Molecular Pharmacology:
From Membrane to Nucleus
Call # 26034 - G 9600 (4pts)
January 22, 2002 - May 16, 2002
The purpose of this course is to provide students with an introduction to
molecular approaches to target identification and drug development and
delivery for cellular and subcellular processes that contribute to human disease.
Material covered includes the principles of drug-receptor interactions; ion
channels as molecular targets of neurohormones and drugs; structure and
function of G-protein coupled receptors; cytoplasmic signaling molecules
including receptor and non-receptor tyrosine kinases and serine-threonine
kinases; neuro-psychopharmacology; the pharmacology of inflammation; and
novel approaches to gene-targeted pharmacology; relationships of target and
modulating drug structures. Integration of molecular processes and human
disease including cancer, neuro degenerative disease; cardiovascular disease,
and psychiatric disorders is stressed. This course is a requirement for students in
the Pharmacology graduate program, but is open to all interested students. Prerequisite: familiarity with basic biochemistry and molecular biology. Course
Director: R.S. Kass