David Woodley, MD
Professor
Chair, Department of Dermatology
Other Publications
1. Woodley DT. Dideirjean L, Regnier M, Saurat JH, Pruneeras M: Bullous
Pemphigoid Antigen Synthesized in Vitro by Human Epidermal Cells. J. Invest.
Dermatol. 75:148-151, 1980.
2. Regnier M, Prenieras M, Woodley DT: Growth and differentiation of adult human
epidermal cells on dermal substrate. Frontiers of Matrix Biol. 9:4-32, 1981.
3. Didierjean L, Woodley DT, Regnier M, Prunieras M, Saurat JH: Skin explant
cultures: expression of cytoplasmic differntiation antigens in outgrowth cells. J.
Invest. Dermatol. 76:38-41, 1981.
4. Woodley DT, Saurat JH, Prunieras M, Regnier M: Pemphigoid, pemphigus and Pr
antigens in adult human keratinocytes grown on nonviable substrates. J. Invest.
Dermatol. 79:23-29, 1982.
5. O'Keefe EJ, Payne Jr. RE, Russell N, Woodley DT: Spreading and enhanced
motility of human keratinocytes on fibronectin. J. Invest. Dermatol. 85:125-130,
1985
6. Woodley DT, Kelebec T, Banes AJ, Link W, Prunieras M, Liotta LA: Adult
human keratinocytes migrating over nonviable dermal collagen produce
collagenolytic enzymes that degrade type I and type IV collagen. J. Invest.
Dermatol. 86:418-423, 1986.
7. Petersen MJ, Woodley DT, Stricklin GP, O'Keefe EJ: Production of collagenase
by cultured human keratinocytes. J. Biol. Chem. 262:835-840, 1987.
8. Woodley DT, Scheidt VJ, Reese MJ, Paller AS, Manning TO, Yoshiike T,
Briggaman RA: Localization of the alpha 3 (V) chain of type V collagen in human
skin. J. Invest. Dermatol. 88:247-253, 1987.
9. Woodley DT, O'Keefe EJ, McDonald JA, Reese MJ, Briggaman RA, Gammon
WR: Specific affinity between fibronectin and the epidermolysis bullosa acquisita
antigen. J. Clin. Invest. 79:1826-1830, 1987.
10. Woodley DT, Stanley JR, Reese MJ, O'Keefe EJ: Human dermal fibroblasts
synthesize laminin. J. Invest. Dermatol. 90:679-683, 1988.
11. Woodley DT, Peterson HD, Herzog SR, Stricklin GP, Burgeson RE, Briggaman
RA, Cronce DJ, O'Keefe EJ: Burn wounds resurfaced by cultured epidermal
autografts show abnormal reconstitution of anchoring fibrils. J.A.M.A. 259:25662571, 1988.
12. Woodley DT, Bachman PM, O'Keefe EJ: Laminin inhibits human keratinocyte
migration. J. Cell Physiol. 136:140-146, 1988.
13. Herzog SR, Meyer A, Woodley DT, Peterson HD: Wound coverage with cultured
autologous keratinocytes: use after burn wound excision including biopsy followup. J. Trauma 28:195-198, 1988.
14. Yamauchi M, Woodley DT, Mechanic GL: Aging and cross-linking of skin
collagen. Biochem. Biophys. Res. Commun. 152:898-903, 1988.
15. Petersen MJ, Woodley DT, Stricklin GP, O'Keefe EJ: Constitutive production of
procollagenase and collagenase inhibitor by human keratinocytes in culture. J.
Invest. Dermatol. 92:156-159, 1989.
16. Petersen MJ, Woodley DT, Stricklin GP, OíKeefe EJ: Enhanced synthesis of
collagenase by human keratinocytes cultured on type I or type IV collagen. J.
Invest. Dermatol. 94:341-346, 1990.
17. Woodley DT, Wynn KC, O'Keefe EJ: Type IV collagen and fibronectin enhance
human keratinocyte thymidine incorporation. J. Invest. Dermatol. 94:139-143,
1990.
18. Petersen MJ, Woodley DT, Stricklin GP, O'Keefe EJ: Enhanced synthesis of
collagenase by human keratinocytes cultured on type I or type IV collagen. J.
Invest. Dermatol. 94:341-346, 1990.
19. Petersen MJ, Lessane B, Woodley DT: Characterization of cellular elements in
healed cultured keratinocyte autografts used to cover burn wounds. Arch.
Dermatol. 126:175-180, l990.
20. Woodley DT: Covering wounds with cultured keratinocytes. JAMA. 262:21402141, l990.
21. Woodley, DT, Wynn, KC, OíKeefe, EG. Type IV collagen and fibronectin
influence keratinocyte thymidine incorporation and spreading in the absence of
soluble growth factors. J. Invest. Dermatol. 94:139-143, 1990.
22. Brown C, Stenn KS, Falk RJ, Woodley DT, O'Keefe EJ: Vitronectin: effects on
keratinocyte motility and inhibition of collagen-induced motility. J. Invest.
Dermatol. 96:724-728, 1991.
23. Yamauchi M, Prisayanh P, Haque Z, Woodley DT: Collagen cross-linking in sunexposed and unexposed sites of aged human skin. J. Invest. Dermatol. 97:938-941,
1991.
24. Stewart MI, Woodley DT: The influence of extracellular matrix upon keratinocyte
behavior. Clinical Materials 8:189-195, 1991.
25. Sarret Y, Woodley DT, Grigsby K, Wynn KC, O'Keefe EJ: Human keratinocyte
locomotion: the effect of selected cytokines. J. Invest. Dermatol. 98:12-16, 1992.
26. Kim JP, Zhang K, Kramer RH, Schall TJ, Woodley DT: Integrin receptors and
RGD sequences in human keratinocyte migration: unique anti-migratory function of
alpha 3 beta 1. J Invest Dermatol 98:764 - 770, 1992.
27. Kim JP, Chen JD, Woodley DT: Mechanism of human keratinocyte migration on
fibronectin: unique roles of RGD site and integrins. J. Cell. Physiol. 151:443-450,
1992.
28. Woodley DT, Chen JD, Kim JP, Sarret Y, Iwasaki T, Kim YH: Reepithelialization human keratinocyte locomotion. Wound Healing 11:641-646,
1993.
29. Chen JD, Kim JP, Zhang K, Sarret Y, Wynn KC, Kramer RH, Woodley DT:
Epidermal growth factor (EGF) promotes human keratinocyte locomotion on
collagen by increasing the alpha 2 integrin subunit. Exp. Cell Res. 209:216-223,
1993.
30. Kim JP, Zhang K, Chen JD, Kramer RH, Woodley DT: Vitronectin-driven human
keratinocyte locomotion is mediated by the alpha v beta 5 integrin receptor. J. Biol.
Chem. 269:(43):26,926-26,932, 1994.
31. Chen JD, Lapiere JC, Sauder DN, Peavey C, Woodley DT: Interleukin-1
stimulates keratinocyte migration through an epidermal growth factor/transforming
growth factor alpha independent pathway. J. Invest. Dermatol. 104:729-733, l995
32. OíToole EA, Goel M, Woodley DT: Hydrogen peroxide inhibits human
keratinocyte migration. Dermatol. Surg. 22:525-529, 1996.
33. O’Toole EA, Marinkovich MP, Hoeffler W, Furthmayr H, Woodley DT: Laminin5 inhibits human keratinocyte migration. Exp. Cell Res. 233:330-339, 1997.
34. O’Toole EA, Marinkovich MP, Peavey C, Amieva MR, Furthmayr H, Mustoe TA,
Woodley DT: Hypoxia increases human keratinocyte motility on connective tissue.
J. Clin. Invest. 100:2881-2891, 1997.
35. Sung CC, O'Toole EA, Lannutti BJ, Hunt J, Woodley DT, Paller AS: Integrin alpha
5 beta 1 expression is required for inhibition of keratinocyte migration by
ganglioside GT1b. Exp. Cell Res. 239:311-319, 1998.
36. Nasca MR, O'Toole EA, Palicharla P, West DP, Woodley DT: Thalidomide
increases human keratinocyte migration and proliferation. J. Invest. Dermatol.
113:720-724, 1999.
37. O'Toole EA, Mak LL, Guitart J, Woodley DT, Hashimoto T, Amagai M, Chan LS:
Induction of keratinocyte IL-8 expression and secretion by IgG autoantibodies as a
novel mechanism of epidermal neutrophil recruitment in a pemphigus variant. Clin.
Exp. Immunol.. 119:217-24, 2000
38. Chen M, O’Toole EA, Muellenhoff M, Medina E, Woodley DT: Development and
characterization of a recombinant truncated type VII collagen “minigene”:
implication for gene therapy of dystrophic epidermolysis bullosa. J. Biol. Chem.
275:24429-24435, 2000.
39. Dey A, She H, Kim L, Boruch A, Guris DL, Carlberg K, Sebti SM, Woodley DT,
Imamoto A, Li W: Colony-stimulating factor-1 receptor utilizes multiple signaling
pathways to induce cyclin D2 expression. Mol. Biol. Cell 11:3835-48, 2000
40. Yurko MA, O'Toole EA, Woodley DT: Phosphorylation of focal adhesion kinase
(pp125(FAK)) is increased in human keratinocytes induced to migrate by
extracellular matrices. J. Cell Physiol. 188:24-32.2001
41. Chen M, Keene DR, Costa FK, Tahk SH, Woodley DT:The carboxyl terminus of
type VII collagen mediates antiparallel dimer formation and constitutes a new
antigenic epitope for epidermolysis Bullosa acquisita autoantibodies. J. Biol. Chem.
276:21649-21655, 2001.
42. Li W, Nadelman C, Henry G, Fan JF, Muellenhoff M, Medina E, Gratch NS, Chen
M, Han JH, Woodley DT: The p38MAPK/SAPK pathway is required for human
keratinocyte migration on dermal collagen. J. Invest. Dermatol. 117:1601-1611,
2001.
43. Li W, Fan J, Woodley DT. Nck/Dock: an adapter between cell surface receptors
and the actin cytoskeleton. Oncogene. 2001 20:6403-17. Review, 2001.
44. Chen M, Costa FK, Lindvay CR, Han YP, Woodley DT: The recombinant
expression of full-length type VII collagen and characterization of molecular
mechanisms underlying dystrophic epidermolysis bullosa. J. Biol. Chem. 277:211821124, 2002
45. Li W, Nadelman C, Gratch NS, Li WQ, Chen M, Kasahara N, Woodley DT: An
important role for protein kinase C- in human keratinocyte migration on dermal
collagen. Exp. Cell Res. 15:219-228, 2002.
46. Chen M, Keene DR, Chan LS, Hoeffler WK, Finlay D, Kasahara N, Woodley DT:
Restoration of type VII collagen expression and function in dystrophic
epidermolysis bullosa. Nature Genetics 32:670-675, 2002.
47. Chen M, Li W, Fan JH, Kasahara N, and Woodley DT: An efficient gene
transduction system for studying gene function in primary dermal fibroblasts and
epidermal keratinocytes. Clin. Exp. Dermatol. 28:193-199, 2003
48. Henry G, Li W, Garner W and Woodley DT: Human serum (but not plasma)
promotes human keratinocyte migration, a critical process for wound reepithelialization. Lancet 361: 574-576, 200
49. Woodley DT, Krueger GG, Fairley JA, Atha T, Huang Y, Chan L, Keene DR, and
Chen M: Normal and gene-corrected dystrophic epidermolysis bullosa fibroblasts
alone can produce type VII collagen at the basement membrane zone. J. Invest.
Dermatol. 121: 1021-1028, 2003
50. Li W, Fan J, Chen M, Guan S, Sawcer D, Bokoch GM, Woodley DT: Mechanism
of human dermal fibroblast migration driven by type I collagen and platelet-derived
growth factor-BB. Mol. Biol. Cell 15:294-309, 2004.
51. Woodley DT, Atha T, Huang Y, Lipman K, Keene DR, Li W, Chen M: Injection of
recombinant human type VII collagen restores collagen function in dystrophic
epidermolysis bullosa. Nat. Med. 10:693-695, 2004
52. Li W, Henry G, Fan JF, Sawcer D, Chen M, Pang K, Woodley DT: The initiation,
augmentation and directionality signals for human keratinocyte migration. J. Invest.
Dermatol. 123:622-633, 2004
53. Li W, Fan J, Chen M, Woodley DT: Mechanisms of human skin cell motility.
Histol Histopathol. 19:1311-1324, 2004
54. Woodley DT, Atha T, Huang Y, Ramin R, Kasahara N, Keene DR, Woodley DT,
Chen M. Intradermal injection of lentiviral vectors corrects regenerated human
dystrophic epidermolysis bullosa skin tissue in vivo. Mol. Ther. 11:318-326, 2004.
55. Li W, Dasgeb B, Phillips T, Li Y, Chen M, Garner W, Woodley DT: Woundhealing perspectives. Dermatol Clin. 23:181-192, 2005
56. Fan JF, Guan X, Cheng CF, Cho M, Chen M, Woodley DT, Li W. Protein kinase C
clustering at the leading edge and mediating PDGF-enhanced, but not collageninitiated, dermal fibroblast migration. J. Invest. Dermatol. 126:1233-1243, 2006
57. Bandyopadhyay B, Fan J, Guan S, Li Y, Chen M, Woodley DT, Li W. A "traffic
control" role for TGFbeta3: orchestrating dermal and epidermal cell motility during
wound healing. J. Cell Biol. 172:1093-1105, 2006
58. Li Y, Chen M, Li W, Woodley DT: Transforming growth factor-alpha elevated in
human serum is the major pro-motility factor for human keratinocytes. J. Invest.
Dermatol. 2006, in press
59. Woodley DT, Ram R, Doostan A, Bandyopadhyay P, Huang Y, Keene DR and
Chen M: Induction of epidermolysis bullosa acquisita in mice by passive transfer of
autoantibodies from patients. J. Invest. Dermatol. 126:1323-1330, 2006
60. Chen M, Woodley DT. Fibroblasts as target cells for DEB gene therapy. J. Invest.
Dermatol. 126:708-710, 2006