BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Jonathan M. Kurie, M.D.
Professor, Department of Thoracic/Head & Neck
Medical Oncology
eRA COMMONS USER NAME
JKURIE
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
University of North Carolina, Chapel Hill, NC
East Carolina University, Greenville, NC
DEGREE
(if applicable)
YEAR(s)
FIELD OF STUDY
B.A.
M.D.
1979
1983
Chemistry
Medicine
A. Personal Statement
My research interest is on the biology of lung cancer metastasis. Our current themes are to understand the
roles of microRNAs expressed in tumor cells as drivers of EMT, invasion, and metastasis and of extracellular
matrix and cellular aspects of the tumor microenvironment as regulators of these tumor cell-autonomous
processes.
B. Positions and Honors
Positions and Employment
07/01/83 – 06/30/84
Intern, Medical College of Georgia, Department of Medicine, Augusta, Georgia
07/01/84 – 06/30/86
Resident, Medical College of Georgia, Department of Medicine, Augusta, Georgia
09/01/86 – 06/30/88
Biotechnology Fellow, National Institutes of Health, Laboratory of Genetics, Bethesda,
Maryland, 20892, Mentor: Dr. Michael Potter
07/01/88 – 06/30/92
Medical Oncology Fellow, Memorial Sloan-Kettering Cancer Center, New York, New
York 10021, Mentor: Dr. Ethan Dmitrovsky
07/01/92 – 06/30/93
Instructor, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New
York, New York 10021
07/01/93 – 08/31/99
Assistant Professor of Medicine, Department of Thoracic/Head and Neck Medical
Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
09/01/99 – 08/31/04
Associate Professor of Medicine, Department of Thoracic/Head and Neck Medical
Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
09/01/04 – Present
Professor of Medicine, Department of Thoracic/Head and Neck Medical Oncology, The
University of Texas M. D. Anderson Cancer Center, Houston, Texas
Other Experience and Professional Memberships
09/86
Diplomate, American Board of Internal Medicine
09/91
Diplomate, Medical Oncology Subspecialty, ABIM (renewed 09/2001)
Honors
1999 – 2001
2001
2005
2007
Sidney Kimmel Scholar Award
American Society for Clinical Investigation
Margaret and James A. Elkins Faculty Achievement Award in Cancer Prevention
Elza A. and Ina Shackelford Freeman Endowed Professorship in Lung Cancer
Research
C. Selected peer-reviewed publications (from a total of 102)
Most relevant to the current application
1. Wislez M, Fujimoto N, Izzo JG, Hanna AE, Cody DD, Langley RR, Tang H, Burdick MD, Sato M, Minna JD,
Mao L, Wistuba I, Strieter RM, Kurie JM. High Expression of Ligands for Chemokine Receptor CXCR2 in
Alveolar Epithelial Neoplasia Induced by Oncogenic Kras. Cancer Res 66:4198-4207, 2006. PMCID:
2.
3.
4.
5.
16618742.
Zhong L, Roybal J, Chaerkady R, Zhang W, Choi K, Alvarez CA, Tran H, Yan S, Strieter RM, Pandey A,
Kurie JM. Identification of Secreted Proteins that Mediate Cell-Cell Interactions in an In Vitro Model of the
Lung Cancer Microenvironment. Cancer Research. 68(17): 7237-7245, 9/2007. PMCID: 2562343.
Gibbons DL, Lin W, Creighton, CJ, Zheng, S, Berel D, Yang Y, Raso MG, Liu DD, Wistuba II, Lozano G,
Kurie JM. Expression Signatures of Metastatic Capacity in a Genetic Mouse Model of Lung
Adenocarcinoma. PLoS One. 4(4): e5401, 4/2009. PMCID: 2671160.
Gibbons DL, Lin W, Creighton CJ, Rizvi ZH, Gregory PA, Goodall GJ, Thilaganathan N, Du L, Zhang Y,
Pertsemlidis A, Kurie JM. Contextual cues promote tumor cell EMT and metastasis by regulating miR-200
family expression. Genes & Development. 23:2140-2151, 2009. PMCID: 2751985.
Yang Y, Ahn YH, Gibbons DL, Zang Y, Lin W, Thilaganathan N, Alvarez CA, Moreira DC, Creighton CJ,
Gregory PA, Goodall GJ, Kurie JM. The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis
through a miR-200-dependent pathway in mice. J Clin Invest 121(4):1373-1385, 4/2011. e-Pub 3/2011.
PMCID: 3069760.
Additional Recent Publications of importance to the field (in chronological order)
1. Fujimoto N, Wislez M, Zhang J, Iwanaga K, Dackor J, Hanna AE, Kalyankrishna, Cody DD, Price RE, Sato
M, Shay JW, Minna JD, Peyton M, Tang X, Massarelli E, Herbst R, Threadgill DW, Wistuba II, Kurie JM.
High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to
inhibition of epidermal growth factor receptor. Cancer Res 65: 11478-11485, 2005. PMCID: 16357156.
2. Srinivas H, Juroske DM, Kalyankrishna S, Cody DD, Price RE, Xu XC, Narayanan R, Weigel NL, Kurie
JM. cJun N-terminal kinase contributes to aberrant retinoid signaling in lung cancer cells by
phosphorylating and inducing proteasomal degradation of retinoic acid receptor-. Mol Cell Biol 25:10541069, 2005. PMCID: 543999.
3. Zheng S, El-Naggar AK, Kim ES, Kurie JM, Lozano G. A genetic mouse model for metastatic lung cancer
with gender differences in survival. Oncogene 7(48):1-9, 5/2007. PMCID: 17486075.
4. Wislez M, Spencer ML, Izzo JG, Juroske DM, Balhara K, Cody DD, Price RE, Hittelman WN, Wistuba II,
Kurie JM. Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by
oncogenic K-ras. Cancer Res 65:3226-35, 2005. PMCID: 15833854.
5. Zhang J, Kalyankrishna S, Wislez M, Thilaganathan N, Saigal B, Wei W, Ma L, Wistuba I, Johnson F, Kurie
JM. Src-family kinases are activated in non-small cell lung cancer and promote the survival of EGFRdependent cell lines. Am. J. Pathol. 170(1):366-376, 2007. PMCID: 1762707.
6. Iwanaga K, Yang Y, Raso MG, Ma L, Hanna AE, Thilaganathan N, Moghaddam S, Evans CM, Li H, Cai W,
Sato M, Minna JD, Wu H, Creighton CJ, Demayo FJ, Wistuba II, Kurie JM. Pten Inactivation Accelerates
Oncogenic K-ras-initiated Tumorigenesis in a Mouse Model of Lung Cancer. Cancer Research. 68:111927, 2008. PMCID: 2750029.
7. Yang Y, Iwanaga I, Raso MG, Wislez M, Hanna AE, Wieder ED, Molldrem JJ, Wistuba II, Powis G,
Demayo FJ, Bender-Kim CF, Kurie JM. Phosphatidylinositol 3-Kinase Mediates Bronchioalveolar Stem
Cell Expansion in Mouse Models of Oncogenic K-ras-induced Lung Cancer. PLoS ONE. 3(5): e2220, 2008.
PMCID: 2376060.
8. Zhang J, Iwanaga K, Choi KC, Wislez M, Raso MG, Wei W., Wistuba II, Kurie JM. Intra-tumoral Epiregulin
is a Marker of Advanced Disease in Non-Small Cell Lung Cancer Patients and Confers Invasive Properties
in EGFR-mutant Cells. Cancer Prev Res. 1(3): 201-207, 2008. PMCID: 19138957.
9. Choi K, Ahn YH, Gibbons DL, Tran HT, Creighton CJ, Girard L, Minna JD, Qin FX, Kurie JM. Distinct
Biological Roles for the Notch Ligands Jagged-1 and Jagged-2. J. Biol. Chem. 284(26), 6/2009. PMCID:
2719415.
10. Ahn YH, Kurie JM. MKK4/SEK1 is negatively regulated through a feedback loop involving the E3 ubiquitin
ligase itch. J Biol Chem. September 8, 2009, doi: 10.1074/jbc.M109.044958. PMCID: 2785572.
D. Research Support
Ongoing Research Support
1-R01-CA157450-01 Kurie (PI)
3/14/2011-2/28/2016
NIH/NCI
Regulation of Lung Cancer Metastasis by miR-200
To determine whether Notch ligands and their receptors drive lung cancer metastasis by suppressing miR-200
through GATA3
Role: Principal Investigator
2-R01-CA105155-08 Kurie (PI)
2/1/2004-6/30/2014
NIH/NCI
Kinase Signaling in Lung Tumorigenesis
The major goal of this project is to examine the role of AKT in lung tumorigenesis.
Role: Principal Investigator
R01-CA117965-05 Kurie (PI)
7/12/2006-5/31/2012
NIH/NCI
(No-Cost Extension)
Mediators of Oncogenic KRAS in Lung Adenocarcinoma
The major goal of this project is to investigate in K-ras-induced mouse models of lung adenocarcinoma the role
of (a) ErbB family members in promoting tumorigenesis and (b) CXCR2 in promoting angiogenesis.
Role: Principal Investigator
5-R01-CA132608-04 Kurie (PI)
5/1/2008-4/30/2013
NIH/NCI
Inflammation in Oncogenic K-ras-induced Lung Tumorigenesis
The major goal of this project is to examine the role of CXCR2 in promoting intratumoral inflammation in lung
tummors that develop due to K-ras mutations.
Role: Principal Investigator
5-P50-CA70907-13 PP-3 Minna (PI)
7/1/2008-5/1/2013
NIH/NCI
SPORE Grant - Targeting the Tumor Microenvironment in NSCLC
The major goal of this study is to examine if K-ras-induced mouse models and cellular models of lung
adenocarcinoma the role of CXCR2 as a mediator of inflammatory cells in promoting BASC proliferation and
tumorigenesis.
Role: Project Leader
BATTLE II (PC-E) (Herbst)
08/18/08 – 08/17/11
Cohen-Reinach Family Family Charitable Foundation
(No-Cost Extension)
Development of Mouse Models to Study Lung Cancer Adrenal Metastasis
Major goal: To develop of mouse models to study lung cancer adrenal metastasis
Role: Co-Investigator
5R01CA116322 (Ji)
06/01/07 - 04/30/12
NIH
(No-Cost Extension)
Tumor and PTK-targeted therapy by FUS1 and PTK inhibitors
Major goal: To develop an integrated therapeutic strategy for treating malignant lung cancer and lung
metastases.
Role: Collaborator
Completed Support
2-T32-CA009666-12 Hong (PI)
1/1/2006-12/31/2009
NIH/NCI
Research Training in Academic Medical Oncology
The major goal of this project is to provide training to medical oncology fellows in basic laboratory research.
Role: Co-Investigator
5 U01 CA084306-07 Jacks (PI)
04/01/04 – 03/31/09
NIH
Role of EGFR in Lung Tumorigenesis
The major goal of this project is to examine the efficacy of small molecule inhibitors of EGFR and AKT in the
blockade of K-ras pathways and K-ras induced lung tumorigenesis.
Role: Co-Investigator
5 U01 CA105352-03 De Mayo (PI)
04/01/04 – 03/31/10 (Extension)
NIH
Modeling Airway Lung Cancer and the Role of Inflammation
Major goal: To develop mouse models examining the role of AKT in lung tumorigenesis.
Role: Co-Investigator
HHMI 01 (Kurie)
7/1/2009-6/30/2011
Howard Hughes Medical Institute
Role of the Scribble Polarity Complex in Lung Cancer Invasion and Metastasis
Major goal: To establish the regulatory relationship between the scribble/basolateral polarity complex and the
epithelial-mesenchymal transition in metastasis of lung adenocarcinoma.
Role: Principal Investigator
IASLC 01 (Kurie)
7/1/2009-6/30/2011
International Assoc for the Study of Lung Cancer
The Role of the MicroRNA-200 Family in Lung Cancer Epithelial-mesencymal Transition and Metastasis
Major goal: To establish the role of microRNA-200 in metastasis of lung adenocarcinoma and the efficacy of
TGF-β blockade in preventing metastasis.
Role: PrincipaI Investigator