Emergency Department Chest Pain Non-STEMI Moderate-High Risk Orders A. PATIENT CARE Cardiac Monitor Vital signs per chest pain routine Pulse Oximeter checks IV access Activity: bedrest with bathroom privileges as tolerated For all Patients receiving Eptifibatide (Integrilin): Neurological Assessment - One time only. Obtain baseline neurological exam before starting Eptifibatide (Integrilin) Vital Signs and Neuro checks- q2H during infusion of Eptifibatide (Integrilin). Assess for headache, level of consciousness, B. orientation, and Glascow Coma Scale. If motor weakness, headache present or other changes noted, a more complete neurological assessment must be performed. Assess all venous/arterial puncture sites, urine, stool, emesis for bleeding and monitor for hypotension, unusual leg or back pain for patients receiving Eptifibatide (Integrilin) Try to avoid / defer venous or arterial punctures during Eptifibatide (Integrilin) infusion. Apply direct pressure or pressure dressing to any compressible site if access required. Avoid automatic blood pressure cuffs. NUTRITION NPO C. PHARMACY C. Sodium Chloride 0.9% flush 3mL q8h Aspirin 162 mg PO (2 baby chewed) one time only OR If allergic give, Clopidogrel (Plavix) 300 mg PO one time only Enoxaparin (Lovenox) 1 mg/kg SQ q12h. (Continue upon transfer to floor) Eptifibatide (Integrilin) 180 mcg/kg bolus over 1-2 minutes (max 22.6 mg) THEN 2 mcg/kg /min infusion (max 15 mg/hr) if dynamic ST-T changes with pain or positive Troponin I. If SCr 2, decrease maintenance dose to 1 mcg/kg/min. Cardiology consult recommended prior to usage in ED. Heparin __________units IV bolus. Dose @ 60 units/kg, THEN IV drip at __________units Dose @ 12 units/kg/hr Heparin drip per pharmacy dosing: CV/Vascular Protocol Metoprolol (Lopressor) 5 mg IV over 2 min x 3 doses at 5 minutes intervals (total 15 mg over 15 min) Metoprolol (Lopressor) 50 mg PO BID. First PO dose to be given 10 minutes after final intravenous dose. (Continue upon transfer to floor) Morphine Sulfate 2-4 mg IV q10min PRN chest pain Nitroglycerin (1/150) 0.4 mg SL q5 min x 3 PRN chest pain Nitrogylcerin 0.4 mg/hr patch one time only for chest pain Nitroglycerin Infusion 10 mcg/min titrate to pain & SBP > 90 mm Hg (Continue upon transfer to floor) LABS STAT collect Troponin I Myoglobin Hemogram (CBC) platelet count INR/PTT Basic Metabolic Panel (includes: sodium, potassium, CO2, glucose, BUN, Creatinine, calcium, anion gap) Troponin I in 4 hours after first draw Myoglobin in 4 hours after first draw E. DIAGNOSTIC IMAGING Chest X-Ray PA/Lat STAT F. PROCEDURES EKG 12 lead STAT and repeat q30min while in Emergency Room per MD Stress Echo if Troponin I / Myoglobin negative at least 6 hours after the onset of chest pain or with cardiology approval. Return to the Emergency Department following Stress Echo. G. RESPIRATORY THERAPY Nasal O2 at 2-4 L/min to keep O2 sats >94% H. CONSULTS Consult Cardiology for consideration of early cath I. DISPOSITION Admit to CSC/CCU with old chart. MD SIGNATURE____________________________PAGER #__________________DATE:________________ FORM #476558 FAIRVIEW HEALTH SYSTEM-PHYSICIAN ORDERS EMERGENCY DEPARTMENT CHEST PAIN NON-STEMI MODERATE-HIGH RISK ORDERS SEP/2003 ORIGINAL: Medical Record COPY: Pharmacy Page 1 of 1