Biological Sequences Analysis, spring semester 2008
Overview:
The course gives an introduction to the field of sequence
analysis in bioinformatics. During the course various
approaches for sequence analysis, and corresponding tools will
be taught.
Course web site
http://bioinfo.tau.ac.il/~intro_bioinfo/mta/
Recommended reading:
Bioinformatics: Sequence and Genome Analysis
Mount, second edition, Cold spring harbor press
Fundamentals of Molecular Evolution
Graur and Li, Sinauer Associates, Sunderland M.A
Teachers:
Nimrod Rubinstein (rubi@post.tau.ac.il)
David Burstein (davidbur@post.tau.ac.il)
Assignments:
2-4 home assignments, to be handed in alone or in pairs. Hand
in date will be defined when the assignment is handed out.
Final assignments:
Midterm quiz and a final project (final project can be done in
either alone or in pairs).
Grade structure:
25% - home assignments
25% - quiz
50% - final project
2007 Course plan (Syllabus):
Lecture date
28-Feb-08
06-Mar-08
13-Mar-08
20-Mar-08
Subject
Computational biology – revolutionizing science at the turn of
the century
Large-scale molecular biology, Part I: Sequencing
Aligning sequences and searching databases (BLAST)
Exercise: Databases + Blast
27-Mar-08
Multiple sequence alignment (MSA) and applications
03-Apr-08
Post-translational modifications; protein domains/motifs and
classification
10-Apr-08
Inside the genome: genome statistics, genome-wide studies
01-May-08
Mid-term Quiz
15-May-08
Phylogenetic trees and their uses
22-May-08
Exercise: Genome browsers, protein domains, MSA and trees
29-May-08
Large-scale molecular biology, Part II: Expression data and
networks
05-Jun-08
Functional prediction in proteins (purifying and positive
selection)
13-Jun-08
Exercise: Consurf and Selecton + course Summary