Weighted-peak assessment of exposure to MRI gradient and static fields – supplemental material Weighted-peak assessment of occupational exposure due to MRI gradient fields and movements in a nonhomogeneous static magnetic field D. Andreuccetti1, G. M. Contessa2, R. Falsaperla2, R. Lodato3, R. Pinto3, N. 5 Zoppetti1 and P. Rossi2 1 IFAC-CNR ("Nello Carrara" Institute for Applied Physics of the Italian National Research Council), via Madonna del Piano 10, 50019 Sesto Fiorentino (Florence), Italy. 10 2 INAIL (Italian Workers' Compensation Authority), Via di Fontana Candida 1, 00040 Monte Porzio Catone (Rome), Italy. 3 ENEA (Italian Agency for New Technologies, Energy and Sustainable Economic Development), Unit of Radiation Biology and Human Health, Casaccia Research Centre, via Anguillarese 301, 00123 Rome, Italy. 15 Corresponding author e-mail: D.Andreuccetti@ifac.cnr.it 1 Weighted-peak assessment of exposure to MRI gradient and static fields – supplemental material Supplemental material (to be published online only) The basic theory and the software development procedure adopted to implement and validate the numerical filters used for the calculation of the weighted-peak indexes in time domain are 20 presented here. Attention is focused on filters relative to the ICNIRP reference levels for occupational exposures and magnetic flux density, as defined in both 1998 and 2010 guidelines.1,2 Filter development The ICNIRP-1998 and ICNIRP-2010 guidelines behave differently below 1 Hz; in particular, 25 ICNIRP-1998 reference levels are constant between 0 Hz and 1 Hz, while ICNIRP-2010 ones are not defined. The amplitude of the numerical transfer function adopted in this study was assumed to be proportional to 1/f2 below 1 Hz. The discrepancy with the reference levels as defined in the guidelines is not critical in the case of exposures to gradient fields, since their spectral contents are much higher than 1 Hz. In the case of movements in SMF, where spectral 30 components below 1 Hz are very important, the 1/f2 trend was assumed for 2010 reference levels only, while the actual constant value was assumed for 1998 ones. The transfer function W1998 in the Laplace domain of a filter is reported in Eq. (1), where s = j2πf and j is the imaginary unit. This filter implements the inverse of the ICNIRP-1998 reference levels (scaled to peak values) for occupational exposures to magnetic flux density. In 35 this expression, a and b are the terms that represent the two ICNIRP-1998 corner frequencies at 8 Hz and 820 Hz. This filter does not take into account the corner frequency at 65 kHz, because it is intended to be used for impressed fields having frequency spectrum contained well below that limit. 2 Weighted-peak assessment of exposure to MRI gradient and static fields – supplemental material s2 W1998 ( s) Af s a s b Af 1 T 1 30.7 10 6 2 (1) with a 2 8Hz b 2 820 Hz 40 A digital version of this filter can be implemented with the so called “zero-pole matching” technique. The transfer function U1998 of this numerical filter is reported in Eq. (2), where z-1 is the delay unit. 3 This is a IIR (Infinite Impulsive Response) filter, that lets the current output sample depend on the current input sample, the previous last two input samples and the 45 previous two output samples. In this expression, Tc is the sampling interval and fn is a normalization frequency (at which the transfer functions of the analog and the numerical filters have the same amplitude) that, in the present study, was chosen equal to 1/200 of the sampling rate 1/Tc. This particular technique has been preferred due to its simplicity and especially because the 50 coefficients of the filter depend explicitly from the sample frequency 1/Tc. This is important because the numerical filter is implemented in a software procedure that can be applied to a generic input waveform, once the sample frequency is known. U1998( z ) K V1998( z ) V1998( z ) 1 2 z 1 z 2 1 a1 b1 z 1 a1 b1 z 2 with a1 e j 2 aTc b1 e j 2 bTc K (2) W1998s j 2f n V1998 z e j 2f nTc Where a, b and W1998 have been defined in Eq. (1). 55 Filter validation Two tests were performed on the numerical filters, in order to validate their implementation. The first one, carried out in the frequency domain, consisted in the comparison of the amplitude 3 Weighted-peak assessment of exposure to MRI gradient and static fields – supplemental material (Fig. 1 and Fig. 2) and the phase (Fig. 3 and Fig. 4) of the analog and the numerical transfer functions. This comparison showed that the agreement between the transfer functions is good 60 on the whole digital filter bandwith only when the higher filter corner frequency is sufficiently lower than the upper limit of this bandwidth, that is the so called Nyquist limit fNyq (i.e. half the sampling rate) (see Fig. 2). More generally, a better agreement is achieved in the lower part of the numerical filter bandwidth; this is particularly evident for the phase response of the numerical filter that is always zero at fNyq (Fig. 3). In order to let the the numerical filter work in 65 the lower part of its bandwidth, a sampling rate sufficently higher (at least double) than the higher filter cut-off frequency should be selected. The second test, executed in the time domain, consisted in feeding the analog and the numerical filters with a waveform composed by four sinusoids with different frequencies and phases. The expression of the input waveform is reported in Eq. (3), while the values chosen for the 70 amplitudes and the phases of its spectral components are listed in Table I (these values were chosen in the frequency range of interest for what concerns the MR gradient fields). 4 f (t ) Ai sin 2 f i t i i 1 (3) In this case, the output of the analog filter (once the transient is finished) is analytically known 75 and can be compared with the output of the numerical filter when its input is feeded with a sampled version of the waveform of Eq. (3). The results are shown in Fig. 5 for the ICNIRP2010 filter. As it can be noted, the absolute difference of the two sequences decreases almost three order of magnitudes in less than 1 ms. The initial discrepancy is generated by the fact that we are 80 comparing the steady-state response of the analog filter with the transient response of the numerical filter. 4 Weighted-peak assessment of exposure to MRI gradient and static fields – supplemental material References ICNIRP (International Commission on Non-Ionizing Radiation Protection), “Guidelines for 1 limiting exposure to time-varying electric, magnetic, and electromagnetic fields (up to 300 85 GHz)”, Health Phys. 74, 494-522 (1998). ICNIRP (International Commission on Non-Ionizing Radiation Protection), “Guidelines for 2 limiting exposure to time-varying electric and magnetic fields (1 Hz to 100 kHz)”, Health Phys. 99, 818-836 (2010). A. V. Oppenheim and R. W. Schafer, “Discrete-Time Signal Processing” 3rd edition, Upper 3 90 Saddle River Pearson (2010). 5 Weighted-peak assessment of exposure to MRI gradient and static fields – supplemental material TABLE I. Amplitudes and phases of the spectral components of the test signal of Eq. (3). i fi Ai φi 1 204 60 µT 0° 2 587 Hz 20 µT 31° 3 1015 Hz 9 µT 156° 4 2312 Hz 6 µT 77° FIG. 1. Amplitude responses of the ICNIRP-2010 filters in continuous (c) and discrete domain, for various sampling rate fs. 95 6 Weighted-peak assessment of exposure to MRI gradient and static fields – supplemental material FIG. 2. Percentage relative differences of analog and digital amplitude responses of ICNIRP-2010 filters, for various sampling rate fs. FIG. 3. Phase responses of the ICNIRP-2010 filters in the continuous (c) and discrete domain, for various sampling rate fs. 7 Weighted-peak assessment of exposure to MRI gradient and static fields – supplemental material FIG. 4. Percentage relative differences of analog and digital phase responses of ICNIRP-2010 filters, for various sampling rate fs. 100 FIG. 5. Results of the filter validation test in time domain: comparison of the steady-state response of the analog filter (teo) and of the numerical filter (num) to the test waveform defined in Eq.(3) and Table I. The absolute difference between teo and num is also reported (secondary axis). 8