UCSF Lab Standard Operating Procedure
Chemical Process, Name or Hazard Class:
Anabasine
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Department:
Date SOP was written:
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Type of SOP:
☐ Process
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☒Hazardous Chemical
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Purpose
Anabasine is a highly toxic chemical that is chemically similar to nicotine. This SOP provides information
about its hazards and how to mitigate them through proper controls, handling, and storage. Anabasine’s
primary industrial use is as an insecticide. It is also used in organic synthesis for formation of pyridine
derivations.
Physical & Chemical Properties/Definition of Chemical Group
CAS#: 13078-04-1
Class: Toxic chemical
Molecular Formula: C10H14N2
Form (physical state): liquid
Color: light yellow
Boiling point: N/A
Potential Hazards/Toxicity
Anabasine
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Date: Click here to enter a date.
Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/)
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully
investigated. May cause irritation of the digestive tract. The toxicological properties of this substance have
not been fully investigated. May cause irritation with redness and pain. May cause irritation, redness and
pain.
Engineering Controls
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
Use in a chemical fume hood.
Personal Protective Equipment (PPE)
Respirator Protection
If lab personnel would like to use respirator on a voluntary basis, they must be trained and fit-tested by
EH&S. This is a regulatory requirement. (http://www.ehs.ucsf.edu/respiratory-protection-program)
Hand Protection
Wear nitrile, natural rubber, neoprene, butyl, PVC or Viton gloves. Any of these glove types are suitable for
handling anabasine.
NOTE: Consult with your preferred glove manufacturer to ensure that the gloves you plan on using are
compatible with anabasine
Refer to glove selection chart from the links below:
http://www.ansellpro.com/download/Ansell_8thEditionChemicalResistanceGuide.pdf
OR
http://www.allsafetyproducts.biz/page/74172
OR
http://www.showabestglove.com/site/default.aspx
OR
http://www.mapaglove.com/
Eye Protection
Wear ANSI approved safety glasses.
Skin and Body Protection
Wear long pants, shirt, closed-toe shoes, and a lab coat while handling.
Hygiene Measures
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Minimize dust
generation and accumulation. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Use only with
adequate ventilation or respiratory protection.
First Aid Procedures
If inhaled
Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get
medical attention.
In case of skin contact
Anabasine
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Date: Click here to enter a date.
Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/)
Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing
and shoes. Wash off with soap and plenty of water. Get medical attention immediately. Wash clothing before
reuse. Thoroughly clean shoes before reuse. Contaminated work clothes should be laundered by individuals
who have been informed of the hazards of exposure to this substance.
In case of eye contact
Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids
occasionally. Get medical attention immediately.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Get medical attention
immediately.
Special Handling and Storage Requirements
Precautions for safe handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Minimize dust
generation and accumulation. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Use only with
adequate ventilation or respiratory protection.
Conditions for safe storage
Store in a tightly closed container. Keep away from contact with oxidizing materials. Store in a cool, dry, wellventilated area away from incompatible substances.
Spill and Accident Procedure
Chemical Spill Dial 9-911 from campus phone or 415-476-1414 from cell phone or 415-2068522 (SFGH only)
Spill – Assess the extent of danger. Assist contaminated or injured persons. Evacuate the spill area.
Avoid breathing vapors. If possible, confine the spill to a small area using a spill kit or absorbent
material. Keep others from entering contaminated area (e.g., use caution tape, barriers, etc.).
Small (<1 L) – If you have training, you may assist in the clean-up effort. Use appropriate personal
protective equipment and clean-up material for chemical spilled. Double bag spill waste in clear
plastic bags, label and take to the next chemical waste pick-up.
Large (>1 L) – Dial 9-911 from campus phone or 415-476-1414 from cell phone or 415-2068522 (SFGH only) for assistance.
Chemical Spill on Body or Clothes – Remove clothing and rinse body thoroughly in emergency
shower for at least 15 minutes. If discomfort persists, proceed to the Emergency Department. If no
further discomfort is experienced, have the SDS ready and contact Poison Control Hotline at 1-800222-1222 for further exposure information. Notify your direct supervisor and EH&S at 415-4761300 during work hours, or 9-911 during non-working hours and weekends.
Anabasine
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Date: Click here to enter a date.
Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/)
Chemical Splash Into Eyes – Immediately rinse eyeball and inner surface of eyelid with water for
15 minutes by forcibly holding the eye open. If discomfort persists, proceed to the Emergency
Department. If no further discomfort is experienced, have the SDS ready and contact Poison
Control Hotline at 1-800-222-1222 for further exposure information. Notify your direct
supervisor and EH&S at 415-476-1300 during work hours, or 9-911 during non-working
hours and weekends.
Medical Emergency Dial 9-911 (campus phone) or 476-6911 (cell phone)
Note: All serious injuries must be reported to EH&S at 415-476-1300 within 8 hours.
Non-Life Threatening Emergency– Go to Occupational Health Programs (OHP) Clinic, 415-8857580, 2330 Post Street, Suite 460 Hours of Operation for Appointments: Monday - Friday
7:30 a.m. - 4:00 p.m. (except Holidays).
Note: All serious injuries must be reported to EH&S at 415-476-1300 within 8 hours.
Needle stick/puncture exposure (as applicable to chemical handling procedure) – Wash the
affected area with antiseptic soap and warm water for 15 minutes. For mucous membrane
exposure, flush the affected area for 15 minutes using an eyewash station. Page the needle stick
nurse by dialing 415-353-7842 (STIC).
Decontamination/Waste Disposal Procedure
Clean contaminated surfaces with soap and water and paper towels. Dispose of the paper towels as
hazardous waste.
Safety Data Sheet (SDS) Location
Online SDS can be accessed at http://www.ehs.ucsf.edu/safety-data-sheet-sds-1
Protocol/Procedure
Quantities covered by this SOP:
______ (g , ml) to _______ (g, ml)
Temperature range covered by this SOP:
__ °C – __ °C
General Overview and Purpose:
Enter the experimental purpose
Procedure:
Enter experimental procedure. You can copy procedure from your lab notebook or from literature.
Anabasine
4
Date: Click here to enter a date.
Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/)
NOTE
Any deviation from this SOP requires approval from the Principal Investigator.
Anabasine
5
Date: Click here to enter a date.
Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/)