COVENANT UNIVERSITY
COLLEGE OF SCIENCE AND TECHNOLOGY
DEPARTMENT OF BIOLOGICAL SCIENCES
PROGRAMME:
MICROBIOLOGY
COURSE CODE:
MCB 415
COUSRE TITLE:
PHARMACEUTICAL MICROBIOLOGY AND
ANTIMICROBIAL AGENTS
UNITS:
3
SEMESTER/SESSION:
ALPHA, 2014/2015
COURSE LECTURER:
Dr. Owolabi J.B.; Dr. Ayepola O.O.
*Course coordinator
Dr. Ayepola O.O.
A. BRIEF OVERVIEW OF COURSE
Pharmaceutical
products
of
microbial
origin.
Industrial
production
of
some
pharmaceutical products. Quality assessment of sterile and non-sterile pharmaceuticals.
Recent techniques in aseptic processing (class I, II, III environment; resolic sterility
testing, pyrogen test, principle of good manufacturing practice). Resistance of
microorganisms to antimicrobials and evaluation of activities of antibiotics and
disinfectants. Screening and assessment of new antibiotics and disinfectant activities.
Expanding the frontiers of medicinal plants.
B. COUSRE OBJECTIVES
At the end of this course, students are expected to:

Have a broad understanding of the importance of microorganisms in the
pharmaceutical industry

Be familiar with microbiological standards for sterile and non-sterile pharmaceutical
products

Understand the principles of methods for control of microorganisms

Have a better understanding of antibiotics and their application in the control of
infectious diseases

Know that plants parts are endowed with medicinal compounds which can be
exploited for chemotherapy.
C. METHODS OF LECTURE DELIVERY/TEACHING AIDS

Guided instructions

Interactive classroom session

Multimedia

Laboratory session
D. COURSE OUTLINE
Module 1
Control of Microorganisms I
Week 1
Definitions of terms, pattern of microbial death,
conditions influencing the effectiveness of
antimicrobial death activity
Week 2
The use of physical agents in control
First Alpha Semester Test
Module 2
Control of Microorganisms II
Module 3
Week 3
Use of chemical agents in control
Week 4
Evaluation of antimicrobial agent effectiveness
Antibiotics
Week 5
Classification of antibiotics and spectrum of activity
Week 6
Mechanisms of activities of antibiotics and resistance
Week 7
Methods in antibiotics susceptibility testing
Second Alpha Semester Test
Module 4
Pharmaceutical Products of Microbial Origin
Week 8
Overview and role of microorganisms in
antibiotic production and other pharmaceuticals
Week 9
Quality assessment of sterile and non-sterile
pharmaceuticals
Week 10
Techniques in aseptic processing of
pharmaceutical products
Week 11
Expanding the frontiers of medicinal plants
Week 12
Revision and evaluation
Third Alpha Semester Test
E.
TUTORIALS

Principles of Sterilization

Sterility testing

Essentials of Good Manufacturing Practice (GMP)
F. STRUCTURE OF THE PROGRAMME/ METHOD OF GRADING
1. Continuous Assessment and Practicals
30 Marks
2. Semester Examination
70 Marks
G. GROUND RULES AND REGULATIONS

Mandatory 90% class attendance

No form of misbehaviour in class and laboratory

Active participation in class

Punctuality to classes
H. TOPICS FOR TERM PAPERS/ASSIGNMENTS/STUDENTS’ ACTIVITIES
1. Development and spread of Antimicrobial Resistance
2. Expanding the frontiers of Phytomedicine
I. ALIGNMENT WITH UNIVERSITY VISION AND GOALS
This course provides a platform for professionalism in the Pharmaceutical Industry
J.
INDUSTRIAL RELEVANCE
This course lays a good foundation for a career in the Pharmaceutical Industry.
K.
RECOMMENDED BOOKS

Microbiology. Prescott LM, Harley JP, Klein DA eds. International edition; 4 th edn.,
McGraw Hill, New York, 1999.

Pharmaceutical Microbiology WB Hugo and AD Russel (ed), 7th Edition. Blackwell
Scientific Publications, UK, 2004.

Medical Microbiology. Baron S. ed., 4th edn., The University of Texas Medical
Branch, Galveston, 1996.

Medical Microbiology and Immunology: Examination and Board Review. Levinson
W, Jawetz eds. International edn., Seventh edn. Lange Medical Books/McGraw-Hill,
London, 2002.

District Laboratory Practice in tropical Countries Part 1. Cheesbrough M ed., Second
edn. Cambridge University Press, Cambridge, 2005.

District Laboratory Practice in tropical Countries Part 2. Cheesbrough M ed., Second
edn. Cambridge University Press, Cambridge, 2005.

Wadsworth-KTL Anaerobic Bacteriology Manual. Jousimies-Somer HR, Summanen
P, Citron DM, Baron EJ, Wexler HM, Finegold SM. Sixth edn., Star Publishing
Company, Belmont, California, 2002.

Introduction to Diagnostic Microbiology. Koneman EW, Allen SD, Janda WM,
Schreckenberger PC, Winn WC Jr. eds. JB Lippincott Company, Philadelphia, 1994.

Butterworths Medical Dictionary. Critchley M. Editor-in-Chief, ELBS/Butherworths,
Kent, 1986.