9th October 2008 – Issue 6
BII NEWS!
Biomedical Imaging Institute – Newsletter
Welcome to the 6th edition of the BII newsletter – if you would like to
submit news items or articles for the October edition, please send them to:
v.catterall@manchester.ac.uk by Fri 24th October.
Goodbye and THANK YOU Lloyd!!
Unfortunately we have had to say goodbye to Lloyd Gregory, who has held the position
of MRIF Manager (formerly TIU Manager) during a period of considerable expansion
and challenge here in Manchester over the past 5 years. Those of us who have been
involved in MR imaging research will know that at times of uncertainty the name
‘Lloyd’ has always been the answer to the question ‘who should I ask?’ This has been
the case whether queries referred to scanning facilities, ethics applications, scan costs,
study design, data analysis, health and safety, MR protocol, external contracts, clinical
requirements, Trust related issues etc. Whether the query came from senior
management or a PhD student made no difference; his approach was thorough and
efficient (often having to respond to very urgent needs). He served us all exceptionally
well over this period. Lloyd originally joined us from the Institute of Psychiatry in
December 2003 where he had conducted fMRI research. He rapidly acquired extensive
MR expertise (as well as diplomacy skills!) in order to be able to best serve the
imaging community. Lloyd played a major role in the establishment of MRIF (alias
TIU) and the consolidation of the MR infrastructure here in Manchester (which now
includes three magnets across three sites). Lloyd invested considerable time and
energy in supporting both scientists and clinicians in their MR needs (which can
sometimes be quite different) and importantly, in many cases he brought members of
these two communities together. Lloyd’s door was always open to those of us who
needed to see him and his excellent (and sometimes wicked!) sense of humour ensured
that even the most tedious or demanding of tasks were accompanied by a healthy
peppering of laughter and giggles. Above all, he was a team player at all levels who
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9th October 2008 – Issue 6
you could count on at any time and if something needed to be done, then Lloyd would
do it, and do it well. His presence within the Manchester MR imaging community is
already sorely missed and will be for some time to come. Lloyd has now taken up a
post at Salford Royal NHS Foundation Trust and we look forward to interacting with
him in his new capacity as R&D lead. We wish him all the very best in his new
position but we send him a few words of warning ‘watch out Lloyd…. You will not get
rid of us that easily!!’
New Grants!!!
Dr Stuart Allan, Prof Nancy Rothwell, Dr Pippa Tyrrell, Dr Steve Hopkins and Mr
Andy King (Salford Royal Foundation NHS Trust) have been awarded £800k from the
MRC re: “Subarachnoid haemorrhage as a valid model for stoke”. The grant is part of
the MRC Models of Disease Strategic Grant scheme and has been awarded for a
duration of three years.
Brain study could lead to new understanding of
depression
Brain scientists have moved a step closer to understanding why some people
may be more prone to depression than others.
Dr Roland Zahn, a clinical neuroscientist in the School of Psychological Sciences, and
his colleagues have identified how the brain links knowledge about social behaviour
with moral sentiments, such as pride and guilt.
The study, carried out at the National Institutes of Neurological Disorders and Stroke
in the US with Dr Jordan Grafman, chief of the Cognitive Neuroscience Section, and
Dr Jorge Moll, now at the LABS-D'Or Center for Neuroscience in Rio de Janeiro,
Brazil, used functional magnetic resonance imaging (fMRI) to scan the brains of 29
healthy individuals while they considered certain social behaviours.
The findings – published in the journal Cerebral Cortex – for the first time chart the
regions of the brain that interact to link knowledge about socially appropriate
behaviour with different moral feelings, depending on the context in which the social
behaviour occurs.
“During everyday life we constantly evaluate social behaviour and this largely affects
how we feel about ourselves and other people,” said Dr Zahn. “But the way we store
and use information about our own and other people’s social behaviour are not well
understood.
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9th October 2008 – Issue 6
“This latest study used functional brain imaging to identify the circuits in the brain
that underpin our ability to differentiate social behaviour that conforms to our values
from behaviour that does not.”
The team observed that social behaviour not conforming to an individual’s values
evoked feelings of anger when carried out by another person or feelings of guilt when
the behaviour stemmed from the individuals themselves.
The fMRI scans of each volunteer could then be analysed to see which parts of the
brain were activated for the different types of feeling being expressed. Of particular
interest to Dr Zahn were the brain scans relating to feelings of guilt, as these have
particular relevance to his current work on depression.
“The most distinctive feature of depressive disorders is an exaggerated negative
attitude to oneself, which is typically accompanied by feelings of guilt,” he said.
“Now that we understand how the brains of healthy individuals respond to feelings of
guilt, we hope to be able to better understand why and where there are differences in
brain activity in people suffering from, or prone to, depression.
“The brain region we have identified to be associated with proneness to guilt has been
shown to be abnormally active in patients with severe depression in several previous
studies, but until now its involvement in guilt had been unknown."
“By translating these basic cognitive neuroscience insights into clinical research we
now have the potential to discover new key functional anatomical characteristics of
the brain that may lie behind depressive disorders.
“The results will hopefully make an important contribution to our understanding of
the causes of depression that will ultimately allow new approaches to find better
treatments and prevention.”
The current clinical study, being carried out with Profs Matthew Lambon Ralph, Bill
Deakin and Alistair Burns at the University, will last four years.
New appointments – Imaging Sciences Research Group
Dr Mahbubannabi Tamal has joined the group to work on a project to develop
nan automatic caries detector. The post is in collaboration with the School of
Dentistry and the project is funded by a UMIP (University of Manchester Intellectual
Property Limited) Proof of Principle fund.
Dr Laura Parkes started as a new lecturer in neuroimaging this month. She has
come from the University of Liverpool and her appointment is associated with Nikos
Logothetis’ 20% Chair in Imaging Science. Laura’s expertise includes modelling the
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9th October 2008 – Issue 6
physiological basis of the fMRI BOLD signal; arterial spin labelling for measurement
of blood flow using MRI; and magnetoencephalography (MEG).
Dr Philip Tresadern has recently joined the group as a Research Associate,
working with Prof Tim Cootes. Phil will be working on the EU-funded MoBio (Mobile
Biometry) project which is developing biometric authentification for mobile phones.
He will be developing algorithms to reliably estimate the positions of facial features on
images and videos taken with mobile devices.
BII Symposium Series
Educational Symposium Series
A monthly symposium series began in October 2007 which is designed to provide an
introduction to areas of biomedical imaging research in Manchester AND to educate people
in how to use a variety of imaging modalities and sub-modalities.
The symposia are ideal for anyone who is involved in or considering getting involved in
research that uses imaging (e.g. PhD students, Postdocs, Clinical Fellows, and established
who are new to an imaging field). Delegates will hopefully leave the symposium knowing
enough to take the first steps in using a given methodology; they will be told who the
relevant key people in Manchester are and what is involved in developing research activity
(whether basic or applied) in a given area.
Our 11th symposium is:
“Hot Molecules – The Future of Imaging in Research”
Thursday 16th October 2008, 2.00-5.00pm
Room 5.206, 5th Floor, School of Nursing, University Place
A flyer is attached to the back of the newsletter!
Register at: http://www.forms.manchester.ac.uk/surveys/hotmolecules/
Refreshments will be available from 1.30pm
1.5T scanner installed in the WMIC
The MR scanner installed in the Wolfson Molecular Imaging Centre is up to field and
should be entering into acceptance testing shortly. The scanner should be available
for use over the next few weeks.
If you would like to contribute news articles, please send them to
v.catterall@manchester.ac.uk
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9th October 2008 – Issue 6
Visit by Dr Mark E Bastin – University of Edinburgh – 5th
December
Dr Mark Bastin, Medical and Radiological Sciences (Medical Physics), from the
University of Edinburgh, will be visiting Manchester on Friday 5 th December 2008.
He will be giving a talk on: “White Matter Integrity and Cognitive Ageing: the Lothian
Birth Cohort 1936 Study” at 2pm, Room G306a, University Place, and refreshments
will be available from 1.30pm.
Biography
Dr Mark Bastin graduated from the Universities of York, Edinburgh and Oxford with
degrees in physics and image processing. He then pursued a long held interest in
medical imaging and magnetic resonance techniques by joining Professor George
Radda’s magnetic resonance spectroscopy (MRS) unit in the Dept. of Biochemistry,
University of Oxford, where he worked on skin and cardiac MRS methods for 4 years
from 1993. He then moved to Edinburgh in 1997 to work on brain MRI in the SFC
Brain Imaging Research Centre. In 2006 he was appointed Reader in Brain Imaging.
Dr. Bastin’s research has concentrated on the development of diffusion tensor MRI
(DT-MRI) and its application to neurological disorders, in particular ischaemic stroke,
intracranial tumours, schizophrenia and ageing. This exciting imaging modality
measures the diffusion of water molecules in vivo, and is the current method of choice
for investigating brain white matter structure and integrity in health and disease.
This methodological development has been so successful that Edinburgh is now one of
the major groups applying DT-MRI to neurological disorders in the UK. In addition to
DT-MTI, he has an interest in other brain MRI techniques, including T1-mapping,
magnetization transfer imaging and dynamic susceptibility contrast perfusion MRI.
Overall this work has led to approximately 70 papers and 100 conference abstracts, 5
PhD students and research grants worth more than £2M. He is also a co-applicant on
the £6M Wellcome Trust Clinical Research Infrastructure Grant for the Clinical
Research Imaging Centre at the Queen’s Medical Research Institute (QMRI), Royal
Infirmary of Edinburgh, which will house research dedicated 3T MRI, PET and CT
scanners.
Please inform Jane Kear if you plan to attend, so she can make the necessary
arrangements – jane.kear@manchester.ac.uk or 0161 275 5761. Thanks.
If you would like to contribute news articles, please send them to
v.catterall@manchester.ac.uk
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9th October 2008 – Issue 6
Forthcoming Imaging Conferences
 BIR (The British Institute of Radiology) – Sensing the Image: Psychology and
Perceptions
- 19 November 2008 – The British Institute of Radiology, London
- A series of clinical and research case studies to examine the
interpretative process: how does the representation of the data affect the
observer? How do we best account for human visual interpretation?
- The meeting will also provide a forum to obtain knowledge and engage in
discussion on the analysis and interpretation of the image
- Drs Susan Astley and Caroline Boggis, University of Manchester, will
speak at the event
- http://www.bir.org.uk/Sensing_the_image.html
 ISMRM (International Society for Magnetic Resonance in Medicine) 17th
Scientific meeting & Exhibition
- 18-24 April 2009 – Honolulu, Hawai’i – CALL FOR ABSTRACTS –
Deadline is Wed 12th November 2008
- Student Stipend Programs and Young Investigator Awards competition
also available.
- http://www.ismrm.org/09/
 UKRC 2009 event – a three-day multidisciplinary Congress covering all aspects
of diagnostic imaging and oncology, as well as radiology informatics and service
delivery
- 8-10 June 2009 – Manchester Central (new name for the Manchester
International Conference Centre and G-MEX), Manchester – CALL FOR
ABSTRACTS – Deadline is Monday 8th December 2008
- http://www.ukrc.org.uk/index.php
If you are aware of forthcoming conference deadlines that are of relevance to BII
members then please send details to Vicky Catterall for inclusion in the Newsletter
Manchester to host the 10th International Conference on
Biomedical Applications of Electrical Impedance
Tomography
16-19th June 2009 – School of Mathematics, University of Manchester
The International Steering Committee on Electrical Impedance Tomography and the
Impedance Imaging Research Centre, Korea, are pleased to announce that the 10 th
EIT conference will take place from 16-19th June at the University. Prof Bill
Lionheart, School of Mathematics, will be the conference chair, with Eung-je Woo and
Richard Bayford as co-chairs.
If you would like to contribute news articles, please send them to
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9th October 2008 – Issue 6
As with past conferences, it will focus on medical applications of Electrical Impedance
Tomography; Magnetic Induction Tomography; and Magnetic Resonance Electrical
Impedance Tomography.
On Thurs 18th June, there will be a special session entitled “EIT lung imaging – on the
way to a clinical use” organized by Inez Frerichs.
Further details can be found at: http://www.maths.manchester.ac.uk/eit2009/
Visit from Prof Jem Hebden – 28th October
Prof Jeremy Hebden, University College London, is visiting the University in October
and has kindly offered to give a talk on “Diffuse optical tomography of the breast and
infant brain” – everyone is invited to attend.
Date: Tues 28th October
Time: 12.30pm
Venue: Room B29, Sackville Street Building
Please inform Jane Kear if you plan to attend so we have an idea of numbers –
jane.kear@manchester.ac.uk
Funding Opportunities – MCRC Collaborative Workshop
Awards
The Manchester Cancer Research Centre (MCRC) has established a new funding
scheme for Collaborative Workshops.
The purpose of this scheme is to support workshops that instigate or consolidate the
collaboration of cancer researchers and clinicians, particularly those that aim to
promote new multidisciplinary interactions and share expertise. It is hoped that the
workshops will help to facilitate collaborations that lead to the development of longterm research projects.
Applications must be submitted by Principal Investigators with academic
appointments in Manchester. Further information can be found on the MCRC
website: http://www.mcrc.manchester.ac.uk/research/awards.htm
If you would like to contribute news articles, please send them to
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9th October 2008 – Issue 6
Postgraduate lectures – ‘Imaging in Medicine’
The Manchester Radiology Training Scheme (MRTS) hosts a series of lectures
involving visiting speakers. The next one is:
30th October – ‘Imaging of the testis and paratesticular masses’ – Dr J Wong-YouCheong, Prof of Diagnostic Radiology and Nuclear Medicine, University of Maryland
and Medical Centre
This will commence at 5.15pm, in Lecture Theatre 2, Stopford Building. Please
contact Karan O’Hagan for further details: karano@manchester.ac.uk
Papers published/In press
Variable size CAD prompts and mammography film reader decisions
Breast Cancer Research, 2008, 10(4):R72
F.J. Gilbert, S.M. Astley, C.R.M. Boggis, M.A. McGee, P.M. Griffiths, S.W. Duffy, O.F.
Agbaje, M.G.C. Gillan, M. Wilson, A. Jain, N. Barr, U.M. Beetles, M.A. Griffiths, J.
Johnson, R.M. Roberts, H.E. Deans, K.A. Duncan, G. Iyengar
The effect of labeling parameters on perfusion-based fMRI in nonhuman primates
Journal of Cerebral Blood Flow and Metabolism, 2008, 28(3):640-52
A.C. Zappe, J. Pfeuffer, H. Merkle, N.K. Logothetis, J.B.M.Goense
Facile Synthesis and Relaxation Properties of Novel Bispolyazamacrocyclic Gd3+
Complexes: An Attempt towards Calcium-Sensitive MRI Contrast Agents
Inorganic Chemistry, 2008, 47(4):1370-81
A. Mishra, P. Fousková, G. Angelovski, E. Balogh, A. K. Mishra, N.K. Logothetis, É. Tóth
Phase-of-Firing Coding of Natural Visual Stimuli in Primary Visual Cortex
Current Biology, 2008, 18(5):375-80
M.A. Montemurro, M.J. Rasch, Y. Murayama, N.K. Logothetis, S. Panzeri
Inferring Spike Trains From Local Field Potentials
Journal of Neurophysiology, 2008, 99(3):1461-76
M.J. Rasch, A. Gretton, Y. Murayama, W. Maass, N.K. Logothetis
Magnetic resonance imaging of cortical connectivity in vivo
Neuroimage, 2008, 40(2):458-72
S. Canals, M. Beyerlein, A.L. Keller, Y. Murayama, N.K. Logothetis
If you would like to contribute news articles, please send them to
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9th October 2008 – Issue 6
The effect of a serotonin-induced dissociation between spiking and perisynaptic activity
on BOLD functional MRI
Proceedings of the National Academy of Sciences of the USA, 2008, 105(18):6759-64
A. Rauch, G. Rainer, N.K. Logothetis
Neurophysiology of the BOLD fMRI Signal in Awake Monkeys
Current Biology, 2008, 18(9):631-40
B.M. Jozien, Goense, N.K. Logothetis
Morphing rhesus monkey vocalizations
Journal of Neuroscience Methods, 2008, 170(1):45-55
S. Chakladar, N.K. Logothetis, C.I. Petkov
Low-Frequency Local Field Potentials and Spikes in Primary Visual Cortex Convey
Independent Visual Information
The Journal of Neuroscience, 2008, 28(22):5696-709
A. Belitski, A. Gretton, C. Magri, Y. Murayama, M. A. Montemurro, N.K. Logothetis, S.
Panzeri
What we can do and what we cannot do with fMRI
Nature, 2008, 453(7197):869-78
N.K. Logothetis
Visual Modulation of Neurons in Auditory Cortex
Cerebral Cortex, 2008, 18(7):1560-74
C. Kayser, C.I. Petkov, N.K. Logothetis
Smart Magnetic Resonance Imaging Agents that Sense Extracellular Calcium
Fluctuations
Chembiochem, 2008, 9(11):1729-34
G. Angelovski, P. Fouskova, I. Mamedov, S. Canals, E. Toth, N.K. Logothetis
Synthesis and characterization of a smart contrast agent sensitive to calcium
Chemical Communications (Cambridge, England), 2008, (29):3444-6
K. Dhingra, M.E. Maier, M. Beyerlein, G. Angelovskia, N.K. Logothetis
Towards extracellular Ca2+ sensing by MRI: synthesis and calcium-dependent 1H and 17O
relaxation studies of two novel bismacrocyclic Gd3+ complexes
Journal of Biological Inorganic Chemistry, 2008, 13(1):35-46
K. Dhingra, P. Fouskova, G. Angelovski, M.E. Maier, N.K. Logothetis, E. Toth
If you would like to contribute news articles, please send them to
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9th October 2008 – Issue 6
fMRI of the temporal lobe of the awake monkey at 7 T
Neuroimage, 2008, 39(3):1081-93
J.B.M. Goense, S. Ku, H. Merkle, A.S. Tolias, N.K. Logothetis
A voice region in the monkey brain
Nature Neuroscience, 2008, 11(3):367-74
C.I. Petkov, C. Kayser, T. Steudel, K. Whittingstall, M. Augath, N.K. Logothetis
Quantitative imaging biomarkers in the clinical development of targeted therapeutics:
current and future perspectives
The Lancet Oncology, 2008, 9: 766-776
J.P.B. O'Connor, A. Jackson, M.-C. Asselin, D.L. Buckley, G.J.M. Parker, G.C. Jayson.
Distortion correction for a double inversion-recovery sequence with an echo-planar
imaging readout
Magnetic Resonance Imaging, 2008, 26(7):943-53
S.J.P. Meara, K.V. Embleton, G.J.M. Parker
Paradoxical embolisation and cerebral white matter lesions in Dementia
The British Journal of Radiology, 2008, 81: 30–34
N. Purandare, R.C.Oude Voschaar, C. McCollum, A. Jackson, A. Burns
Age-Associated Losses of Brain Volume Predict Longitudinal Cognitive
Declines Over 8 to 20 Years
Neuropsychology, 2008, 22(1):3-9
P. Rabbitt, S. Ibrahim, M. Lunn, M. Scott, N. Thacker, C. Hutchinson, M. Horan, N.
Pendleton, A. Jackson
Cerebral blood flow and intracranial pressure
Anaesthesia and Intensive Care Medicine, 2008, 9(5):222-225
E. Shardlow, A. Jackson
Does black blood MRA have a role in the assessment of intracerebral aneurysms?
European Radiology, 2008
S.M. Stivaros, J.N. Harris, W. Adams, A. Jackson
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9th October 2008 – Issue 6
Late tissue effects following radiotherapy and neoadjuvant hormone therapy of the
prostate measured with quantitative magnetic resonance imaging
Radiotherapy and Oncology, 2008, 88(1):127–134
L. E. Kershaw, J.P. Logue, C.E. Hutchinson, N.W. Clarke, D.L. Buckley
The role of the dental surgeon in detecting osteoporosis: the OSTEODENT study
British Dental Journal, 2008, 204(10):E16; discussion 560-1
H. Devlin, P. Allen, J. Graham, R. Jacobs, K. Nicopoulou-Karayianni, C. Lindh, E.
Marjanovic, J. Adams, S. Pavitt, P. van der Stelt, K. Horner
Probalistic fibre tracking: Differentiation of connections from chance events
NeuroImage, 2008, 42: 1329-1339
D. M. Morris, K. V. Embleton, G. J. M. Parker
Vertebral morphometry: current methods and recent advances
European Radiology, 2008, 18(7): 1484-96
G. Guglielmi, D. Diacinti, C. Van Kuijk, F. Aparisi, C. Crestan, J. E. Adams, T. M. Link
Effect of anastrozole on bone mineral density: 5-year results from the anastrozole,
tamoxifen, alone or in combination trial 18233230
Journal of Clinical Oncology, 2008, 26(7): 1051-1057
R. Eastell, J.E. Adams, R.E. Coleman, A. Howell, R.A. Hannon, J. Cuzick, J.R.
Mackey, M.W. Beckmann, G. Clack
The use of visual assessment of dental radiographs for identifying women at risk of
having osteoporosis: the OSTEODENT project.
Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, 2008,
106(2): 285-93
Lindh C, Horner K, Jonasson G, Olsson P, Rohlin M, Jacobs R, Karayianni K, van der
Stelt P, Adams J, Marjanovic E, Pavitt S, Devlin H.
The cost-effectiveness of alendronate in the management of osteoporosis
Bone, 2008, 42(1): 4-15
Kanis JA, Adams J, Borgström F, Cooper C, Jönsson B, Preedy D, Selby P, Compston
J
Clinical use of quantitative computed tomography and peripheral quantitative
computed tomography in the management of osteoporosis in adults: the 2007 ISCD
Official Positions.
Journal of Clinical Densitometry, 2008, 11(1): 123-62
Engelke K, Adams JE, Armbrecht G, Augat P, Bogado CE, Bouxsein ML, Felsenberg
D, Ito M, Prevrhal S, Hans DB, Lewiecki EM
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9th October 2008 – Issue 6
Bone status of children aged 5-8 years, treated with dexamethasone for chronic lung
disease of prematurity.
Archives of Disease in Childhood, 2008, 93(3): 222-4
Eelloo JA, Roberts SA, Emmerson AJ, Ward KA, Adams JE, Mughal MZ
Genetic Variation in Sex Hormone Genes Influences Heel Ultrasound Parameters in
Middle Aged and Elderly Men: Results From the European Male Ageing Study
(EMAS).
Journal of Bone and Mineral Research, 2008, Epub ahead of print
Limer KL, Pye SR, Thomson W, Boonen S, Borghs H, Vanderschueren D, Huhtaniemi
IT, Adams JE, Ward KA, Platt H, Payne D, John SL, Bartfai G, Casanueva F, Finn
JD, Forti G, Giwercman A, Han TS, Kula K, Lean ME, Pendleton N, Punab M, Silman
AJ, Wu FC, O'Neill TW; the EMAS study group†.
Past issues of the newsletter can be found at:
http://www.bii.manchester.ac.uk/aboutus/newsletters/
If you would like to contribute news articles, please send them to
v.catterall@manchester.ac.uk
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9th October 2008 – Issue 6
If you would like to contribute news articles, please send them to
v.catterall@manchester.ac.uk
13