Special Report on Genetics and:
Gout
23 Selected Articles From 1998 to
December 6, 2007
Our purpose is to provide both general and focused information regarding the
interplay between genetics, health, and the environment,
including but not limited to nutrition.
Genetics matter, but in most cases your
lifestyle and environment matter even more.
It’s often said, “Genetics loads the gun, but the environment pulls the trigger.”
Genetics alone do not determine your future health and well-being.
The Public needs the expertise of Professionals, and
Professionals need the awareness and engagement of the Public.
Our goal is to help both the the Public and Professionals by
providing the relevant literature needed to form
true partnerships together for better health.
Although much remains to be learned,
we invite you to look inside to see for yourself what
genetics-related information is already available on gout.
Be sure to check the indexes to look for
items of special interest.
Bridging the gap between nature and nurture.TM
© Copyright 2007 Nutrigenetics Unlimited, Inc. All Rights Reserved.
1
Table of Contents:
Pages
1) References . . . . . . . . . . . . . . . . . . . . 3-4
Bibliography of selected articles, with the
PubMed® ID number (PMID) shown near the
right margin in descending order (larger
numbers indicate more recent additions to
PubMed®).
Individual links to online PubMed® citations
are provided, but the PMID number can also
be used as search criteria in PubMed®.
In addition to these selected articles, additional
articles may be found by conducting auxiliary
searches at: www.pubmed.gov
2) Easy Abstract Retrieval . . . . . . . . . . . . .
5
Any available abstracts for all of the references
can be obtained all at once by following the
directions provided.
3) Index Summary . . . . . . . . . . . . . . . . . 6-7
This abbreviated index shows the number
of articles among the References which
address the other topics which are “Also
Mentioned.”
This is useful for quickly spotting subtopics of special interest, including specific
genes and polymorphisms (common gene
variations) which might otherwise escape
attention.
4) Index Details . . . . . . . . . . . . . . . . . . . 8-15
This index identifies the specific articles
among the References which address the
other topics “Also Mentioned.”
2
References on:
Gout
23 Selected Articles From 1998 to Date
(For individual abstracts, use Ctrl-Click on links in blue text, or see page 3 to see all at once.)
Title, Link*, Year, Citation, PubMed ID Number (PMID), and Any Comments
Date: 12/6/07
Homozygous frameshift mutation in the SLC22A12 gene in a patient with primary gout and high levels of serum
uric acid.
Reference
2007
J Clin Pathol. 2007 Aug;60(8):947-8.
17660342
Tumor necrosis factor-alpha and interleukin-4 gene polymorphisms in Chinese patients with gout.
Abstract
2007 Clin Exp Rheumatol. 2007 May-Jun;25(3):385-9.
17631734
Identification of a new single-nucleotide mutation on the hypoxanthine-guanine phosphoribosyltransferase
gene from 983 cases with gout in Taiwan.
Abstract
2007
J Rheumatol. 2007 Apr;34(4):794-7. Epub 2007 Feb 15.
17309125
Correlation of oestrogen receptor gene polymorphism with gouty arthritis.
Free
2006 Ann Rheum Dis. 2006 Dec;65(12):1673-4.
17105861
Genetically determined gout: characteristics of the course. [Article in Russian]
Abstract
2006 Tsitol Genet. 2006 May-Jun;40(3):72-7.
16933856
Association between intronic SNP in urate-anion exchanger gene, SLC22A12, and serum uric acid levels in
Japanese.
Abstract
2006
Life Sci. 2006 Nov 2;79(23):2234-7. Epub 2006 Aug 1.
16920156
New developments in the epidemiology and genetics of gout.
Abstract
2006 Curr Rheumatol Rep. 2006 Jun;8(3):215-23.
16901080
Molecular analysis of the SLC22A12 (URAT1) gene in patients with primary gout.
Abstract
2007 Rheumatology (Oxford). 2007 Feb;46(2):215-9. Epub 2006 Jul 11.
16837472
Gout--new insights into a forgotten disease.
Reference 2006 Horm Metab Res. 2006 Mar;38(3):203-4.
16673214
Hyperuricemia and gout: diagnosis and therapy. [Article in German]
Abstract
2006 Internist (Berl). 2006 May;47(5):509-20; quiz 521.
16586130
Genetic factors associated with gout and hyperuricemia.
Abstract
2006 Adv Chronic Kidney Dis. 2006 Apr;13(2):124-30.
16580613
Proteomic analysis of Down's syndrome patients with gout.
Abstract
2006 Clin Chim Acta. 2006 Jul 15;369(1):89-94. Epub 2006 Feb 28.
16500633
A common mutation in an organic anion transporter gene, SLC22A12, is a suppressing factor for the
development of gout.
Free
2005
Arthritis Rheum. 2005 Aug;52(8):2576-7.
16059895
Interleukin-1 receptor antagonist gene polymorphism in Taiwanese patients with gout.
Abstract
2005 Clin Exp Rheumatol. 2005 Jan-Feb;23(1):85-8.
HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol.
3
15789892
Free
2005
Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4134-9. Epub 2005 Mar 2.
15743917
Hereditary hyperuricemia and renal disease.
Abstract
2005 Semin Nephrol. 2005 Jan;25(1):9-18.
15660329
Genomewide scan for gout in Taiwanese aborigines reveals linkage to chromosome 4q25.
Free
2004 Am J Hum Genet. 2004 Sep;75(3):498-503. Epub 2004 Jul 13.
15252757
Contribution of polymorphisms in the apolipoprotein AI-CIII-AIV cluster to hyperlipidaemia in patients with
Free
2005 Ann Rheum Dis. 2005 Jan;64(1):85-8. Epub 2004 Apr 28.
15115711
Interleukin-1beta gene polymorphisms in Taiwanese patients with gout.
Abstract
2005 Rheumatol Int. 2005 Apr;25(3):179-82. Epub 2003 Dec 6.
14661113
The elevated prevalence of apolipoprotein E2 in patients with gout is associated with reduced renal excretion of
urates.
Free
2003
Rheumatology (Oxford). 2003 Mar;42(3):468-72.
12626798
Clinical features of familial gout and effects of probable genetic association between gout and its related
Abstract
2001 Metabolism. 2001 Oct;50(10):1203-7.
11586494
Gout: diagnosis, pathogenesis, and clinical manifestations.
Abstract
2001 Curr Opin Rheumatol. 2001 May;13(3):234-9.
11333355
Identification of a new single nucleotide substitution on the hypoxanthine-guanine phosphoribosyltransferase
gene (HPRT(Tsou) from a Taiwanese aboriginal family with severe gout.
Abstract
1999
J Rheumatol. 1999 Aug;26(8):1802-7.
10451080
* Ctrl+Click on the blue hyperlinks to see the full citations in PubMed®; any articles marked as "Free" can be
downloaded in PDF format by following the link provided there. This listing is a selected subset of those found on
PubMed® with emphasis on the interplay between genetics and the environment, including but not limited to
nutrition. The available subset includes many articles related to genetics from 2003 to date, with lighter coverage
and emphasis on review articles from 1998 through 2002. Additional relevant references may be found at
www.PubMed.gov.
Listings such as this can be used to stimulate discussions and partnerships with your
healthcare professionals, which we encourage. Information from this report is
not intended to be used for the diagnosis or treatment of any medical condition.
Please seek guidance from, and partnership with, a qualified healthcare Professional.
Nutrigenetics Unlimited, Inc.
4
www.nutrigenetics.net
Easy Abstract Retrieval on:
Gout
Selected Articles From 1998 to Date
You can retrieve the complete PubMed® references (most with abstracts) for all of the above references by
using the following procedure:
Use your browser and go to www.PubMed.gov
Copy the following paragraph as one block of text, paste it into the search box found on PubMed, then press the
Go button:
17660342[pmid] OR 17631734[pmid] OR 17309125[pmid] OR 17105861[pmid] OR 16933856[pmid] OR
16920156[pmid] OR 16901080[pmid] OR 16837472[pmid] OR 16673214[pmid] OR 16586130[pmid] OR
16580613[pmid] OR 16500633[pmid] OR 16059895[pmid] OR 15789892[pmid] OR 15743917[pmid] OR
15660329[pmid] OR 15252757[pmid] OR 15115711[pmid] OR 14661113[pmid] OR 12626798[pmid] OR
11586494[pmid] OR 11333355[pmid] OR 10451080[pmid]
Use PubMed’s “Display” drop-down box to select “Abstract” or one of the other display options found there.
If desired, you can use the “Send to” drop-down box to select one of the several download choices, such as Text
(to allow pasting into your word processor), or File (to download to your hard drive).
5
Index Summary for:
Gout
For 23 Selected Articles from 1998 to Date
Of the 23 selected articles, the list below shows how many articles also mention the other topics shown.
The terminology used for genes and polymorphisms is based largely on the OMIM database (Online Mendelian
Inheritance in Man), which can be viewed and searched at: www.ncbi.nlm.nih.gov/sites/entrez?db=OMIM
See “Topic Description” for synonyms which might otherwise appear in the cited articles.
Number of
Articles
Also Mentioned
Description
Date: 12/6/07
1
1
3
Age of Onset
Aging
Alcohol
As found in beer, wine, etc. (also known as ethanol).
1
Allopurinol
Drug.
1
2
Antioxidant
APOA1
Apolipoprotein A-I - gene or related protein.
1
APOA1 -75G-A
Polymorphism of APOA1.
1
APOA4
Apolipoprotein A-IV - gene or related protein.
1
APOC3
Apolipoprotein C-III - gene or related protein.
1
APOC3 SstI
Polymorphism of APOC3.
1
APOE
Apolipoprotein E - gene or related protein.
1
APOE E2
Polymorphism of APOE (combination of Cys112 and Cys158, also known as
epsilon 2, or as apoE2).
1
Cerebrovascular Disease
Disorders which result in defective brain arteries, including stroke (both
hemorrhagic and ischemic).
6
China
Country or region, but used for Chinese ethnicity as well.
2
Diabetes Type 2
Diabetes Mellitus Type 2 (also known as NIDDM).
3
1
1
1
1
Diagnosis
Down Syndrome
Drug Metabolism
Environment ***
Epidemiology
Factors affecting health and illness of populations, as for identifying risk factors.
1
Epigenetics
Alterations in gene expression which do not involve actual alterations in DNA.
1
ESR1
Estrogen Receptor Alpha (also known as Estrogen Receptor) - gene or related
protein.
2
Familial Juvenile Hyperuricemic
Genetic disorder.
1
Gene Expression
(See also Transcriptomics.)
5
Gene Frequency
The frequency of occurrence of a polymorphism within a population.
1
Haplotypes
Group of several SNPs which are linked physically on a single chromosome.
1
HLA-B
Major Histocompatibility Complex Class I B - gene or related protein.
1
HLA-B*5801
Genetic variant of HLA-B.
1
HP
Haptoglobin - gene or related protein.
4
HPRT1
Hypoxanthine Guanine Phosphoribosyltransferase 1 - gene or related protein.
1
1
1
3
11
1
1
Hypercholesterolemia
Hyperlipidemia
Hypertension
Hypertriglyceridemia
Hyperuricemia
IL1B
IL1RN
Interleukin-1 Beta - gene or related protein.
IL-1 Receptor Antagonist (with antiinflammatory properties) - gene or related
protein.
6
1
IL4
Interleukin-4 - gene or related protein.
1
IL4 -590C-T
Polymorphism of IL4.
1
IL4 VNTR
Polymorphism in intron 3 of IL4.
2
1
1
Inflammation
Insulin Resistance
Japan
Country or region, but used for Japanese ethnicity as well.
2
1
1
1
Kidney Disease
Kidney Stones
LOD Score
Major Histocompatibility Complex
Family of genes that encode key receptors of the immune response.
3
2
1
Medullary Cystic Kidney Disease
Metabolic Syndrome
Mexico
Country or region.
1
2
2
1
1
Monogenic Disorders
Obesity
Pathophysiology
Pharmacogenetics
Polygenic Disorders
Disorders affected by many genes, each with relatively small effects.
1
1
6
1
5
Proteomics
Risk Estimates
Risk Factors
Safety
SLC22A12
1
SLC22A12 rs893006
Polymorphism of SLC22A12 (G-T).
6
Taiwan
Country or region.
1
TNF
Tumor Necrosis Factor Alpha (also known as TNF-alpha) - gene or related
1
TNF -308G-A
Polymorphism of TNF (also known as TNF NcoI, or as rs1800629).
2
4
Treatment
Triglycerides
Fats, usually as they might be reported in a blood lipid test.
1
UMOD
Uromodulin - gene or related protein.
1
VLDL Cholesterol
Very-Low Density Lipoprotein Cholesterol.
Solute Carrier Family 22 (Urate Transporter) Member 12 (also known as OAT4L,
or as URAT1) - gene or related protein.
Listings such as this can be used to stimulate discussions and partnerships with your
healthcare professionals, which we encourage. Information from this report is
not intended to be used for the diagnosis or treatment of any medical condition.
Please seek guidance from, and partnership with, a qualified healthcare Professional.
Nutrigenetics Unlimited, Inc.
7
www.nutrigenetics.net
Index Details for:
Gout
For 23 Selected Articles from 1998 to Date
The terminology used for genes and polymorphisms is based largely on the OMIM database (Online Mendelian Inheritance in Man), which can be viewed and
searched at: www.ncbi.nlm.nih.gov/sites/entrez?db=OMIM
See “Topic Description” for synonyms which might otherwise appear in the cited articles.
Topic, Link, Year, Title, and PubMed ID (PMID) *
Date: 12/6/07
Sorted By PMID
____________________________________________________________________________________________________________________________________________
Age of Onset -Abstract 2001 Clinical features of familial gout and effects of probable genetic association between gout and its related disorders.
11586494
____________________________________________________________________________________________________________________________________________
Aging -Abstract 2006 New developments in the epidemiology and genetics of gout.
16901080
____________________________________________________________________________________________________________________________________________
Alcohol -- As found in beer, wine, etc. (also known as ethanol).
Abstract 2006 New developments in the epidemiology and genetics of gout.
16901080
Abstract 2006 Genetic factors associated with gout and hyperuricemia.
16580613
Free
2004 Genomewide scan for gout in Taiwanese aborigines reveals linkage to chromosome 4q25.
15252757
____________________________________________________________________________________________________________________________________________
Allopurinol -- Drug.
Free
2005 HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol.
15743917
____________________________________________________________________________________________________________________________________________
Antioxidant -Abstract 2001 Gout: diagnosis, pathogenesis, and clinical manifestations.
11333355
____________________________________________________________________________________________________________________________________________
APOA1 -- Apolipoprotein A-I - gene or related protein.
Abstract 2006 Proteomic analysis of Down's syndrome patients with gout.
16500633
Free
2005 Contribution of polymorphisms in the apolipoprotein AI-CIII-AIV cluster to hyperlipidaemia in patients with gout.
15115711
____________________________________________________________________________________________________________________________________________
APOA1 -75G-A -- Polymorphism of APOA1.
Free
2005 Contribution of polymorphisms in the apolipoprotein AI-CIII-AIV cluster to hyperlipidaemia in patients with gout.
15115711
____________________________________________________________________________________________________________________________________________
APOA4 -- Apolipoprotein A-IV - gene or related protein.
8
Free
2005 Contribution of polymorphisms in the apolipoprotein AI-CIII-AIV cluster to hyperlipidaemia in patients with gout.
15115711
____________________________________________________________________________________________________________________________________________
APOC3 -- Apolipoprotein C-III - gene or related protein.
Free
2005 Contribution of polymorphisms in the apolipoprotein AI-CIII-AIV cluster to hyperlipidaemia in patients with gout.
15115711
____________________________________________________________________________________________________________________________________________
APOC3 SstI -- Polymorphism of APOC3.
Free
2005 Contribution of polymorphisms in the apolipoprotein AI-CIII-AIV cluster to hyperlipidaemia in patients with gout.
15115711
____________________________________________________________________________________________________________________________________________
APOE -- Apolipoprotein E - gene or related protein.
Free
2003 The elevated prevalence of apolipoprotein E2 in patients with gout is associated with reduced renal excretion of urates.
12626798
____________________________________________________________________________________________________________________________________________
APOE E2 -- Polymorphism of APOE (combination of Cys112 and Cys158, also known as epsilon 2, or as apoE2).
Free
2003 The elevated prevalence of apolipoprotein E2 in patients with gout is associated with reduced renal excretion of urates.
12626798
____________________________________________________________________________________________________________________________________________
Cerebrovascular Disease -- Disorders which result in defective brain arteries, including stroke (both hemorrhagic and ischemic).
Abstract 2006 Genetically determined gout: characteristics of the course. [Article in Russian]
16933856
____________________________________________________________________________________________________________________________________________
China -- Country or region, but used for Chinese ethnicity as well.
Abstract 2007 Tumor necrosis factor-alpha and interleukin-4 gene polymorphisms in Chinese patients with gout.
17631734
Abstract 2007 Identification of a new single-nucleotide mutation on the hypoxanthine-guanine phosphoribosyltransferase gene from 983 cases with gout
17309125
in Taiwan.
Abstract 2005 Interleukin-1 receptor antagonist gene polymorphism in Taiwanese patients with gout.
15789892
Abstract 2005 Interleukin-1beta gene polymorphisms in Taiwanese patients with gout.
14661113
Abstract 2001 Clinical features of familial gout and effects of probable genetic association between gout and its related disorders.
11586494
Abstract 1999 Identification of a new single nucleotide substitution on the hypoxanthine-guanine phosphoribosyltransferase gene (HPRT(Tsou) from a
10451080
Taiwanese aboriginal family with severe gout.
____________________________________________________________________________________________________________________________________________
Diabetes Type 2 -- Diabetes Mellitus Type 2 (also known as NIDDM).
Abstract 2006 Genetic factors associated with gout and hyperuricemia.
16580613
Abstract 2001 Clinical features of familial gout and effects of probable genetic association between gout and its related disorders.
11586494
____________________________________________________________________________________________________________________________________________
Diagnosis -Abstract 2006 Hyperuricemia and gout: diagnosis and therapy. [Article in German]
16586130
Abstract 2006 Genetic factors associated with gout and hyperuricemia.
16580613
Abstract 2001 Gout: diagnosis, pathogenesis, and clinical manifestations.
11333355
____________________________________________________________________________________________________________________________________________
Down Syndrome -Abstract 2006 Proteomic analysis of Down's syndrome patients with gout.
16500633
____________________________________________________________________________________________________________________________________________
Drug Metabolism --
9
Free
2005 HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol.
15743917
____________________________________________________________________________________________________________________________________________
Environment -Abstract 2001 Gout: diagnosis, pathogenesis, and clinical manifestations.
11333355
____________________________________________________________________________________________________________________________________________
Epidemiology -- Factors affecting health and illness of populations, as for identifying risk factors.
Abstract 2006 New developments in the epidemiology and genetics of gout.
16901080
____________________________________________________________________________________________________________________________________________
Epigenetics -- Alterations in gene expression which do not involve actual alterations in DNA.
Abstract 2006 Genetic factors associated with gout and hyperuricemia.
16580613
____________________________________________________________________________________________________________________________________________
ESR1 -- Estrogen Receptor Alpha (also known as Estrogen Receptor) - gene or related protein.
Free
2006 Correlation of oestrogen receptor gene polymorphism with gouty arthritis.
17105861
____________________________________________________________________________________________________________________________________________
Familial Juvenile Hyperuricemic Nephropathy -- Genetic disorder.
Abstract 2006 Genetic factors associated with gout and hyperuricemia.
16580613
Abstract 2005 Hereditary hyperuricemia and renal disease.
15660329
____________________________________________________________________________________________________________________________________________
Gene Expression -- (See also Transcriptomics.)
Abstract 2006 Proteomic analysis of Down's syndrome patients with gout.
16500633
____________________________________________________________________________________________________________________________________________
Gene Frequency -- The frequency of occurrence of a polymorphism within a population.
Abstract 2007 Tumor necrosis factor-alpha and interleukin-4 gene polymorphisms in Chinese patients with gout.
17631734
Abstract 2007 Identification of a new single-nucleotide mutation on the hypoxanthine-guanine phosphoribosyltransferase gene from 983 cases with gout
17309125
in Taiwan.
Abstract 2005 Interleukin-1 receptor antagonist gene polymorphism in Taiwanese patients with gout.
15789892
Free
2005 HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol.
15743917
Abstract 2005 Interleukin-1beta gene polymorphisms in Taiwanese patients with gout.
14661113
____________________________________________________________________________________________________________________________________________
Haplotypes -- Group of several SNPs which are linked physically on a single chromosome.
Free
2005 HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol.
15743917
____________________________________________________________________________________________________________________________________________
HLA-B -- Major Histocompatibility Complex Class I B - gene or related protein.
Free
2005 HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol.
15743917
____________________________________________________________________________________________________________________________________________
HLA-B*5801 -- Genetic variant of HLA-B.
Free
2005 HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol.
15743917
____________________________________________________________________________________________________________________________________________
HP -- Haptoglobin - gene or related protein.
Abstract 2006 Proteomic analysis of Down's syndrome patients with gout.
16500633
10
____________________________________________________________________________________________________________________________________________
HPRT1 -- Hypoxanthine Guanine Phosphoribosyltransferase 1 - gene or related protein.
Abstract 2007 Identification of a new single-nucleotide mutation on the hypoxanthine-guanine phosphoribosyltransferase gene from 983 cases with gout
17309125
in Taiwan.
Abstract 2006 Proteomic analysis of Down's syndrome patients with gout.
16500633
Abstract 2005 Hereditary hyperuricemia and renal disease.
15660329
Abstract 1999 Identification of a new single nucleotide substitution on the hypoxanthine-guanine phosphoribosyltransferase gene (HPRT(Tsou) from a
10451080
Taiwanese aboriginal family with severe gout.
____________________________________________________________________________________________________________________________________________
Hypercholesterolemia -Abstract 2001 Clinical features of familial gout and effects of probable genetic association between gout and its related disorders.
11586494
____________________________________________________________________________________________________________________________________________
Hyperlipidemia -Free
2005 Contribution of polymorphisms in the apolipoprotein AI-CIII-AIV cluster to hyperlipidaemia in patients with gout.
15115711
____________________________________________________________________________________________________________________________________________
Hypertension -Abstract 2001 Clinical features of familial gout and effects of probable genetic association between gout and its related disorders.
11586494
____________________________________________________________________________________________________________________________________________
Hypertriglyceridemia -Abstract 2007 Tumor necrosis factor-alpha and interleukin-4 gene polymorphisms in Chinese patients with gout.
17631734
Abstract 2005 Interleukin-1beta gene polymorphisms in Taiwanese patients with gout.
14661113
Abstract 2001 Clinical features of familial gout and effects of probable genetic association between gout and its related disorders.
11586494
____________________________________________________________________________________________________________________________________________
Hyperuricemia -Reference 2007 Homozygous frameshift mutation in the SLC22A12 gene in a patient with primary gout and high levels of serum uric acid.
17660342
Abstract 2006 Association between intronic SNP in urate-anion exchanger gene, SLC22A12, and serum uric acid levels in Japanese.
16920156
Abstract 2006 New developments in the epidemiology and genetics of gout.
16901080
Abstract 2006 Hyperuricemia and gout: diagnosis and therapy. [Article in German]
16586130
Abstract 2006 Genetic factors associated with gout and hyperuricemia.
16580613
Free
2005 HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol.
15743917
Abstract 2005 Hereditary hyperuricemia and renal disease.
15660329
Free
2004 Genomewide scan for gout in Taiwanese aborigines reveals linkage to chromosome 4q25.
15252757
Free
2005 Contribution of polymorphisms in the apolipoprotein AI-CIII-AIV cluster to hyperlipidaemia in patients with gout.
15115711
Free
2003 The elevated prevalence of apolipoprotein E2 in patients with gout is associated with reduced renal excretion of urates.
12626798
Abstract 2001 Gout: diagnosis, pathogenesis, and clinical manifestations.
11333355
____________________________________________________________________________________________________________________________________________
IL1B -- Interleukin-1 Beta - gene or related protein.
Abstract 2005 Interleukin-1beta gene polymorphisms in Taiwanese patients with gout.
14661113
____________________________________________________________________________________________________________________________________________
IL1RN -- IL-1 Receptor Antagonist (with antiinflammatory properties) - gene or related protein.
Abstract 2005 Interleukin-1 receptor antagonist gene polymorphism in Taiwanese patients with gout.
11
15789892
____________________________________________________________________________________________________________________________________________
IL4 -- Interleukin-4 - gene or related protein.
Abstract 2007 Tumor necrosis factor-alpha and interleukin-4 gene polymorphisms in Chinese patients with gout.
17631734
____________________________________________________________________________________________________________________________________________
IL4 -590C-T -- Polymorphism of IL4.
Abstract 2007 Tumor necrosis factor-alpha and interleukin-4 gene polymorphisms in Chinese patients with gout.
17631734
____________________________________________________________________________________________________________________________________________
IL4 VNTR -- Polymorphism in intron 3 of IL4.
Abstract 2007 Tumor necrosis factor-alpha and interleukin-4 gene polymorphisms in Chinese patients with gout.
17631734
____________________________________________________________________________________________________________________________________________
Inflammation -Abstract 2006 Hyperuricemia and gout: diagnosis and therapy. [Article in German]
16586130
Abstract 2001 Gout: diagnosis, pathogenesis, and clinical manifestations.
11333355
____________________________________________________________________________________________________________________________________________
Insulin Resistance -Free
2005 Contribution of polymorphisms in the apolipoprotein AI-CIII-AIV cluster to hyperlipidaemia in patients with gout.
15115711
____________________________________________________________________________________________________________________________________________
Japan -- Country or region, but used for Japanese ethnicity as well.
Abstract 2006 Association between intronic SNP in urate-anion exchanger gene, SLC22A12, and serum uric acid levels in Japanese.
16920156
____________________________________________________________________________________________________________________________________________
Kidney Disease -Abstract 2006 Genetic factors associated with gout and hyperuricemia.
16580613
Abstract 2005 Hereditary hyperuricemia and renal disease.
15660329
____________________________________________________________________________________________________________________________________________
Kidney Stones -Abstract 2006 Genetically determined gout: characteristics of the course. [Article in Russian]
16933856
____________________________________________________________________________________________________________________________________________
LOD Score -Free
2004 Genomewide scan for gout in Taiwanese aborigines reveals linkage to chromosome 4q25.
15252757
____________________________________________________________________________________________________________________________________________
Major Histocompatibility Complex -- Family of genes that encode key receptors of the immune response.
Free
2005 HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol.
15743917
____________________________________________________________________________________________________________________________________________
Medullary Cystic Kidney Disease -Abstract 2006 New developments in the epidemiology and genetics of gout.
16901080
Abstract 2006 Genetic factors associated with gout and hyperuricemia.
16580613
Abstract 2005 Hereditary hyperuricemia and renal disease.
15660329
____________________________________________________________________________________________________________________________________________
Metabolic Syndrome --
12
Abstract 2006 New developments in the epidemiology and genetics of gout.
16901080
Abstract 2006 Hyperuricemia and gout: diagnosis and therapy. [Article in German]
16586130
____________________________________________________________________________________________________________________________________________
Mexico -- Country or region.
Reference 2007 Homozygous frameshift mutation in the SLC22A12 gene in a patient with primary gout and high levels of serum uric acid.
17660342
____________________________________________________________________________________________________________________________________________
Monogenic Disorders -Abstract 2006 Genetic factors associated with gout and hyperuricemia.
16580613
____________________________________________________________________________________________________________________________________________
Obesity -Abstract 2006 Genetic factors associated with gout and hyperuricemia.
16580613
Abstract 2001 Clinical features of familial gout and effects of probable genetic association between gout and its related disorders.
11586494
____________________________________________________________________________________________________________________________________________
Pathophysiology -Abstract 2006 Genetic factors associated with gout and hyperuricemia.
16580613
Free
2005 Contribution of polymorphisms in the apolipoprotein AI-CIII-AIV cluster to hyperlipidaemia in patients with gout.
15115711
____________________________________________________________________________________________________________________________________________
Pharmacogenetics -Free
2005 HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol.
15743917
____________________________________________________________________________________________________________________________________________
Polygenic Disorders -- Disorders affected by many genes, each with relatively small effects.
Free
2005 Contribution of polymorphisms in the apolipoprotein AI-CIII-AIV cluster to hyperlipidaemia in patients with gout.
15115711
____________________________________________________________________________________________________________________________________________
Proteomics -Abstract 2006 Proteomic analysis of Down's syndrome patients with gout.
16500633
____________________________________________________________________________________________________________________________________________
Risk Estimates -Free
2005 HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol.
15743917
____________________________________________________________________________________________________________________________________________
Risk Factors -Abstract 2006 Association between intronic SNP in urate-anion exchanger gene, SLC22A12, and serum uric acid levels in Japanese.
16920156
Abstract 2006 New developments in the epidemiology and genetics of gout.
16901080
Abstract 2006 Genetic factors associated with gout and hyperuricemia.
16580613
Free
2005 A common mutation in an organic anion transporter gene, SLC22A12, is a suppressing factor for the development of gout.
16059895
Free
2005 HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol.
15743917
Free
2003 The elevated prevalence of apolipoprotein E2 in patients with gout is associated with reduced renal excretion of urates.
12626798
____________________________________________________________________________________________________________________________________________
Safety -Free
2005 HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol.
15743917
____________________________________________________________________________________________________________________________________________
13
SLC22A12 -- Solute Carrier Family 22 (Urate Transporter) Member 12 (also known as OAT4L, or as URAT1) - gene or related protein.
Reference 2007 Homozygous frameshift mutation in the SLC22A12 gene in a patient with primary gout and high levels of serum uric acid.
17660342
Abstract 2006 Association between intronic SNP in urate-anion exchanger gene, SLC22A12, and serum uric acid levels in Japanese.
16920156
Abstract 2007 Molecular analysis of the SLC22A12 (URAT1) gene in patients with primary gout.
16837472
Reference 2006 Gout--new insights into a forgotten disease.
16673214
Free
2005 A common mutation in an organic anion transporter gene, SLC22A12, is a suppressing factor for the development of gout.
16059895
____________________________________________________________________________________________________________________________________________
SLC22A12 rs893006 -- Polymorphism of SLC22A12 (G-T).
Abstract 2006 Association between intronic SNP in urate-anion exchanger gene, SLC22A12, and serum uric acid levels in Japanese.
16920156
____________________________________________________________________________________________________________________________________________
Taiwan -- Country or region.
Abstract 2007 Tumor necrosis factor-alpha and interleukin-4 gene polymorphisms in Chinese patients with gout.
17631734
Abstract 2007 Identification of a new single-nucleotide mutation on the hypoxanthine-guanine phosphoribosyltransferase gene from 983 cases with gout
17309125
in Taiwan.
Abstract 2005 Interleukin-1 receptor antagonist gene polymorphism in Taiwanese patients with gout.
15789892
Abstract 2005 Interleukin-1beta gene polymorphisms in Taiwanese patients with gout.
14661113
Abstract 2001 Clinical features of familial gout and effects of probable genetic association between gout and its related disorders.
11586494
Abstract 1999 Identification of a new single nucleotide substitution on the hypoxanthine-guanine phosphoribosyltransferase gene (HPRT(Tsou) from a
10451080
Taiwanese aboriginal family with severe gout.
____________________________________________________________________________________________________________________________________________
TNF -- Tumor Necrosis Factor Alpha (also known as TNF-alpha) - gene or related protein.
Abstract 2007 Tumor necrosis factor-alpha and interleukin-4 gene polymorphisms in Chinese patients with gout.
17631734
____________________________________________________________________________________________________________________________________________
TNF -308G-A -- Polymorphism of TNF (also known as TNF NcoI, or as rs1800629).
Abstract 2007 Tumor necrosis factor-alpha and interleukin-4 gene polymorphisms in Chinese patients with gout.
17631734
____________________________________________________________________________________________________________________________________________
Treatment -Abstract 2006 Hyperuricemia and gout: diagnosis and therapy. [Article in German]
16586130
Abstract 2006 Genetic factors associated with gout and hyperuricemia.
16580613
____________________________________________________________________________________________________________________________________________
Triglycerides -- Fats, usually as they might be reported in a blood lipid test.
Abstract 2007 Tumor necrosis factor-alpha and interleukin-4 gene polymorphisms in Chinese patients with gout.
17631734
Abstract 2007 Molecular analysis of the SLC22A12 (URAT1) gene in patients with primary gout.
16837472
Abstract 2005 Interleukin-1beta gene polymorphisms in Taiwanese patients with gout.
14661113
Free
2003 The elevated prevalence of apolipoprotein E2 in patients with gout is associated with reduced renal excretion of urates.
12626798
____________________________________________________________________________________________________________________________________________
UMOD -- Uromodulin - gene or related protein.
Abstract 2005 Hereditary hyperuricemia and renal disease.
15660329
____________________________________________________________________________________________________________________________________________
VLDL Cholesterol -- Very-Low Density Lipoprotein Cholesterol.
Free
2003 The elevated prevalence of apolipoprotein E2 in patients with gout is associated with reduced renal excretion of urates.
14
12626798
____________________________________________________________________________________________________________________________________________
* Ctrl+Click on the blue hyperlinks to see the full citations in PubMed®; any articles marked as "Free" can
be downloaded in PDF format by following the link provided there. This listing is a selected subset of those found
on PubMed® with emphasis on the interplay between genetics and the environment, including but not limited to
nutrition. The available subset includes many articles related to genetics from 2003 to date, with lighter coverage
and emphasis on review articles from 1998 through 2002. Additional relevant references may be found at
www.PubMed.gov.
Listings such as this can be used to stimulate discussions and partnerships with your
healthcare professionals, which we encourage. Information from this report is
not intended to be used for the diagnosis or treatment of any medical condition.
Please seek guidance from, and partnership with, a qualified healthcare Professional.
Nutrigenetics Unlimited, Inc.
15
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