赣 南 医 学 院 教 案
教研室：Department of biochemistry
课程名称
授课内容
教学目的
教学重点
教学难点
教具和媒
体使用
教学方法
Biochemistry
Chapter 6
教师姓名： Fan Qilan
授课专业
Biological Oxidation
Clinical medicine major
授课学时
4
【Master】
1．The concept and physiological significance of biological oxidation
2．The concept of respiratory chain. Two respiratory chains of
mitochondrion: constituents and arranging order of NADH oxidation
respiratory chain and succinic acid respiratory chain.
3．The concept and coupling site of oxidative phosphorylation.
【Understand】
1．Influence factor of oxidative phosphorylation.
2．Types of high-energy phosphate compound. Utilization of ATP.
3．Two transport mechanisms of NADH oxidation in cytosol: α
—glycerol phosphate shuttle and malate-aspartate shuttle.
【Know】
1．Chemosmosis hypothesis.
2．The structure of ATP synthase and synthesis mechanism of ATP.
3．Other oxidation systems in organism: aerobic dehydrogenase and
aerobic oxidase, oxidases in peroxisome, superoxide dismutase and
oxidase in mitochondrion—monooxygenase and dioxygenase.
1．The concept and physiological significance of biological oxidation
2．The concept of respiratory chain. Two respiratory chains of
mitochondrion: constituents and arranging order of NADH oxidation
respiratory chain and succinic acid respiratory chain.
3．The concept and coupling site of oxidative phosphorylation.
1．Two respiratory chains of mitochondrion: constituents and arranging
order of NADH oxidation respiratory chain and succinic acid respiratory
chain.
2．Two transport mechanisms of NADH oxidation in cytosol: α
—glycerol phosphate shuttle and malate-aspartate shuttle.
3．The structure of ATP synthase and synthesis mechanism of ATP.
1． Theaching aid: computer, projector, mike, chalk, ferule, multimedia
courseware
2． Theaching means: utilize modernization teaching means and methods,
make good courseware, combine pictures with words well; integrate
languge expression, apporiate writing and teaching with multimedia.
1． Introduce introduce the content of this chapter and the concept of
biological metablism from three stages of nutrition substance metablism
and energe of vital activity; Recall related chemistry knowledge which
have been learned, emphasize understanding the electric transfer and
hydrogen carrier; At the same time, explain the importance of studying
biological metabolism combining some clinical diseases ( CO
intoxication), activate the students’ interest attending lectures.
2． Give prominence to the emphases, explain the difficulty clearly, explain
the profound things in a simple way, with the words popularly and
understanded easily.
3． Communicate students with a great variety of channel, motivate
students’ positivity adequately.
1．Organise teaching: Introduce introduce the content of this chapter and
the concept of biological metablism from three stages of nutrition
substance metablism and energe of vital activity; Recall related
chemistry knowledge which have been learned, emphasize
understanding the electric transfer and hydrogen carrier; At the same
time, explain the importance of studying biological metabolism
combining some clinical diseases ( CO intoxication), activate the
students’ interest attending lectures.
2．Review old lessons, introduce a new lesson: review generality of
substance metabolism, glycometabolism and lipidmetabolism, introduce
the content of this chapter.
教学过程
讲授新进展
内容
3．Teach new teaching content
（See multimedia courseware in detail）
Section 1 Oxidation system of ATP production
1. Respiratory chain
2. oxidative phosphorylation
3. Influence factor of oxidative phosphorylation
4. ATP
5. Substance transport through the inner membrane of mitochondrion
Section 2 Other oxidation systems
1. Aerobic dehydrogenase and aerobic oxidase
2. Oxidases in peroxisome
3. superoxide dismutase
4. Oxidase in microsome
Mitochondrial DNA mutation in clinical medicine
ATP synthase emulated through nanometer technology
参考书籍
思考题或/及
作业
1．Review the emphases in this chapter.
2．
课后总结
The key points are recited in the chapter: the concept and physiological
significance of biological oxidation, the concept of respiratory chain. Two
respiratory chains of mitochondrion: constituents and arranging order of
NADH oxidation respiratory chain and succinic acid respiratory chain. The
concept and coupling site of oxidative phosphorylation.
The other points are recited in the chapter: influence factor of oxidative
phosphorylation. Types of high-energy phosphate compound. Utilization of
ATP. Two transport mechanisms of NADH oxidation in cytosol: α
—glycerol phosphate shuttle and malate-aspartate shuttle. Chemosmosis
hypothesis. The structure of ATP synthase and synthesis mechanism of ATP.
Other oxidation systems in organism: aerobic dehydrogenase and aerobic
oxidase, oxidases in peroxisome, superoxide dismutase and oxidase in
mitochondrion—monooxygenase and dioxygenase.