to give consent to their child’s participation in the evaluation part of the study. Parents of only two students refused to take part in the data collection. The students completed an anonymous questionnaire of about 60 minutes’ length, administered by project staff or trained teachers at each measurement occasion in the classroom. At the first measurement occasion, project staff showed the students how to fill out the questionnaire and answered further questions. Study participants in both the intervention and the control group received small incentives for filling out the questionnaires at each wave of data collection (e.g., a pen with the study logo). Measures Intervention Status. Participation in the IPSY program was treated as a dummy-coded variable where 0 referred to the control group and 1 to the intervention group. Tobacco Use. At each measurement occasion students were asked how often they had smoked in the last 30 days. The response categories were “never”, “less frequently than once in a month”, “once in a month”, “once a week”, “several times a week”, and “on a daily basis”. The categories were re-coded to reflect the number of days in a month on which the adolescents presumably smoked, with 0 indicating the “never” category and 30 “on a daily basis”. As could be expected, average frequency of tobacco use was increasing from M1 = .43 (SD1 = 2.80) over M2 = .96 (SD2 = 4.43), M3 = 2.18 (SD3 = 6.88), and M4 = 4.43 (SD4 = 9.90) to M5 = 5.51 (SD5 = 11.06), meaning that smoking was virtually non-existent at the pre-test measurement and increased to approximately five or six days in a month at which students aged 14 years smoked on average. Retest correlations between single measurement occasions also systematically increased from r = .43 between pre-test and post-test to r = .66 between the last two measurement occasions. This finding indicates an incremental consolidation of smoking behavior throughout young adolescence and, in comparison with other studies, also supports the validity of the measure used. In fact, Brener et al. (2002), for instance, have found an average retest reliability of κ = .69 for different measures related to tobacco use in a large survey on youth risk behavior, although the adolescents in that study were from grade 9 to 12 and thus probably more established smokers, and the retest interval was only two weeks. Self-Concept on Stability against Group Influences. Self-concept on the stability against group influences was measured by a subscale of the Frankfurt Self-Concept Scales (Deusinger, 1986). Stability against groups relates to cognitions and emotions of an individual in interaction with others (primarily peers, but also those in authority) and skills to communicate one’s own standpoint and attitudes effectively. Information on twelve items was gathered, of which two were reverse coded. Examples of the items are “It is hard for me to advance my own view in front of a group”, “I do not feel so confident in a group because others often have more ideas than I have”, or “It makes me feel uncomfortable when I have the impression that someone has got an opinion different from mine”. Students were asked to rate the items on a 6-point Likert scale. Internal consistency of the mean-composite scales ranged from .69 < α < .89 with lower values at the beginning of the study. The mean endorsement to the items answers increased from M1 = 3.92 (SD1 = .83) over M2 = 4.05 (SD2 = .86), M3 = 4.21 (SD3 = 0.90), and M4 = 4.24 (SD4 = 0.90) to M5 = 4.34 (SD5 = .90) and stability raised from r = .46 between pre-test and post-test to r = .60 between the last two measurement occasions. Knowledge about Self-Confident Behavior. Knowledge on self-confident behaviors was assessed with six self-developed items that described self-confident, aggressive or unconfident behaviors as taught within the program. Students were given examples of behavioral styles and they had to indicate whether the examples represented self-confident or aggressive behavior. Examples are “looking the counterpart in the eyes” (indicating selfconfident behavior) or “not giving any explanations” (indicating aggressive behavior). The number of correct answers was counted to form an indicator for knowledge on self-confident behaviors. The average number of right answers increased from M1 = 1.91 (SD1 = 1.28) over M2 = 2.29 (SD2 = 1.37), M3 = 2.65 (SD3 = 1.43), and M4 = 3.02 (SD4 = 1.45) to M5 = 3.10 (SD5 = 1.45) and the retest reliability between adjacent measurement occasions rose from r = .35 between pre-test and post-test to r = .54 between the fifth and the sixth measurement occasion. Yielding to Peer Pressure. Peer pressure was measured by a scale of eight items proposed by Santor, Messervey, and Kusumakar (2000). Item wordings were, for instance, “If other students want something from me, I can hardly say no”, “When my friends are drinking alcohol it is difficult for me not to join them”, or “Sometimes I do stupid or dangerous things just because other want me to do so”. Students were asked to rate how much the items applied to them on a 5-point Likert scale and higher values meant more yielding to peer pressure, or less peer pressure resistance. Internal consistency was satisfactory and ranged between .67 < α < .83 with the lowest value at the pre-test measurement. Average endorsement to this scale was rather low (M1 = 1.74, SD1 = .66; M2 = 1.80, SD2 = .66; M3 = 1.78, SD3 = .66; M4 = 1.93, SD4 = .71; M5 = 2.01, SD5 = .68) as was the stability between adjacent measurement occasions (.35 < r < .43). Statistical Analyses We used the framework of latent growth modeling (see Bollan & Curran, 2006; Muthén & Curran, 1997) to identify linear trajectories of intra-individual change in the frequency of tobacco use and to predict this change by intervention status. A latent growth model with intervention status as a covariate was used to address Hypothesis 1. It was hypothesized that participation in the IPSY program would predict a slower increase of tobacco use over time (i.e., slope). Concerning the prediction of the intercept of tobacco use, we expected no effect of participation in the IPSY program as such an effect would indicate shortcomings in the random assignment to the intervention and control groups. In order to test the hypothesized mediation effects we modeled the outcome variable simultaneously with each of the supposed mediating variables in a parallel process latent growth curve model as suggested by Cheong, MacKinnon, and Khoo (2003). This approach allowed us to investigate how the mediation process affected the progression of tobacco use as a function of participation in the IPSY program. As can be seen in Figure 1, the parallel process model consists of basically three parts. The first part summarizes the manifest longitudinal measurements of the mediator (M1, M2, ...) into two growth components: the intercept at the first measurement occasion (η1) and a linear slope (η2). Both the intercept and the slope component has got a mean representing the average group trajectory and a variance representing inter-individual variation around the average trajectory. It is assumed that the longitudinal change in the mediator can be sufficiently described by the two growth components. Accordingly, the manifest longitudinal measurements of the outcome variable (Y1, Y2, …) are described in terms of an intercept (η3) and a slope (η4) which again have a mean and a variance and provide a sufficient description of longitudinal change in the outcome variable. The third part of the model simply comprises a manifest predictor of intervention status (X) which in our case is a dichotomous variable carrying the information whether a participant belonged to the intervention or the control group. By setting up structural paths between the three parts of the model it is possible to test the relationships between intervention status, longitudinal change in the mediator, and longitudinal change in the outcome. For the purpose of a mediation analysis, three paths are of particular relevance. First, the path from intervention status to the slope of the mediator variable (α) represents the effect of the intervention on change in the mediator. If it is significant, it shows that the slopes of the mediator were significantly different for the intervention and the control group. The intervention group might, for instance, more strongly increase their knowledge about self-confident behavior over time. Second, the path from the slope of the mediator to the slope of the outcome (β) represents the association between change in the one variable with change in the other variable. A significant path might, for instance, indicate that children whose knowledge about self-confident behavior increases more strongly increase their tobacco use less steeply. Finally, the path from intervention status to the slope of the outcome (τ') represents the residual intervention effect that cannot be explained by the mediator. If path τ' is not significant but paths α and β are, one can assume that the effect of the intervention was totally mediated by the mediator. Mediation itself is tested directly by assessing whether the indirect effect from intervention status via the slope of the mediator to the slope of the outcome (αβ) is significantly different from zero. If this is the case one can assume that changes in the outcome are a function of changes in the mediator which in turn is influenced by the intervention status. Growth models in general have been advocated as the best available method for addressing individual change over time (e.g., Rogosa, 1988). They are particularly well suited for investigating the longitudinal relationship between a mediator and an outcome when one or more of these variables exhibits a meaningful trajectory of change (Selig & Preacher, 2009), as is the case for adolescent tobacco use. However, it has to be noted that when using parallel process models the direction of effects is not tested empirically but rather assumed theoretically, as both the mediator and the outcome are assessed simultaneously and the mediator is not assigned randomly (see Cheong et al., 2003). Such modeling thus requires a strong theory as it is not possible to decide empirically via model fit whether the assumed mediator mediates the program effect to the assumed outcome or whether the assumed outcome mediates the program effect to the assumed mediator. For all calculations, we used the Mplus software version 6.1 (Muthén & Muthén, 2010). Missing data were treated by full information maximum likelihood for the growth curve models (see Enders, 2010; Schafer, 1997). Analyses were conducted separately for the three potential mediators (i.e., self-concept on stability against groups, knowledge on self-confident behavior, and yielding to peer pressure). All growth models were specified taking into account the different measurement intervals between the pre-test and the post-test on the one hand, and between the follow-up measurements on the other. Results Program Effect on Frequency of Tobacco Use We hypothesized that the program IPSY has an intervention effect on adolescent tobacco use in terms of a slower increase in frequency of tobacco use in the intervention as compared to the control group (H1).The linear latent growth model describing the frequency of tobacco use conditional on the intervention status fit the data reasonably well, χ²(13) = 140.98, p < .01, RMSEA = .065, SRMR = .058 and thus we accepted this model. Both the intercept (M = 0.43) and the slope of tobacco use (M = 1.74) were significantly different from zero (p < .01) and the two variance components were positively correlated (r = .31; p < .01). The effect of the intervention status on the intercept of tobacco use was small (β = -.02) and non-significant, while the effect of the intervention status on the slope of tobacco use was β = -.09 (p < .01). Whereas the former finding suggested that the intervention group was not different from the control group in terms of tobacco use before treatment, the latter finding suggested a slower increase in the frequency of tobacco use in the intervention group as compared to the control group during the course of the study, which confirmed Hypothesis 1. The beta weight of the slope of tobacco use on intervention status translates into an effect size of ES = -.19 which corresponds to a “small” effect size according to Cohen (1988), but is comparable with effect sizes of other interactive programs (see Tobler & Stratton, 1997). Mediator Analyses In our second hypothesis (H2), we expected that skills needed to resist peer influences (i.e., stability against groups, self-confident behavior) and yielding to peer pressure mediate the program effect of IPSY on frequency of tobacco use. In the following section, results on mediation analyses were presented separately by the three variables. Self-Concept on Stability against Groups. The parallel process model, based on N = 2,362 observations, fit the data reasonably well, χ²(49) = 328.01, p < .01, RMSEA = .049, SRMR = .067, and was thus accepted. Intercept (M = 4.02) and slope (M = .09) of the mediator were significantly different from zero (p < .01). The latent regression paths of this model are presented in Table 1. First of all, there is a significant direct effect of intervention status on the slope of tobacco use (τ') indicating that, if at all, stability against groups can only be a partial mediator of the program effect. The intervention seems to have positively influenced the slope of stability against groups (α) which in turn is unrelated to the slope of tobacco use (β). Taking the two paths together, the indirect effect of IPSY through the variable stability against groups on smoking is not significant, αβ = .01, p = .22, thus, in contrast to hypothesis 2, self-concept on stability against groups did not act as mediator of the program effects of IPSY on adolescent smoking. In addition, there is a significant effect of intervention status on the intercept of the mediator (γ1) which suggests the intervention group was lower on stability against groups at baseline as compared to the control group. Knowledge of Self-Confident Behavior. The parallel process model, based on N = 2,376 observations, fit the data reasonably well, χ²(49) = 321.38, p < .01, RMSEA = .048, SRMR = .049, and was thus accepted. Intercept (M = 2.00) and slope (M = .32) of the mediator were significantly different from zero (p < .01) which indicates the knowledge of self-confident behavior increases over time. Again, the central parameters of this model can be found in Table 1. It is noteworthy that the intervention increased knowledge of self-confident behavior (α = .11; p < .05) which in turn has a substantial negative effect on the slope of smoking (β = .28; p < .01). The indirect effect (αβ = -.03) is also significant (p < .05) so that, in line with hypothesis 2, increased knowledge of self-confident behavior mediates the effect of IPSY on the increase in tobacco use. Furthermore, we found that higher levels of knowledge at baseline were also associated with less smoking (γ4) which affirms that self-confident behavior represents a powerful protective factor against adolescent smoking. Yielding to Peer Pressure. The parallel process model, based on N = 2,357 observations fit the data reasonably well, χ²(49) = 278.63, p < .01, RMSEA = .045, SRMR = .054, and was thus accepted. We found that both the intercept (M = 1.73) and the slope (M = .09) of yielding to peer pressure were significantly different from zero (p < .01). As can be seen in Table 1, IPSY participants more likely decreased their yielding to peer pressure (α = -.14; p < .05) as compared to the control group. High yielding to peer pressure, in turn, was positively associated with increasing tobacco use (β = .36; p < .01). The two effects together resulted in a significant indirect effect of IPSY on tobacco use (αβ = -.03; p < .05), which suggests, in line with hypothesis 2, that yielding to peer pressure acts as mediator to explain the positive program effects of IPSY on smoking. We furthermore found that a higher level of yielding to peer pressure at baseline predicted a higher increase in the frequency of smoking throughout adolescence (γ4). This implies that yielding to peer pressure resembles an important risk factor for adolescent smoking behavior which as early as around age 10 puts children at risk for an unfavorable trajectory of tobacco use during adolescence. Discussion This study investigated the effects of the Life Skills program IPSY on tobacco use in a sample of young adolescents from Germany. While the majority of existing studies did not include a long-term perspective and focused on older age groups, effects were analyzed over a fouryear study interval from age 10 to 14. We found, in line with our hypotheses, a significant effect of program participation on the slope of tobacco use over time, indicating that IPSY reduced the age-typical increase in smoking frequency from early to mid adolescence. The effect size (.19) is low, but according to Tobler et al. (2000) it lies in the upper range of what can be expected of a school-based interactive Life Skills program. Consequently, this program can be deemed an effective strategy to prevent youth smoking behavior during early and mid adolescence. We were in particular interested in whether competencies conducive to effective peer interactions and for resisting peer influence in the intra- and interpersonal domain (selfconcept on stability against groups, knowledge on self-confident behavior, and yielding to peer-pressure) cause the program effects on smoking. This expectation was based on earlier theoretical and empirical work stressing the importance of peer influences as risk factors for adolescent smoking behavior (Kobus, 2003; MacKinnon et al., 2002). First, we tested whether or not the program influenced the potential mediators in the area of peer interactions positively. We found that the Life Skills Program IPSY was effective in promoting competencies relevant for effective peer interactions, namely stability against groups, selfconfidence, and resisting (vs. yielding) to peer-pressure. This was evidenced by the fact that program participation significantly predicted the slope of these variables over time. This result resembles findings concerning other Life Skills programs which aim at the prevention of adolescent substance use and also found positive effects on skills and competencies conducive for peer interactions (e.g., Botvin & Griffin, 2004; Botvin, Griffin, Diaz, & Ifill-Williams, 2001; Bühler, Schröder, & Silbereisen, 2007). Our findings demonstrated that competencies relevant for effective peer interactions can be changed via the Life Skills program over several years, instead of the usually shorter time periods as shown in earlier research. This was probably the case because skills are practiced and applied in age-typical challenging situations within same-aged peer groups in a systematic fashion over three years of program implementation. Thereby, suggestions for optimal design of Life Skills curriculums across several years, as introduced by WHO (1997), were realized for program development. The lessons dealing with assertiveness and selfconfidence of the IPSY program start out with the facilitation of basic skills which subsequently are trained within more and more specific situations with regard to substance use during the subsequent booster sessions in grades 6 and 7. Consequently, a curriculum designed to promote skills to deal with peer influences implemented across several years of education seems to be particularly effective to improve competencies at long-term. However, knowing that a program is effective to promote skills for resisting peer influence does not necessarily mean that these skills indeed are responsible for a less pronounced increase in consumption of cigarettes observable after taking part in the intervention. Consequently, mediation analyses were performed to investigate whether the change in risk and protective factors transmits the effects of group assignment on change in substance use (Howe et al., 2002). Such analyses were rarely conducted based on longitudinal, well designed intervention studies including a randomization element. The current study tried to fill this gap, thereby demonstrating that the higher increase in knowledge on self-confident behaviors and the lower increase in yielding (or higher resistance) to peer pressure as compared to the control group mediated the program effects on the frequency of smoking cigarettes in German students during early and mid adolescence. This result is in line with findings on other Life Skills programs which showed for somewhat older students that selfconfidence, resistance to peer pressure, and a reduction in peer influence were mediators of program effects on substance use (e.g., Botvin et al., 1995; Orlando et al., 2005). In addition, Bühler et al. (2007) showed that knowledge on skilled behavior such as on assertiveness partly mediated the effect of a Life Skills program on smoking during early adolescence. Thus, both, knowledge acquired to act self-confidently, and lower yielding to peer-pressure to engage in deviant and unhealthy behaviors seem to be important protective factors against youth tobacco use from early to mid adolescence. Against our expectations, we found that self-concept on stability against groups was positively influenced by the program, but did not mediate the effect on tobacco use. Although based on somewhat different measurements, similar results were obtained in other studies with older U.S. American samples (Cujipers, 2002; Orlando et al., 2005). However, it could be that a positive self-concept contributes to the ability to resist pressure within peer interactions indirectly (i.e., youth with a more positive self-concept are better able to implement peer refusal strategies in their peer context; Epstein, Griffin, & Botvin, 2000). This line of argumentation suggests that program components focusing on these issues are not necessarily inefficient. Consequently, further studies are needed to explore the role of the promotion of general intrapersonal Life Skills in explaining effects of Life Skills programs in more depth. This study has strengths but also several weaknesses. Its strengths include the randomized quasi-experimental study design including an intervention group and a control group as well as assessments covering four years of development. Another positive aspect of this study is that the selection of possible mediators of program effects was based on a strong theoretical and empirical basis (Cuijpers, 2002; Kobus, 2003; Pandina et al., 2010). In addition, data were analyzed using especially suitable statistical methods (i.e., the framework of complex longitudinal growth modeling; Bollan & Curran, 2006). The parallel process growth modeling used in testing mediation effects (Cheong et al., 2003) enabled us not only to provide a gross assessment of whether the program worked or not. More importantly, it allowed us to identify the underlying mechanism of how the program achieved its effects by capturing longitudinal change in the mediating variables and the outcome, rather than simple differences in these variables before and after the intervention. Several researchers have argued that longitudinal growth modeling is superior for answering questions about longitudinal change whereas assessing pre- and post-intervention scores might even prove inadequate in many research contexts (e.g., Rogosa, 1988; Rogosa, Brandt, & Zimowski, 1982; Willet & Sayer, 1994). Major advantages of our approach were the estimation of individual differences in change over time, the simultaneous modeling of both the mediator and outcome process, the advantage of obtaining an unbiased estimate of the average long-term treatment effect (see Raudenbush, 2001), the high robustness of the method against short-term fluctuations of scores between two single time points, and the use of the maximum of information on individual change that was available. Limitations of this study include the fact that we covered only three aspects of competencies conducive to effectively interacting with peers and resisting peer pressure. It may well be that other facets of interpersonal behavior or aspects of self-concept which were not measured within this study might be also important to mediate the program effects. Although we found that the direct effect of program participation disappeared by introducing the mediators (i.e., knowledge on self-confident behaviors, yielding to peer-pressure) into the model, we cannot conclude from this study that the other program components included in the IPSY program are ineffective. The facilitation of broad Life Skills, creating an unusual learning environment with new rules on how to interact with each other, and the open discussion of critical topics, as it is usual for Life Skills programs, might represent an important basis for learning and practicing how to resist peer pressure. Higher school involvement and better classroom climate as stimulated by the IPSY program, for instance, have been shown to act as mediators of program effects on alcohol use (Wenzel, Weichold, & Silbereisen, 2009). Thus, further research should include more (also qualitative) measures on Life Skills and school environment. To conclude, this study is one of the few examining mediation effects of a Life Skills program on tobacco use based on a longitudinal study of students from early to mid adolescence, applying modern and complex techniques for data analysis. The results stress the importance of the promotion of skills relevant to interacting with peers and resisting peer influence to effectively combat early tobacco use in young adolescents and its various negative health and psychosocial outcomes in later life (Mathers et al., 2006). 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Standardized estimates, notation of parameters corresponds with Figure 1; α = slope of moderator on intervention status; β = slope of outcome on slope of moderator; τ' = slope of outcome on intervention status; γ1 = intercept of moderator on intervention status; γ2 = slope of mediator on intercept of outcome; γ3 = intercept of outcome on intervention status; γ4 = slope of outcome on intercept of mediator; * p < .05; ** p < .01 Figure 1: A parallel process latent growth model for mediation. Reprinted with permission from Cheong, J., MacKinnon, D. P., & Khoo, S. T. (2003). Investigation of mediational processes using parallel process latent growth curve modeling. Structural Equation Modeling, 10, 238-262.