Draft program for the EuroBoNeT Research Line 2 “Osteogenic tumours and related sarcomas” workshop in Oslo June 9th to 11th 2008. Venue Lysebu Conference Centre (www.lysebu.no/Eng), Lysebuv. 12, 0790 Oslo, Tel +47 2151 1000, Fax +47 2151 1001, email booking@lysebu.com Monday 9th Early arrivers, sightseeing Frognerparken sculpture park 20.00 Dinner Tuesday 10th 7.00 Breakfast 9.00 Welcome 9.05 Clinical relevance and relation to EURAMOS Clinic Head Sigbjørn Smeland (10 min) 9.15 Work Package Progress, Plans and Challenges 9.15 Work Package 1 Biology and genetics of OS (30 min) 9.45 Work Package 2 Drug response and pharmacogenomics in OS (30 min) 10.15 Work Package 3 Osteolytic lesions: improvement of knowledge on MFH, fibrosarcoma, chordoma and vascular tumors (30 min) 10.45 Coffee 11.15 Multidrug resistance in OS using the Solvo MDQ assay (Leiden) (20 min) 11.35 Status and plans for the RL2 tissue microarray (Lutz) (20 min) 12.00 RL2 Business meeting (30 min) Horst Bürger, Pancras Hogendorn 12.30 Lunch 14.00 Genomics projects (15 min each) 14.00 Status report on expression profiling (Anne-Marie) (15 min) 14.15 Status report on genomic profiling (Leonardo) (15 min) 14:30 Status report characterisation of Eurobonet OS cell line panel (Lutz) (15 min) 14.45 Preliminary Methylation analysis of the OS cell line panel (Stine) (15 min) 15.00 Microarray analysis on fibrosarcomas, spindle cell sarcomas, and MFH (Tarja) (15 min) 15.15 Data analysis and integration (Eberhard) (15 min) 15:30 Discussion data integration (30 min) 16.00 Coffee 16.30 Further planning of profiling effort (30min) 17.00 Proposal to join the International Cancer Genome Consortium (icgc.org, Adrienne Flanagan) (30 min) 17.30 Further discussions from previous sessions (30 min) 18.00 Local sightseeing Holmenkollen Ski Jump & City view 19.30 Dinner Wednesday 11th 7.00 Breakfast 9.00 Research reports (20 min each) 9.00 Alex Mohseny: “Signal Transduction Pathways Involved In Osteosarcoma Tumorigenesis” (20 min) 9.20 Konstantin Agelopoulos “Ongoing projects” (20 min) 9.40 Arjan Lankester “Interactions between the immune system and osteosarcomas” (20 min) 10.00 Leiden “Skeletogenesis pathways in OS, mesenchymal stem cells and osteoblasts” (20 min) 10:20 Coffee break and checkout 10.45 Sofie Verbeke “Primary Malignant Vascular Tumours of Bone” (20 min) 11.05 Hege O. Ohnstad “further investigations on the presence of stem-like cells in OS (20 min) 11:25 Final discussion and concluding remarks 12.30 Lunch 14.00 Sightseeing Bygdøy; Viking ships, Fram, Kon-Tiki, Folk Museum (stave church etc)