COVENANT UNIVERSITY
COLLEGE OF SCIENCE AND TECHNOLOGY
DEPARTMENT OF BIOLOGICAL SCIENCES
PROGRAMME:
MICROBIOLOGY
COURSE CODE:
MCB 415
COUSRE TITLE:
PHARMACEUTICAL MICROBIOLOGY AND
ANTIMICROBIAL AGENTS
UNITS:
3
SEMESTER/SESSION:
ALPHA, 2014/2015
COURSE LECTURER:
Dr. J.O. Owolabi, Ayepola O.O.
*Course coordinator
Ayepola O.O.
A. BRIEF OVERVIEW OF COURSE
Pharmaceutical products of microbial origin. Industrial production of some
pharmaceutical
products.
Quality
assessment
of
sterile
and
non-sterile
pharmaceuticals. Recent techniques in aseptic processing (class I, II, III environment;
resolic sterility testing, pyrogen test, principle of good manufacturing practice).
Resistance of microorganisms to antimicrobials and evaluation of activities of
antibiotics and disinfectants. Screening and assessment of new antibiotics and
disinfectant activities. Expanding the frontiers of medicinal plants.
B. COUSRE OBJECTIVES
At the end of this course, students are expected to:

Identify the importance of microorganisms in the pharmaceutical industry

Be familiar with microbiological standards for sterile and non-sterile
pharmaceutical products

Apply the principles of methods for control of microorganisms

Have a proper knowledge of antibiotics and their application in the control of
infectious diseases

Know that plants parts are endowed with medicinal compounds which can be
exploited for chemotherapy.
C. METHODS OF LECTURE DELIVERY/TEACHING AIDS

Guided instructions

Interactive classroom session

Multimedia

Laboratory session
D. COURSE OUTLINE
Module 1
Control of Microorganisms I
Week 1
Definitions of terms, pattern of microbial death,
conditions influencing the effectiveness of
antimicrobial death activity
Week 2
The use of physical agents in control
First Alpha Semester Test
Module 2
Module 3
Control of Microorganisms II
Week 3
Use of chemical agents in control
Week 4
Evaluation of antimicrobial agent effectiveness
Antibiotics
Week 5
Classification of antibiotics and spectrum of activity
Week 6
Mechanisms of activities of antibiotics and resistance
Week 7
Methods in antibiotics susceptibility testing
Second Alpha Semester Test
Module 4
Pharmaceutical Products of Microbial Origin
Week 8
Overview and role of microorganisms in
antibiotic production and other pharmaceuticals
Week 9
Quality assessment of sterile and non-sterile
pharmaceuticals
Week 10
Techniques in aseptic processing of
pharmaceutical products
Week 11
Expanding the frontiers of medicinal plants
Week 12
Revision and evaluation
E.
TUTORIALS

Principles of Sterilization

Sterility testing

Essentials of Good Manufacturing Practice (GMP)
F. STRUCTURE OF THE PROGRAMME/ METHOD OF GRADING
1. Continuous Assessment and Practicals
30 Marks
2. Semester Examination
70 Marks
G. GROUND RULES AND REGULATIONS

Mandatory 90% class attendance

No form of misbehaviour in class and laboratory

Active participation in class

Punctuality to classes
H. TOPICS
FOR
TERM
PAPERS/ASSIGNMENTS/STUDENTS’
ACTIVITIES
1. Development and spread of Antimicrobial Resistance
2. Expanding the frontiers of Phytomedicine
I. ALIGNMENT WITH UNIVERSITY VISION AND GOALS
This course provides a platform for professionalism in the Pharmaceutical
Industry
J.
INDUSTRIAL RELEVANCE
This course lays a good foundation for a career in the Pharmaceutical Industry.
K.
RECOMMENDED BOOKS

Microbiology. Prescott LM, Harley JP, Klein DA eds. International edition; 4th
edn., McGraw Hill, New York, 1999.

Pharmaceutical Microbiology WB Hugo and AD Russel (ed), 7th Edition.
Blackwell Scientific Publications, UK, 2004.

Medical Microbiology. Baron S. ed., 4th edn., The University of Texas Medical
Branch, Galveston, 1996.

Medical Microbiology and Immunology: Examination and Board Review.
Levinson W, Jawetz eds. International edn., Seventh edn. Lange Medical
Books/McGraw-Hill, London, 2002.

District Laboratory Practice in tropical Countries Part 1. Cheesbrough M ed.,
Second edn. Cambridge University Press, Cambridge, 2005.

District Laboratory Practice in tropical Countries Part 2. Cheesbrough M ed.,
Second edn. Cambridge University Press, Cambridge, 2005.

Wadsworth-KTL Anaerobic Bacteriology Manual. Jousimies-Somer HR,
Summanen P, Citron DM, Baron EJ, Wexler HM, Finegold SM. Sixth edn., Star
Publishing Company, Belmont, California, 2002.

Introduction to Diagnostic Microbiology. Koneman EW, Allen SD, Janda WM,
Schreckenberger PC, Winn WC Jr. eds. JB Lippincott Company, Philadelphia,
1994.

Butterworths
Medical
Dictionary.
ELBS/Butherworths, Kent, 1986.
Critchley
M.
Editor-in-Chief,